Detailed information for compound 891483

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 471.501 | Formula: C28H25NO6
  • H donors: 1 H acceptors: 3 LogP: 4.54 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cccc(c1)C1C(=C(C(=O)N1Cc1ccccc1)O)C(=O)c1ccc2c(c1)OCCO2
  • InChi: 1S/C28H25NO6/c1-2-33-21-10-6-9-19(15-21)25-24(26(30)20-11-12-22-23(16-20)35-14-13-34-22)27(31)28(32)29(25)17-18-7-4-3-5-8-18/h3-12,15-16,25,31H,2,13-14,17H2,1H3
  • InChiKey: BNJPJAGVIDCKNB-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0067 0.0184
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0067 0.0209
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0032 0.0017
Brugia malayi GNS1/SUR4 family protein 0.0069 0.0399 0.1206
Leishmania major fatty acid elongase, putative 0.0069 0.0399 0.1247
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0284 0.2595 0.2584
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0157 0.1292 0.1289
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0157 0.1292 0.1279
Echinococcus granulosus cyclins 0.0046 0.0157 0.0142
Loa Loa (eye worm) fatty acid elongation protein 3 0.0069 0.0399 0.0385
Entamoeba histolytica type A flavoprotein, putative 0.0107 0.0784 1
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0107 0.0784 0.2412
Trypanosoma cruzi fatty acid elongase, putative 0.0344 0.3203 1
Trichomonas vaginalis D-aminoacylase, putative 0.0157 0.1292 0.5028
Brugia malayi Glycosyl hydrolases family 31 protein 0.0166 0.1389 0.4311
Treponema pallidum flavodoxin 0.0107 0.0784 1
Loa Loa (eye worm) ELO-9 protein 0.0069 0.0399 0.0385
Entamoeba histolytica type A flavoprotein, putative 0.0107 0.0784 1
Loa Loa (eye worm) hypothetical protein 0.0241 0.2156 0.2145
Leishmania major long chain polyunsaturated fatty acid elongation enzyme-like protein 0.0069 0.0399 0.1247
Giardia lamblia Nitric oxide synthase, inducible 0.0248 0.2225 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0074 0.0444 0.1345
Giardia lamblia Kinase, PLK 0.0074 0.0444 0.194
Trichomonas vaginalis penicillin-binding protein, putative 0.0157 0.1292 0.5028
Echinococcus multilocularis GTP binding nuclear protein Ran 0.007 0.0401 0.0386
Brugia malayi GNS1/SUR4 family protein 0.0344 0.3203 1
Toxoplasma gondii flavodoxin domain-containing protein 0.0139 0.1109 0.3463
Schistosoma mansoni microtubule-associated protein tau 0.0539 0.5198 0.5191
Schistosoma mansoni hypothetical protein 0.1008 1 1
Toxoplasma gondii NADH-cytochrome b5 reductase 1, putative 0.0032 0.0015 0.0047
Toxoplasma gondii ferredoxin NADP+ oxidoreductase FNR 0.0032 0.0015 0.0047
Mycobacterium ulcerans beta-lactamase 0.0157 0.1292 0.5038
Loa Loa (eye worm) hypothetical protein 0.0054 0.0238 0.0223
Leishmania major GTP-binding protein, putative 0.007 0.0401 0.125
Schistosoma mansoni elongation of fatty acids protein 1 0.0069 0.0399 0.0385
Echinococcus multilocularis beta LACTamase domain containing family member 0.0157 0.1292 0.1279
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0157 0.1292 0.1289
Plasmodium falciparum nitric oxide synthase, putative 0.028 0.255 0.7953
Schistosoma mansoni ran 0.007 0.0401 0.0386
Toxoplasma gondii integral membrane protein, GNS1/SUR4 family protein, putative 0.0344 0.3203 1
Leishmania major fatty acid elongase, putative 0.0069 0.0399 0.1247
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0032 0.0015 0.0047
Trichomonas vaginalis cyclin B, putative 0.0067 0.0375 0.14
Schistosoma mansoni cytochrome P450 reductase 0.028 0.255 0.2539
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.077 0.0757
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0034 0.0061
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0284 0.2595 0.2584
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0141 0.1133 0.1119
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0032 0.0015 0.0047
Echinococcus granulosus NADPH cytochrome P450 reductase 0.028 0.255 0.2539
Loa Loa (eye worm) GNS1/SUR4 family protein 0.0069 0.0399 0.0385
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0032 0.0053
Trypanosoma brucei importin beta-1 subunit, putative 0.0094 0.0655 0.2009
Giardia lamblia Hypothetical protein 0.0248 0.2225 1
Brugia malayi ImpB/MucB/SamB family protein 0.0034 0.0034 0.0061
Brugia malayi beta-lactamase 0.0157 0.1292 0.4007
Loa Loa (eye worm) hypothetical protein 0.0106 0.077 0.0757
Schistosoma mansoni NADPH flavin oxidoreductase 0.0141 0.1131 0.1118
Brugia malayi Cyclin, N-terminal domain containing protein 0.0067 0.0375 0.1128
Leishmania major fatty acid elongase, putative 0.0069 0.0399 0.1247
Schistosoma mansoni survival motor neuron protein 0.0049 0.0193 0.0178
Trypanosoma brucei Fatty acid elongase 0.0069 0.0399 0.1206
Schistosoma mansoni elongation of fatty acids protein 1 0.0069 0.0399 0.0385
Loa Loa (eye worm) hypothetical protein 0.0157 0.1292 0.1279
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0034 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0034 0.0061
Mycobacterium tuberculosis Probable hydrolase 0.0157 0.1292 0.1289
Echinococcus granulosus dna polymerase kappa 0.0034 0.0034 0.0019
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0032 0.0017
Schistosoma mansoni DNA polymerase eta 0.0054 0.0238 0.0223
Echinococcus multilocularis cyclins 0.0046 0.0157 0.0142
Leishmania major NADH-dependent fumarate reductase-like protein 0.0032 0.0015 0.0047
Trichomonas vaginalis esterase, putative 0.0157 0.1292 0.5028
Plasmodium vivax hypothetical protein, conserved 0.0107 0.0784 0.2412
Leishmania major importin beta-1 subunit, putative 0.0077 0.0473 0.1476
Plasmodium vivax importin-beta 2, putative 0.0094 0.0655 0.2009
Onchocerca volvulus Elongation of very long chain fatty acids protein homolog 0.0069 0.0399 0.3009
Plasmodium vivax hypothetical protein, conserved 0.0157 0.1292 0.4007
Mycobacterium ulcerans hypothetical protein 0.0157 0.1292 0.5038
Schistosoma mansoni terminal deoxycytidyl transferase 0.0034 0.0034 0.0019
Trichomonas vaginalis D-aminoacylase, putative 0.0157 0.1292 0.5028
Trypanosoma cruzi p450 reductase, putative 0.0032 0.0015 0.0047
Mycobacterium ulcerans DNA polymerase IV 0.0034 0.0034 0.0077
Trichomonas vaginalis DNA polymerase eta, putative 0.0034 0.0034 0.0056
Giardia lamblia G2/mitotic-specific cyclin B 0.0067 0.0375 0.1627
Trypanosoma cruzi cytochrome P450 reductase, putative 0.028 0.255 0.7963
Echinococcus multilocularis cyclin B3 1 0.0046 0.0157 0.0142
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0067 0.0433
Echinococcus granulosus cyclins 0.0046 0.0157 0.0142
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.0444 0.1674
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0284 0.2595 0.2584
Brugia malayi fatty acid elongation protein 3 0.0069 0.0399 0.1206
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.007 0.0401 0.121
Leishmania major reductase, putative 0.0032 0.0015 0.0047
Trypanosoma cruzi p450 reductase, putative 0.028 0.255 0.7963
Entamoeba histolytica type A flavoprotein, putative 0.0107 0.0784 1
Trypanosoma cruzi fatty acid elongase, putative 0.0344 0.3203 1
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0067 0.0375 0.1169
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0067 0.0433
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0063 0.0169
Plasmodium falciparum ataxin-2 like protein, putative 0.0039 0.0092 0.0242
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.007 0.0401 0.121
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0107 0.0784 0.3019
Leishmania major hypothetical protein, conserved 0.0157 0.1292 0.4035
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0193 0.0558
Loa Loa (eye worm) hypothetical protein 0.0039 0.0092 0.0077
Entamoeba histolytica type A flavoprotein, putative 0.0107 0.0784 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0034 0.0061
Loa Loa (eye worm) hypothetical protein 0.028 0.255 0.2539
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0032 0.0015 0.0047
Echinococcus multilocularis GPCR, family 2 0.0033 0.0032 0.0017
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0034 0.0034 0.0019
Plasmodium vivax long chain polyunsaturated fatty acid elongation enzyme, putative 0.0069 0.0399 0.1206
Trypanosoma brucei Long chain fatty acyl elongase 0.0069 0.0399 0.1206
Brugia malayi FAD binding domain containing protein 0.0173 0.1456 0.4521
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0032 0.0053
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0032 0.0015 0.0047
Echinococcus multilocularis dna polymerase kappa 0.0034 0.0034 0.0019
Loa Loa (eye worm) MH2 domain-containing protein 0.0092 0.0633 0.0619
Trypanosoma brucei hypothetical protein, conserved 0.0157 0.1292 0.4007
Giardia lamblia Cyclin A 0.0046 0.0157 0.0642
Leishmania major DNA polymerase eta, putative 0.0054 0.0238 0.0742
Trypanosoma cruzi DNA polymerase kappa, putative 0.0034 0.0034 0.0107
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0032 0.0015 0.0047
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0032 0.0017
Trypanosoma brucei PAB1-binding protein , putative 0.0039 0.0092 0.0242
Leishmania major fatty acid elongase, putative 0.0069 0.0399 0.1247
Echinococcus granulosus elongation of very long chain fatty acids 0.0069 0.0399 0.0385
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0157 0.1292 0.1279
Trypanosoma cruzi fatty acid elongase, putative 0.0069 0.0399 0.1247
Echinococcus multilocularis importin subunit beta 1 0.0094 0.0655 0.0642
Onchocerca volvulus 0.0069 0.0399 0.3009
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0032 0.0015 0.0047
Echinococcus multilocularis snurportin 1 0.1008 1 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.007 0.0401 0.0386
Echinococcus multilocularis methionine synthase reductase 0.0173 0.1456 0.1443
Mycobacterium ulcerans lipase LipD 0.0157 0.1292 0.5038
Leishmania major oxidoreductase-like protein 0.0032 0.0015 0.0047
Trichomonas vaginalis cyclin A, putative 0.0067 0.0375 0.14
Leishmania major fatty acid elongase, putative 0.0069 0.0399 0.1247
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0067 0.0163
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.007 0.0401 0.125
Trichomonas vaginalis importin beta-1, putative 0.0077 0.0473 0.1789
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0034 0.0034 0.0019
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0032 0.0015 0.0047
Echinococcus granulosus importin subunit beta 1 0.0094 0.0655 0.0642
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.007 0.0401 0.1745
Leishmania major fatty acid elongase, putative 0.0069 0.0399 0.1247
Loa Loa (eye worm) hypothetical protein 0.0157 0.1292 0.1279
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0067 0.0184
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0067 0.0184
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0067 0.0184
Trypanosoma cruzi PAB1-binding protein , putative 0.0039 0.0092 0.0287
Schistosoma mansoni elongation of fatty acids protein 1 0.0069 0.0399 0.0385
Brugia malayi fatty acid elongation protein 3 0.0069 0.0399 0.1206
Trichomonas vaginalis cyclin D, putative 0.0046 0.0157 0.054
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0284 0.2595 0.2584
Leishmania major NADH-cytochrome b5 reductase, putative 0.0032 0.0015 0.0047
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0444 0.0429
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.007 0.0401 0.121
Entamoeba histolytica Ran family GTPase 0.007 0.0401 0.4885
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0157 0.1292 0.5038
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0067 0.0209
Loa Loa (eye worm) transcription factor SMAD2 0.0092 0.0633 0.0619
Echinococcus multilocularis cyclins 0.0046 0.0157 0.0142
Entamoeba histolytica type A flavoprotein, putative 0.0107 0.0784 1
Toxoplasma gondii flavodoxin domain-containing protein 0.0139 0.1109 0.3463
Brugia malayi Cyclin, N-terminal domain containing protein 0.0067 0.0375 0.1128
Toxoplasma gondii GNS1/SUR4 family protein 0.0344 0.3203 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0032 0.0017
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0074 0.0444 0.0429
Echinococcus granulosus cyclin B3 1 0.0046 0.0157 0.0142
Schistosoma mansoni elongation of fatty acids protein 1 0.0069 0.0399 0.0385
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0077 0.0473 0.1789
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0429 0.1297
Loa Loa (eye worm) FAD binding domain-containing protein 0.0173 0.1456 0.1443
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.1389 0.1376
Echinococcus granulosus cyclin b3 0.0046 0.0157 0.0142
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.028 0.255 0.7963
Onchocerca volvulus 0.0067 0.0375 0.2816
Trichomonas vaginalis D-aminoacylase, putative 0.0157 0.1292 0.5028
Echinococcus granulosus microtubule associated protein 2 0.0539 0.5198 0.5191
Echinococcus granulosus beta LACTamase domain containing family member 0.0157 0.1292 0.1279
Echinococcus multilocularis cyclins 0.0046 0.0157 0.0142
Leishmania major nitrate reductase, putative 0.0032 0.0015 0.0047
Plasmodium vivax GNS1/SUR4 domain containing protein 0.0344 0.3203 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0067 0.0184
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0067 0.0184
Brugia malayi beta-lactamase family protein 0.0157 0.1292 0.4007
Plasmodium falciparum long chain polyunsaturated fatty acid elongation enzyme, putative 0.0069 0.0399 0.1206
Loa Loa (eye worm) fatty acid elongation protein 3 0.0069 0.0399 0.0385
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.028 0.255 0.7963
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0032 0.0015 0.0047
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0034 0.0034 0.0019
Echinococcus granulosus cyclin B 0.0067 0.0375 0.036
Brugia malayi Fatty acid elongation protein 3 0.0344 0.3203 1
Entamoeba histolytica cyclin, putative 0.0067 0.0375 0.4538
Loa Loa (eye worm) fatty acid elongation protein 3 0.0069 0.0399 0.0385
Schistosoma mansoni hypothetical protein 0.0268 0.2434 0.2423
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0284 0.2595 0.2584
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0107 0.0784 0.3019
Trypanosoma brucei mitotic cyclin 6 0.0067 0.0375 0.1128
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.0444 0.1674
Leishmania major hypothetical protein, conserved 0.0039 0.0092 0.0287
Echinococcus multilocularis microtubule associated protein 2 0.0539 0.5198 0.5191
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.007 0.0401 0.125
Leishmania major fatty acid elongase, putative 0.0069 0.0399 0.1247
Trypanosoma brucei Fatty acid elongase 0.0069 0.0399 0.1206
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0067 0.0209
Echinococcus multilocularis dna polymerase eta 0.0054 0.0238 0.0223
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0157 0.054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0284 0.2595 0.2584
Brugia malayi Hypothetical 34.1 kDa protein C40H1.4 in chromosome III 0.0069 0.0399 0.1206
Trypanosoma cruzi DNA polymerase kappa, putative 0.0034 0.0034 0.0107
Trypanosoma cruzi fatty acid elongase, putative 0.0344 0.3203 1
Schistosoma mansoni hypothetical protein 0.0072 0.0429 0.0414
Trichomonas vaginalis cyclins, putative 0.0067 0.0375 0.14
Brugia malayi fatty acid elongation protein 3 0.0069 0.0399 0.1206
Trichomonas vaginalis cyclins, putative 0.0067 0.0375 0.14
Loa Loa (eye worm) hypothetical protein 0.0067 0.0375 0.036
Trypanosoma cruzi cytochrome P450 reductase, putative 0.028 0.255 0.7963
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0107 0.0784 0.2412
Trypanosoma cruzi DNA polymerase kappa, putative 0.0034 0.0034 0.0107
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0034 0.0061
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.028 0.255 0.2539
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.028 0.255 0.2539
Trichomonas vaginalis cyclins, putative 0.0067 0.0375 0.14
Plasmodium falciparum cyclin 0.0046 0.0157 0.0445
Onchocerca volvulus Elongation of very long chain fatty acids protein 5 homolog 0.0069 0.0399 0.3009
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.028 0.255 0.7953
Trypanosoma brucei Fatty acid elongase 0.0344 0.3203 1
Plasmodium vivax ataxin-2 like protein, putative 0.0039 0.0092 0.0242
Leishmania major cyclin 0.0067 0.0375 0.1169
Trypanosoma cruzi cyclin, putative 0.0067 0.0375 0.1169
Leishmania major fatty acid elongase, putative 0.0069 0.0399 0.1247
Mycobacterium tuberculosis Conserved protein 0.0157 0.1292 0.1289
Echinococcus granulosus elongation of very long chain fatty acids 0.0069 0.0399 0.0385
Trypanosoma cruzi cyclin 6, putative 0.0067 0.0375 0.1169
Chlamydia trachomatis sulfite reductase 0.0173 0.1456 1
Trypanosoma cruzi CYC2-like cyclin, putative 0.0067 0.0375 0.1169
Schistosoma mansoni alpha glucosidase 0.0037 0.0067 0.0052
Trypanosoma cruzi PAB1-binding protein , putative 0.0039 0.0092 0.0287
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0107 0.0784 0.2448
Schistosoma mansoni hypothetical protein 0.0033 0.0032 0.0017
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.1389 0.1376
Trypanosoma cruzi fatty acid elongase, putative 0.0069 0.0399 0.1247
Echinococcus granulosus cyclins 0.0046 0.0157 0.0142
Trypanosoma brucei elongation of very long chain fatty acids protein, putative 0.0069 0.0399 0.1206
Plasmodium falciparum importin beta, putative 0.0094 0.0655 0.2009
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0067 0.0184
Leishmania major cytochrome-b5 reductase, putative 0.0032 0.0015 0.0047
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1001 0.9928 1
Schistosoma mansoni fatty acid acyl transferase-related 0.0069 0.0399 0.0385
Leishmania major cytochrome-b5 reductase, putative 0.0032 0.0015 0.0047
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0034 0.0034 0.002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0157 0.1292 0.1279
Plasmodium falciparum ataxin-2 like protein, putative 0.0039 0.0092 0.0242
Schistosoma mansoni ran 0.007 0.0401 0.0386
Toxoplasma gondii hypothetical protein 0.0035 0.0044 0.0138
Leishmania major DNA polymerase kappa, putative 0.0034 0.0034 0.0107
Schistosoma mansoni kinase 0.0037 0.0073 0.0058
Trypanosoma cruzi hypothetical protein, conserved 0.0157 0.1292 0.4035
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0067 0.0209
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.0238 0.0699
Echinococcus granulosus dna polymerase eta 0.0054 0.0238 0.0223
Onchocerca volvulus Elongation of very long chain fatty acids protein homolog 0.0069 0.0399 0.3009
Schistosoma mansoni alpha-glucosidase 0.0143 0.1153 0.1139
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.1008 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0032 0.0017
Trypanosoma cruzi fatty acid elongase, putative 0.0069 0.0399 0.1247
Leishmania major fatty acid elongase, putative 0.0069 0.0399 0.1247
Echinococcus granulosus GPCR family 2 0.0033 0.0032 0.0017
Leishmania major cytochrome P450 reductase, putative 0.0248 0.2225 0.6947
Loa Loa (eye worm) hypothetical protein 0.0069 0.0399 0.0385
Trypanosoma cruzi importin beta-1 subunit, putative 0.0077 0.0473 0.1476
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.007 0.0401 0.125
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0238 0.0699
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0074 0.0444 0.0429
Onchocerca volvulus 0.0049 0.0193 0.1393
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.028 0.255 0.7953
Schistosoma mansoni importin beta-1 0.0094 0.0655 0.0642
Onchocerca volvulus 0.0069 0.0399 0.3009
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.028 0.255 0.7953
Leishmania major fatty acid elongase, putative 0.0344 0.3203 1
Trichomonas vaginalis cyclins, putative 0.0046 0.0157 0.054
Plasmodium falciparum fatty acid elongation protein, GNS1/SUR4 family, putative 0.0344 0.3203 1
Entamoeba histolytica hypothetical protein 0.0077 0.0473 0.5849
Leishmania major NADH-cytochrome b5 reductase, putative 0.0032 0.0015 0.0047
Schistosoma mansoni hypothetical protein 0.0033 0.0032 0.0017
Trypanosoma brucei unspecified product 0.0034 0.0034 0.0061
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0032 0.0015 0.0047
Mycobacterium tuberculosis Conserved protein 0.0157 0.1292 0.1289
Brugia malayi hypothetical protein 0.0241 0.2156 0.6717
Schistosoma mansoni alpha-glucosidase 0.0143 0.1153 0.1139
Echinococcus multilocularis cyclin b3 0.0046 0.0157 0.0142
Schistosoma mansoni hypothetical protein 0.0049 0.0193 0.0178
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0032 0.0015 0.0047
Schistosoma mansoni hypothetical protein 0.0033 0.0032 0.0017
Echinococcus multilocularis elongation of very long chain fatty acids 0.0069 0.0399 0.0385
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.077 0.237
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0173 0.1456 0.1443
Toxoplasma gondii LsmAD domain-containing protein 0.0039 0.0092 0.0287
Brugia malayi Cyclin, N-terminal domain containing protein 0.0141 0.1133 0.3506
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.007 0.0401 0.0386
Mycobacterium ulcerans DNA polymerase IV 0.0034 0.0034 0.0077
Echinococcus multilocularis survival motor neuron protein 1 0.0241 0.2156 0.2145
Loa Loa (eye worm) hypothetical protein 0.0157 0.1292 0.1279
Entamoeba histolytica serine/threonine protein kinase, putative 0.0074 0.0444 0.546
Brugia malayi Importin beta-1 subunit 0.0094 0.0655 0.2009
Plasmodium falciparum long chain fatty acid elongation enzyme, putative 0.0344 0.3203 1
Plasmodium vivax elongation of very long chain fatty acids protein 3, putative 0.0069 0.0399 0.1206
Brugia malayi beta-lactamase family protein 0.0157 0.1292 0.4007
Brugia malayi FAD binding domain containing protein 0.028 0.255 0.7953
Mycobacterium ulcerans esterase/lipase LipP 0.0157 0.1292 0.5038
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0077 0.0473 0.1789
Trypanosoma cruzi oxidoreductase-protein, putative 0.0032 0.0015 0.0047
Leishmania major fatty acid elongase, putative 0.0069 0.0399 0.1247
Loa Loa (eye worm) hypothetical protein 0.0157 0.1292 0.1279
Toxoplasma gondii fatty acid elongase 0.0069 0.0399 0.1247
Echinococcus granulosus geminin 0.0268 0.2434 0.2423
Echinococcus granulosus cyclins 0.0046 0.0157 0.0142
Trichomonas vaginalis cyclin B, putative 0.0067 0.0375 0.14
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0157 0.1292 0.1289
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0034 0.0061
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0107 0.0784 0.2412
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0034 0.0061
Leishmania major hypothetical protein, conserved 0.0107 0.0784 0.2448
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0284 0.2595 0.8093
Mycobacterium tuberculosis Probable esterase LipL 0.0157 0.1292 0.1289
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0032 0.0015 0.0047
Plasmodium vivax flavodoxin domain containing protein 0.0248 0.2225 0.6933
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0032 0.0015 0.0047
Mycobacterium tuberculosis Conserved protein 0.0157 0.1292 0.1289
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0032 0.0015 0.0047
Echinococcus granulosus survival motor neuron protein 1 0.0241 0.2156 0.2145
Mycobacterium tuberculosis Probable lipase LipE 0.0157 0.1292 0.1289
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0238 0.0742
Toxoplasma gondii ABC1 family protein 0.0157 0.1292 0.4035
Trypanosoma cruzi fatty acid elongase, putative 0.0069 0.0399 0.1247
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0107 0.0784 0.3019
Loa Loa (eye worm) hypothetical protein 0.0067 0.0375 0.036
Trichomonas vaginalis sulfite reductase, putative 0.028 0.255 1
Loa Loa (eye worm) beta-lactamase 0.0157 0.1292 0.1279
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0067 0.0052
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0166 0.1389 0.1376
Loa Loa (eye worm) hypothetical protein 0.0094 0.0655 0.0642
Trypanosoma brucei polo-like protein kinase 0.0074 0.0444 0.1345
Trypanosoma cruzi reductase, putative 0.0032 0.0015 0.0047
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0067 0.0184
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0626 0.6095 0.6089
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0284 0.2595 0.2584
Trypanosoma cruzi fatty acid elongase, putative 0.0069 0.0399 0.1247
Trichomonas vaginalis cyclin B, putative 0.0046 0.0157 0.054
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.077 0.237
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0248 0.2225 0.8715
Leishmania major p450 reductase, putative 0.028 0.255 0.7963
Trypanosoma brucei glucosidase, putative 0.0037 0.0067 0.0163
Schistosoma mansoni cyclins 0.0046 0.0157 0.0142
Echinococcus multilocularis cyclins 0.0046 0.0157 0.0142
Trichomonas vaginalis penicillin-binding protein, putative 0.0157 0.1292 0.5028
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0034 0.0061
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0034 0.0034 0.0056
Echinococcus multilocularis cyclin B 0.0067 0.0375 0.036
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0107 0.0784 0.2448
Trichomonas vaginalis cyclin B3, putative 0.0046 0.0157 0.054
Loa Loa (eye worm) hypothetical protein 0.0157 0.1292 0.1279
Brugia malayi flavodoxin family protein 0.028 0.255 0.7953
Echinococcus multilocularis elongation of very long chain fatty acids 0.0069 0.0399 0.0385
Entamoeba histolytica cyclin family protein 0.0046 0.0157 0.1633
Trypanosoma cruzi DNA polymerase kappa, putative 0.0034 0.0034 0.0107
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0284 0.2595 0.2584
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0034 0.0061
Mycobacterium leprae conserved hypothetical protein 0.0157 0.1292 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.0444 0.1674
Trichomonas vaginalis cyclin D, putative 0.0046 0.0157 0.054
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0034 0.0034 0.0107
Trypanosoma brucei importin beta-1 subunit, putative 0.0094 0.0655 0.2009
Onchocerca volvulus Serine\/threonine kinase homolog 0.0074 0.0444 0.3356
Echinococcus granulosus methionine synthase reductase 0.0173 0.1456 0.1443
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0063 0.0169
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.007 0.0401 0.121
Loa Loa (eye worm) cyclin domain-containing protein 0.0141 0.1133 0.1119
Leishmania major fatty acid elongase, putative 0.0344 0.3203 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0074 0.0444 0.0429
Trypanosoma cruzi nitrate reductase, putative 0.0032 0.0015 0.0047
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.0444 0.1674
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.0444 0.1674
Mycobacterium tuberculosis Conserved hypothetical protein 0.0034 0.0034 0.002
Loa Loa (eye worm) GNS1/SUR4 family protein 0.0344 0.3203 0.3193
Echinococcus multilocularis cyclins 0.0046 0.0157 0.0142
Loa Loa (eye worm) fatty acid elongation protein 3 0.0344 0.3203 0.3193
Onchocerca volvulus 0.0157 0.1292 1
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.028 0.255 0.2539
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0034 0.0061
Mycobacterium tuberculosis Probable lipase LipD 0.0157 0.1292 0.1289
Onchocerca volvulus 0.0096 0.0673 0.5149
Schistosoma mansoni hypothetical protein 0.0268 0.2434 0.2423
Entamoeba histolytica cyclin family protein 0.0046 0.0157 0.1633
Onchocerca volvulus 0.0157 0.1292 1
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.0444 0.1674
Brugia malayi fatty acid elongation protein 3 0.0069 0.0399 0.1206
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.0444 0.1674
Loa Loa (eye worm) FAD binding domain-containing protein 0.028 0.255 0.2539
Brugia malayi flavodoxin family protein 0.0107 0.0784 0.2412
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0067 0.0052
Brugia malayi hypothetical protein 0.0039 0.0092 0.0242
Leishmania major NADH-dependent fumarate reductase, putative 0.0032 0.0015 0.0047
Trichomonas vaginalis cyclin B, putative 0.0067 0.0375 0.14
Brugia malayi RNA, U transporter 1 0.0269 0.2436 0.7595
Toxoplasma gondii HEAT repeat-containing protein 0.0094 0.0655 0.2047
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0034 0.0034 0.0019
Schistosoma mansoni diflavin oxidoreductase 0.0139 0.1109 0.1096
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.028 0.255 0.7953
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0034 0.0061
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0067 0.0184
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0067 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0034 0.0061
Brugia malayi MH2 domain containing protein 0.0092 0.0633 0.1938
Trichomonas vaginalis ran, putative 0.007 0.0401 0.1503
Trypanosoma cruzi fatty acid elongase, putative 0.0344 0.3203 1
Leishmania major fatty acid elongase, putative 0.0344 0.3203 1
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0141 0.1133 0.1119
Schistosoma mansoni cyclin B 0.0067 0.0375 0.036
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0157 0.1292 0.4007
Trypanosoma cruzi polo-like protein kinase, putative 0.0074 0.0444 0.1385
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0032 0.0015 0.0047
Echinococcus granulosus cyclins 0.0046 0.0157 0.0142
Trypanosoma cruzi fatty acid elongase, putative 0.0069 0.0399 0.1247
Onchocerca volvulus 0.0157 0.1292 1
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.028 0.255 0.7953
Entamoeba histolytica cyclin, putative 0.0046 0.0157 0.1633
Echinococcus multilocularis cyclins 0.0046 0.0157 0.0142
Trichomonas vaginalis cyclins, putative 0.0067 0.0375 0.14
Loa Loa (eye worm) flavodoxin family protein 0.0107 0.0784 0.077
Trichomonas vaginalis cyclin B, putative 0.0067 0.0375 0.14
Echinococcus granulosus lysosomal alpha glucosidase 0.0166 0.1389 0.1376
Echinococcus multilocularis cyclins 0.0046 0.0157 0.0142
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0032 0.0015 0.0047
Trypanosoma cruzi cyclin, putative 0.0067 0.0375 0.1169
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0034 0.0061
Trypanosoma cruzi polo-like protein kinase, putative 0.0074 0.0444 0.1385
Giardia lamblia Hypothetical protein 0.0046 0.0157 0.0642
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0107 0.0784 0.3019
Echinococcus multilocularis geminin 0.0268 0.2434 0.2423
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0107 0.0784 0.2448
Schistosoma mansoni hypothetical protein 0.0033 0.0032 0.0017
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0074 0.0444 0.1385
Trypanosoma cruzi hypothetical protein, conserved 0.0157 0.1292 0.4035
Leishmania major NADH-cytochrome b5 reductase, putative 0.0032 0.0015 0.0047
Schistosoma mansoni cyclin B3 0.0141 0.1133 0.1119
Giardia lamblia DINP protein human, muc B family 0.0034 0.0034 0.0088
Loa Loa (eye worm) hypothetical protein 0.0072 0.0429 0.0414
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.028 0.255 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.1292 0.1279
Mycobacterium leprae Probable lipase LipE 0.0157 0.1292 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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