Detailed information for compound 893603

Basic information

Technical information
  • TDR Targets ID: 893603
  • Name: N-(3-chloro-2-methylphenyl)-2-[[5-(phenylmeth yl)-4-propyl-1,2,4-triazol-3-yl]sulfanyl]acet amide
  • MW: 414.952 | Formula: C21H23ClN4OS
  • H donors: 1 H acceptors: 3 LogP: 4.95 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCn1c(SCC(=O)Nc2cccc(c2C)Cl)nnc1Cc1ccccc1
  • InChi: 1S/C21H23ClN4OS/c1-3-12-26-19(13-16-8-5-4-6-9-16)24-25-21(26)28-14-20(27)23-18-11-7-10-17(22)15(18)2/h4-11H,3,12-14H2,1-2H3,(H,23,27)
  • InChiKey: NDRKMZOISLKQHT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-chloro-2-methyl-phenyl)-2-[[5-(phenylmethyl)-4-propyl-1,2,4-triazol-3-yl]sulfanyl]acetamide
  • N-(3-chloro-2-methylphenyl)-2-[[5-(phenylmethyl)-4-propyl-1,2,4-triazol-3-yl]thio]acetamide
  • 2-[[5-(benzyl)-4-propyl-1,2,4-triazol-3-yl]thio]-N-(3-chloro-2-methyl-phenyl)acetamide
  • N-(3-chloro-2-methyl-phenyl)-2-[[5-(phenylmethyl)-4-propyl-1,2,4-triazol-3-yl]sulfanyl]ethanamide
  • ZINC02837630

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis dro:myosuppressin receptor 0.0042 0.0709 0.0709
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0042 0.0709 0.0709
Brugia malayi hypothetical protein 0.0042 0.0709 0.0709
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0087 0.2138 0.2138
Brugia malayi neuropeptide F receptor 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0037 0.0568 0.0568
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0709 0.0709
Brugia malayi ORL1-like opioid receptor 0.0042 0.0709 0.0709
Echinococcus multilocularis neuropeptides capa receptor 0.0042 0.0709 0.0709
Schistosoma mansoni biogenic amine receptor 0.0042 0.0709 0.0709
Schistosoma mansoni biogenic amine (5HT) receptor 0.0042 0.0709 0.0709
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0042 0.0709 0.0709
Schistosoma mansoni neuropeptide F-like receptor 0.0042 0.0709 0.0709
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0709 0.0709
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0037 0.0568 0.0568
Echinococcus multilocularis musashi 0.0026 0.0221 0.0221
Echinococcus granulosus high affinity choline transporter 1 0.0337 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.0709 0.0709
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0133 0.358 0.358
Brugia malayi hypothetical protein 0.0042 0.0709 0.0709
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0709 0.0709
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0709 0.0709
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.1082 0.1082
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0709 0.0709
Echinococcus multilocularis geminin 0.0164 0.4567 0.4567
Onchocerca volvulus 0.0042 0.0709 0.226
Schistosoma mansoni histamine h1 receptor 0.0042 0.0709 0.0709
Brugia malayi hypothetical protein 0.0042 0.0709 0.0709
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0907 0.0907
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0042 0.0709 0.0709
Loa Loa (eye worm) G-protein coupled receptor 0.0042 0.0709 0.0709
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0709 0.0709
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0133 0.358 0.358
Brugia malayi larval opioid receptor 0.0042 0.0709 0.0709
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0133 0.358 1
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0133 0.358 1
Echinococcus multilocularis sex peptide receptor 0.0042 0.0709 0.0709
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0133 0.358 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Schistosoma mansoni lamin 0.0026 0.0221 0.0221
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0087 0.2138 0.2138
Schistosoma mansoni amine GPCR 0.0042 0.0709 0.0709
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0709 0.0709
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0042 0.0709 0.0709
Brugia malayi AKH receptor 0.0042 0.0709 0.0709
Brugia malayi putative neuropeptide receptor NPR1 0.0042 0.0709 0.0709
Onchocerca volvulus 0.0048 0.0907 0.2893
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0042 0.0709 0.0709
Echinococcus granulosus neuropeptide Y receptor 0.0042 0.0709 0.0709
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0042 0.0709 0.0709
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.0709 0.0709
Echinococcus granulosus neuropeptide s receptor 0.0042 0.0709 0.0709
Echinococcus multilocularis neuropeptides capa receptor 0.0042 0.0709 0.0709
Onchocerca volvulus 0.0042 0.0709 0.226
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Echinococcus multilocularis equilibrative nucleoside transporter protein 0.008 0.191 0.191
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Echinococcus granulosus alpha 1A adrenergic receptor 0.0042 0.0709 0.0709
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.008 0.191 0.3903
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0037 0.0568 0.0568
Echinococcus multilocularis tumor protein p63 0.0328 0.9704 0.9704
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0709 0.0709
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0709 0.0709
Loa Loa (eye worm) melatonin receptor type 1A 0.0042 0.0709 0.0709
Echinococcus multilocularis neuropeptide s receptor 0.0042 0.0709 0.0709
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0133 0.358 1
Onchocerca volvulus 0.0042 0.0709 0.226
Echinococcus multilocularis neuropeptide Y receptor 0.0042 0.0709 0.0709
Schistosoma mansoni inositol transporter 0.0037 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.008 0.191 0.191
Onchocerca volvulus Huntingtin homolog 0.0119 0.3135 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0037 0.0568 0.0568
Brugia malayi G-protein coupled receptor 0.0042 0.0709 0.0709
Echinococcus multilocularis serotonin receptor 0.0042 0.0709 0.0709
Echinococcus granulosus tumor protein p63 0.0328 0.9704 0.9704
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Onchocerca volvulus 0.0042 0.0709 0.226
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0709 0.0709
Echinococcus granulosus sodium:myo inositol cotransporter 0.0037 0.0568 0.0568
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0133 0.358 0.5
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Brugia malayi G protein-coupled receptor F59B2.13 0.0042 0.0709 0.0709
Brugia malayi follicle stimulating hormone receptor 0.0042 0.0709 0.0709
Brugia malayi Serotonin receptor 0.0042 0.0709 0.0709
Onchocerca volvulus 0.0037 0.0568 0.1811
Onchocerca volvulus 0.0042 0.0709 0.226
Brugia malayi G protein-coupled receptor 0.0042 0.0709 0.0709
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0087 0.2136 0.1354
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0037 0.0568 0.0568
Loa Loa (eye worm) neuropeptide F receptor 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Brugia malayi intermediate filament protein 0.0026 0.0221 0.0221
Echinococcus granulosus geminin 0.0164 0.4567 0.4567
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0133 0.358 0.358
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Brugia malayi Tachykinin-like peptides receptor 99D 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Onchocerca volvulus 0.0042 0.0709 0.226
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0066 0.1474 0.1474
Brugia malayi hypothetical protein 0.0119 0.3135 0.3135
Echinococcus granulosus lamin 0.0026 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Entamoeba histolytica nucleoside transporter, putative 0.008 0.191 0.1544
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0133 0.358 1
Echinococcus granulosus fmrfamide receptor 0.0042 0.0709 0.0709
Schistosoma mansoni lamin 0.0026 0.0221 0.0221
Echinococcus multilocularis serotonin receptor 0.0042 0.0709 0.0709
Echinococcus multilocularis neuropeptide receptor 0.0042 0.0709 0.0709
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0133 0.358 1
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0087 0.2138 0.2138
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.008 0.191 0.3903
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.1605 0.1605
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0042 0.0709 0.0709
Schistosoma mansoni amine GPCR 0.0042 0.0709 0.0709
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.0709 0.0709
Schistosoma mansoni growth hormone secretagogue receptor 0.0042 0.0709 0.0709
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0133 0.358 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Echinococcus granulosus orexin receptor type 2 0.0042 0.0709 0.0709
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0133 0.358 1
Schistosoma mansoni sodium/solute symporter 0.0037 0.0568 0.0568
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0133 0.358 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0042 0.0709 0.0709
Echinococcus multilocularis orexin receptor type 2 0.0042 0.0709 0.0709
Echinococcus granulosus neuropeptide receptor 0.0042 0.0709 0.0709
Echinococcus granulosus biogenic amine 5HT receptor 0.0042 0.0709 0.0709
Echinococcus granulosus neuropeptides capa receptor 0.0042 0.0709 0.0709
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0709 0.0709
Schistosoma mansoni biogenic amine receptor 0.0042 0.0709 0.0709
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0709 0.0709
Schistosoma mansoni adenoreceptor 0.0042 0.0709 0.0709
Echinococcus multilocularis neuropeptide receptor A26 0.0042 0.0709 0.0709
Echinococcus multilocularis lamin dm0 0.0026 0.0221 0.0221
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0709 0.0709
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0087 0.2136 0.4996
Brugia malayi hypothetical protein 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Echinococcus multilocularis g-protein coupled receptor 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Schistosoma mansoni hypothetical protein 0.0042 0.0709 0.0709
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Schistosoma mansoni lipoxygenase 0.0054 0.1082 0.1082
Echinococcus granulosus 7tm_1 domain containing protein 0.0042 0.0709 0.0709
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0133 0.358 1
Schistosoma mansoni inositol transporter 0.0037 0.0568 0.0568
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0709 0.0709
Onchocerca volvulus 0.0042 0.0709 0.226
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0133 0.358 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Brugia malayi GnHR receptor homolog 0.0042 0.0709 0.0709
Onchocerca volvulus 0.0042 0.0709 0.226
Schistosoma mansoni neuropeptide f receptor 76f 0.0042 0.0709 0.0709
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.0709 0.0709
Brugia malayi hypothetical protein 0.0042 0.0709 0.0709
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0042 0.0709 0.0709
Schistosoma mansoni biogenic amine (5HT) receptor 0.0042 0.0709 0.0709
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0042 0.0709 0.0709
Onchocerca volvulus 0.0042 0.0709 0.226
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0133 0.358 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0042 0.0709 0.0709
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0133 0.358 0.358
Echinococcus multilocularis neuropeptide FF receptor 2 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0709 0.0709
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.008 0.191 0.6091
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0709 0.0709
Onchocerca volvulus 0.0026 0.0221 0.0705
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0042 0.0709 0.0709
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0042 0.0709 0.0709
Echinococcus multilocularis lamin 0.0026 0.0221 0.0221
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0133 0.358 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.2138 0.2138
Schistosoma mansoni neuropeptide F-like receptor 0.0042 0.0709 0.0709
Brugia malayi Dopamine receptor protein 1 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.008 0.191 0.191
Echinococcus granulosus equilibrative nucleoside transporter 0.008 0.191 0.191
Brugia malayi putative neuropeptide receptor 0.0042 0.0709 0.0709
Echinococcus granulosus allatostatin A receptor 0.0042 0.0709 0.0709
Onchocerca volvulus 0.0042 0.0709 0.226
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0133 0.358 0.358
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0133 0.358 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0133 0.358 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0042 0.0709 0.0709
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0046 0.0841 0.0841
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0709 0.0709
Echinococcus multilocularis neuropeptide Y receptor 0.0042 0.0709 0.0709
Schistosoma mansoni myosin xvIII 0.0042 0.0709 0.0709
Brugia malayi RE15519p 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0048 0.0907 0.0907
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.0709 0.0709
Echinococcus granulosus sodium:glucose cotransporter 0.0037 0.0568 0.0568
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0709 0.0709
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0046 0.0843 0.5
Onchocerca volvulus 0.0042 0.0709 0.226
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0087 0.2138 0.4737
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0709 0.0709
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0221 0.0221
Echinococcus granulosus neuropeptides capa receptor 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0133 0.358 0.358
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Echinococcus multilocularis somatostatin receptor 0.0042 0.0709 0.0709
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0133 0.358 1
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0133 0.358 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0087 0.2138 0.4737
Schistosoma mansoni opsin-like receptor 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Brugia malayi Dopamine receptor protein 2 0.0042 0.0709 0.0709
Echinococcus granulosus neuropeptide Y receptor 0.0042 0.0709 0.0709
Echinococcus multilocularis fmrfamide receptor 0.0042 0.0709 0.0709
Onchocerca volvulus Huntingtin homolog 0.0119 0.3135 1
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0133 0.358 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0042 0.0709 0.0709
Echinococcus granulosus g protein coupled receptor 0.0042 0.0709 0.0709
Schistosoma mansoni biogenic amine receptor 0.0042 0.0709 0.0709
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0042 0.0709 0.0709
Echinococcus granulosus biogenic amine 5HT receptor 0.0042 0.0709 0.0709
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.008 0.191 0.3903
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.1605 0.1605
Loa Loa (eye worm) TYRA-2 protein 0.0042 0.0709 0.0709
Onchocerca volvulus 0.0042 0.0709 0.226
Onchocerca volvulus 0.0026 0.0221 0.0705
Echinococcus multilocularis allatostatin A receptor 0.0042 0.0709 0.0709
Brugia malayi Sodium:solute symporter family protein 0.0037 0.0568 0.0568
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.008 0.191 0.191
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0133 0.358 0.358
Brugia malayi Serotonin receptor 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Brugia malayi hypothetical protein 0.0042 0.0709 0.0709
Onchocerca volvulus 0.0042 0.0709 0.226
Brugia malayi hypothetical protein 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0709 0.0709
Onchocerca volvulus 0.0042 0.0709 0.226
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0041 0.0694 0.0694
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.008 0.191 0.3903
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0221 0.0221
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.008 0.191 0.6091
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0092 0.2285 0.2285
Loa Loa (eye worm) hypothetical protein 0.0119 0.3135 0.3135
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Schistosoma mansoni neuropeptide receptor 0.0042 0.0709 0.0709
Echinococcus granulosus G protein coupled receptor 139 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.008 0.191 0.191
Schistosoma mansoni neuropeptide receptor 0.0042 0.0709 0.0709
Echinococcus granulosus somatostatin receptor 0.0042 0.0709 0.0709
Echinococcus granulosus equilibrative nucleoside transporter 3 0.008 0.191 0.191
Echinococcus granulosus g protein coupled receptor 0.0042 0.0709 0.0709
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0042 0.0709 0.0709
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0042 0.0709 0.0709
Echinococcus multilocularis solute carrier family 5 0.0037 0.0568 0.0568
Echinococcus granulosus sex peptide receptor 0.0042 0.0709 0.0709
Schistosoma mansoni transcription factor LCR-F1 0.007 0.1605 0.1605
Loa Loa (eye worm) hypothetical protein 0.0119 0.3135 0.3135
Echinococcus granulosus neuropeptide receptor A26 0.0042 0.0709 0.0709
Schistosoma mansoni opsin-like receptor 0.0042 0.0709 0.0709
Onchocerca volvulus 0.0042 0.0709 0.226
Schistosoma mansoni hypothetical protein 0.0042 0.0709 0.0709
Echinococcus multilocularis high affinity choline transporter 1 0.0337 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0709 0.0709
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.1082 0.1082
Brugia malayi Melatonin receptor type 1A 0.0042 0.0709 0.0709
Schistosoma mansoni opsin-like receptor 0.0042 0.0709 0.0709
Onchocerca volvulus 0.0042 0.0709 0.226
Echinococcus granulosus hypothetical protein 0.0042 0.0709 0.0709
Echinococcus granulosus tachykinin peptides receptor 99D 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0042 0.0709 0.0709
Brugia malayi hypothetical protein 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0092 0.2285 0.2285
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0042 0.0709 0.0709
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0133 0.358 1
Brugia malayi hypothetical protein 0.0042 0.0709 0.0709
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0042 0.0709 0.0709
Schistosoma mansoni neuropeptide receptor 0.0042 0.0709 0.0709
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0042 0.0709 0.0709
Echinococcus granulosus g-protein coupled receptor 0.0042 0.0709 0.0709
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0133 0.358 0.5
Schistosoma mansoni intermediate filament proteins 0.0026 0.0221 0.0221
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0087 0.2136 0.4996
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0042 0.0709 0.0709
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0133 0.358 1
Schistosoma mansoni amine GPCR 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0133 0.358 0.358
Echinococcus granulosus dro:myosuppressin receptor 0.0042 0.0709 0.0709
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0042 0.0709 0.0709
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.304 0.304
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0133 0.358 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Echinococcus multilocularis G protein coupled receptor 139 0.0042 0.0709 0.0709
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0042 0.0709 0.0709
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0042 0.0709 0.0709
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0046 0.0843 0.5
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0042 0.0709 0.226
Schistosoma mansoni hypothetical protein 0.0164 0.4567 0.4567
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0709 0.0709
Brugia malayi neuropeptide F receptor 0.0042 0.0709 0.0709
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0709 0.0709
Schistosoma mansoni amine GPCR 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0042 0.0709 0.0709
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0042 0.0709 0.0709
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.304 0.304
Brugia malayi hypothetical protein 0.008 0.191 0.191
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0042 0.0709 0.0709
Schistosoma mansoni hypothetical protein 0.0164 0.4567 0.4567
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0337 1 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0133 0.358 1
Echinococcus granulosus lamin dm0 0.0026 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0026 0.0221 0.0221
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0133 0.358 0.5
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0133 0.358 0.358
Brugia malayi sulfakinin receptor protein 0.0042 0.0709 0.0709
Brugia malayi hypothetical protein 0.0042 0.0709 0.0709
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0133 0.358 1
Echinococcus granulosus sodium:glucose cotransporter 2 0.0037 0.0568 0.0568
Echinococcus granulosus solute carrier family 5 0.0037 0.0568 0.0568
Schistosoma mansoni high-affinity choline transporter 0.0337 1 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0042 0.0709 0.0709
Onchocerca volvulus Neuropeptide F receptor homolog 0.0042 0.0709 0.226
Schistosoma mansoni hypothetical protein 0.0042 0.0709 0.0709
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0042 0.0709 0.0709
Echinococcus granulosus intermediate filament protein 0.0026 0.0221 0.0221
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0709 0.0709
Brugia malayi G-protein coupled receptor 0.0042 0.0709 0.0709
Echinococcus multilocularis fmrfamide receptor 0.0042 0.0709 0.0709
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0133 0.358 0.5
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0221 0.0221
Echinococcus granulosus neuropeptide receptor 0.0042 0.0709 0.0709
Echinococcus granulosus g protein coupled receptor 0.0042 0.0709 0.0709
Echinococcus granulosus peptide allatostatin:somatostatin 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0042 0.0709 0.0709
Onchocerca volvulus 0.0042 0.0709 0.226
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0042 0.0709 0.0709
Brugia malayi hypothetical protein 0.007 0.1605 0.1605
Schistosoma mansoni hypothetical protein 0.007 0.1605 0.1605
Brugia malayi MH2 domain containing protein 0.0116 0.304 0.304
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0087 0.2138 0.2138
Loa Loa (eye worm) G-protein coupled receptor 0.0042 0.0709 0.0709
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0709 0.0709
Echinococcus granulosus 7TM GPCR rhodopsin 0.0042 0.0709 0.0709
Echinococcus multilocularis G-protein coupled receptor, putative 0.0042 0.0709 0.0709
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0709 0.0709
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0042 0.0709 0.0709
Schistosoma mansoni hypothetical protein 0.0042 0.0709 0.0709
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0133 0.358 1
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0709 0.0709
Echinococcus granulosus serotonin receptor 0.0042 0.0709 0.0709
Echinococcus multilocularis neuropeptide receptor 0.0042 0.0709 0.0709
Loa Loa (eye worm) neuropeptide F receptor 0.0042 0.0709 0.0709
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0133 0.358 1
Brugia malayi Dopamine receptor 0.0042 0.0709 0.0709
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0026 0.0206 0.0206
Schistosoma mansoni alpha-1 adrenergic receptor 0.0042 0.0709 0.0709
Schistosoma mansoni amine GPCR 0.0042 0.0709 0.0709
Schistosoma mansoni neuropeptide receptor 0.0042 0.0709 0.0709
Brugia malayi Nucleoside transporter family protein 0.008 0.191 0.191

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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