Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0097 | 1 | 0.5 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0027 | 0.0549 | 0.1781 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0027 | 0.0549 | 0.1781 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0027 | 0.0549 | 0.5 |
Toxoplasma gondii | sterol carrier protein-2 HAD-2SCP-2 | 0.0041 | 0.2441 | 1 |
Mycobacterium ulcerans | dehydratase | 0.0046 | 0.308 | 1 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0027 | 0.0549 | 0.5 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0027 | 0.0549 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase. | 0.0046 | 0.308 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0046 | 0.308 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 1 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0027 | 0.0549 | 0.5 |
Toxoplasma gondii | MaoC family domain-containing protein | 0.0028 | 0.063 | 0.0432 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0097 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.308 | 0.308 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0027 | 0.0549 | 0.5 |
Brugia malayi | maoC like domain containing protein | 0.0046 | 0.308 | 0.308 |
Mycobacterium tuberculosis | Probable 3-hydroxyacyl-thioester dehydratase HtdY | 0.0046 | 0.308 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0.0549 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0027 | 0.0549 | 0.5 |
Onchocerca volvulus | 0.0097 | 1 | 0.5 | |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0027 | 0.0549 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0027 | 0.0549 | 0.5 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0097 | 1 | 0.5 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0027 | 0.0549 | 0.1781 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.