Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | maoC like domain containing protein | 0.0077 | 0.308 | 0.308 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0046 | 0.0549 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.308 | 0.308 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0162 | 1 | 0.5 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0046 | 0.0549 | 0.1781 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0046 | 0.0549 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0046 | 0.0549 | 0.5 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0162 | 1 | 0.5 |
Onchocerca volvulus | 0.0162 | 1 | 0.5 | |
Mycobacterium tuberculosis | Probable 3-hydroxyacyl-thioester dehydratase HtdY | 0.0077 | 0.308 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0046 | 0.0549 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0046 | 0.0549 | 0.5 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0046 | 0.0549 | 0.5 |
Toxoplasma gondii | sterol carrier protein-2 HAD-2SCP-2 | 0.0069 | 0.2441 | 1 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0162 | 1 | 0.5 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0046 | 0.0549 | 0.1781 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0046 | 0.0549 | 0.1781 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 1 | 1 |
Toxoplasma gondii | MaoC family domain-containing protein | 0.0047 | 0.063 | 0.0432 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0046 | 0.0549 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase. | 0.0077 | 0.308 | 1 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0046 | 0.0549 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0077 | 0.308 | 1 |
Mycobacterium ulcerans | dehydratase | 0.0077 | 0.308 | 1 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0046 | 0.0549 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.