Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | hypothetical protein, conserved | 0.0026 | 0.0549 | 0.5 |
Toxoplasma gondii | MaoC family domain-containing protein | 0.0027 | 0.063 | 0.0432 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0044 | 0.308 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase. | 0.0044 | 0.308 | 1 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0026 | 0.0549 | 0.5 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0026 | 0.0549 | 0.5 |
Mycobacterium ulcerans | dehydratase | 0.0044 | 0.308 | 1 |
Toxoplasma gondii | sterol carrier protein-2 HAD-2SCP-2 | 0.0039 | 0.2441 | 1 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0026 | 0.0549 | 0.5 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0026 | 0.0549 | 0.1781 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0026 | 0.0549 | 0.1781 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0092 | 1 | 0.5 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0026 | 0.0549 | 0.1781 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0092 | 1 | 0.5 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0026 | 0.0549 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0026 | 0.0549 | 0.5 |
Onchocerca volvulus | 0.0092 | 1 | 0.5 | |
Mycobacterium leprae | conserved hypothetical protein | 0.0026 | 0.0549 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0026 | 0.0549 | 0.5 |
Mycobacterium tuberculosis | Probable 3-hydroxyacyl-thioester dehydratase HtdY | 0.0044 | 0.308 | 1 |
Brugia malayi | maoC like domain containing protein | 0.0044 | 0.308 | 0.308 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0026 | 0.0549 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.308 | 0.308 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0092 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.