Detailed information for compound 902297

Basic information

Technical information
  • TDR Targets ID: 902297
  • Name: Oprea1_442697
  • MW: 359.443 | Formula: C18H21N3O3S
  • H donors: 3 H acceptors: 2 LogP: 2.49 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cccc(c1O)C1NC(=O)c2c(N1)sc1c2CCN(C1)C
  • InChi: 1S/C18H21N3O3S/c1-3-24-12-6-4-5-11(15(12)22)16-19-17(23)14-10-7-8-21(2)9-13(10)25-18(14)20-16/h4-6,16,20,22H,3,7-9H2,1-2H3,(H,19,23)
  • InChiKey: XRFPOESYOPYPRP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • STOCK3S-21269

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0778 1 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0187 0.2095 1
Brugia malayi Papain family cysteine protease containing protein 0.0053 0.0304 0.0257
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0013
Schistosoma mansoni hypothetical protein 0.0172 0.1895 0.1856
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0187 0.2095 0.5973
Onchocerca volvulus Cathepsin F homolog 0.0187 0.2095 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0052 0.0292 0.0245
Brugia malayi Cathepsin L-like precursor 0.0054 0.0325 0.0278
Schistosoma mansoni microtubule-associated protein tau 0.0517 0.6514 0.6497
Toxoplasma gondii cathepsin B 0.0277 0.3303 1
Entamoeba histolytica cysteine protease, putative 0.0107 0.103 0.4095
Entamoeba histolytica cysteine proteinase, putative 0.0187 0.2095 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0132 0.1369 0.1327
Echinococcus multilocularis cysteine protease 0.0187 0.2095 0.2095
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0053 0.0304 0.0257
Echinococcus granulosus cathepsin L cysteine protease 0.0107 0.103 0.103
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0187 0.2095 0.5973
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0053 0.0304 0.0069
Entamoeba histolytica cysteine protease, putative 0.0053 0.0304 0.0069
Onchocerca volvulus 0.0053 0.0304 0.1251
Schistosoma mansoni hypothetical protein 0.0172 0.1895 0.1856
Onchocerca volvulus 0.0187 0.2095 1
Loa Loa (eye worm) cathepsin B 0.0277 0.3303 0.3271
Brugia malayi Glycosyl hydrolases family 31 protein 0.0128 0.1309 0.1267
Entamoeba histolytica cysteine protease, putative 0.0107 0.103 0.4095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0187 0.2095 0.5973
Onchocerca volvulus 0.0187 0.2095 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0307 0.3701 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.0304 0.0013
Entamoeba histolytica cysteine protease, putative 0.0107 0.103 0.4095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0107 0.103 0.2421
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0187 0.2095 0.5973
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0052 0.0292 0.0245
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0422 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0082 0.0699 0.0699
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0187 0.2095 0.5973
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0187 0.2095 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0325 0.0278
Leishmania major cathepsin L-like protease 0.0307 0.3701 1
Echinococcus granulosus cathepsin b 0.0778 1 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0128 0.1309 0.1267
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0187 0.2095 0.2057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0307 0.3701 1
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0422 0.0375
Loa Loa (eye worm) hypothetical protein 0.0053 0.0304 0.0257
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0054 0.0325 0.0278
Entamoeba histolytica cysteine proteinase, putative 0.0107 0.103 0.4095
Plasmodium vivax vivapain-2 0.0187 0.2095 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0048 0.0048
Echinococcus multilocularis cathepsin b 0.0778 1 1
Echinococcus multilocularis cathepsin L 0.0107 0.103 0.103
Loa Loa (eye worm) hypothetical protein 0.0054 0.0325 0.0278
Echinococcus granulosus geminin 0.0172 0.1895 0.1895
Giardia lamblia Cathepsin B precursor 0.0277 0.3303 1
Entamoeba histolytica cysteine protease, putative 0.0107 0.103 0.4095
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0053 0.0304 0.0257
Schistosoma mansoni cathepsin F (C01 family) 0.0187 0.2095 0.2057
Echinococcus granulosus cathepsin L 0.0053 0.0304 0.0304
Echinococcus granulosus cathepsin L cysteine proteinase 0.0187 0.2095 0.2095
Entamoeba histolytica cysteine protease, putative 0.0107 0.103 0.4095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.103 0.2166
Loa Loa (eye worm) fibroinase 0.0187 0.2095 0.2057
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0048 0.0048
Entamoeba histolytica cysteine proteinase, putative 0.0132 0.1369 0.5974
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0053 0.0304 0.0257
Schistosoma mansoni cathepsin B (C01 family) 0.0053 0.0304 0.0257
Leishmania major cathepsin L-like protease 0.0187 0.2095 0.529
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0274 0.0227
Onchocerca volvulus 0.0187 0.2095 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0132 0.1369 0.3551
Echinococcus granulosus lysosomal alpha glucosidase 0.0128 0.1309 0.1309
Entamoeba histolytica cysteine protease, putative 0.0107 0.103 0.4095
Leishmania major cathepsin L-like protease 0.0187 0.2095 0.529
Brugia malayi cathepsin L-like cysteine proteinase 0.0053 0.0304 0.0257
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0107 0.103 0.0987
Brugia malayi Cathepsin L-like precursor 0.0187 0.2095 0.2057
Echinococcus multilocularis cathepsin L cysteine protease 0.0187 0.2095 0.2095
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0048 0.0048
Echinococcus multilocularis cathepsin L 0.0053 0.0304 0.0304
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0053 0.0304 0.0257
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0277 0.3303 0.3271
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0422 0.0375
Trypanosoma cruzi cruzipain precursor, putative 0.0054 0.0325 0.0034
Brugia malayi cathepsin F-like cysteine proteinase 0.0054 0.0325 0.0278
Onchocerca volvulus 0.0184 0.2056 0.9809
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0048 0.0048
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0107 0.103 0.0761
Loa Loa (eye worm) hypothetical protein 0.0132 0.1369 0.1327
Entamoeba histolytica cysteine protease, putative 0.0107 0.103 0.4095
Trypanosoma cruzi cysteine peptidase, putative 0.0307 0.3701 0.3512
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0082 0.0699 0.0699
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0422 0.0422
Entamoeba histolytica cysteine proteinase 2 0.0107 0.103 0.4095
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0053 0.0304 0.0257
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0187 0.2095 0.5973
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0187 0.2095 0.5973
Brugia malayi Papain family cysteine protease containing protein 0.0107 0.103 0.0987
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0053 0.0304 0.0257
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0187 0.2095 0.2095
Brugia malayi cathepsin L precursor 0.0053 0.0304 0.0257
Brugia malayi cathepsin Z-like cysteine proteinase 0.0053 0.0304 0.0257
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0053 0.0304 0.0257
Schistosoma mansoni cathepsin F (C01 family) 0.0187 0.2095 0.2057
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0054 0.0325 0.0278
Echinococcus granulosus cathepsin b 0.0778 1 1
Trichomonas vaginalis set domain proteins, putative 0.0184 0.2056 0.5843
Schistosoma mansoni hypothetical protein 0.0035 0.0061 0.0013
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0052 0.0292 0.0292
Schistosoma mansoni cathepsin s 0.0054 0.0325 0.0278
Entamoeba histolytica cysteine proteinase, putative 0.0107 0.103 0.4095
Plasmodium vivax unspecified product 0.0107 0.103 0.4054
Brugia malayi Cathepsin L-like precursor 0.0132 0.1369 0.1327
Entamoeba histolytica cysteine protease, putative 0.0053 0.0304 0.0069
Loa Loa (eye worm) hypothetical protein 0.0053 0.0304 0.0257
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0778 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0082 0.0699 0.0699
Plasmodium vivax unspecified product 0.0054 0.0325 0.0117
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0274 0.0227
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0053 0.0304 0.0257
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0053 0.0304 0.0257
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0307 0.3701 1
Loa Loa (eye worm) hypothetical protein 0.0778 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0422 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0061 0.0013
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0048 0.0048
Entamoeba histolytica cysteine protease, putative 0.0107 0.103 0.4095
Entamoeba histolytica cysteine protease, putative 0.0187 0.2095 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0048 0.0048
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0048 0.0048
Loa Loa (eye worm) cysteine protease 0.0187 0.2095 0.2057
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0277 0.3303 0.3102
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0053 0.0304 0.0257
Entamoeba histolytica cysteine proteinase, putative 0.0187 0.2095 1
Echinococcus multilocularis microtubule associated protein 2 0.0517 0.6514 0.6514
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0187 0.2095 0.5973
Echinococcus multilocularis cathepsin b 0.0778 1 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.2095 0.2057
Onchocerca volvulus Cathepsin L homolog 0.0187 0.2095 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0307 0.3701 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0277 0.3303 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0053 0.0304 0.0257
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0187 0.2095 0.2095
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0052 0.0292 0.0245
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0307 0.3701 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0053 0.0304 0.0257
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0187 0.2095 0.5973
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0307 0.3701 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0128 0.1309 0.1309
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0274 0.0227
Schistosoma mansoni cathepsin C 0.0053 0.0304 0.0257
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0778 1 1
Echinococcus granulosus cathepsin l1 0.0187 0.2095 0.2095
Brugia malayi cathepsin Z-like cysteine proteinase 0.0053 0.0304 0.0257
Plasmodium falciparum cysteine proteinase falcipain 1 0.0107 0.103 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.0053 0.0304 0.0257
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0082 0.0699 0.0654
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0187 0.2095 0.5973
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0053 0.0304 0.0257
Plasmodium vivax vivapain-1 0.0107 0.103 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0307 0.3701 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0252 0.2975 0.2764
Trypanosoma cruzi cysteine proteinase, putative 0.0107 0.103 0.0761
Trypanosoma cruzi cruzipain precursor, putative 0.0307 0.3701 0.3512
Leishmania major cathepsin L-like protease 0.0187 0.2095 0.529
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0048 0.0048
Brugia malayi fibroinase precursor 0.0053 0.0304 0.0257
Onchocerca volvulus 0.0187 0.2095 1
Entamoeba histolytica cysteine protease, putative 0.0053 0.0304 0.0069
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0048 0.0048
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0187 0.2095 0.5973
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.0048 0.0048
Entamoeba histolytica cysteine protease, putative 0.0107 0.103 0.4095
Toxoplasma gondii cathepsin CPL 0.0187 0.2095 0.5973
Entamoeba histolytica cysteine protease, putative 0.0053 0.0304 0.0069
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0053 0.0304 0.0257
Plasmodium vivax vivapain-3 0.0107 0.103 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0053 0.0304 0.0257
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0778 1 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0304 0.0257
Echinococcus multilocularis geminin 0.0172 0.1895 0.1895
Onchocerca volvulus Cathepsin L homolog 0.0187 0.2095 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0053 0.0304 0.0069
Echinococcus granulosus cathepsin l1 0.0132 0.1369 0.1369
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0048 0.0048
Loa Loa (eye worm) ctsf protein 0.0187 0.2095 0.2057
Entamoeba histolytica cysteine protease, putative 0.0107 0.103 0.4095
Entamoeba histolytica cysteine protease, putative 0.0107 0.103 0.4095
Brugia malayi Cathepsin L-like precursor 0.0187 0.2095 0.2057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0307 0.3701 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0187 0.2095 0.5973
Brugia malayi Cathepsin L-like precursor 0.0187 0.2095 0.2057
Brugia malayi Cathepsin L-like precursor 0.0187 0.2095 0.2057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0187 0.2095 0.5973
Entamoeba histolytica cysteine protease, putative 0.0053 0.0304 0.0069
Schistosoma mansoni alpha-glucosidase 0.011 0.1071 0.1028
Leishmania major cathepsin L-like protease 0.0187 0.2095 0.529
Echinococcus granulosus cathepsin l cysteine peptidase 0.0187 0.2095 0.2095
Brugia malayi Papain family cysteine protease containing protein 0.0187 0.2095 0.2057
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0187 0.2095 0.2057
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0107 0.103 0.0987
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0187 0.2095 0.5973
Onchocerca volvulus 0.0132 0.1369 0.6453
Onchocerca volvulus Cathepsin L homolog 0.0053 0.0304 0.1251
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0187 0.2095 0.5973
Trypanosoma cruzi cysteine protease, putative 0.0107 0.103 0.0761
Brugia malayi Cathepsin L-like precursor 0.0132 0.1369 0.1327
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.0325 0.0034
Echinococcus granulosus cathepsin L 0.0107 0.103 0.103
Onchocerca volvulus 0.0187 0.2095 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0082 0.0699 0.0699
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0187 0.2095 0.5973
Leishmania major cathepsin L-like protease 0.0307 0.3701 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0274 0.0227
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0187 0.2095 0.5973
Echinococcus multilocularis cysteine protease 0.0187 0.2095 0.2095
Entamoeba histolytica cysteine protease, putative 0.0107 0.103 0.4095
Trypanosoma cruzi major cysteine proteinase, putative 0.0173 0.191 0.1667
Loa Loa (eye worm) hypothetical protein 0.0053 0.0304 0.0257
Leishmania major cathepsin L-like protease 0.0187 0.2095 0.529
Schistosoma mansoni cathepsin S (C01 family) 0.0053 0.0304 0.0257
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0187 0.2095 0.5973
Onchocerca volvulus 0.0074 0.0588 0.2637
Echinococcus granulosus cysteine protease 0.0107 0.103 0.103
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0082 0.0699 0.0654
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0187 0.2095 0.5973
Loa Loa (eye worm) hypothetical protein 0.0054 0.0325 0.0278
Leishmania major cathepsin L-like protease 0.0307 0.3701 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0132 0.1369 0.3551
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0422 0.5
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0422 0.0422
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0422 0.0381
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0307 0.3701 1
Brugia malayi Pre-SET motif family protein 0.0161 0.1758 0.1718
Plasmodium falciparum cysteine proteinase falcipain 3 0.0187 0.2095 1
Giardia lamblia Cathepsin B precursor 0.0277 0.3303 1
Echinococcus granulosus microtubule associated protein 2 0.0517 0.6514 0.6514
Trypanosoma cruzi cysteine peptidase, putative 0.0107 0.103 0.0761
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0187 0.2095 0.5973
Brugia malayi Cathepsin L-like precursor 0.0187 0.2095 0.2057
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0422 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0082 0.0699 0.0654
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0307 0.3701 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0778 1 1
Entamoeba histolytica cysteine protease, putative 0.0053 0.0304 0.0069
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0107 0.103 0.0987
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0187 0.2095 0.5973
Trypanosoma brucei cysteine peptidase C (CPC) 0.0277 0.3303 0.8832
Leishmania major cysteine peptidase A (CPA) 0.0187 0.2095 0.529
Entamoeba histolytica cysteine proteinase 1, putative 0.0107 0.103 0.4095
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.0048 0.0048
Brugia malayi Cathepsin L-like cysteine proteinase 0.0132 0.1369 0.1327
Brugia malayi Papain family cysteine protease containing protein 0.0053 0.0304 0.0257
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0187 0.2095 0.5973
Trypanosoma cruzi cysteine peptidase, putative 0.0187 0.2095 0.1858
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0307 0.3701 1
Brugia malayi Cathepsin L-like precursor 0.0187 0.2095 0.2057
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0052 0.0292 0.0292
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0187 0.2095 0.5973
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0048 0.0048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.103 0.2166
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0048 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0187 0.2095 0.5973
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0048 0.0048
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0082 0.0699 0.0654
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0107 0.103 0.2421
Entamoeba histolytica cysteine proteinase, putative 0.0107 0.103 0.4095
Entamoeba histolytica cysteine protease, putative 0.0107 0.103 0.4095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0187 0.2095 0.5973
Brugia malayi cathepsin L-like precursor 0.0132 0.1369 0.1327
Schistosoma mansoni cathepsin F (C01 family) 0.0132 0.1369 0.1327
Plasmodium vivax vivapain-2 0.0187 0.2095 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0161 0.1758 0.1718
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0422 0.0392
Onchocerca volvulus 0.0187 0.2095 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0277 0.3303 0.8832
Entamoeba histolytica hypothetical protein 0.0053 0.0304 0.0069
Trypanosoma cruzi cysteine proteinase, putative 0.0107 0.103 0.0761
Schistosoma mansoni alpha-glucosidase 0.011 0.1071 0.1028
Echinococcus multilocularis cathepsin L cysteine protease 0.0187 0.2095 0.2095
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0048 0.0048
Echinococcus multilocularis lysosomal alpha glucosidase 0.0128 0.1309 0.1309
Giardia lamblia Cathepsin B precursor 0.0277 0.3303 1
Brugia malayi Papain family cysteine protease containing protein 0.0107 0.103 0.0987
Entamoeba histolytica cysteine proteinase, putative 0.0107 0.103 0.4095
Loa Loa (eye worm) hypothetical protein 0.0132 0.1369 0.1327
Loa Loa (eye worm) hypothetical protein 0.0053 0.0304 0.0257
Trypanosoma cruzi cysteine peptidase, putative 0.0307 0.3701 0.3512
Trypanosoma cruzi cysteine peptidase, putative 0.0307 0.3701 0.3512
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0082 0.0699 0.0654
Onchocerca volvulus 0.0187 0.2095 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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