Detailed information for compound 902302

Basic information

Technical information
  • TDR Targets ID: 902302
  • Name: N-[3-[(2,4-dimethylphenyl)amino]quinoxalin-2- yl]-4-methylbenzenesulfonamide
  • MW: 418.511 | Formula: C23H22N4O2S
  • H donors: 2 H acceptors: 4 LogP: 5.03 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)S(=O)(=O)Nc1nc2ccccc2nc1Nc1ccc(cc1C)C
  • InChi: 1S/C23H22N4O2S/c1-15-8-11-18(12-9-15)30(28,29)27-23-22(24-19-13-10-16(2)14-17(19)3)25-20-6-4-5-7-21(20)26-23/h4-14H,1-3H3,(H,24,25)(H,26,27)
  • InChiKey: HMVLFGAHWQXAKN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[3-[(2,4-dimethylphenyl)amino]quinoxalin-2-yl]-4-methyl-benzenesulfonamide
  • N-[3-[(2,4-dimethylphenyl)amino]-2-quinoxalinyl]-4-methylbenzenesulfonamide
  • EU-0005236
  • ZINC03075039

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum ataxin-2 like protein, putative 0.0094 0.0091 0.0436
Trichomonas vaginalis chromobox protein, putative 0.0025 0.001 0.0022
Brugia malayi ImpB/MucB/SamB family protein 0.0101 0.01 0.0099
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1287 0.1502 0.4275
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0528 0.0604 0.1717
Loa Loa (eye worm) glutaminase 2 0.0285 0.0317 0.0317
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0021 0.002
Schistosoma mansoni tar DNA-binding protein 0.0259 0.0287 0.0286
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0056 0.0046 0.0126
Schistosoma mansoni serine/threonine protein kinase 0.0168 0.0178 0.0178
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0003 0.0002
Brugia malayi Cathepsin L-like precursor 0.1268 0.148 0.1479
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0002 0.0001
Schistosoma mansoni tar DNA-binding protein 0.0259 0.0287 0.0286
Plasmodium falciparum glutathione reductase 0.0018 0.0002 0.0005
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0528 0.0604 0.0604
Echinococcus granulosus phd:f box containing protein 0.0035 0.0022 0.0022
Plasmodium falciparum serine repeat antigen 9 0.0528 0.0604 0.2907
Echinococcus multilocularis lamin dm0 0.0029 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0109 0.0109 0.0108
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.8476 1 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0168 0.0178 0.0178
Toxoplasma gondii PHD-finger domain-containing protein 0.0109 0.0109 0.0308
Trypanosoma cruzi cysteine peptidase, putative 0.1033 0.1201 0.1201
Loa Loa (eye worm) hypothetical protein 0.0078 0.0073 0.0072
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0001
Schistosoma mansoni phd/f-box containing protein 0.0035 0.0022 0.0021
Echinococcus multilocularis lysine specific demethylase 5A 0.0131 0.0136 0.0136
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0001 0.0001
Plasmodium falciparum serine repeat antigen 7 0.0528 0.0604 0.2907
Onchocerca volvulus Cathepsin L homolog 0.1773 0.2077 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0528 0.0604 0.1717
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0025 0.001 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0046 0.013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1773 0.2077 0.5914
Loa Loa (eye worm) CXXC zinc finger family protein 0.0067 0.0059 0.0059
Toxoplasma gondii histone lysine methyltransferase SET1 0.0129 0.0133 0.0377
Trypanosoma cruzi DNA polymerase kappa, putative 0.0056 0.0046 0.0046
Schistosoma mansoni chromobox protein 0.0151 0.0159 0.0158
Brugia malayi mothers against decapentaplegic homolog 3 0.0027 0.0012 0.0012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0002 0.0001
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0119 0.0122 0.167
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1773 0.2077 0.5914
Trypanosoma cruzi major cysteine proteinase, putative 0.0606 0.0697 0.0697
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0528 0.0604 0.1717
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.1033 0.1201 0.1201
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0005 0.0005
Echinococcus multilocularis phd:f box containing protein 0.0035 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0141 0.0147 0.0146
Loa Loa (eye worm) hypothetical protein 0.0094 0.0091 0.0091
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0026 0.0072
Loa Loa (eye worm) hypothetical protein 0.0034 0.0021 0.002
Echinococcus multilocularis bloom syndrome protein 0.0042 0.0031 0.0031
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0014 0.0014
Plasmodium vivax hypothetical protein, conserved 0.0025 0.001 0.0042
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0035 0.0022 0.0062
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0009
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0528 0.0604 0.2907
Loa Loa (eye worm) MH2 domain-containing protein 0.0888 0.1031 0.103
Leishmania major cathepsin L-like protease 0.1773 0.2077 0.5916
Loa Loa (eye worm) latrophilin receptor protein 2 0.0115 0.0117 0.0116
Giardia lamblia Cathepsin L precursor 0.0528 0.0604 0.1719
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0002 0.002
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.0042 0.0042
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0021 0.002
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0528 0.0604 0.0604
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0001
Toxoplasma gondii cathepsin CPL 0.1773 0.2077 0.5915
Brugia malayi Muscleblind-like protein 0.0321 0.036 0.0359
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.0042 0.0042
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.004 0.0027 0.0073
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1287 0.1502 0.4275
Brugia malayi MH2 domain containing protein 0.0888 0.1031 0.103
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0002 0.0002
Plasmodium falciparum cysteine proteinase falcipain 3 0.1773 0.2077 1
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0528 0.0604 0.2907
Trichomonas vaginalis CAMK family protein kinase 0.0168 0.0178 0.0503
Onchocerca volvulus 0.1268 0.148 0.7112
Schistosoma mansoni glutaminase 0.0285 0.0317 0.0317
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0003 0.0003
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0001 0.0001
Plasmodium vivax vivapain-2 0.1773 0.2077 1
Entamoeba histolytica cysteine proteinase, putative 0.1773 0.2077 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0042 0.003 0.003
Trypanosoma cruzi cysteine proteinase, putative 0.1033 0.1201 0.1201
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0002 0.0005
Echinococcus multilocularis dna polymerase kappa 0.0056 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0456 0.052 0.052
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0002 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0046 0.013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1773 0.2077 0.5914
Loa Loa (eye worm) hypothetical protein 0.0034 0.0021 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0001 0.0001
Loa Loa (eye worm) MH1 domain-containing protein 0.0061 0.0052 0.0051
Schistosoma mansoni smad1 5 8 and 0.0061 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.012 0.0122 0.0121
Schistosoma mansoni phosphatidylserine receptor 0.0035 0.0022 0.0021
Brugia malayi hypothetical protein 0.0025 0.001 0.0009
Echinococcus granulosus bloom syndrome protein 0.0042 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0249 0.0275 0.0274
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0021 0.0021
Plasmodium vivax JmjC domain containing protein 0.0035 0.0022 0.0101
Onchocerca volvulus 0.1773 0.2077 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0021 0.002
Echinococcus granulosus intermediate filament protein 0.0029 0.0015 0.0015
Brugia malayi cathepsin F-like cysteine proteinase 0.0505 0.0577 0.0577
Echinococcus multilocularis cathepsin L cysteine protease 0.1773 0.2077 0.2077
Echinococcus granulosus mothers against decapentaplegic 6 0.0027 0.0012 0.0012
Echinococcus multilocularis cathepsin L cysteine protease 0.1773 0.2077 0.2077
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.1347 0.1573 0.1572
Echinococcus granulosus cpg binding protein 0.0073 0.0066 0.0066
Plasmodium falciparum serine repeat antigen 6 0.0528 0.0604 0.2907
Leishmania major trypanothione reductase 0.0052 0.0042 0.0119
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0026 0.0011 0.0011
Leishmania major cathepsin L-like protease 0.1852 0.217 0.618
Onchocerca volvulus 0.1773 0.2077 1
Trichomonas vaginalis CAMK family protein kinase 0.0168 0.0178 0.0503
Entamoeba histolytica cysteine protease, putative 0.1033 0.1201 0.5764
Schistosoma mansoni hypothetical protein 0.0115 0.0117 0.0116
Brugia malayi Cathepsin L-like precursor 0.1773 0.2077 0.2076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0021 0.002
Brugia malayi Cathepsin L-like precursor 0.1773 0.2077 0.2076
Trypanosoma brucei unspecified product 0.0038 0.0026 0.0072
Loa Loa (eye worm) hypothetical protein 0.0528 0.0604 0.0603
Loa Loa (eye worm) hypothetical protein 0.0029 0.0015 0.0014
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0019 0.0018
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0002 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1773 0.2077 0.5914
Loa Loa (eye worm) hypothetical protein 0.1268 0.148 0.1479
Leishmania major cathepsin L-like protease 0.1852 0.217 0.618
Loa Loa (eye worm) CHromoDomain protein family member 0.0031 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0001
Echinococcus multilocularis chromobox protein 1 0.0151 0.0159 0.0159
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.001 0.0122
Schistosoma mansoni cpg binding protein 0.0073 0.0066 0.0066
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0365 0.0412 0.0411
Brugia malayi Papain family cysteine protease containing protein 0.0528 0.0604 0.0603
Entamoeba histolytica cysteine proteinase, putative 0.1033 0.1201 0.5764
Trypanosoma cruzi cysteine peptidase, putative 0.1852 0.217 0.2169
Brugia malayi MH1 domain containing protein 0.0061 0.0052 0.0051
Schistosoma mansoni intermediate filament proteins 0.0029 0.0015 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0021 0.002
Brugia malayi steroid hormone receptor 0.0034 0.0021 0.002
Plasmodium falciparum serine repeat antigen 5 0.0528 0.0604 0.2907
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.003 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0035 0.0022 0.0022
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0002 0.0004
Echinococcus granulosus ATP dependent DNA helicase Q1 0.003 0.0015 0.0015
Onchocerca volvulus Alhambra homolog 0.0109 0.0109 0.048
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0021 0.0021
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0056 0.0046 0.013
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0001
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0021 0.002
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0002 0.0001
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0085 0.008 0.008
Trypanosoma brucei DNA polymerase eta, putative 0.0101 0.01 0.0282
Echinococcus multilocularis JmjC domain containing protein 4 0.0035 0.0022 0.0022
Echinococcus granulosus cathepsin L cysteine proteinase 0.1773 0.2077 0.2077
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0002 0.0004
Echinococcus granulosus lamin 0.0029 0.0015 0.0015
Brugia malayi chromobox protein homolog 3 0.0085 0.008 0.008
Echinococcus multilocularis cathepsin L 0.1033 0.1201 0.1201
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2986 0.351 0.351
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0021 0.002
Leishmania major cathepsin L-like protease 0.1773 0.2077 0.5916
Echinococcus multilocularis chromobox protein 1 0.0151 0.0159 0.0159
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0052 0.0042 0.0042
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1287 0.1502 0.4275
Echinococcus multilocularis dna polymerase eta 0.0101 0.01 0.01
Trypanosoma cruzi cysteine peptidase, putative 0.1773 0.2077 0.2076
Brugia malayi PHD-finger family protein 0.0109 0.0109 0.0108
Giardia lamblia Encystation-specific protease 0.0528 0.0604 0.1719
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0002 0.0001
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0168 0.0178 0.0507
Brugia malayi CHD4 protein 0.0031 0.0017 0.0016
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0528 0.0604 0.0604
Plasmodium vivax vivapain-1 0.1033 0.1201 0.5782
Trypanosoma cruzi polo-like protein kinase, putative 0.0168 0.0178 0.0178
Echinococcus granulosus mothers against decapentaplegic 5 0.0061 0.0052 0.0052
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.003 0.0015 0.0015
Trypanosoma brucei cysteine peptidase C (CPC) 0.2986 0.351 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.2986 0.351 1
Brugia malayi cathepsin L-like precursor 0.1268 0.148 0.1479
Brugia malayi hypothetical protein 0.0094 0.0091 0.0091
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.001 0.0122
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0021 0.002
Onchocerca volvulus 0.1773 0.2077 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0528 0.0604 0.0604
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0021 0.002
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0002 0.0005
Trichomonas vaginalis DNA helicase recq, putative 0.0042 0.0031 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0021 0.002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0207 0.0225 0.0225
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0259 0.0287 0.0286
Onchocerca volvulus 0.0066 0.0059 0.0238
Brugia malayi RNA binding protein 0.0259 0.0287 0.0286
Entamoeba histolytica cysteine proteinase 1, putative 0.1033 0.1201 0.5764
Brugia malayi Valyl-tRNA synthetase 0.0025 0.001 0.0009
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.0021 0.002
Brugia malayi Cathepsin L-like precursor 0.1773 0.2077 0.2076
Loa Loa (eye worm) hypothetical protein 0.0528 0.0604 0.0603
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0629 0.0723 1
Plasmodium falciparum serine repeat antigen 3 0.0528 0.0604 0.2907
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1033 0.1201 0.3421
Toxoplasma gondii LsmAD domain-containing protein 0.0094 0.0091 0.0258
Loa Loa (eye worm) TAR-binding protein 0.0259 0.0287 0.0286
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0021 0.002
Entamoeba histolytica cysteine proteinase, putative 0.1773 0.2077 1
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0025 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0045 0.0034 0.0033
Loa Loa (eye worm) hypothetical protein 0.0101 0.01 0.0099
Schistosoma mansoni hypothetical protein 0.0115 0.0117 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1773 0.2077 0.5914
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0629 0.0723 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0001 0.0001
Echinococcus granulosus geminin 0.0456 0.052 0.052
Echinococcus granulosus Smad4 0.0061 0.0052 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0528 0.0604 0.1717
Loa Loa (eye worm) hypothetical protein 0.0528 0.0604 0.0603
Brugia malayi hypothetical protein 0.0018 0.0002 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0168 0.0178 0.0503
Brugia malayi Calcitonin receptor-like protein seb-1 0.0365 0.0412 0.0411
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0528 0.0604 0.1719
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1773 0.2077 0.5914
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1773 0.2077 0.5914
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0002 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1033 0.1201 0.3419
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0025 0.001 0.0042
Echinococcus multilocularis cathepsin b 0.8476 1 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0021 0.002
Loa Loa (eye worm) fibroinase 0.1773 0.2077 0.2076
Schistosoma mansoni cathepsin S (C01 family) 0.0528 0.0604 0.0604
Plasmodium vivax serine-repeat antigen (SERA) 0.0528 0.0604 0.2907
Giardia lamblia Cathepsin L-like protease 0.0528 0.0604 0.1719
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0005 0.0004
Brugia malayi ecdysteroid receptor 0.0034 0.0021 0.002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0002 0.0001
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0041 0.0029 0.0029
Onchocerca volvulus 0.0067 0.0059 0.0241
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0528 0.0604 0.2907
Schistosoma mansoni cathepsin B (C01 family) 0.0528 0.0604 0.0604
Mycobacterium tuberculosis Probable oxidoreductase 0.0133 0.0137 0.1888
Loa Loa (eye worm) hypothetical protein 0.0034 0.0021 0.002
Echinococcus granulosus JmjC domain containing protein 4 0.0035 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1033 0.1201 0.3419
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1852 0.217 0.618
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0528 0.0604 0.1717
Brugia malayi nuclear hormone receptor 0.0034 0.0021 0.002
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0056 0.0046 0.0046
Plasmodium vivax vivapain-3 0.1033 0.1201 0.5782
Leishmania major cathepsin L-like protease 0.1773 0.2077 0.5916
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0141 0.0147 0.0147
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0027 0.0073
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0027 0.0073
Loa Loa (eye worm) hypothetical protein 0.0043 0.0031 0.003
Leishmania major DNA polymerase kappa, putative 0.0017 0.0001 0.0001
Entamoeba histolytica cysteine proteinase, putative 0.1268 0.148 0.7112
Entamoeba histolytica cysteine protease, putative 0.1033 0.1201 0.5764
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0002 0.0015
Loa Loa (eye worm) hypothetical protein 0.1773 0.2077 0.2076
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1852 0.217 0.618
Trypanosoma cruzi polo-like protein kinase, putative 0.0168 0.0178 0.0178
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0002 0.0015
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0021 0.002
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0035 0.0022 0.006
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0002 0.0002
Plasmodium falciparum JmjC domain-containing protein, putative 0.0035 0.0022 0.0101
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2986 0.351 0.351
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0025 0.001 0.0025
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0528 0.0604 0.2907
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.008 0.0224
Brugia malayi Papain family cysteine protease containing protein 0.1773 0.2077 0.2076
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0002 0.0001
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0119 0.0122 0.1569
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0021 0.002
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0021 0.002
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0035 0.0022 0.0021
Echinococcus multilocularis smad 0.0061 0.0052 0.0052
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0002 0.0017
Plasmodium falciparum phd finger protein, putative 0.0109 0.0109 0.052
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0002 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.001 0.0022
Onchocerca volvulus 0.0029 0.0015 0.0025
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0002 0.0001
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0002 0.5
Entamoeba histolytica hypothetical protein 0.0141 0.0147 0.0663
Schistosoma mansoni hypothetical protein 0.0025 0.001 0.0009
Echinococcus granulosus cathepsin l1 0.1773 0.2077 0.2077
Loa Loa (eye worm) hypothetical protein 0.0034 0.0021 0.002
Schistosoma mansoni hypothetical protein 0.0115 0.0117 0.0116
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0002 0.0005
Trypanosoma brucei polo-like protein kinase 0.0168 0.0178 0.0507
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0025 0.001 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1033 0.1201 0.3421
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0009
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0987 0.1147 0.1147
Trichomonas vaginalis CAMK family protein kinase 0.0168 0.0178 0.0503
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0528 0.0604 0.2877
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0528 0.0604 0.0603
Echinococcus granulosus cathepsin l1 0.1268 0.148 0.148
Trichomonas vaginalis DNA helicase recq, putative 0.0032 0.0019 0.0048
Mycobacterium tuberculosis Probable dehydrogenase 0.0119 0.0122 0.167
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1773 0.2077 1
Leishmania major hypothetical protein, conserved 0.0094 0.0091 0.0259
Brugia malayi cathepsin Z-like cysteine proteinase 0.0528 0.0604 0.0603
Brugia malayi Cathepsin L-like precursor 0.1773 0.2077 0.2076
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0021 0.0021
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0056 0.0046 0.0624
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.001 0.0119
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0021 0.0021
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.004 0.0027 0.0127
Loa Loa (eye worm) hypothetical protein 0.0505 0.0577 0.0577
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.0021 0.0053
Trypanosoma brucei unspecified product 0.0056 0.0046 0.013
Schistosoma mansoni transcription factor LCR-F1 0.0141 0.0147 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.001 0.0022
Schistosoma mansoni chromobox protein 0.0025 0.001 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.001 0.0022
Brugia malayi Cathepsin L-like precursor 0.1773 0.2077 0.2076
Echinococcus multilocularis GPCR, family 2 0.0115 0.0117 0.0117
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0018 0.0046
Trichomonas vaginalis chromobox protein, putative 0.0091 0.0088 0.0245
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0001
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0001 0.0001
Schistosoma mansoni jumonji domain containing protein 0.0283 0.0314 0.0314
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1852 0.217 0.618
Loa Loa (eye worm) hypothetical protein 0.0029 0.0014 0.0013
Trichomonas vaginalis chromobox protein, putative 0.0025 0.001 0.0022
Loa Loa (eye worm) hypothetical protein 0.0186 0.02 0.02
Mycobacterium ulcerans DNA polymerase IV 0.0056 0.0046 0.0627
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.8476 1 1
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0002 0.0007
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1287 0.1502 0.7217
Leishmania major DNA polymerase eta, putative 0.0062 0.0054 0.0153
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0091 0.0088 0.0379
Giardia lamblia Cathepsin B precursor 0.0528 0.0604 0.1719
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0021 0.002
Entamoeba histolytica cysteine proteinase, putative 0.1033 0.1201 0.5764
Echinococcus granulosus dna polymerase kappa 0.0056 0.0046 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1852 0.217 0.618
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1773 0.2077 0.5914
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.0063 0.0063
Leishmania major DNA polymerase eta, putative 0.0101 0.01 0.0282
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0119 0.0122 0.167
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0528 0.0604 0.0603
Trichomonas vaginalis chromobox protein, putative 0.0025 0.001 0.0022
Brugia malayi nuclear receptor NHR-88 0.0034 0.0021 0.002
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0002 0.0001
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1033 0.1201 0.1201
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0007 0.0007
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0528 0.0604 0.2907
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.001 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1268 0.148 0.4213
Entamoeba histolytica serine/threonine protein kinase, putative 0.0168 0.0178 0.0817
Giardia lamblia Cathepsin L precursor 0.0528 0.0604 0.1719
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0051 0.0141
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0001 0.0002
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0528 0.0604 0.0604
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0001 0.0001
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.004 0.0027 0.0073
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0031 0.0017 0.0016
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0528 0.0604 0.2907
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0025 0.001 0.0009
Brugia malayi Latrophilin receptor protein 2 0.0115 0.0117 0.0116
Echinococcus multilocularis cathepsin L 0.0528 0.0604 0.0604
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0025 0.001 0.0045
Onchocerca volvulus Cathepsin L homolog 0.0528 0.0604 0.2877
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0035 0.0022 0.006
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.8476 1 1
Loa Loa (eye worm) nuclear factor I 0.0033 0.002 0.0019
Onchocerca volvulus 0.1773 0.2077 1
Brugia malayi hypothetical protein 0.0061 0.0052 0.0051
Loa Loa (eye worm) hypothetical protein 0.0041 0.0029 0.0029
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0528 0.0604 0.1717
Brugia malayi jmjC domain containing protein 0.0356 0.0401 0.04
Loa Loa (eye worm) heterochromatin protein 1 0.0151 0.0159 0.0158
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0021 0.0021
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0061 0.0052 0.0052
Echinococcus granulosus lysine specific demethylase 6a 0.0035 0.0022 0.0022
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0035 0.0022 0.0062
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0021 0.0021
Echinococcus multilocularis PHD finger protein rhinoceros 0.0109 0.0109 0.0109
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0056 0.0046 0.0045
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0528 0.0604 0.0604
Giardia lamblia Cathepsin L precursor 0.0528 0.0604 0.1719
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0629 0.0723 1
Trypanosoma brucei DNA damage repair protein, putative 0.0017 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.062 0.0713 0.0712
Echinococcus granulosus chromobox protein 2 0.0025 0.001 0.001
Echinococcus multilocularis zinc finger protein 0.0025 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1773 0.2077 0.5914
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0046 0.013
Trypanosoma cruzi cysteine protease, putative 0.1033 0.1201 0.1201
Brugia malayi Cathepsin L-like cysteine proteinase 0.1268 0.148 0.1479
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0528 0.0604 0.1717
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0021 0.0021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0004 0.0004
Brugia malayi Thioredoxin reductase 0.0052 0.0042 0.0042
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0015 0.0014
Entamoeba histolytica cysteine protease, putative 0.0528 0.0604 0.2877
Trypanosoma brucei chrX additional, unordered contigs 0.0017 0.0001 0.0001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0021 0.0021
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0014 0.0014
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0119 0.0122 0.167
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0528 0.0604 0.1719
Schistosoma mansoni tar DNA-binding protein 0.0259 0.0287 0.0286
Plasmodium vivax glutathione reductase, putative 0.0052 0.0042 0.02
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0207 0.0225 0.0224
Loa Loa (eye worm) jmjC domain-containing protein 0.0224 0.0245 0.0245
Schistosoma mansoni chromobox protein 0.0025 0.001 0.0009
Brugia malayi AMP-binding enzyme family protein 0.0025 0.001 0.0009
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0025 0.001 0.000000000069908
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0027 0.0073
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0001
Echinococcus granulosus lamin dm0 0.0029 0.0015 0.0015
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.0021 0.0053
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0002 0.0011
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.001 0.0122
Onchocerca volvulus 0.0528 0.0604 0.2877
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1852 0.217 0.618
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0014 0.0014
Plasmodium vivax hypothetical protein, conserved 0.004 0.0027 0.0127
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0207 0.0225 0.0224
Schistosoma mansoni kinase 0.0085 0.0081 0.0081
Echinococcus granulosus GPCR family 2 0.0115 0.0117 0.0117
Schistosoma mansoni coup transcription factor 0.0034 0.0021 0.002
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.0042 0.0571
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1773 0.2077 0.5914
Toxoplasma gondii PHD-finger domain-containing protein 0.0109 0.0109 0.0308
Trypanosoma cruzi DNA polymerase kappa, putative 0.0056 0.0046 0.0046
Trypanosoma cruzi cysteine peptidase, putative 0.1852 0.217 0.2169
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0001
Loa Loa (eye worm) glutaminase 0.0285 0.0317 0.0317
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1773 0.2077 0.5914
Echinococcus granulosus tar DNA binding protein 0.0259 0.0287 0.0287
Toxoplasma gondii cathepsin B 0.2986 0.351 1
Echinococcus multilocularis cpg binding protein 0.0073 0.0066 0.0066
Entamoeba histolytica cysteine protease, putative 0.1033 0.1201 0.5764
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0062 0.0054 0.0152
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0528 0.0604 0.0604
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0021 0.002
Brugia malayi Heterochromatin protein 1 0.0151 0.0159 0.0158
Echinococcus multilocularis jumonji domain containing protein 0.0151 0.0159 0.0159
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1852 0.217 0.618
Echinococcus multilocularis muscleblind protein 1 0.0321 0.036 0.036
Echinococcus granulosus Chromo domain 0.0025 0.001 0.001
Giardia lamblia Cathepsin B precursor 0.0528 0.0604 0.1719
Brugia malayi RNA recognition motif domain containing protein 0.0259 0.0287 0.0286
Echinococcus multilocularis cathepsin b 0.8476 1 1
Giardia lamblia Cathepsin L precursor 0.0528 0.0604 0.1719
Plasmodium vivax hypothetical protein, conserved 0.0109 0.0109 0.052
Echinococcus granulosus jumonji domain containing protein 0.0151 0.0159 0.0159
Schistosoma mansoni tar DNA-binding protein 0.0259 0.0287 0.0286
Giardia lamblia Cathepsin L precursor 0.0528 0.0604 0.1719
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.8476 1 1
Loa Loa (eye worm) Smad1 0.0061 0.0052 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0051 0.0141
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0002 0.0001
Entamoeba histolytica cysteine protease, putative 0.0528 0.0604 0.2877
Trichomonas vaginalis CAMK family protein kinase 0.0083 0.0078 0.0218
Entamoeba histolytica cysteine protease, putative 0.1773 0.2077 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0141 0.0147 0.0147
Schistosoma mansoni terminal deoxycytidyl transferase 0.0056 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0528 0.0604 0.1717
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0528 0.0604 0.2907
Brugia malayi cathepsin L-like cysteine proteinase 0.0528 0.0604 0.0603
Echinococcus multilocularis musashi 0.0029 0.0015 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0021 0.002
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.001 0.0022
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0365 0.0412 0.0411
Plasmodium vivax unspecified product 0.0528 0.0604 0.2907
Trypanosoma cruzi PAB1-binding protein , putative 0.0094 0.0091 0.0091
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0207 0.0225 0.0225
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.001 0.0122
Leishmania major hypothetical protein, conserved 0.0035 0.0022 0.0061
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0003 0.0003
Loa Loa (eye worm) RNA binding protein 0.0259 0.0287 0.0286
Trichomonas vaginalis glutaminase, putative 0.0285 0.0317 0.09
Entamoeba histolytica cysteine protease, putative 0.1033 0.1201 0.5764
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0022 0.0061
Brugia malayi MH2 domain containing protein 0.0061 0.0052 0.0051
Onchocerca volvulus 0.1773 0.2077 1
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.001 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0528 0.0604 0.1717
Toxoplasma gondii cathepsin CPC1 0.0528 0.0604 0.1719
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0528 0.0604 0.0603
Trichomonas vaginalis conserved hypothetical protein 0.0528 0.0604 0.1717
Brugia malayi AF-10 protein 0.0035 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0027 0.0012 0.0012
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0115 0.0117 0.0117
Loa Loa (eye worm) transcription factor SMAD2 0.0888 0.1031 0.103
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1852 0.217 0.618
Brugia malayi glutathione reductase 0.0052 0.0042 0.0042
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0027 0.0073
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0015 0.0014
Echinococcus multilocularis muscleblind protein 0.0321 0.036 0.036
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1773 0.2077 0.2076
Trypanosoma cruzi cruzipain precursor, putative 0.1852 0.217 0.2169
Brugia malayi PHD-finger family protein 0.0031 0.0018 0.0017
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0002 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.0015 0.0015
Echinococcus granulosus histone lysine methyltransferase setb 0.002 0.0004 0.0004
Trypanosoma cruzi cruzipain precursor, putative 0.0505 0.0577 0.0577
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0528 0.0604 0.2907
Leishmania major cysteine peptidase A (CPA) 0.1773 0.2077 0.5916
Brugia malayi intermediate filament protein 0.0029 0.0015 0.0014
Brugia malayi Associated with TFs and helicases family protein 0.0025 0.001 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1773 0.2077 0.5914
Schistosoma mansoni jumonji/arid domain-containing protein 0.0137 0.0143 0.0142
Echinococcus granulosus cathepsin b 0.8476 1 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0027 0.0013 0.0012
Entamoeba histolytica cysteine protease, putative 0.0528 0.0604 0.2877
Plasmodium falciparum serine repeat antigen 2 0.0528 0.0604 0.2907
Schistosoma mansoni protein phosphatase 2C 0.0035 0.0022 0.0021
Toxoplasma gondii cathepsin CPC2 0.0528 0.0604 0.1719
Mycobacterium ulcerans hypothetical protein 0.0025 0.001 0.0122
Brugia malayi M-phase phosphoprotein, mpp8 0.0025 0.001 0.0009
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0002 0.0004
Plasmodium falciparum thioredoxin reductase 0.0052 0.0042 0.02
Schistosoma mansoni Smad4 0.0061 0.0052 0.0052
Schistosoma mansoni jumonji domain containing protein 0.0035 0.0022 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.001 0.0022
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0025 0.001 0.0025
Entamoeba histolytica cysteine protease, putative 0.0528 0.0604 0.2877
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0041 0.0029 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0021 0.002
Echinococcus granulosus TGF beta signal transducer SmadC 0.0061 0.0052 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1773 0.2077 0.5914
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0025 0.001 0.000000000069908
Loa Loa (eye worm) helicase 0.0025 0.001 0.0009
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0033 0.002 0.0019
Giardia lamblia Cathepsin B precursor 0.2986 0.351 1
Schistosoma mansoni lamin 0.0029 0.0015 0.0014
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0019 0.0052
Giardia lamblia Cysteine protease 0.0528 0.0604 0.1719
Loa Loa (eye worm) hypothetical protein 0.1268 0.148 0.1479
Brugia malayi Bromodomain containing protein 0.0087 0.0083 0.0082
Entamoeba histolytica cysteine protease, putative 0.1033 0.1201 0.5764
Onchocerca volvulus 0.1773 0.2077 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0115 0.0117 0.0117
Plasmodium vivax unspecified product 0.0505 0.0577 0.2777
Plasmodium vivax serine-repeat antigen (SERA) 0.0528 0.0604 0.2907
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1773 0.2077 0.5914
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0001 0.0001
Entamoeba histolytica cysteine proteinase, putative 0.1033 0.1201 0.5764
Echinococcus granulosus zinc finger protein 0.0025 0.0011 0.0011
Leishmania major cathepsin L-like protease 0.1773 0.2077 0.5916
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0115 0.0117 0.0117
Leishmania major DNA damage repair protein, putative 0.0017 0.0001 0.0001
Echinococcus granulosus cathepsin l cysteine peptidase 0.1773 0.2077 0.2077
Brugia malayi Bromodomain containing protein 0.0111 0.0112 0.0111
Brugia malayi Bloom's syndrome protein homolog 0.0042 0.0031 0.003
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0528 0.0604 0.0603
Echinococcus granulosus cathepsin L 0.1033 0.1201 0.1201
Echinococcus multilocularis Chromobox protein 3 0.0025 0.001 0.001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0021 0.0021
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0009
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0168 0.0178 0.0178
Trypanosoma brucei trypanothione reductase 0.0052 0.0042 0.0119
Entamoeba histolytica cysteine proteinase 2 0.1033 0.1201 0.5764
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.0042 0.02
Plasmodium falciparum thioredoxin reductase 0.0018 0.0002 0.0005
Brugia malayi nuclear receptor RXR 0.0018 0.0002 0.0001
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0021 0.0021
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0528 0.0604 0.2907
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0035 0.0022 0.0021
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.0063 0.0063
Trichomonas vaginalis chromobox protein, putative 0.0151 0.0159 0.0447
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1773 0.2077 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0321 0.036 0.0359
Entamoeba histolytica hypothetical protein 0.0141 0.0147 0.0663
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0021 0.002
Trichomonas vaginalis DNA helicase recq1, putative 0.0042 0.0031 0.0082
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0207 0.0225 0.0225
Giardia lamblia Fructose-bisphosphate aldolase 0.1287 0.1502 0.4276
Loa Loa (eye worm) hypothetical protein 0.0505 0.0577 0.0577
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0356 0.0401 0.0401
Trichomonas vaginalis chromobox protein, putative 0.0151 0.0159 0.0447
Loa Loa (eye worm) ctsf protein 0.1773 0.2077 0.2076
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1852 0.217 0.618
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0085 0.008 0.0342
Trichomonas vaginalis DNA polymerase eta, putative 0.0056 0.0046 0.0126
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0026 0.0072
Loa Loa (eye worm) hypothetical protein 0.8476 1 1
Schistosoma mansoni hypothetical protein 0.0249 0.0275 0.0275
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0003 0.0002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0027 0.0073
Mycobacterium ulcerans glutaminase 0.0285 0.0317 0.4381
Entamoeba histolytica cysteine protease, putative 0.1033 0.1201 0.5764
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0115 0.0117 0.0116
Trichomonas vaginalis Heterochromatin protein, putative 0.0025 0.001 0.0022
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0027 0.0012 0.0014
Schistosoma mansoni bromodomain containing protein 0.0074 0.0068 0.0067
Giardia lamblia Cathepsin B precursor 0.0528 0.0604 0.1719
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0019 0.0049
Loa Loa (eye worm) hypothetical protein 0.0321 0.036 0.0359
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1773 0.2077 0.5914
Echinococcus granulosus cathepsin L 0.0528 0.0604 0.0604
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0025 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0034 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0034 0.0021 0.002
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0505 0.0577 0.0577
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1852 0.217 0.618
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0528 0.0604 0.1719
Trichomonas vaginalis CAMK family protein kinase 0.0168 0.0178 0.0503
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1773 0.2077 0.2077
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0025 0.001 0.0042
Schistosoma mansoni cpg binding protein 0.0067 0.0059 0.0059
Onchocerca volvulus 0.062 0.0713 0.3403
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.0012 0.0012
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0001 0.0002
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0002 0.0004
Plasmodium falciparum serine repeat antigen 8 0.0528 0.0604 0.2907
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1268 0.148 0.4213
Giardia lamblia Cathepsin B precursor 0.2986 0.351 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0528 0.0604 0.0604
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0005 0.0005
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0022 0.0021
Schistosoma mansoni hypothetical protein 0.0453 0.0516 0.0516
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0009
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0001 0.0001
Brugia malayi MH2 domain containing protein 0.0027 0.0012 0.0012
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0001
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0528 0.0604 0.2907
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0528 0.0604 0.1717
Entamoeba histolytica cysteine protease, putative 0.1033 0.1201 0.5764
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0002 0.0001
Brugia malayi jmjC domain containing protein 0.0137 0.0143 0.0142
Trichomonas vaginalis CAMK family protein kinase 0.0168 0.0178 0.0503
Brugia malayi MH1 domain containing protein 0.0033 0.002 0.0019
Brugia malayi serine/threonine-protein kinase plk-2 0.0168 0.0178 0.0178
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.001 0.0022
Plasmodium falciparum heterochromatin protein 1 0.0025 0.001 0.0042
Leishmania major DNA polymerase kappa, putative 0.0056 0.0046 0.013
Mycobacterium tuberculosis Probable reductase 0.0119 0.0122 0.167
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0021 0.002
Trichomonas vaginalis CAMK family protein kinase 0.0168 0.0178 0.0503
Loa Loa (eye worm) cysteine protease 0.1773 0.2077 0.2076
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0009
Brugia malayi Papain family cysteine protease containing protein 0.1033 0.1201 0.12
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0027 0.0073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1773 0.2077 0.5914
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.001 0.0026
Echinococcus granulosus Chromobox protein 3 0.0025 0.001 0.001
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0002 0.0001
Schistosoma mansoni zinc finger protein 0.0025 0.0011 0.001
Mycobacterium tuberculosis Conserved hypothetical protein 0.0056 0.0046 0.0624
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0004
Brugia malayi jmjC domain containing protein 0.0035 0.0022 0.0021
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0002 0.0007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1287 0.1502 0.4275
Giardia lamblia Cysteine protease 0.0528 0.0604 0.1719
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1773 0.2077 0.5914
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1033 0.1201 0.1201
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0356 0.0401 0.0401
Schistosoma mansoni DNA helicase recq1 0.003 0.0015 0.0015
Giardia lamblia Cathepsin L-like protease 0.0528 0.0604 0.1719
Loa Loa (eye worm) hypothetical protein 0.1268 0.148 0.1479
Trypanosoma brucei DNA polymerase IV, putative 0.0056 0.0046 0.013
Brugia malayi Cathepsin L-like precursor 0.1268 0.148 0.1479
Echinococcus granulosus dna polymerase eta 0.0101 0.01 0.01
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0142 0.0148 0.0147
Entamoeba histolytica hypothetical protein 0.0025 0.001 0.000000000069908
Schistosoma mansoni jumonji/arid domain-containing protein 0.0137 0.0143 0.0142
Echinococcus granulosus cathepsin L cysteine protease 0.1033 0.1201 0.1201
Brugia malayi ImpB/MucB/SamB family protein 0.0056 0.0046 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1773 0.2077 0.5914
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0528 0.0604 0.1717
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0021 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0046 0.013
Plasmodium falciparum cysteine proteinase falcipain 1 0.1033 0.1201 0.5782
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.0021 0.0021
Brugia malayi Cathepsin L-like precursor 0.0505 0.0577 0.0577
Echinococcus granulosus peregrin 0.0111 0.0112 0.0112
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0001 0.0001
Trichomonas vaginalis chromobox protein, putative 0.0091 0.0088 0.0245
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0115 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0365 0.0412 0.0411
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0019 0.0049
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0002 1
Plasmodium vivax hypothetical protein, conserved 0.0025 0.001 0.0042
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0001 0.0001
Giardia lamblia Cathepsin B precursor 0.2986 0.351 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0528 0.0604 0.1719
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0001 0.0001
Brugia malayi jmjC domain containing protein 0.0035 0.0022 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0021 0.002
Echinococcus granulosus jumonji domain containing 1A 0.0035 0.0022 0.0022
Onchocerca volvulus 0.0026 0.0011 0.0008
Trypanosoma cruzi DNA polymerase kappa, putative 0.0056 0.0046 0.0046
Entamoeba histolytica cysteine protease, putative 0.1033 0.1201 0.5764
Entamoeba histolytica cysteine proteinase, putative 0.1033 0.1201 0.5764
Brugia malayi Cathepsin L-like precursor 0.1773 0.2077 0.2076
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.001 0.0026
Trichomonas vaginalis CAMK family protein kinase 0.0083 0.0078 0.0218
Leishmania major cathepsin L-like protease 0.1773 0.2077 0.5916
Brugia malayi hypothetical protein 0.062 0.0713 0.0712
Onchocerca volvulus Cathepsin L homolog 0.1773 0.2077 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.003 0.0015 0.0015
Loa Loa (eye worm) cathepsin B 0.2986 0.351 0.351
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0002 0.0001
Echinococcus multilocularis Smad4 0.0061 0.0052 0.0052
Onchocerca volvulus 0.1773 0.2077 1
Echinococcus granulosus mothers against decapentaplegic 2 0.0027 0.0012 0.0012
Echinococcus granulosus cysteine protease 0.1033 0.1201 0.1201
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.003 0.0015 0.0015
Trypanosoma cruzi PAB1-binding protein , putative 0.0094 0.0091 0.0091
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0046 0.013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0021 0.002
Giardia lamblia PHD finger protein 15 0.0109 0.0109 0.0308
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0207 0.0225 0.0224
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.004 0.0027 0.0128
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0207 0.0225 0.0224
Schistosoma mansoni cpg binding protein 0.0073 0.0066 0.0066
Trypanosoma brucei DNA polymerase IV, putative 0.0056 0.0046 0.013
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1773 0.2077 0.5914
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0021 0.002
Echinococcus granulosus dnaJ subfamily B 0.0453 0.0516 0.0516
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1287 0.1502 0.4275
Echinococcus granulosus lysine specific demethylase 5A 0.0137 0.0143 0.0143
Echinococcus multilocularis lysine specific demethylase 6a 0.0035 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0035 0.0022 0.0021
Brugia malayi cathepsin Z-like cysteine proteinase 0.0528 0.0604 0.0603
Schistosoma mansoni cathepsin F (C01 family) 0.1773 0.2077 0.2076
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0021 0.0021
Trypanosoma cruzi major cysteine proteinase, putative 0.0528 0.0604 0.0604
Schistosoma mansoni hypothetical protein 0.0115 0.0117 0.0116
Brugia malayi MH2 domain containing protein 0.0061 0.0052 0.0051
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1287 0.1502 0.7217
Mycobacterium ulcerans DNA polymerase IV 0.0056 0.0046 0.0627
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0528 0.0604 0.0604
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0021 0.0021
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0021 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0046 0.013
Echinococcus multilocularis peregrin 0.0111 0.0112 0.0112
Entamoeba histolytica cysteine protease, putative 0.0528 0.0604 0.2877
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0021 0.0021
Loa Loa (eye worm) MH2 domain-containing protein 0.0061 0.0052 0.0051
Echinococcus multilocularis lamin 0.0029 0.0015 0.0015
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1773 0.2077 0.2077
Plasmodium vivax heterochromatin protein 1, putative 0.0025 0.001 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1773 0.2077 0.5914
Brugia malayi fibroinase precursor 0.0528 0.0604 0.0603
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0021 0.002
Schistosoma mansoni DNA helicase recq5 0.003 0.0015 0.0015
Echinococcus granulosus cathepsin b 0.8476 1 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0119 0.0122 0.167
Brugia malayi PHD-finger family protein 0.0041 0.0029 0.0029
Schistosoma mansoni Smad4 0.0027 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0528 0.0604 0.1717
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1287 0.1502 0.4275
Brugia malayi cathepsin L precursor 0.0528 0.0604 0.0603
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0168 0.0178 0.0178
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.001 0.0022
Brugia malayi Smad1 0.0061 0.0052 0.0051
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.003 0.0015 0.0015
Brugia malayi hypothetical protein 0.0018 0.0002 0.0001
Schistosoma mansoni cathepsin F (C01 family) 0.1773 0.2077 0.2076
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0035 0.0022 0.0061
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0015 0.0042
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1033 0.1201 0.1201
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0528 0.0604 0.2907
Trypanosoma cruzi DNA polymerase eta, putative 0.0101 0.01 0.0099
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.001 0.0122
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0056 0.0046 0.0046
Schistosoma mansoni chromobox protein 0.0151 0.0159 0.0158
Treponema pallidum fructose-bisphosphate aldolase 0.1287 0.1502 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0002 0.0004
Brugia malayi MH1 domain containing protein 0.0061 0.0052 0.0051
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0001 0.0001
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0505 0.0577 0.0577
Echinococcus granulosus chromobox protein 1 0.0151 0.0159 0.0159
Plasmodium falciparum ataxin-2 like protein, putative 0.0094 0.0091 0.0436
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0133 0.0137 0.179
Schistosoma mansoni cathepsin F (C01 family) 0.1268 0.148 0.1479
Schistosoma mansoni smad1 5 8 and 0.0061 0.0052 0.0052
Loa Loa (eye worm) glutathione reductase 0.0052 0.0042 0.0042
Plasmodium vivax unspecified product 0.1033 0.1201 0.5782
Echinococcus multilocularis mothers against decapentaplegic 2 0.0027 0.0012 0.0012
Entamoeba histolytica cysteine protease, putative 0.0528 0.0604 0.2877
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.001 0.0022
Loa Loa (eye worm) hypothetical protein 0.0109 0.0109 0.0108
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0025 0.001 0.0025
Giardia lamblia Cathepsin L precursor 0.0528 0.0604 0.1719
Brugia malayi CXXC zinc finger family protein 0.0067 0.0059 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1773 0.2077 0.5914
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0528 0.0604 0.2877
Echinococcus granulosus PHD finger protein rhinoceros 0.0109 0.0109 0.0109
Trypanosoma brucei DNA damage repair protein, putative 0.0017 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0528 0.0604 0.2877
Echinococcus granulosus chromobox protein 1 0.0151 0.0159 0.0159
Entamoeba histolytica cysteine protease, putative 0.1033 0.1201 0.5764
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0001 0.0001
Schistosoma mansoni cathepsin s 0.0505 0.0577 0.0577
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0061 0.0052 0.0052
Plasmodium vivax ataxin-2 like protein, putative 0.0094 0.0091 0.0436
Brugia malayi jmjC domain containing protein 0.0035 0.0022 0.0021
Onchocerca volvulus Serine\/threonine kinase homolog 0.0168 0.0178 0.0817
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0015 0.0042
Entamoeba histolytica cysteine protease, putative 0.1033 0.1201 0.5764
Entamoeba histolytica hypothetical protein 0.0141 0.0147 0.0663
Loa Loa (eye worm) jmjC domain-containing protein 0.0137 0.0143 0.0142
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0025 0.001 0.0025
Giardia lamblia Kinase, PLK 0.0168 0.0178 0.0506
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0021 0.002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0056 0.0046 0.0046
Giardia lamblia Cathepsin B precursor 0.0528 0.0604 0.1719
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0021 0.002
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.001 0.0122
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.002 0.0004 0.0004
Echinococcus multilocularis tar DNA binding protein 0.0259 0.0287 0.0287
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0002 0.0004
Echinococcus multilocularis Chromo domain 0.0025 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0456 0.052 0.052
Echinococcus granulosus muscleblind protein 0.0321 0.036 0.036
Brugia malayi latrophilin 2 splice variant baaae 0.0249 0.0275 0.0274
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0528 0.0604 0.2907
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.0042 0.0042
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.001 0.0026
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.0021 0.0021
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0004 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1773 0.2077 0.5914
Entamoeba histolytica recQ family helicase, putative 0.0032 0.0019 0.0043
Entamoeba histolytica cysteine protease, putative 0.1033 0.1201 0.5764
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0002 0.0015
Plasmodium falciparum serine repeat antigen 1 0.0528 0.0604 0.2907
Onchocerca volvulus 0.0029 0.0015 0.0025
Brugia malayi Protein cec-1. 0.0025 0.001 0.0009
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0019 0.0052
Plasmodium falciparum serine repeat antigen 4 0.0528 0.0604 0.2907
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0207 0.0225 0.0225
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0035 0.0022 0.0021
Trypanosoma brucei unspecified product 0.0038 0.0026 0.0072
Schistosoma mansoni smad 0.0027 0.0012 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0004 0.0004
Trypanosoma cruzi DNA polymerase eta, putative 0.0062 0.0054 0.0054
Brugia malayi AMP-binding enzyme family protein 0.0025 0.001 0.0009
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0035 0.0022 0.0061
Loa Loa (eye worm) PHD-finger family protein 0.0109 0.0109 0.0108
Loa Loa (eye worm) hypothetical protein 0.0115 0.0117 0.0116
Entamoeba histolytica cysteine protease, putative 0.1033 0.1201 0.5764
Entamoeba histolytica hypothetical protein 0.0141 0.0147 0.0663
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0022 0.0021
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.003 0.0015 0.0071
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0042 0.003 0.003
Plasmodium falciparum glutathione reductase 0.0052 0.0042 0.02
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0021 0.002
Giardia lamblia Hypothetical protein 0.0528 0.0604 0.1719
Trypanosoma cruzi cysteine proteinase, putative 0.1033 0.1201 0.1201
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1773 0.2077 0.5914
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0002 0.0001
Schistosoma mansoni cathepsin C 0.0528 0.0604 0.0604
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1287 0.1502 0.4275
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0046 0.013
Giardia lamblia Cysteine protease 0.0528 0.0604 0.1719
Schistosoma mansoni smad 0.0061 0.0052 0.0052
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0001 0.0002
Echinococcus granulosus ATP dependent DNA helicase Q5 0.003 0.0015 0.0015
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0021 0.002
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0031 0.0017 0.0017
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0133 0.0137 0.1888
Schistosoma mansoni tar DNA-binding protein 0.0259 0.0287 0.0286
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0042 0.0042
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0002 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0026 0.0072
Echinococcus multilocularis dnaJ subfamily B 0.0453 0.0516 0.0516
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0021 0.002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1773 0.2077 0.5914
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0025 0.001 0.000000000069908
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0021 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.001 0.0022
Entamoeba histolytica cysteine protease, putative 0.1033 0.1201 0.5764
Trypanosoma cruzi cysteine peptidase, putative 0.0505 0.0577 0.0577
Echinococcus granulosus smad 0.0061 0.0052 0.0052
Echinococcus multilocularis mothers against decapentaplegic 5 0.0061 0.0052 0.0052
Brugia malayi TAR-binding protein 0.0259 0.0287 0.0286
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1287 0.1502 0.4275
Echinococcus multilocularis chromobox protein 2 0.0025 0.001 0.001
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0002 0.0004
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0133 0.0137 0.1888
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.2986 0.351 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1852 0.217 0.618
Echinococcus multilocularis geminin 0.0456 0.052 0.052
Schistosoma mansoni hypothetical protein 0.0042 0.003 0.003
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.001 0.0122
Loa Loa (eye worm) hypothetical protein 0.0035 0.0022 0.0021
Brugia malayi F/Y-rich N-terminus family protein 0.0058 0.0049 0.0048
Trichomonas vaginalis hypothetical protein 0.0025 0.001 0.0022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0528 0.0604 0.1717
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0109 0.0109 0.0108
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0528 0.0604 0.1717
Echinococcus multilocularis mothers against decapentaplegic 6 0.0027 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0034 0.0021 0.002
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0031 0.0017 0.0017
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0001 0.0001
Schistosoma mansoni Smad4 0.0027 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0051 0.0041 0.004
Brugia malayi MH1 domain containing protein 0.0033 0.002 0.0019
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0528 0.0604 0.2907
Schistosoma mansoni smad1 5 8 and 0.0061 0.0052 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0046 0.013
Leishmania major cathepsin L-like protease 0.1852 0.217 0.618
Plasmodium vivax vivapain-2 0.1773 0.2077 1
Schistosoma mansoni hypothetical protein 0.0023 0.0007 0.0007
Giardia lamblia Sgs1 DNA helicase, putative 0.003 0.0015 0.0042
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0009
Brugia malayi Papain family cysteine protease containing protein 0.1033 0.1201 0.12
Brugia malayi cathepsin F-like cysteine proteinase 0.0528 0.0604 0.0603
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0002 0.0001
Trypanosoma cruzi cysteine peptidase, putative 0.1852 0.217 0.2169
Loa Loa (eye worm) RecQ helicase 0.0042 0.0031 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0528 0.0604 0.1717
Giardia lamblia DINP protein human, muc B family 0.0056 0.0046 0.0129
Giardia lamblia Cathepsin B precursor 0.0528 0.0604 0.1719
Loa Loa (eye worm) hypothetical protein 0.0066 0.0059 0.0058
Giardia lamblia Hypothetical protein 0.0528 0.0604 0.1719
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.0012 0.0012
Onchocerca volvulus Cathepsin F homolog 0.1773 0.2077 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0207 0.0225 0.0224
Trypanosoma brucei PAB1-binding protein , putative 0.0094 0.0091 0.0259
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1852 0.217 0.618
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0056 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0528 0.0604 0.1717
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0025 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0009
Brugia malayi hypothetical protein 0.0141 0.0147 0.0146
Brugia malayi Bromodomain containing protein 0.0042 0.0031 0.003
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0528 0.0604 0.0603
Entamoeba histolytica deoxycytidyl transferase, putative 0.0056 0.0046 0.0177
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.008 0.0224
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0001 0.0001
Echinococcus multilocularis cysteine protease 0.1773 0.2077 0.2077
Brugia malayi glutaminase DH11.1 0.0285 0.0317 0.0317
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.001 0.0119
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0505 0.0577 0.0577
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0021 0.0021
Schistosoma mansoni DNA polymerase eta 0.0101 0.01 0.0099
Echinococcus multilocularis cysteine protease 0.1773 0.2077 0.2077
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.8476 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0528 0.0604 0.1717
Brugia malayi jmjC domain containing protein 0.0035 0.0022 0.0021
Schistosoma mansoni lamin 0.0029 0.0015 0.0014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1773 0.2077 0.5914
Brugia malayi SET domain containing protein 0.0026 0.0011 0.0011
Toxoplasma gondii preprocathepsin c precursor, putative 0.0528 0.0604 0.1719
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.0021 0.0053
Brugia malayi Papain family cysteine protease containing protein 0.0528 0.0604 0.0603
Brugia malayi Papain family cysteine protease containing protein 0.0528 0.0604 0.0603
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1773 0.2077 0.2076
Loa Loa (eye worm) hypothetical protein 0.0528 0.0604 0.0603
Brugia malayi AMP-binding enzyme family protein 0.0025 0.001 0.0009
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0002 0.0003
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0022 0.0021
Toxoplasma gondii thioredoxin reductase 0.0052 0.0042 0.0118
Giardia lamblia Cysteine protease 0.0528 0.0604 0.1719
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0021 0.002
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0528 0.0604 0.0603
Trypanosoma brucei DNA polymerase IV, putative 0.0056 0.0046 0.013
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0002 0.0005
Echinococcus multilocularis jumonji domain containing 1A 0.0035 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0528 0.0604 0.1717
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0046 0.013
Onchocerca volvulus 0.0034 0.0021 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0046 0.013
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0021 0.0021

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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