Detailed information for compound 902308

Basic information

Technical information
  • TDR Targets ID: 902308
  • Name: ethyl 2-(1-phenyltetrazol-5-yl)sulfanylpropan oate
  • MW: 278.33 | Formula: C12H14N4O2S
  • H donors: 0 H acceptors: 4 LogP: 2.76 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C(Sc1nnnn1c1ccccc1)C
  • InChi: 1S/C12H14N4O2S/c1-3-18-11(17)9(2)19-12-13-14-15-16(12)10-7-5-4-6-8-10/h4-9H,3H2,1-2H3
  • InChiKey: ZFSJOKGWFHKQTA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(1-phenyl-5-tetrazolyl)thio]propanoic acid ethyl ester
  • 2-[(1-phenyltetrazol-5-yl)thio]propionic acid ethyl ester
  • ethyl 2-[(1-phenyl-1,2,3,4-tetrazol-5-yl)sulfanyl]propanoate
  • CBMicro_012353
  • A2126/0089251
  • BIM-0012345.P001
  • EU-0018757

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Papain family cysteine protease containing protein 0.014 0.068 0.0665
Brugia malayi fibroinase precursor 0.014 0.068 0.0665
Loa Loa (eye worm) hypothetical protein 0.0149 0.0727 0.0718
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1969 1 1
Entamoeba histolytica cysteine protease, putative 0.014 0.068 0.0613
Giardia lamblia Cathepsin B precursor 0.014 0.068 0.0407
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0507 0.2553 0.6639
Entamoeba histolytica cysteine proteinase, putative 0.0507 0.2553 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0289 0.1439 0.1439
Brugia malayi cathepsin F-like cysteine proteinase 0.014 0.068 0.0665
Giardia lamblia Cathepsin L-like protease 0.014 0.068 0.0407
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.068 0.0407
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0116 0.0558 0.0543
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0507 0.2553 0.6639
Brugia malayi Protein kinase domain containing protein 0.0677 0.3419 0.3409
Leishmania major cathepsin L-like protease 0.0507 0.2553 0.6639
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0507 0.2553 0.6639
Brugia malayi cathepsin F-like cysteine proteinase 0.0149 0.0727 0.0712
Plasmodium vivax serine-repeat antigen (SERA) 0.014 0.068 0.0613
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0507 0.2553 0.6639
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.014 0.068 0.0613
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.014 0.068 0.0407
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.014 0.068 0.0613
Giardia lamblia Cathepsin L precursor 0.014 0.068 0.0407
Leishmania major cathepsin L-like protease 0.0507 0.2553 0.6639
Loa Loa (eye worm) hypothetical protein 0.014 0.068 0.0671
Onchocerca volvulus Cathepsin F homolog 0.0507 0.2553 1
Entamoeba histolytica cysteine protease, putative 0.0289 0.1439 0.4418
Trypanosoma cruzi cysteine protease, putative 0.0289 0.1439 0.0933
Echinococcus multilocularis cathepsin b 0.1969 1 1
Entamoeba histolytica cysteine protease, putative 0.014 0.068 0.0613
Giardia lamblia Cysteine protease 0.014 0.068 0.0407
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0006
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.014 0.068 0.068
Echinococcus granulosus aurora kinase A 0.0116 0.0558 0.0543
Giardia lamblia Dipeptidyl-peptidase I precursor 0.014 0.068 0.0407
Entamoeba histolytica cysteine protease, putative 0.0289 0.1439 0.4418
Entamoeba histolytica papain family cysteine protease domain containing protein 0.014 0.068 0.0613
Loa Loa (eye worm) hypothetical protein 0.0358 0.1793 0.1785
Loa Loa (eye worm) papain family cysteine protease containing protein 0.014 0.068 0.0671
Onchocerca volvulus Cathepsin L homolog 0.0507 0.2553 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0289 0.1439 0.1439
Plasmodium vivax serine-repeat antigen (SERA), putative 0.014 0.068 0.0613
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0507 0.2553 0.2541
Schistosoma mansoni cathepsin F (C01 family) 0.0507 0.2553 0.2553
Entamoeba histolytica cysteine proteinase 1, putative 0.0289 0.1439 0.4418
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0507 0.2553 0.6639
Trypanosoma cruzi cruzipain precursor, putative 0.0507 0.2553 0.2113
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0507 0.2553 0.2541
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.014 0.068 0.068
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0289 0.1439 0.1439
Entamoeba histolytica cysteine proteinase, putative 0.0507 0.2553 1
Giardia lamblia Cathepsin L precursor 0.014 0.068 0.0407
Trypanosoma cruzi cysteine peptidase, putative 0.0507 0.2553 0.2113
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0507 0.2553 0.6639
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0116 0.0558 0.0543
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0507 0.2553 0.2545
Onchocerca volvulus 0.0507 0.2553 1
Trypanosoma cruzi cysteine peptidase, putative 0.0149 0.0727 0.0179
Echinococcus multilocularis cysteine protease 0.0507 0.2553 0.2541
Loa Loa (eye worm) AUR protein kinase 0.0116 0.0558 0.0548
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.014 0.068 0.0407
Trypanosoma cruzi cysteine proteinase, putative 0.0289 0.1439 0.0933
Leishmania major cathepsin L-like protease 0.0507 0.2553 0.6639
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0507 0.2553 0.6639
Echinococcus granulosus roundabout 2 0.0015 0.0044 0.0028
Entamoeba histolytica cysteine protease, putative 0.0289 0.1439 0.4418
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0507 0.2553 0.6639
Leishmania major cathepsin L-like protease 0.0507 0.2553 0.6639
Trypanosoma cruzi cysteine peptidase, putative 0.0289 0.1439 0.0933
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.068 0.0407
Giardia lamblia Cathepsin B precursor 0.0706 0.3562 1
Entamoeba histolytica cysteine proteinase, putative 0.0289 0.1439 0.4418
Plasmodium falciparum serine repeat antigen 3 0.014 0.068 0.0613
Onchocerca volvulus 0.0507 0.2553 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0507 0.2553 0.2541
Loa Loa (eye worm) hypothetical protein 0.0358 0.1793 0.1785
Trypanosoma cruzi cruzipain precursor, putative 0.0149 0.0727 0.0179
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.014 0.068 0.0613
Entamoeba histolytica cysteine protease, putative 0.014 0.068 0.0613
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0507 0.2553 0.6639
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.014 0.068 0.068
Echinococcus multilocularis cysteine protease 0.0507 0.2553 0.2541
Brugia malayi Immunoglobulin I-set domain containing protein 0.0153 0.0746 0.0731
Brugia malayi cathepsin Z-like cysteine proteinase 0.014 0.068 0.0665
Schistosoma mansoni cell adhesion molecule 0.0012 0.0031 0.0031
Giardia lamblia Cathepsin B precursor 0.0706 0.3562 1
Trypanosoma cruzi major cysteine proteinase, putative 0.014 0.068 0.0129
Plasmodium vivax vivapain-3 0.0289 0.1439 0.4418
Toxoplasma gondii cathepsin CPC1 0.014 0.068 0.0407
Trichomonas vaginalis conserved hypothetical protein 0.014 0.068 0.0407
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.014 0.068 0.0407
Leishmania major cathepsin L-like protease 0.0507 0.2553 0.6639
Loa Loa (eye worm) fibroinase 0.0507 0.2553 0.2545
Brugia malayi Cathepsin L-like precursor 0.0507 0.2553 0.2541
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0706 0.3562 0.3182
Brugia malayi Cathepsin L-like precursor 0.0358 0.1793 0.178
Echinococcus granulosus cathepsin L 0.0289 0.1439 0.1426
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.014 0.068 0.0407
Loa Loa (eye worm) AUR protein kinase 0.0116 0.0558 0.0548
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0507 0.2553 0.6639
Onchocerca volvulus 0.0507 0.2553 1
Brugia malayi Papain family cysteine protease containing protein 0.014 0.068 0.0665
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0507 0.2553 0.6639
Toxoplasma gondii cathepsin CPC2 0.014 0.068 0.0407
Giardia lamblia Cathepsin L precursor 0.014 0.068 0.0407
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0289 0.1439 0.0933
Loa Loa (eye worm) hypothetical protein 0.1969 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0507 0.2553 0.6639
Entamoeba histolytica cysteine protease, putative 0.0289 0.1439 0.4418
Giardia lamblia Cathepsin L precursor 0.014 0.068 0.0407
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0507 0.2553 0.6639
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0507 0.2553 0.6639
Echinococcus multilocularis cathepsin L cysteine protease 0.0507 0.2553 0.2541
Loa Loa (eye worm) AUR protein kinase 0.0116 0.0558 0.0548
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0006
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0009 0.0016 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0507 0.2553 0.6639
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0507 0.2553 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0358 0.1793 0.178
Loa Loa (eye worm) hypothetical protein 0.014 0.068 0.0671
Echinococcus granulosus cathepsin L cysteine proteinase 0.0507 0.2553 0.2541
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0006
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0009 0.0016 0.0016
Onchocerca volvulus Cathepsin L homolog 0.014 0.068 0.0011
Brugia malayi Cathepsin L-like precursor 0.0507 0.2553 0.2541
Echinococcus granulosus cathepsin l1 0.0507 0.2553 0.2541
Echinococcus granulosus twitchin 0.0015 0.0042 0.0027
Giardia lamblia Cysteine protease 0.014 0.068 0.0407
Entamoeba histolytica cysteine protease, putative 0.0289 0.1439 0.4418
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.068 0.0407
Schistosoma mansoni nephrin 0.0012 0.0028 0.0028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0507 0.2553 0.6639
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.014 0.068 0.0407
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0507 0.2553 0.6639
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.014 0.068 0.0407
Echinococcus granulosus cysteine protease 0.0289 0.1439 0.1426
Schistosoma mansoni cathepsin F (C01 family) 0.0358 0.1793 0.1793
Entamoeba histolytica cysteine proteinase, putative 0.0289 0.1439 0.4418
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.014 0.068 0.0407
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0006
Entamoeba histolytica cysteine protease, putative 0.0289 0.1439 0.4418
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0358 0.1793 0.1309
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0507 0.2553 0.6639
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.014 0.068 0.0407
Onchocerca volvulus Cathepsin L homolog 0.0507 0.2553 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0289 0.1439 0.2933
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.014 0.068 0.0613
Entamoeba histolytica hypothetical protein 0.014 0.068 0.0613
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0507 0.2553 0.6639
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0507 0.2553 0.6639
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.014 0.068 0.0407
Echinococcus granulosus cathepsin L cysteine protease 0.0289 0.1439 0.1426
Brugia malayi Papain family cysteine protease containing protein 0.0507 0.2553 0.2541
Entamoeba histolytica cysteine protease, putative 0.0289 0.1439 0.4418
Leishmania major cathepsin L-like protease 0.0507 0.2553 0.6639
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.014 0.068 0.0407
Loa Loa (eye worm) hypothetical protein 0.0149 0.0727 0.0718
Toxoplasma gondii cathepsin B 0.0706 0.3562 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0706 0.3562 0.3562
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.014 0.068 0.0407
Entamoeba histolytica cysteine proteinase, putative 0.0289 0.1439 0.4418
Giardia lamblia Encystation-specific protease 0.014 0.068 0.0407
Echinococcus multilocularis cathepsin L 0.014 0.068 0.0665
Echinococcus multilocularis cathepsin b 0.1969 1 1
Onchocerca volvulus 0.0507 0.2553 1
Brugia malayi serine/threonine-protein kinase 6 0.0116 0.0558 0.0543
Leishmania major cathepsin L-like protease 0.0507 0.2553 0.6639
Plasmodium vivax vivapain-2 0.0507 0.2553 1
Plasmodium falciparum serine repeat antigen 9 0.014 0.068 0.0613
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0706 0.3562 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.014 0.068 0.068
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.014 0.068 0.0613
Entamoeba histolytica cysteine proteinase, putative 0.0358 0.1793 0.6194
Loa Loa (eye worm) hypothetical protein 0.014 0.068 0.0671
Entamoeba histolytica cysteine protease, putative 0.0507 0.2553 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.014 0.068 0.0407
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0507 0.2553 0.6639
Plasmodium falciparum cysteine proteinase falcipain 1 0.0289 0.1439 0.4418
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0507 0.2553 0.6639
Entamoeba histolytica cysteine protease, putative 0.0289 0.1439 0.4418
Plasmodium falciparum cysteine proteinase falcipain 3 0.0507 0.2553 1
Brugia malayi Papain family cysteine protease containing protein 0.0289 0.1439 0.1426
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0507 0.2553 0.6639
Trypanosoma cruzi cysteine peptidase, putative 0.0507 0.2553 0.2113
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.014 0.068 0.0671
Echinococcus multilocularis neuroglian 0.0012 0.0028 0.0012
Onchocerca volvulus 0.0358 0.1793 0.5951
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0289 0.1439 0.2933
Giardia lamblia Hypothetical protein 0.014 0.068 0.0407
Schistosoma mansoni cathepsin B (C01 family) 0.014 0.068 0.068
Plasmodium vivax unspecified product 0.0289 0.1439 0.4418
Loa Loa (eye worm) cathepsin B 0.0706 0.3562 0.3556
Brugia malayi Cathepsin L-like precursor 0.0507 0.2553 0.2541
Onchocerca volvulus 0.0507 0.2553 1
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.014 0.068 0.0613
Brugia malayi cathepsin Z-like cysteine proteinase 0.014 0.068 0.0665
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0507 0.2553 0.6639
Loa Loa (eye worm) hypothetical protein 0.0507 0.2553 0.2545
Loa Loa (eye worm) papain family cysteine protease containing protein 0.014 0.068 0.0671
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0289 0.1439 0.2933
Entamoeba histolytica cysteine protease, putative 0.0289 0.1439 0.4418
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.014 0.068 0.068
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0507 0.2553 0.6639
Plasmodium vivax vivapain-1 0.0289 0.1439 0.4418
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1969 1 1
Trypanosoma cruzi major cysteine proteinase, putative 0.014 0.068 0.0129
Trypanosoma brucei cysteine peptidase C (CPC) 0.0706 0.3562 1
Entamoeba histolytica cysteine protease, putative 0.014 0.068 0.0613
Plasmodium falciparum serine repeat antigen 1 0.014 0.068 0.0613
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0507 0.2553 0.6639
Entamoeba histolytica cysteine protease, putative 0.0289 0.1439 0.4418
Toxoplasma gondii cathepsin CPL 0.0507 0.2553 0.6639
Schistosoma mansoni vesicular amine transporter 0.0009 0.0016 0.0016
Echinococcus granulosus neuroglian 0.0012 0.0028 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0507 0.2553 0.6639
Brugia malayi cathepsin L-like cysteine proteinase 0.014 0.068 0.0665
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.014 0.068 0.0613
Brugia malayi Papain family cysteine protease containing protein 0.0289 0.1439 0.1426
Echinococcus granulosus cathepsin l1 0.0358 0.1793 0.178
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1969 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.068 0.0407
Schistosoma mansoni protein kinase 0.0116 0.0558 0.0558
Brugia malayi Cathepsin L-like precursor 0.0507 0.2553 0.2541
Entamoeba histolytica cysteine proteinase, putative 0.0289 0.1439 0.4418
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0149 0.0727 0.0718
Onchocerca volvulus 0.0507 0.2553 1
Giardia lamblia Hypothetical protein 0.014 0.068 0.0407
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0507 0.2553 0.6639
Giardia lamblia Cathepsin B precursor 0.014 0.068 0.0407
Schistosoma mansoni cathepsin S (C01 family) 0.014 0.068 0.068
Brugia malayi serine/threonine kinase 12 0.0116 0.0558 0.0543
Giardia lamblia Dipeptidyl-peptidase I precursor 0.014 0.068 0.0407
Echinococcus multilocularis cathepsin L cysteine protease 0.0507 0.2553 0.2541
Echinococcus multilocularis cathepsin L 0.0289 0.1439 0.1426
Entamoeba histolytica cysteine protease, putative 0.0289 0.1439 0.4418
Plasmodium vivax serine-repeat antigen (SERA), putative 0.014 0.068 0.0613
Leishmania major cysteine peptidase A (CPA) 0.0507 0.2553 0.6639
Schistosoma mansoni serine/threonine protein kinase 0.0116 0.0558 0.0558
Echinococcus multilocularis roundabout 2 0.0015 0.0044 0.0028
Brugia malayi cathepsin L-like precursor 0.0358 0.1793 0.178
Entamoeba histolytica papain family cysteine protease domain containing protein 0.014 0.068 0.0613
Trypanosoma cruzi cysteine peptidase, putative 0.0507 0.2553 0.2113
Schistosoma mansoni cathepsin s 0.0149 0.0727 0.0727
Loa Loa (eye worm) hypothetical protein 0.014 0.068 0.0671
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0149 0.0727 0.0712
Brugia malayi Cathepsin L-like precursor 0.0507 0.2553 0.2541
Entamoeba histolytica cysteine protease, putative 0.0289 0.1439 0.4418
Loa Loa (eye worm) ctsf protein 0.0507 0.2553 0.2545
Giardia lamblia Cathepsin B precursor 0.014 0.068 0.0407
Loa Loa (eye worm) hypothetical protein 0.0358 0.1793 0.1785
Loa Loa (eye worm) hypothetical protein 0.014 0.068 0.0671
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.068 0.0407
Plasmodium falciparum serine repeat antigen 5 0.014 0.068 0.0613
Plasmodium falciparum serine repeat antigen 4 0.014 0.068 0.0613
Giardia lamblia Cathepsin L precursor 0.014 0.068 0.0407
Loa Loa (eye worm) hypothetical protein 0.0012 0.0031 0.0021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0507 0.2553 0.6639
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0706 0.3562 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0358 0.1793 0.4112
Entamoeba histolytica cysteine proteinase 2 0.0289 0.1439 0.4418
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0289 0.1439 0.2933
Plasmodium vivax unspecified product 0.0149 0.0727 0.0849
Trichomonas vaginalis conserved hypothetical protein 0.014 0.068 0.0407
Leishmania major cathepsin L-like protease 0.0507 0.2553 0.6639
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0507 0.2553 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.014 0.068 0.0665
Toxoplasma gondii preprocathepsin c precursor, putative 0.014 0.068 0.0407
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.014 0.068 0.0613
Onchocerca volvulus Tyrosine kinase homolog 0.0143 0.0694 0.0088
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0012 0.0031 0.0016
Loa Loa (eye worm) hypothetical protein 0.0009 0.0016 0.0006
Brugia malayi serine/threonine protein kinase 6 0.0116 0.0558 0.0543
Echinococcus granulosus cathepsin b 0.1969 1 1
Onchocerca volvulus 0.014 0.068 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0507 0.2553 0.6639
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0358 0.1793 0.4112
Plasmodium vivax unspecified product 0.014 0.068 0.0613
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.014 0.068 0.0613
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.014 0.068 0.068
Brugia malayi Cathepsin L-like precursor 0.0149 0.0727 0.0712
Onchocerca volvulus 0.0507 0.2553 1
Schistosoma mansoni cathepsin C 0.014 0.068 0.068
Plasmodium falciparum serine repeat antigen 2 0.014 0.068 0.0613
Loa Loa (eye worm) hypothetical protein 0.0149 0.0727 0.0718
Plasmodium falciparum serine repeat antigen 8 0.014 0.068 0.0613
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.014 0.068 0.068
Loa Loa (eye worm) hypothetical protein 0.014 0.068 0.0671
Brugia malayi Cathepsin L-like precursor 0.0358 0.1793 0.178
Giardia lamblia Cathepsin B precursor 0.014 0.068 0.0407
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0153 0.0746 0.0736
Giardia lamblia Cathepsin L-like protease 0.014 0.068 0.0407
Brugia malayi cathepsin L precursor 0.014 0.068 0.0665
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1969 1 1
Plasmodium falciparum serine repeat antigen 6 0.014 0.068 0.0613
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1969 1 1
Brugia malayi Papain family cysteine protease containing protein 0.014 0.068 0.0665
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.014 0.068 0.068
Echinococcus multilocularis aurora kinase A 0.0116 0.0558 0.0543
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0507 0.2553 0.6639
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.014 0.068 0.068
Plasmodium vivax serine-repeat antigen (SERA) 0.014 0.068 0.0613
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.014 0.068 0.0613
Giardia lamblia Cysteine protease 0.014 0.068 0.0407
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.014 0.068 0.0613
Trypanosoma cruzi cysteine proteinase, putative 0.0289 0.1439 0.0933
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0507 0.2553 0.6639
Entamoeba histolytica cysteine protease, putative 0.014 0.068 0.0613
Giardia lamblia Cathepsin B precursor 0.0706 0.3562 1
Plasmodium vivax vivapain-2 0.0507 0.2553 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0507 0.2553 0.6639
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.068 0.0407
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0507 0.2553 0.6639
Loa Loa (eye worm) cysteine protease 0.0507 0.2553 0.2545
Echinococcus granulosus cathepsin b 0.1969 1 1
Brugia malayi Cathepsin L-like precursor 0.0507 0.2553 0.2541
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0034
Schistosoma mansoni cathepsin F (C01 family) 0.0507 0.2553 0.2553
Giardia lamblia Cathepsin L precursor 0.014 0.068 0.0407
Giardia lamblia Dipeptidyl-peptidase I precursor 0.014 0.068 0.0407
Schistosoma mansoni serine/threonine protein kinase 0.0677 0.3419 0.3419
Echinococcus granulosus cathepsin L 0.014 0.068 0.0665
Entamoeba histolytica cysteine protease, putative 0.014 0.068 0.0613
Trypanosoma cruzi cysteine peptidase, putative 0.0507 0.2553 0.2113
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0507 0.2553 0.6639
Plasmodium falciparum serine repeat antigen 7 0.014 0.068 0.0613
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0677 0.3419 0.3413
Giardia lamblia Cathepsin B precursor 0.014 0.068 0.0407
Giardia lamblia Cysteine protease 0.014 0.068 0.0407
Entamoeba histolytica cysteine protease, putative 0.0289 0.1439 0.4418
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0507 0.2553 0.6639
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0507 0.2553 0.2545

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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