Detailed information for compound 902564

Basic information

Technical information
  • TDR Targets ID: 902564
  • Name: 2-[(4-pentoxyphenyl)methylidene]indene-1,3-di one
  • MW: 320.382 | Formula: C21H20O3
  • H donors: 0 H acceptors: 2 LogP: 5.27 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCOc1ccc(cc1)C=C1C(=O)c2c(C1=O)cccc2
  • InChi: 1S/C21H20O3/c1-2-3-6-13-24-16-11-9-15(10-12-16)14-19-20(22)17-7-4-5-8-18(17)21(19)23/h4-5,7-12,14H,2-3,6,13H2,1H3
  • InChiKey: UYTUTQSOXBXHHT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(4-pentoxyphenyl)methylene]indane-1,3-dione
  • 2-(4-amoxybenzylidene)indane-1,3-quinone
  • ZINC02023361
  • CBDivE_013219
  • 2-[4-(Pentyloxy)benzylidene]-1,3-indandione
  • 2-[4-(Pentyloxy)benzylidene]-1H-indene-1,3(2H)-dione

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cathepsin L cysteine proteinase 0.0297 0.5372 0.5372
Brugia malayi Cathepsin L-like precursor 0.0297 0.5372 0.5737
Giardia lamblia Cathepsin B precursor 0.0066 0.0885 0.2585
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0066 0.0885 0.1039
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0489 0.9093 1
Giardia lamblia Cysteine protease 0.0066 0.0885 0.2585
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0197 0.3423 0.6109
Onchocerca volvulus 0.0066 0.0885 0.1039
Echinococcus multilocularis neuropeptide s receptor 0.0536 1 1
Plasmodium vivax pyruvate kinase, putative 0.0039 0.0365 0.0679
Leishmania major cathepsin L-like protease 0.0297 0.5372 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0297 0.5372 1
Plasmodium vivax unspecified product 0.0159 0.2704 0.5033
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0297 0.5372 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0885 0.0834
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0297 0.5372 1
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0066 0.0885 0.1647
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0297 0.5372 1
Trypanosoma cruzi cysteine protease, putative 0.0159 0.2704 0.268
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0159 0.2704 0.4672
Plasmodium falciparum cysteine proteinase falcipain 1 0.0159 0.2704 0.5033
Onchocerca volvulus Cathepsin L homolog 0.0297 0.5372 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0297 0.5372 1
Brugia malayi Cathepsin L-like precursor 0.0297 0.5372 0.5737
Loa Loa (eye worm) hypothetical protein 0.0203 0.3553 0.3813
Plasmodium falciparum serine repeat antigen 4 0.0066 0.0885 0.1647
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0297 0.5372 0.5372
Toxoplasma gondii cathepsin CPL 0.0297 0.5372 1
Entamoeba histolytica cysteine protease, putative 0.0159 0.2704 0.4903
Giardia lamblia Cysteine protease 0.0066 0.0885 0.2585
Giardia lamblia Cathepsin L precursor 0.0066 0.0885 0.2585
Loa Loa (eye worm) hypothetical protein 0.0489 0.9093 1
Entamoeba histolytica cysteine protease, putative 0.0159 0.2704 0.4903
Brugia malayi cathepsin Z-like cysteine proteinase 0.0066 0.0885 0.0596
Echinococcus granulosus cathepsin b 0.0489 0.9093 0.9093
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0297 0.5372 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0885 0.0834
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0066 0.0885 0.0834
Leishmania major cathepsin L-like protease 0.0297 0.5372 1
Plasmodium vivax vivapain-3 0.0159 0.2704 0.5033
Plasmodium falciparum serine repeat antigen 5 0.0066 0.0885 0.1647
Leishmania major cysteine peptidase A (CPA) 0.0297 0.5372 1
Entamoeba histolytica cysteine proteinase, putative 0.0159 0.2704 0.4903
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0066 0.0885 0.2585
Entamoeba histolytica cysteine protease, putative 0.0159 0.2704 0.4903
Brugia malayi cathepsin L-like cysteine proteinase 0.0066 0.0885 0.0596
Giardia lamblia Cathepsin B precursor 0.0197 0.3423 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0489 0.9093 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0066 0.0885 0.2585
Giardia lamblia Cysteine protease 0.0066 0.0885 0.2585
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0066 0.0885 0.0973
Trypanosoma cruzi cysteine proteinase, putative 0.0159 0.2704 0.268
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0297 0.5372 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0297 0.5372 1
Brugia malayi Cathepsin L-like precursor 0.0297 0.5372 0.5737
Brugia malayi Papain family cysteine protease containing protein 0.0066 0.0885 0.0596
Mycobacterium leprae Probable pyruvate kinase PykA 0.0039 0.0365 0.5
Onchocerca volvulus 0.0297 0.5372 1
Brugia malayi Cathepsin L-like precursor 0.0094 0.1435 0.1226
Trypanosoma cruzi major cysteine proteinase, putative 0.0066 0.0885 0.0596
Giardia lamblia Cathepsin L precursor 0.0066 0.0885 0.2585
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0297 0.5372 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0297 0.5372 1
Plasmodium vivax vivapain-1 0.0159 0.2704 0.5033
Schistosoma mansoni pyruvate kinase 0.0039 0.0365 0.0401
Trypanosoma cruzi cruzipain precursor, putative 0.0297 0.5372 0.5737
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0197 0.3423 0.3504
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0365 0.0253
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0066 0.0885 0.1039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0203 0.3553 0.6367
Giardia lamblia Cathepsin L precursor 0.0066 0.0885 0.2585
Echinococcus multilocularis pyruvate kinase 0.0039 0.0365 0.0365
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0066 0.0885 0.1647
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0066 0.0885 0.1647
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0159 0.2704 0.2974
Onchocerca volvulus 0.0203 0.3553 0.6367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0066 0.0885 0.1039
Entamoeba histolytica cysteine protease, putative 0.0159 0.2704 0.4903
Brugia malayi Cathepsin L-like precursor 0.0297 0.5372 0.5737
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0066 0.0885 0.1039
Brugia malayi Cathepsin L-like cysteine proteinase 0.0203 0.3553 0.3653
Loa Loa (eye worm) hypothetical protein 0.0094 0.1435 0.1448
Trypanosoma cruzi cruzipain precursor, putative 0.0094 0.1435 0.1226
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0066 0.0885 0.1647
Brugia malayi cathepsin L-like precursor 0.0203 0.3553 0.3653
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0159 0.2704 0.4672
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0066 0.0885 0.1039
Loa Loa (eye worm) hypothetical protein 0.0066 0.0885 0.0834
Brugia malayi Papain family cysteine protease containing protein 0.0066 0.0885 0.0596
Trypanosoma cruzi major cysteine proteinase, putative 0.0066 0.0885 0.0596
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0297 0.5372 1
Echinococcus multilocularis pyruvate kinase 0.0031 0.0207 0.0207
Schistosoma mansoni cathepsin B (C01 family) 0.0066 0.0885 0.0973
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0297 0.5372 1
Onchocerca volvulus 0.0297 0.5372 1
Entamoeba histolytica cysteine protease, putative 0.0066 0.0885 0.1427
Entamoeba histolytica cysteine protease, putative 0.0066 0.0885 0.1427
Plasmodium vivax unspecified product 0.0094 0.1435 0.2671
Giardia lamblia Encystation-specific protease 0.0066 0.0885 0.2585
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0297 0.5372 1
Schistosoma mansoni cathepsin F (C01 family) 0.0203 0.3553 0.3907
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0066 0.0885 0.1647
Entamoeba histolytica cysteine protease, putative 0.0159 0.2704 0.4903
Loa Loa (eye worm) hypothetical protein 0.0094 0.1435 0.1448
Echinococcus multilocularis pyruvate kinase 0.0039 0.0365 0.0365
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0159 0.2704 0.2974
Onchocerca volvulus 0.0297 0.5372 1
Echinococcus multilocularis neuropeptide receptor A26 0.0536 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0066 0.0885 0.1039
Entamoeba histolytica cysteine proteinase, putative 0.0203 0.3553 0.6524
Plasmodium vivax serine-repeat antigen (SERA) 0.0066 0.0885 0.1647
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0066 0.0885 0.0973
Onchocerca volvulus 0.0297 0.5372 1
Entamoeba histolytica cysteine protease, putative 0.0159 0.2704 0.4903
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0066 0.0885 0.1427
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0066 0.0885 0.0973
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0365 0.0253
Giardia lamblia Cathepsin L-like protease 0.0066 0.0885 0.2585
Toxoplasma gondii cathepsin B 0.0197 0.3423 0.6373
Plasmodium falciparum serine repeat antigen 3 0.0066 0.0885 0.1647
Echinococcus multilocularis cathepsin L 0.0159 0.2704 0.2704
Entamoeba histolytica hypothetical protein 0.0066 0.0885 0.1427
Trypanosoma cruzi cysteine peptidase, putative 0.0094 0.1435 0.1226
Giardia lamblia Hypothetical protein 0.0066 0.0885 0.2585
Giardia lamblia Cathepsin L precursor 0.0066 0.0885 0.2585
Entamoeba histolytica cysteine protease, putative 0.0066 0.0885 0.1427
Brugia malayi cathepsin B-like cysteine proteinase 0.0489 0.9093 1
Plasmodium falciparum pyruvate kinase 0.0039 0.0365 0.0679
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0066 0.0885 0.1039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0066 0.0885 0.1039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0297 0.5372 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0066 0.0885 0.2585
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0489 0.9093 1
Brugia malayi Papain family cysteine protease containing protein 0.0066 0.0885 0.0596
Plasmodium falciparum serine repeat antigen 9 0.0066 0.0885 0.1647
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0066 0.0885 0.0834
Echinococcus granulosus cathepsin l1 0.0297 0.5372 0.5372
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0489 0.9093 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0297 0.5372 1
Plasmodium vivax vivapain-2 0.0297 0.5372 1
Toxoplasma gondii cathepsin CPC2 0.0066 0.0885 0.1647
Giardia lamblia Cathepsin B precursor 0.0066 0.0885 0.2585
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0066 0.0885 0.0973
Echinococcus granulosus cathepsin L 0.0159 0.2704 0.2704
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0297 0.5372 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0066 0.0885 0.1039
Toxoplasma gondii cathepsin CPC1 0.0066 0.0885 0.1647
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0066 0.0885 0.1647
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0297 0.5372 1
Entamoeba histolytica cysteine proteinase, putative 0.0297 0.5372 1
Loa Loa (eye worm) fibroinase 0.0297 0.5372 0.5845
Echinococcus granulosus cathepsin L 0.0066 0.0885 0.0885
Giardia lamblia Cathepsin B precursor 0.0066 0.0885 0.2585
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0489 0.9093 1
Leishmania major cathepsin L-like protease 0.0297 0.5372 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0297 0.5372 0.5372
Chlamydia trachomatis pyruvate kinase 0.0039 0.0365 0.5
Schistosoma mansoni cathepsin F (C01 family) 0.0297 0.5372 0.5908
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0066 0.0885 0.1647
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0066 0.0885 0.1647
Entamoeba histolytica cysteine proteinase, putative 0.0159 0.2704 0.4903
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0297 0.5372 1
Loa Loa (eye worm) cysteine protease 0.0297 0.5372 0.5845
Loa Loa (eye worm) hypothetical protein 0.0066 0.0885 0.0834
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0066 0.0885 0.1039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0297 0.5372 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0297 0.5372 1
Plasmodium falciparum serine repeat antigen 7 0.0066 0.0885 0.1647
Brugia malayi Papain family cysteine protease containing protein 0.0159 0.2704 0.268
Giardia lamblia Hypothetical protein 0.0066 0.0885 0.2585
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0066 0.0885 0.0834
Loa Loa (eye worm) hypothetical protein 0.0039 0.0365 0.0253
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0094 0.1435 0.1226
Plasmodium falciparum serine repeat antigen 1 0.0066 0.0885 0.1647
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0066 0.0885 0.1647
Giardia lamblia Cysteine protease 0.0066 0.0885 0.2585
Plasmodium falciparum serine repeat antigen 8 0.0066 0.0885 0.1647
Echinococcus granulosus neuropeptide receptor A26 0.0536 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0297 0.5372 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0297 0.5372 0.5372
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0297 0.5372 0.5845
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0094 0.1435 0.1448
Brugia malayi Papain family cysteine protease containing protein 0.0297 0.5372 0.5737
Entamoeba histolytica cysteine proteinase, putative 0.0297 0.5372 1
Onchocerca volvulus 0.0297 0.5372 1
Entamoeba histolytica cysteine protease, putative 0.0159 0.2704 0.4903
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0297 0.5372 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0066 0.0885 0.1647
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0066 0.0885 0.1039
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0066 0.0885 0.2585
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0066 0.0885 0.1039
Trypanosoma cruzi cysteine peptidase, putative 0.0297 0.5372 0.5737
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0066 0.0885 0.0973
Giardia lamblia Cathepsin L-like protease 0.0066 0.0885 0.2585
Echinococcus granulosus pyruvate kinase 0.0039 0.0365 0.0365
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0066 0.0885 0.0973
Loa Loa (eye worm) hypothetical protein 0.0175 0.3009 0.3206
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0066 0.0885 0.1647
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0066 0.0885 0.0973
Giardia lamblia Cathepsin B precursor 0.0197 0.3423 1
Onchocerca volvulus 0.0297 0.5372 1
Entamoeba histolytica cysteine proteinase, putative 0.0159 0.2704 0.4903
Echinococcus multilocularis cathepsin b 0.0489 0.9093 0.9093
Echinococcus multilocularis cathepsin L 0.0066 0.0885 0.0885
Onchocerca volvulus Cathepsin L homolog 0.0066 0.0885 0.1039
Schistosoma mansoni cathepsin S (C01 family) 0.0066 0.0885 0.0973
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0297 0.5372 1
Entamoeba histolytica cysteine protease, putative 0.0159 0.2704 0.4903
Echinococcus multilocularis cathepsin L cysteine protease 0.0297 0.5372 0.5372
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0297 0.5372 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0159 0.2704 0.2974
Entamoeba histolytica cysteine protease, putative 0.0066 0.0885 0.1427
Echinococcus granulosus cathepsin l1 0.0203 0.3553 0.3553
Entamoeba histolytica cysteine proteinase 2 0.0159 0.2704 0.4903
Onchocerca volvulus Cathepsin L homolog 0.0297 0.5372 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0203 0.3553 0.3653
Entamoeba histolytica cysteine protease, putative 0.0159 0.2704 0.4903
Giardia lamblia Cathepsin B precursor 0.0066 0.0885 0.2585
Loa Loa (eye worm) hypothetical protein 0.0203 0.3553 0.3813
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0297 0.5372 1
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0885 0.1039
Loa Loa (eye worm) ctsf protein 0.0297 0.5372 0.5845
Echinococcus multilocularis cysteine protease 0.0297 0.5372 0.5372
Giardia lamblia Pyruvate kinase 0.0039 0.0365 0.1065
Leishmania major cathepsin L-like protease 0.0297 0.5372 1
Brugia malayi Cathepsin L-like precursor 0.0203 0.3553 0.3653
Echinococcus granulosus cathepsin L cysteine protease 0.0159 0.2704 0.2704
Loa Loa (eye worm) hypothetical protein 0.0066 0.0885 0.0834
Leishmania major cathepsin L-like protease 0.0297 0.5372 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0297 0.5372 1
Brugia malayi Papain family cysteine protease containing protein 0.0159 0.2704 0.268
Brugia malayi fibroinase precursor 0.0066 0.0885 0.0596
Plasmodium vivax unspecified product 0.0066 0.0885 0.1647
Toxoplasma gondii pyruvate kinase PyK1 0.0039 0.0365 0.0679
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0297 0.5372 1
Echinococcus granulosus cysteine protease 0.0159 0.2704 0.2704
Leishmania major cathepsin L-like protease 0.0297 0.5372 1
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0365 0.0253
Trypanosoma brucei cysteine peptidase C (CPC) 0.0197 0.3423 0.6109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0297 0.5372 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.0066 0.0885 0.1647
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0066 0.0885 0.1039
Loa Loa (eye worm) hypothetical protein 0.0203 0.3553 0.3813
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0297 0.5372 1
Trypanosoma cruzi cysteine peptidase, putative 0.0297 0.5372 0.5737
Brugia malayi cathepsin F-like cysteine proteinase 0.0094 0.1435 0.1226
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0203 0.3553 0.6367
Giardia lamblia Cathepsin L precursor 0.0066 0.0885 0.2585
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0066 0.0885 0.1039
Onchocerca volvulus 0.0175 0.3009 0.5281
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0297 0.5372 1
Brugia malayi cathepsin L precursor 0.0066 0.0885 0.0596
Loa Loa (eye worm) hypothetical protein 0.0066 0.0885 0.0834
Plasmodium falciparum cysteine proteinase falcipain 3 0.0297 0.5372 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0066 0.0885 0.0973
Entamoeba histolytica cysteine protease, putative 0.0159 0.2704 0.4903
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0066 0.0885 0.1427
Leishmania major cathepsin L-like protease 0.0297 0.5372 1
Entamoeba histolytica cysteine protease, putative 0.0066 0.0885 0.1427
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0297 0.5372 1
Giardia lamblia Cathepsin B precursor 0.0197 0.3423 1
Echinococcus granulosus cathepsin b 0.0489 0.9093 0.9093
Echinococcus multilocularis cysteine protease 0.0297 0.5372 0.5372
Echinococcus granulosus cathepsin l cysteine peptidase 0.0297 0.5372 0.5372
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0159 0.2704 0.268
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0885 0.1039
Echinococcus granulosus pyruvate kinase 0.0039 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.0297 0.5372 0.5845
Giardia lamblia Cathepsin L precursor 0.0066 0.0885 0.2585
Trypanosoma cruzi cysteine peptidase, putative 0.0159 0.2704 0.268
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0297 0.5372 0.5845
Echinococcus multilocularis cathepsin b 0.0489 0.9093 0.9093
Schistosoma mansoni cathepsin C 0.0066 0.0885 0.0973
Leishmania major cathepsin L-like protease 0.0297 0.5372 1
Brugia malayi Cathepsin L-like precursor 0.0297 0.5372 0.5737
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0197 0.3423 0.6109
Plasmodium vivax vivapain-2 0.0297 0.5372 1
Plasmodium falciparum serine repeat antigen 6 0.0066 0.0885 0.1647
Entamoeba histolytica cysteine proteinase 1, putative 0.0159 0.2704 0.4903
Brugia malayi cathepsin Z-like cysteine proteinase 0.0066 0.0885 0.0596
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0297 0.5372 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0297 0.5372 1
Mycobacterium ulcerans pyruvate kinase 0.0039 0.0365 0.5
Brugia malayi Cathepsin L-like precursor 0.0203 0.3553 0.3653
Schistosoma mansoni pyruvate kinase 0.0039 0.0365 0.0401
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0066 0.0885 0.1039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0159 0.2704 0.4672
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0039 0.0365 0.5
Plasmodium vivax serine-repeat antigen (SERA) 0.0066 0.0885 0.1647
Onchocerca volvulus Cathepsin F homolog 0.0297 0.5372 1
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0066 0.0885 0.1647
Trypanosoma cruzi cysteine peptidase, putative 0.0297 0.5372 0.5737
Giardia lamblia Cathepsin B precursor 0.0066 0.0885 0.2585
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0297 0.5372 1
Loa Loa (eye worm) cathepsin B 0.0197 0.3423 0.3669
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0066 0.0885 0.1039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0297 0.5372 1
Onchocerca volvulus 0.0297 0.5372 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0066 0.0885 0.0596
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0159 0.2704 0.4672
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0297 0.5372 1
Brugia malayi hypothetical protein 0.0175 0.3009 0.3029
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0197 0.3423 0.3765
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0066 0.0885 0.0596
Trypanosoma cruzi cysteine proteinase, putative 0.0159 0.2704 0.268
Entamoeba histolytica cysteine protease, putative 0.0066 0.0885 0.1427
Brugia malayi Cathepsin L-like precursor 0.0297 0.5372 0.5737
Entamoeba histolytica cysteine protease, putative 0.0159 0.2704 0.4903
Schistosoma mansoni cathepsin F (C01 family) 0.0297 0.5372 0.5908
Entamoeba histolytica cysteine protease, putative 0.0159 0.2704 0.4903
Entamoeba histolytica cysteine proteinase, putative 0.0159 0.2704 0.4903
Entamoeba histolytica cysteine protease, putative 0.0297 0.5372 1
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0066 0.0885 0.1647
Schistosoma mansoni cathepsin s 0.0094 0.1435 0.1578
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0066 0.0885 0.0973
Trypanosoma cruzi cysteine peptidase, putative 0.0297 0.5372 0.5737
Loa Loa (eye worm) hypothetical protein 0.0094 0.1435 0.1448
Entamoeba histolytica cysteine protease, putative 0.0159 0.2704 0.4903
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0066 0.0885 0.1039
Plasmodium falciparum serine repeat antigen 2 0.0066 0.0885 0.1647
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0297 0.5372 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0297 0.5372 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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