TDR Targets

Basic information

Technical information

TDR Targets ID: 906595
Name: 2-chloro-N-[2-(3,4-dimethylphenyl)-4-oxoquina zolin-3-yl]-4-fluorobenzamide
MW: 421.851 | Formula: C23H17ClFN3O2
H donors: 1 H acceptors: 2 LogP: 5.16 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(c(c1)Cl)C(=O)Nn1c(nc2c(c1=O)cccc2)c1ccc(c(c1)C)C
InChi: 1S/C23H17ClFN3O2/c1-13-7-8-15(11-14(13)2)21-26-20-6-4-3-5-18(20)23(30)28(21)27-22(29)17-10-9-16(25)12-19(17)24/h3-12H,1-2H3,(H,27,29)
InChiKey: OSNBQFAUMCTJPT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-chloro-N-[2-(3,4-dimethylphenyl)-4-oxo-quinazolin-3-yl]-4-fluoro-benzamide
2-chloro-N-[2-(3,4-dimethylphenyl)-4-oxo-3-quinazolinyl]-4-fluorobenzamide
2-chloro-N-[2-(3,4-dimethylphenyl)-4-keto-quinazolin-3-yl]-4-fluoro-benzamide
Oprea1_391059

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.2102	0.2683	0.6288
Entamoeba histolytica	cysteine protease, putative	0.1215	0.1542	0.5557
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0105	0.0115	0.0137
Schistosoma mansoni	cathepsin F (C01 family)	0.2102	0.2683	0.2667
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4466	0.5726	1
Echinococcus granulosus	cathepsin L cysteine protease	0.1215	0.1542	0.2274
Loa Loa (eye worm)	hypothetical protein	0.0605	0.0757	0.1099
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.014	0.0159	0.0137
Onchocerca volvulus	Cathepsin F homolog	0.2102	0.2683	1
Leishmania major	cathepsin L-like protease	0.2102	0.2683	0.4686
Plasmodium falciparum	plasmepsin IV	0.1106	0.1403	0.5228
Trypanosoma cruzi	ribonucleoside-diphosphate reductase large chain, putative	0.0194	0.0229	0.0341
Leishmania major	cathepsin L-like protease	0.2102	0.2683	0.4686
Plasmodium vivax	serine-repeat antigen (SERA)	0.061	0.0764	0.2847
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1215	0.1542	0.1523
Echinococcus multilocularis	cathepsin L cysteine protease	0.2102	0.2683	0.3982
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2102	0.2683	0.6288
Onchocerca volvulus		0.0353	0.0434	0.156
Onchocerca volvulus		0.2102	0.2683	1
Brugia malayi	aspartic protease BmAsp-1, identical	0.0353	0.0434	0.0615
Plasmodium falciparum	cysteine proteinase falcipain 3	0.2102	0.2683	1
Brugia malayi	Cathepsin L-like precursor	0.2102	0.2683	0.3982
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1215	0.1542	0.2693
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.061	0.0764	0.2527
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.2102	0.2683	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2102	0.2683	0.6288
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4466	0.5726	1
Trypanosoma cruzi	cysteine proteinase, putative	0.1215	0.1542	0.23
Echinococcus multilocularis	kelch ECH associated protein 1	0.0276	0.0335	0.0467
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0165	0.0213
Entamoeba histolytica	cysteine protease, putative	0.061	0.0764	0.2527
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.061	0.0764	0.2847
Schistosoma mansoni	hypothetical protein	0.0046	0.0038	0.0015
Brugia malayi	aspartic protease BmAsp-2, identical	0.0353	0.0434	0.0615
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2102	0.2683	0.6288
Plasmodium vivax	vivapain-3	0.1215	0.1542	0.5747
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2102	0.2683	0.6288
Brugia malayi	Cathepsin L-like cysteine proteinase	0.1497	0.1905	0.2817
Plasmodium vivax	aspartyl protease, putative	0.0353	0.0434	0.1617
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2102	0.2683	0.6288
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0277	0.0336	0.0314
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.061	0.0764	0.0743
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.061	0.0764	0.2847
Onchocerca volvulus		0.2102	0.2683	1
Onchocerca volvulus		0.2102	0.2683	1
Leishmania major	cathepsin L-like protease	0.2102	0.2683	0.4686
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.1106	0.1403	0.1383
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1497	0.1905	0.4464
Plasmodium falciparum	serine repeat antigen 6	0.061	0.0764	0.2847
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2102	0.2683	0.6288
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.061	0.0764	0.179
Entamoeba histolytica	cysteine protease, putative	0.1215	0.1542	0.5557
Plasmodium falciparum	plasmepsin X	0.0353	0.0434	0.1617
Onchocerca volvulus		0.061	0.0764	0.2798
Brugia malayi	hypothetical protein	0.0353	0.0434	0.0615
Echinococcus granulosus	cathepsin L	0.061	0.0764	0.1109
Loa Loa (eye worm)	hypothetical protein	0.061	0.0764	0.1109
Plasmodium falciparum	plasmepsin VI	0.1106	0.1403	0.5228
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.061	0.0764	0.2847
Brugia malayi	fibroinase precursor	0.061	0.0764	0.1109
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.5227	0.6705	0.6697
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0046	0.0038	0.0023
Echinococcus granulosus	GPCR family 2	0.0046	0.0038	0.0023
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2102	0.2683	0.6288
Trichomonas vaginalis	replication factor A 1, rfa1, putative	0.0034	0.0023	0.0053
Brugia malayi	Cathepsin L-like precursor	0.2102	0.2683	0.3982
Trypanosoma cruzi	cruzipain precursor, putative	0.4466	0.5726	0.854
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.1106	0.1403	0.2065
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0072	0.0072	0.005
Brugia malayi	Latrophilin receptor protein 2	0.0046	0.0038	0.0023
Trypanosoma cruzi	cysteine peptidase, putative	0.4466	0.5726	0.854
Schistosoma mansoni	cathepsin D (A01 family)	0.289	0.3698	0.3683
Echinococcus multilocularis	Kelch repeat type 1	0.0277	0.0336	0.0468
Schistosoma mansoni	hypothetical protein	0.0046	0.0038	0.0015
Entamoeba histolytica	cysteine protease, putative	0.2102	0.2683	1
Entamoeba histolytica	cysteine proteinase, putative	0.1215	0.1542	0.5557
Echinococcus granulosus	kelch ECH associated protein 1	0.0276	0.0335	0.0467
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0205	0.0243	0.0329
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0605	0.0757	0.1099
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2102	0.2683	0.6288
Schistosoma mansoni	cathepsin S (C01 family)	0.061	0.0764	0.0743
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0353	0.0434	0.0412
Plasmodium falciparum	plasmepsin VIII, putative	0.0353	0.0434	0.1617
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2102	0.2683	0.6288
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.061	0.0764	0.0743
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.061	0.0764	0.2847
Plasmodium vivax	ribonucleoside-diphosphate reductase large chain, putative	0.0194	0.0229	0.0853
Loa Loa (eye worm)	hypothetical protein	0.0353	0.0434	0.0615
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.061	0.0764	0.2847
Loa Loa (eye worm)	hypothetical protein	0.1497	0.1905	0.2817
Onchocerca volvulus		0.0353	0.0434	0.156
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0145	0.0165	0.0213
Mycobacterium tuberculosis	Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase)	0.0059	0.0055	0.1152
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0243	0.0329
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1497	0.1905	0.4464
Echinococcus granulosus	kelch ECH associated protein 1 like	0.0276	0.0335	0.0467
Plasmodium falciparum	serine repeat antigen 8	0.061	0.0764	0.2847
Leishmania major	cysteine peptidase A (CPA)	0.2102	0.2683	0.4686
Mycobacterium leprae	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN)	0.0164	0.019	0.5401
Entamoeba histolytica	cysteine protease, putative	0.1215	0.1542	0.5557
Schistosoma mansoni	Nep2 peptidase (M13 family)	0.014	0.0159	0.0137
Plasmodium falciparum	serine repeat antigen 3	0.061	0.0764	0.2847
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.5227	0.6705	1
Mycobacterium leprae	probable zinc metalloprotease	0.0277	0.0336	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.061	0.0764	0.2847
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.061	0.0764	0.0743
Plasmodium vivax	aspartyl protease, putative	0.0353	0.0434	0.1617
Brugia malayi	hypothetical protein	0.0105	0.0115	0.0137
Trypanosoma cruzi	cysteine peptidase, putative	0.0605	0.0757	0.1129
Entamoeba histolytica	cysteine protease, putative	0.1215	0.1542	0.5557
Plasmodium vivax	plasmepsin V, putative	0.0353	0.0434	0.1617
Brugia malayi	Papain family cysteine protease containing protein	0.061	0.0764	0.1109
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2102	0.2683	0.6288
Loa Loa (eye worm)	hypothetical protein	0.0605	0.0757	0.1099
Schistosoma mansoni	hypothetical protein	0.0277	0.0336	0.0314
Brugia malayi	Papain family cysteine protease containing protein	0.061	0.0764	0.1109
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.2102	0.2683	0.3982
Onchocerca volvulus		0.2102	0.2683	1
Toxoplasma gondii	peptidase family M13 protein	0.0277	0.0336	0.0787
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.061	0.0764	0.179
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2102	0.2683	0.6288
Onchocerca volvulus		0.1497	0.1905	0.708
Leishmania major	cathepsin L-like protease	0.2102	0.2683	0.4686
Entamoeba histolytica	cysteine proteinase, putative	0.1215	0.1542	0.5557
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0046	0.0038	0.0023
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.1106	0.1403	0.3287
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2102	0.2683	0.6288
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0068	0.0066	0.0043
Schistosoma mansoni	family A2 unassigned peptidase (A02 family)	0.1416	0.1801	0.1782
Brugia malayi	cathepsin L-like precursor	0.1497	0.1905	0.2817
Entamoeba histolytica	hypothetical protein	0.061	0.0764	0.2527
Entamoeba histolytica	cysteine protease, putative	0.1215	0.1542	0.5557
Mycobacterium ulcerans	zinc metalloprotease	0.0277	0.0336	1
Plasmodium falciparum	serine repeat antigen 4	0.061	0.0764	0.2847
Plasmodium vivax	vivapain-2	0.2102	0.2683	1
Entamoeba histolytica	cysteine protease, putative	0.1215	0.1542	0.5557
Toxoplasma gondii	cathepsin B	0.3333	0.4267	1
Echinococcus granulosus	cysteine protease	0.1215	0.1542	0.2274
Onchocerca volvulus		0.0137	0.0156	0.0516
Loa Loa (eye worm)	hypothetical protein	0.021	0.0249	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0243	0.0329
Entamoeba histolytica	cysteine protease, putative	0.1215	0.1542	0.5557
Trypanosoma cruzi	major cysteine proteinase, putative	0.2974	0.3806	0.5677
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.061	0.0764	0.2847
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.1106	0.1403	0.3287
Entamoeba histolytica	cysteine protease, putative	0.061	0.0764	0.2527
Onchocerca volvulus		0.2102	0.2683	1
Plasmodium falciparum	plasmepsin II	0.1106	0.1403	0.5228
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0353	0.0434	0.0615
Trypanosoma cruzi	cysteine proteinase, putative	0.1215	0.1542	0.23
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4466	0.5726	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4466	0.5726	1
Loa Loa (eye worm)	hypothetical protein	0.061	0.0764	0.1109
Loa Loa (eye worm)	ribonucleoside-diphosphate reductase large subunit	0.0194	0.0229	0.0308
Treponema pallidum	ribonucleotide-diphosphate reductase subunit alpha	0.0194	0.0229	0.5
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.014	0.0159	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0106	0.0125
Schistosoma mansoni	hypothetical protein	0.0046	0.0038	0.0015
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.061	0.0764	0.179
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.1215	0.1542	0.23
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4466	0.5726	1
Mycobacterium ulcerans	ribonucleotide-diphosphate reductase subunit alpha	0.0164	0.019	0.5401
Loa Loa (eye worm)	hypothetical protein	0.061	0.0764	0.1109
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.061	0.0764	0.179
Brugia malayi	Papain family cysteine protease containing protein	0.2102	0.2683	0.3982
Entamoeba histolytica	cysteine protease, putative	0.061	0.0764	0.2527
Schistosoma mansoni	transcription factor LCR-F1	0.0105	0.0115	0.0092
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1215	0.1542	0.3613
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.061	0.0764	0.179
Plasmodium vivax	aspartyl proteinase, putative	0.0353	0.0434	0.1617
Echinococcus multilocularis	cysteine protease	0.2102	0.2683	0.3982
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.061	0.0764	0.179
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2102	0.2683	0.6288
Loa Loa (eye worm)	hypothetical protein	0.0277	0.0336	0.0468
Brugia malayi	Cathepsin L-like precursor	0.1497	0.1905	0.2817
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.2102	0.2683	0.3982
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4466	0.5726	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0099	0.0106	0.0125
Giardia lamblia	Cathepsin B precursor	0.3333	0.4267	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1215	0.1542	0.2693
Schistosoma mansoni	neprilysin-2 (M13 family)	0.014	0.0159	0.0137
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.061	0.0764	0.179
Toxoplasma gondii	aspartyl protease ASP3	0.0353	0.0434	0.1017
Trypanosoma cruzi	cysteine peptidase, putative	0.4466	0.5726	0.854
Brugia malayi	cathepsin L precursor	0.061	0.0764	0.1109
Plasmodium vivax	unspecified product	0.1215	0.1542	0.5747
Brugia malayi	Peptidase family M13 containing protein	0.0277	0.0336	0.0468
Trypanosoma brucei	ribonucleoside-diphosphate reductase large chain	0.0194	0.0229	0.04
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4466	0.5726	1
Echinococcus multilocularis	cathepsin b	0.5227	0.6705	1
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.061	0.0764	0.2527
Echinococcus multilocularis	endothelin converting enzyme 1	0.0277	0.0336	0.0468
Trypanosoma cruzi	ribonucleoside-diphosphate reductase large chain, putative	0.005	0.0044	0.0065
Schistosoma mansoni	hypothetical protein	0.0072	0.0072	0.005
Leishmania major	cathepsin L-like protease	0.2102	0.2683	0.4686
Giardia lamblia	Cathepsin B precursor	0.3333	0.4267	1
Loa Loa (eye worm)	hypothetical protein	0.1497	0.1905	0.2817
Loa Loa (eye worm)	cysteine protease	0.2102	0.2683	0.3982
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.061	0.0764	0.179
Trypanosoma cruzi	cysteine protease, putative	0.1215	0.1542	0.23
Schistosoma mansoni	cathepsin s	0.0605	0.0757	0.0736
Loa Loa (eye worm)	hypothetical protein	0.0277	0.0336	0.0468
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2102	0.2683	0.6288
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.3333	0.4267	0.4254
Brugia malayi	peptidase family M13 containing protein	0.0068	0.0066	0.0065
Echinococcus granulosus	endothelin converting enzyme 1	0.0277	0.0336	0.0468
Echinococcus granulosus	ribonucleoside diphosphate reductase large	0.0194	0.0229	0.0308
Schistosoma mansoni	hypothetical protein	0.0072	0.0072	0.005
Loa Loa (eye worm)	aspartyl protease 6	0.0353	0.0434	0.0615
Schistosoma mansoni	cathepsin F (C01 family)	0.2102	0.2683	0.2667
Entamoeba histolytica	cysteine protease, putative	0.1215	0.1542	0.5557
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0243	0.0329
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.061	0.0764	0.179
Entamoeba histolytica	cysteine proteinase, putative	0.1497	0.1905	0.6971
Plasmodium falciparum	serine repeat antigen 7	0.061	0.0764	0.2847
Echinococcus granulosus	cathepsin b	0.5227	0.6705	1
Trichomonas vaginalis	ribonucleoside-diphosphate reductase alpha chain, putative	0.0164	0.019	0.0445
Mycobacterium tuberculosis	Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein)	0.0164	0.019	0.5401
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.061	0.0764	0.179
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.061	0.0764	0.2847
Entamoeba histolytica	cysteine protease, putative	0.1215	0.1542	0.5557
Trichomonas vaginalis	replication factor A 1, rfa1, putative	0.0032	0.0021	0.0048
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2102	0.2683	0.6288
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2102	0.2683	0.6288
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4466	0.5726	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.061	0.0764	0.1109
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0353	0.0434	0.0412
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	0.0277	0.0336	0.0468
Leishmania major	ribonucleoside-diphosphate reductase large chain, putative	0.0194	0.0229	0.04
Onchocerca volvulus	Cathepsin L homolog	0.2102	0.2683	1
Schistosoma mansoni	hypothetical protein	0.0099	0.0106	0.0084
Plasmodium vivax	plasmepsin IV, putative	0.1106	0.1403	0.5228
Schistosoma mansoni	cathepsin C	0.061	0.0764	0.0743
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0046	0.0038	0.0023
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.061	0.0764	0.0743
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2102	0.2683	0.6288
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0038	0.0023
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0068	0.0066	0.0043
Loa Loa (eye worm)	hypothetical protein	0.021	0.0249	0.0338
Entamoeba histolytica	cysteine protease, putative	0.1215	0.1542	0.5557
Trypanosoma brucei	cysteine peptidase C (CPC)	0.3333	0.4267	0.7453
Schistosoma mansoni	hypothetical protein	0.0105	0.0115	0.0092
Plasmodium falciparum	plasmepsin IX	0.0353	0.0434	0.1617
Schistosoma mansoni	hypothetical protein	0.0072	0.0072	0.005
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0046	0.0038	0.0023
Onchocerca volvulus		0.2102	0.2683	1
Trichomonas vaginalis	replication factor A 1, rfa1, putative	0.0034	0.0023	0.0053
Loa Loa (eye worm)	hypothetical protein	0.1497	0.1905	0.2817
Brugia malayi	hypothetical protein	0.0353	0.0434	0.0615
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0353	0.0434	0.0412
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.061	0.0764	0.0743
Echinococcus granulosus	cathepsin l cysteine peptidase	0.2102	0.2683	0.3982
Schistosoma mansoni	hypothetical protein	0.0072	0.0072	0.005
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0105	0.0115	0.0137
Plasmodium falciparum	plasmepsin III	0.0353	0.0434	0.1617
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.061	0.0764	0.0743
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.061	0.0764	0.2847
Brugia malayi	Papain family cysteine protease containing protein	0.1215	0.1542	0.2274
Brugia malayi	Cathepsin L-like precursor	0.2102	0.2683	0.3982
Schistosoma mansoni	cathepsin B (C01 family)	0.061	0.0764	0.0743
Entamoeba histolytica	cysteine protease, putative	0.1215	0.1542	0.5557
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0145	0.0165	0.0213
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.2102	0.2683	0.3982
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0353	0.0434	0.0615
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.014	0.0159	0.0137
Schistosoma mansoni	endothelin-converting enzyme-related	0.0068	0.0066	0.0043
Entamoeba histolytica	cysteine proteinase, putative	0.2102	0.2683	1
Plasmodium falciparum	plasmepsin I	0.1106	0.1403	0.5228
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.061	0.0764	0.179
Trypanosoma cruzi	cysteine peptidase, putative	0.2102	0.2683	0.4002
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.1106	0.1403	0.2065
Entamoeba histolytica	cysteine proteinase, putative	0.1215	0.1542	0.5557
Schistosoma mansoni	cathepsin D (A01 family)	0.289	0.3698	0.3683
Brugia malayi	Cathepsin L-like precursor	0.2102	0.2683	0.3982
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.061	0.0764	0.2847
Loa Loa (eye worm)	hypothetical protein	0.061	0.0764	0.1109
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4466	0.5726	1
Toxoplasma gondii	cathepsin CPC1	0.061	0.0764	0.179
Schistosoma mansoni	cathepsin F (C01 family)	0.1497	0.1905	0.1887
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.061	0.0764	0.2847
Echinococcus multilocularis	cathepsin b	0.5227	0.6705	1
Toxoplasma gondii	aspartyl protease	0.0353	0.0434	0.1017
Onchocerca volvulus		0.2102	0.2683	1
Schistosoma mansoni	endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase)	0.0068	0.0066	0.0043
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2102	0.2683	0.6288
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1215	0.1542	0.3613
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0046	0.0038	0.0023
Brugia malayi	Cathepsin L-like precursor	0.2102	0.2683	0.3982
Plasmodium falciparum	serine repeat antigen 1	0.061	0.0764	0.2847
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0156	0.0199
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.3333	0.4267	0.7453
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.2102	0.2683	0.3982
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0605	0.0757	0.1099
Plasmodium vivax	vivapain-1	0.1215	0.1542	0.5747
Entamoeba histolytica	cysteine proteinase 2	0.1215	0.1542	0.5557
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1215	0.1542	0.1523
Loa Loa (eye worm)	hypothetical protein	0.2102	0.2683	0.3982
Echinococcus multilocularis	cathepsin L cysteine protease	0.2102	0.2683	0.3982
Leishmania major	cathepsin L-like protease	0.4466	0.5726	1
Echinococcus granulosus	cathepsin l1	0.1497	0.1905	0.2817
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.061	0.0764	0.179
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0353	0.0434	0.0412
Loa Loa (eye worm)	fibroinase	0.2102	0.2683	0.3982
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.3333	0.4267	0.6365
Entamoeba histolytica	cysteine proteinase, putative	0.1215	0.1542	0.5557
Schistosoma mansoni	ribonucleoside-diphosphate reductase alpha subunit	0.0194	0.0229	0.0207
Plasmodium falciparum	ribonucleoside-diphosphate reductase large subunit, putative	0.0194	0.0229	0.0853
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0046	0.0038	0.0023
Plasmodium falciparum	serine repeat antigen 9	0.061	0.0764	0.2847
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.061	0.0764	0.0743
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.5227	0.6705	0.6697
Echinococcus multilocularis	cathepsin L	0.1215	0.1542	0.2274
Trichomonas vaginalis	conserved hypothetical protein	0.061	0.0764	0.179
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4466	0.5726	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2102	0.2683	0.6288
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.061	0.0764	0.1109
Loa Loa (eye worm)	hypothetical protein	0.1106	0.1403	0.2065
Onchocerca volvulus	Cathepsin L homolog	0.2102	0.2683	1
Loa Loa (eye worm)	hypothetical protein	0.061	0.0764	0.1109
Entamoeba histolytica	cysteine protease, putative	0.1215	0.1542	0.5557
Brugia malayi	Cathepsin L-like precursor	0.2102	0.2683	0.3982
Entamoeba histolytica	cysteine protease, putative	0.1215	0.1542	0.5557
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.061	0.0764	0.1109
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.5227	0.6705	0.6697
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.061	0.0764	0.179
Schistosoma mansoni	hypothetical protein	0.0072	0.0072	0.005
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0243	0.0329
Plasmodium falciparum	plasmepsin VII	0.0353	0.0434	0.1617
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.061	0.0764	0.0743
Plasmodium falciparum	serine repeat antigen 5	0.061	0.0764	0.2847
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.3861	0.4948	0.7379
Loa Loa (eye worm)	hypothetical protein	0.0277	0.0336	0.0468
Brugia malayi	Papain family cysteine protease containing protein	0.061	0.0764	0.1109
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.5227	0.6705	0.6697
Loa Loa (eye worm)	hypothetical protein	0.021	0.0249	0.0338
Entamoeba histolytica	cysteine protease, putative	0.061	0.0764	0.2527
Loa Loa (eye worm)	hypothetical protein	0.061	0.0764	0.1109
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.061	0.0764	0.0743
Loa Loa (eye worm)	hypothetical protein	0.5227	0.6705	1
Loa Loa (eye worm)	hypothetical protein	0.021	0.0249	0.0338
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2102	0.2683	0.6288
Plasmodium vivax	vivapain-2	0.2102	0.2683	1
Giardia lamblia	Cathepsin B precursor	0.3333	0.4267	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0605	0.0757	0.1099
Echinococcus granulosus	kelch ECH associated protein 1 like	0.0276	0.0335	0.0467
Schistosoma mansoni	hypothetical protein	0.0072	0.0072	0.005
Schistosoma mansoni	neprilysin	0.0072	0.0072	0.005
Brugia malayi	cathepsin Z-like cysteine proteinase	0.061	0.0764	0.1109
Plasmodium vivax	unspecified product	0.0605	0.0757	0.2822
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2102	0.2683	0.6288
Plasmodium falciparum	cysteine proteinase falcipain 1	0.1215	0.1542	0.5747
Loa Loa (eye worm)	hypothetical protein	0.0605	0.0757	0.1099
Trypanosoma cruzi	cruzipain precursor, putative	0.0605	0.0757	0.1129
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0068	0.0066	0.0043
Brugia malayi	Pepsin A precursor	0.0353	0.0434	0.0615
Wolbachia endosymbiont of Brugia malayi	ribonucleotide-diphosphate reductase subunit alpha	0.0164	0.019	0.5
Leishmania major	cathepsin L-like protease	0.4466	0.5726	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.3333	0.4267	1
Brugia malayi	cathepsin L-like cysteine proteinase	0.061	0.0764	0.1109
Chlamydia trachomatis	ribonucleoside-diphosphate reductase subunit alpha	0.0194	0.0229	1
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.061	0.0764	0.2847
Echinococcus multilocularis	cysteine protease	0.2102	0.2683	0.3982
Echinococcus granulosus	cathepsin b	0.5227	0.6705	1
Loa Loa (eye worm)	ctsf protein	0.2102	0.2683	0.3982
Loa Loa (eye worm)	hypothetical protein	0.0353	0.0434	0.0615
Entamoeba histolytica	cysteine proteinase, putative	0.2102	0.2683	1
Echinococcus multilocularis	kelch ECH associated protein 1	0.0276	0.0335	0.0467
Schistosoma mansoni	memapsin-2 (A01 family)	0.2824	0.3613	0.3599
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0353	0.0434	0.0412
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0353	0.0434	0.0412
Brugia malayi	Papain family cysteine protease containing protein	0.1215	0.1542	0.2274
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2102	0.2683	0.6288
Trypanosoma cruzi	cysteine peptidase, putative	0.4466	0.5726	0.854
Plasmodium falciparum	serine repeat antigen 2	0.061	0.0764	0.2847
Toxoplasma gondii	eukaryotic aspartyl protease superfamily protein	0.0353	0.0434	0.1017
Leishmania major	cathepsin L-like protease	0.4466	0.5726	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.061	0.0764	0.179
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.061	0.0764	0.1109
Entamoeba histolytica	cysteine protease, putative	0.061	0.0764	0.2527
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.061	0.0764	0.2847
Plasmodium vivax	aspartyl protease, putative	0.0353	0.0434	0.1617
Loa Loa (eye worm)	cathepsin B	0.3333	0.4267	0.6352
Trichomonas vaginalis	conserved hypothetical protein	0.061	0.0764	0.179
Brugia malayi	ribonucleoside-diphosphate reductase large chain, putative	0.0194	0.0229	0.0308
Echinococcus multilocularis	ribonucleoside diphosphate reductase large	0.0194	0.0229	0.0308
Loa Loa (eye worm)	hypothetical protein	0.021	0.0249	0.0338
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.2102	0.2683	0.6288
Toxoplasma gondii	cathepsin CPL	0.2102	0.2683	0.6288
Echinococcus multilocularis	cathepsin L	0.061	0.0764	0.1109
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0353	0.0434	0.0412
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.1106	0.1403	0.2065
Toxoplasma gondii	preprocathepsin c precursor, putative	0.061	0.0764	0.179
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.061	0.0764	0.179
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.4466	0.5726	1
Echinococcus multilocularis	GPCR, family 2	0.0046	0.0038	0.0023
Echinococcus granulosus	cathepsin l1	0.2102	0.2683	0.3982
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0205	0.0243	0.0329
Brugia malayi	Cathepsin L-like precursor	0.0605	0.0757	0.1099
Plasmodium vivax	aspartyl proteinase, putative	0.1106	0.1403	0.5228
Trypanosoma cruzi	cysteine peptidase, putative	0.1215	0.1542	0.23
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0353	0.0434	0.0412
Entamoeba histolytica	cysteine proteinase 1, putative	0.1215	0.1542	0.5557
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2102	0.2683	0.6288
Brugia malayi	cathepsin B-like cysteine proteinase	0.5227	0.6705	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.061	0.0764	0.179
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.2102	0.2683	1
Plasmodium vivax	serine-repeat antigen (SERA)	0.061	0.0764	0.2847
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1215	0.1542	0.1523
Echinococcus granulosus	cathepsin L cysteine proteinase	0.2102	0.2683	0.3982
Toxoplasma gondii	cathepsin CPC2	0.061	0.0764	0.179
Plasmodium vivax	unspecified product	0.061	0.0764	0.2847
Brugia malayi	cathepsin F-like cysteine proteinase	0.061	0.0764	0.1109
Loa Loa (eye worm)	hypothetical protein	0.021	0.0249	0.0338
Schistosoma mansoni	hypothetical protein	0.0046	0.0038	0.0015
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0068	0.0066	0.0043
Plasmodium falciparum	plasmepsin V	0.0353	0.0434	0.1617
Mycobacterium tuberculosis	Probable zinc metalloprotease Zmp1	0.0277	0.0336	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.061	0.0764	0.1139
Brugia malayi	Cathepsin L-like precursor	0.1497	0.1905	0.2817
Toxoplasma gondii	ribonucleoside-diphosphate reductase large chain	0.0194	0.0229	0.0536
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.061	0.0764	0.179
Echinococcus granulosus	cathepsin L	0.1215	0.1542	0.2274
Loa Loa (eye worm)	zinc metallopeptidase 4	0.0068	0.0066	0.0065
Toxoplasma gondii	aspartyl protease ASP1	0.1106	0.1403	0.3287
Entamoeba histolytica	cysteine protease, putative	0.061	0.0764	0.2527
Brugia malayi	cathepsin Z-like cysteine proteinase	0.061	0.0764	0.1109
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0145	0.0165	0.0213
Onchocerca volvulus	Cathepsin L homolog	0.061	0.0764	0.2798

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 906595