Detailed information for compound 906765

Basic information

Technical information
  • TDR Targets ID: 906765
  • Name: 4-[(3-methoxyphenyl)methylidene]-2-(5-methyl- 3-phenyl-1,2-oxazol-4-yl)-1,3-oxazol-5-one
  • MW: 360.363 | Formula: C21H16N2O4
  • H donors: 0 H acceptors: 2 LogP: 4.04 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)/C=C/1\N=C(OC1=O)c1c(C)onc1c1ccccc1
  • InChi: 1S/C21H16N2O4/c1-13-18(19(23-27-13)15-8-4-3-5-9-15)20-22-17(21(24)26-20)12-14-7-6-10-16(11-14)25-2/h3-12H,1-2H3/b17-12-
  • InChiKey: OBWFHNDOHOGRRS-ATVHPVEESA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4Z)-4-[(3-methoxyphenyl)methylidene]-2-(5-methyl-3-phenyl-1,2-oxazol-4-yl)-1,3-oxazol-5-one
  • 4-[(3-methoxyphenyl)methylene]-2-(5-methyl-3-phenyl-isoxazol-4-yl)oxazol-5-one
  • (4Z)-4-[(3-methoxyphenyl)methylene]-2-(5-methyl-3-phenyl-isoxazol-4-yl)oxazol-5-one
  • 4-[(3-methoxyphenyl)methylene]-2-(5-methyl-3-phenyl-4-isoxazolyl)-5-oxazolone
  • (4Z)-4-[(3-methoxyphenyl)methylene]-2-(5-methyl-3-phenyl-4-isoxazolyl)-5-oxazolone
  • (4Z)-4-(3-methoxybenzylidene)-2-(5-methyl-3-phenyl-isoxazol-4-yl)oxazol-5-one
  • 4-(3-methoxybenzylidene)-2-(5-methyl-3-phenyl-isoxazol-4-yl)oxazol-5-one
  • SMR000129396
  • ZINC01515568
  • MLS000518976

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cysteine proteinase, putative 0.0112 0.0615 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1017 1 1
Brugia malayi Cathepsin L-like precursor 0.019 0.1422 0.1422
Loa Loa (eye worm) hypothetical protein 0.0199 0.1515 0.1515
Entamoeba histolytica cysteine proteinase, putative 0.0112 0.0615 0.4054
Brugia malayi cathepsin F-like cysteine proteinase 0.0059 0.0064 0.0064
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.019 0.1422 0.1422
Loa Loa (eye worm) hypothetical protein 0.0137 0.0871 0.0871
Entamoeba histolytica cysteine proteinase, putative 0.019 0.1422 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0214 0.1673 0.5235
Brugia malayi fibroinase precursor 0.0059 0.0064 0.0064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.1422 0.3201
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0059 0.0064 0.0064
Entamoeba histolytica cysteine proteinase, putative 0.0112 0.0615 0.4054
Onchocerca volvulus 0.019 0.1422 1
Entamoeba histolytica cysteine protease, putative 0.0112 0.0615 0.4054
Plasmodium falciparum cysteine proteinase falcipain 3 0.019 0.1422 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1422 0.4419
Schistosoma mansoni cathepsin S (C01 family) 0.0059 0.0064 0.0064
Echinococcus multilocularis cathepsin l cysteine peptidase 0.019 0.1422 0.1367
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.019 0.1422 0.4419
Brugia malayi cathepsin Z-like cysteine proteinase 0.0059 0.0064 0.0064
Brugia malayi Cathepsin L-like precursor 0.019 0.1422 0.1422
Entamoeba histolytica cysteine protease, putative 0.0112 0.0615 0.4054
Echinococcus multilocularis cathepsin L cysteine protease 0.019 0.1422 0.1367
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.1422 0.3201
Echinococcus multilocularis cathepsin L cysteine protease 0.019 0.1422 0.1367
Plasmodium vivax vivapain-1 0.0112 0.0615 0.4322
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0137 0.0871 0.2627
Schistosoma mansoni cathepsin F (C01 family) 0.019 0.1422 0.1422
Trypanosoma cruzi cysteine protease, putative 0.0112 0.0615 0.0615
Brugia malayi Cathepsin L-like cysteine proteinase 0.0137 0.0871 0.0871
Loa Loa (eye worm) hypothetical protein 0.0059 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0066 0.0139 0.0139
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0059 0.0064 0.0064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.1422 0.3201
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.019 0.1422 0.4419
Trypanosoma cruzi cysteine peptidase, putative 0.019 0.1422 0.1422
Brugia malayi Cathepsin L-like precursor 0.0137 0.0871 0.0871
Trypanosoma brucei cysteine peptidase C (CPC) 0.0356 0.3137 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0112 0.0615 0.0615
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.019 0.1422 0.4419
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.1422 0.3201
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0615 0.1791
Plasmodium falciparum cysteine proteinase falcipain 1 0.0112 0.0615 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.019 0.1422 0.4419
Plasmodium vivax unspecified product 0.0112 0.0615 0.4322
Entamoeba histolytica cysteine proteinase, putative 0.0137 0.0871 0.5946
Plasmodium falciparum cysteine proteinase falcipain 2b 0.019 0.1422 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.019 0.1422 0.1422
Brugia malayi Cathepsin L-like precursor 0.019 0.1422 0.1422
Echinococcus granulosus cysteine protease 0.0112 0.0615 0.0554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1422 0.4419
Trypanosoma cruzi major cysteine proteinase, putative 0.0059 0.0064 0.0064
Trypanosoma cruzi cruzipain precursor, putative 0.019 0.1422 0.1422
Trypanosoma cruzi major cysteine proteinase, putative 0.0059 0.0064 0.0064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.1422 0.3201
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0059 0.0064 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0137 0.0871 0.2627
Schistosoma mansoni cathepsin F (C01 family) 0.0137 0.0871 0.0871
Plasmodium vivax serine-repeat antigen (SERA) 0.0059 0.0064 0.0451
Onchocerca volvulus Cathepsin L homolog 0.019 0.1422 1
Schistosoma mansoni cathepsin F (C01 family) 0.019 0.1422 0.1422
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.1422 0.3201
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0066 0.0139 0.0075
Brugia malayi cathepsin L-like cysteine proteinase 0.0059 0.0064 0.0064
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0356 0.3137 0.3137
Echinococcus multilocularis cathepsin b 0.1017 1 1
Loa Loa (eye worm) hypothetical protein 0.1017 1 1
Loa Loa (eye worm) ctsf protein 0.019 0.1422 0.1422
Plasmodium vivax vivapain-2 0.019 0.1422 1
Plasmodium vivax unspecified product 0.0059 0.0064 0.0451
Brugia malayi Papain family cysteine protease containing protein 0.0059 0.0064 0.0064
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0059 0.0064 0.0451
Schistosoma mansoni voltage-gated potassium channel 0.0066 0.0139 0.0139
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0229 0.1829 0.1777
Brugia malayi Papain family cysteine protease containing protein 0.0059 0.0064 0.0064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.1422 0.3201
Loa Loa (eye worm) hypothetical protein 0.019 0.1422 0.1422
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.019 0.1422 0.4419
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0229 0.1829 0.1777
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1422 0.4419
Entamoeba histolytica cysteine protease, putative 0.0112 0.0615 0.4054
Onchocerca volvulus 0.019 0.1422 1
Trypanosoma cruzi cysteine peptidase, putative 0.0112 0.0615 0.0615
Onchocerca volvulus Cathepsin L homolog 0.019 0.1422 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0112 0.0615 0.0615
Entamoeba histolytica cysteine protease, putative 0.0112 0.0615 0.4054
Echinococcus multilocularis cysteine protease 0.019 0.1422 0.1367
Brugia malayi Papain family cysteine protease containing protein 0.019 0.1422 0.1422
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0356 0.3137 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.019 0.1422 0.4419
Brugia malayi Cathepsin L-like precursor 0.019 0.1422 0.1422
Loa Loa (eye worm) hypothetical protein 0.0137 0.0871 0.0871
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.1422 0.3201
Onchocerca volvulus 0.019 0.1422 1
Echinococcus granulosus cathepsin L 0.0112 0.0615 0.0554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1422 0.4419
Loa Loa (eye worm) hypothetical protein 0.0059 0.0064 0.0064
Brugia malayi Cathepsin L-like precursor 0.0137 0.0871 0.0871
Toxoplasma gondii cathepsin B 0.0356 0.3137 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.019 0.1422 0.4419
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1017 1 1
Trypanosoma cruzi cysteine proteinase, putative 0.0112 0.0615 0.0615
Brugia malayi Papain family cysteine protease containing protein 0.0112 0.0615 0.0615
Entamoeba histolytica cysteine protease, putative 0.0112 0.0615 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.019 0.1422 0.4419
Echinococcus granulosus cathepsin L cysteine protease 0.0112 0.0615 0.0554
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0059 0.0064 0.0451
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0059 0.0064 0.0064
Loa Loa (eye worm) fibroinase 0.019 0.1422 0.1422
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0066 0.0139 0.0075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.1422 0.3201
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1017 1 1
Entamoeba histolytica cysteine protease, putative 0.0112 0.0615 0.4054
Entamoeba histolytica cysteine protease, putative 0.019 0.1422 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1422 0.4419
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0059 0.0064 0.0064
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1017 1 1
Echinococcus granulosus cathepsin b 0.1017 1 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0059 0.0064 0.0451
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0059 0.0064 0.0064
Brugia malayi Cathepsin L-like precursor 0.019 0.1422 0.1422
Echinococcus granulosus cathepsin l1 0.019 0.1422 0.1367
Onchocerca volvulus 0.019 0.1422 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1422 0.4419
Loa Loa (eye worm) hypothetical protein 0.0059 0.0064 0.0064
Echinococcus granulosus cathepsin l cysteine peptidase 0.019 0.1422 0.1367
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0137 0.0871 0.0871
Loa Loa (eye worm) cathepsin B 0.0356 0.3137 0.3137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1422 0.4419
Toxoplasma gondii cathepsin CPL 0.019 0.1422 0.4419
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0059 0.0064 0.0064
Entamoeba histolytica cysteine proteinase, putative 0.0112 0.0615 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1422 0.4419
Entamoeba histolytica cysteine protease, putative 0.0112 0.0615 0.4054
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0059 0.0064 0.0451
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0112 0.0615 0.0615
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1422 0.4419
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0112 0.0615 0.0615
Entamoeba histolytica cysteine protease, putative 0.0112 0.0615 0.4054
Schistosoma mansoni voltage-gated potassium channel 0.0251 0.2048 0.2048
Echinococcus multilocularis cathepsin l cysteine peptidase 0.019 0.1422 0.1367
Brugia malayi Cathepsin L-like precursor 0.019 0.1422 0.1422
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1422 0.4419
Entamoeba histolytica cysteine proteinase 1, putative 0.0112 0.0615 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1422 0.4419
Schistosoma mansoni voltage-gated potassium channel 0.0066 0.0139 0.0139
Onchocerca volvulus 0.019 0.1422 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.019 0.1422 0.1367
Schistosoma mansoni cathepsin B (C01 family) 0.0059 0.0064 0.0064
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1017 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.1422 0.3201
Entamoeba histolytica cysteine protease, putative 0.0112 0.0615 0.4054
Plasmodium vivax vivapain-2 0.019 0.1422 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0059 0.0064 0.0064
Loa Loa (eye worm) cysteine protease 0.019 0.1422 0.1422
Brugia malayi Papain family cysteine protease containing protein 0.0112 0.0615 0.0615
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0229 0.1829 0.1829
Giardia lamblia Cathepsin B precursor 0.0356 0.3137 1
Giardia lamblia Cathepsin B precursor 0.0356 0.3137 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0059 0.0064 0.0064
Trypanosoma cruzi cysteine peptidase, putative 0.019 0.1422 0.1422
Plasmodium vivax vivapain-3 0.0112 0.0615 0.4322
Schistosoma mansoni voltage-gated potassium channel 0.0251 0.2048 0.2048
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0059 0.0064 0.0064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.019 0.1422 0.4419
Onchocerca volvulus 0.019 0.1422 1
Entamoeba histolytica cysteine protease, putative 0.0112 0.0615 0.4054
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0059 0.0064 0.0451
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0059 0.0064 0.0064
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0356 0.3137 0.3137
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0059 0.0064 0.0451
Loa Loa (eye worm) hypothetical protein 0.0059 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0059 0.0064 0.0064
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0059 0.0064 0.0451
Brugia malayi cathepsin L precursor 0.0059 0.0064 0.0064
Echinococcus multilocularis voltage gated potassium channel 0.0066 0.0139 0.0075
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0059 0.0064 0.0064
Echinococcus multilocularis cysteine protease 0.019 0.1422 0.1367
Schistosoma mansoni cathepsin C 0.0059 0.0064 0.0064
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0059 0.0064 0.0451
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1422 0.4419
Trypanosoma cruzi cysteine peptidase, putative 0.019 0.1422 0.1422
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.019 0.1422 0.4419
Brugia malayi Papain family cysteine protease containing protein 0.0059 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0137 0.0871 0.0871
Loa Loa (eye worm) hypothetical protein 0.0059 0.0064 0.0064
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0229 0.1829 0.1829
Entamoeba histolytica cysteine protease, putative 0.0112 0.0615 0.4054
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0059 0.0064 0.0451
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0615 0.1791
Echinococcus granulosus cathepsin l1 0.0137 0.0871 0.0813
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0356 0.3137 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1422 0.4419
Plasmodium falciparum cysteine proteinase falcipain 2a 0.019 0.1422 1
Giardia lamblia Cathepsin B precursor 0.0356 0.3137 1
Entamoeba histolytica cysteine protease, putative 0.0112 0.0615 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.019 0.1422 0.3201
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0066 0.0139 0.0139
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0214 0.1673 0.5235
Echinococcus granulosus cathepsin b 0.1017 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.019 0.1422 0.4419
Echinococcus multilocularis cathepsin b 0.1017 1 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0059 0.0064 0.0064
Entamoeba histolytica cysteine protease, putative 0.0112 0.0615 0.4054
Brugia malayi cathepsin L-like precursor 0.0137 0.0871 0.0871
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0059 0.0064 0.0451
Echinococcus multilocularis cathepsin L 0.0112 0.0615 0.0554
Echinococcus granulosus voltage gated potassium channel 0.0066 0.0139 0.0075
Onchocerca volvulus 0.019 0.1422 1
Trypanosoma cruzi cysteine proteinase, putative 0.0112 0.0615 0.0615
Trypanosoma cruzi cysteine peptidase, putative 0.019 0.1422 0.1422
Entamoeba histolytica cysteine proteinase, putative 0.019 0.1422 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.019 0.1422 0.4419
Onchocerca volvulus Cathepsin F homolog 0.019 0.1422 1
Onchocerca volvulus 0.0137 0.0871 0.5946
Entamoeba histolytica cysteine proteinase 2 0.0112 0.0615 0.4054
Plasmodium vivax serine-repeat antigen (SERA) 0.0059 0.0064 0.0451
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0059 0.0064 0.0064

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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