TDR Targets

Basic information

Technical information

TDR Targets ID: 906769
Name: 2-(2-chloro-5-nitrophenyl)-4-[(2-ethoxyphenyl )methylidene]-1,3-oxazol-5-one
MW: 372.759 | Formula: C18H13ClN2O5
H donors: 0 H acceptors: 3 LogP: 4.36 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccccc1C=C1N=C(OC1=O)c1cc(ccc1Cl)[N+](=O)[O-]
InChi: 1S/C18H13ClN2O5/c1-2-25-16-6-4-3-5-11(16)9-15-18(22)26-17(20-15)13-10-12(21(23)24)7-8-14(13)19/h3-10H,2H2,1H3/b15-9-
InChiKey: MKEKUJZWZYTKKM-DHDCSXOGSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(4Z)-2-(2-chloro-5-nitrophenyl)-4-[(2-ethoxyphenyl)methylidene]-1,3-oxazol-5-one
(4Z)-2-(2-chloro-5-nitro-phenyl)-4-[(2-ethoxyphenyl)methylene]oxazol-5-one
2-(2-chloro-5-nitro-phenyl)-4-[(2-ethoxyphenyl)methylene]oxazol-5-one
(4Z)-2-(2-chloro-5-nitrophenyl)-4-[(2-ethoxyphenyl)methylene]-5-oxazolone
2-(2-chloro-5-nitrophenyl)-4-[(2-ethoxyphenyl)methylene]-5-oxazolone
(4Z)-2-(2-chloro-5-nitro-phenyl)-4-(2-ethoxybenzylidene)oxazol-5-one
2-(2-chloro-5-nitro-phenyl)-4-(2-ethoxybenzylidene)oxazol-5-one
(4Z)-2-(2-chloro-5-nitro-phenyl)-4-[(2-ethoxyphenyl)methylidene]-1,3-oxazol-5-one
2-(2-chloro-5-nitro-phenyl)-4-[(2-ethoxyphenyl)methylidene]-1,3-oxazol-5-one
ZINC01755964
STOCK3S-42256

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0079	0.1125	0.1125
Brugia malayi	Cathepsin L-like precursor	0.0057	0.0555	0.0555
Brugia malayi	Cathepsin L-like precursor	0.0079	0.1125	0.1125
Brugia malayi	MH2 domain containing protein	0.0116	0.208	0.208
Echinococcus multilocularis	cathepsin b	0.0424	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0079	0.1125	0.1125
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.208	0.1614
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.1125	0.3201
Onchocerca volvulus		0.0079	0.1125	1
Echinococcus granulosus	cathepsin l1	0.0079	0.1125	0.1125
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0079	0.1125	0.1125
Loa Loa (eye worm)	ctsf protein	0.0079	0.1125	0.0603
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.1125	0.3201
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1125	0.14
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0289	0.2572
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0057	0.0555	0.0555
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.1125	0.3201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1125	0.14
Trypanosoma cruzi	cysteine peptidase, putative	0.0079	0.1125	0.086
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0289	0.2572
Entamoeba histolytica	cysteine proteinase, putative	0.0079	0.1125	1
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0289	0.2572
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0148	0.2899	0.2688
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.1125	0.3201
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0079	0.1125	0.0603
Plasmodium vivax	vivapain-2	0.0079	0.1125	1
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0289	0.2572
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0057	0.0555	0.0274
Onchocerca volvulus		0.0079	0.1125	1
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0289	0.2572
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0289	0.2572
Loa Loa (eye worm)	cysteine protease	0.0079	0.1125	0.0603
Entamoeba histolytica	cysteine protease, putative	0.0079	0.1125	1
Onchocerca volvulus	Cathepsin F homolog	0.0079	0.1125	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.1125	0.3201
Schistosoma mansoni	cathepsin F (C01 family)	0.0057	0.0555	0.0555
Brugia malayi	Cathepsin L-like precursor	0.0057	0.0555	0.0555
Trypanosoma cruzi	cysteine peptidase, putative	0.0079	0.1125	0.086
Entamoeba histolytica	cysteine proteinase, putative	0.0057	0.0555	0.4935
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0079	0.1125	0.0603
Plasmodium vivax	vivapain-2	0.0079	0.1125	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0289	0.0289
Brugia malayi	glutaminase DH11.1	0.0279	0.6258	0.6258
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1125	0.14
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0079	0.1125	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1125	0.14
Echinococcus multilocularis	cathepsin L	0.0047	0.0289	0.0289
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1125	0.14
Schistosoma mansoni	cathepsin F (C01 family)	0.0079	0.1125	0.1125
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0424	1	1
Echinococcus granulosus	cathepsin b	0.0424	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1125	0.14
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.1125	0.3201
Giardia lamblia	Cathepsin B precursor	0.0148	0.2899	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1125	0.14
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0289	0.2572
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0148	0.2899	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1125	0.14
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1125	0.14
Onchocerca volvulus		0.0079	0.1125	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0079	0.1125	0.086
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0079	0.1125	0.1125
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.1125	0.3201
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0148	0.2899	0.2899
Loa Loa (eye worm)	fibroinase	0.0079	0.1125	0.0603
Echinococcus granulosus	cysteine protease	0.0047	0.0289	0.0289
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0555	0.0445
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.1125	0.3201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0079	0.1125	0.14
Brugia malayi	Cathepsin L-like precursor	0.0079	0.1125	0.1125
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0289	0.2572
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0424	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.0289	0.0289
Mycobacterium ulcerans	glutaminase	0.0279	0.6258	0.5
Brugia malayi	Cathepsin L-like precursor	0.0079	0.1125	0.1125
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.0289	0.0289
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.1125	0.3201
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0424	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1125	0.14
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0289	0.2572
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1125	0.0603
Entamoeba histolytica	cysteine proteinase 2	0.0047	0.0289	0.2572
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0424	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1125	0.14
Entamoeba histolytica	cysteine proteinase, putative	0.0079	0.1125	1
Echinococcus multilocularis	cysteine protease	0.0079	0.1125	0.1125
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.1125	0.3201
Loa Loa (eye worm)	hypothetical protein	0.0424	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0079	0.1125	1
Trichomonas vaginalis	glutaminase, putative	0.0279	0.6258	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0079	0.1125	0.086
Onchocerca volvulus		0.0079	0.1125	1
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0289	0.2572
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1125	0.14
Echinococcus multilocularis	cathepsin L cysteine protease	0.0079	0.1125	0.1125
Entamoeba histolytica	cysteine proteinase 1, putative	0.0047	0.0289	0.2572
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0289	0.2572
Onchocerca volvulus	Cathepsin L homolog	0.0079	0.1125	1
Onchocerca volvulus		0.0079	0.1125	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1125	0.14
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0289	0.0289
Onchocerca volvulus		0.0079	0.1125	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1125	0.14
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1125	0.14
Giardia lamblia	Cathepsin B precursor	0.0148	0.2899	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0079	0.1125	0.3201
Echinococcus multilocularis	cathepsin b	0.0424	1	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0079	0.1125	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0047	0.0289	0.0289
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1125	0.14
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1125	0.14
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0289	0.0289
Brugia malayi	Cathepsin L-like precursor	0.0079	0.1125	0.1125
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0289	0.2572
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0148	0.2899	0.4372
Toxoplasma gondii	cathepsin B	0.0148	0.2899	1
Loa Loa (eye worm)	cathepsin B	0.0148	0.2899	0.2482
Echinococcus multilocularis	cysteine protease	0.0079	0.1125	0.1125
Giardia lamblia	Cathepsin B precursor	0.0148	0.2899	0.5
Loa Loa (eye worm)	glutaminase 2	0.0279	0.6258	0.6039
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0289	0.2572
Echinococcus multilocularis	cathepsin L cysteine protease	0.0079	0.1125	0.1125
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1125	0.14
Trypanosoma cruzi	cysteine peptidase, putative	0.0079	0.1125	0.086
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1125	0.14
Brugia malayi	Papain family cysteine protease containing protein	0.0079	0.1125	0.1125
Onchocerca volvulus		0.0079	0.1125	1
Echinococcus granulosus	cathepsin L	0.0047	0.0289	0.0289
Schistosoma mansoni	glutaminase	0.0279	0.6258	0.6258
Loa Loa (eye worm)	glutaminase	0.0279	0.6258	0.6039
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0079	0.1125	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0079	0.1125	0.14
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0148	0.2899	1
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0289	0.2572
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0289	0.2572
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0555	0.0445
Echinococcus granulosus	cathepsin l1	0.0057	0.0555	0.0555
Brugia malayi	Cathepsin L-like precursor	0.0079	0.1125	0.1125
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0424	1	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.208	0.1614
Echinococcus granulosus	cathepsin b	0.0424	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0079	0.1125	0.1125
Brugia malayi	Cathepsin L-like precursor	0.0079	0.1125	0.1125
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1125	0.14
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0289	0.2572
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0079	0.1125	0.14
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0289	0.2572
Brugia malayi	cathepsin L-like precursor	0.0057	0.0555	0.0555
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1125	0.14
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0079	0.1125	0.14

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 906769