TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 348.438 | Formula: C22H24N2O2
H donors: 2 H acceptors: 1 LogP: 3.96 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)C1Nc2ccccc2N=C2C1=C(O)CC(C2)(C)C
InChi: 1S/C22H24N2O2/c1-22(2)12-18-20(19(25)13-22)21(14-7-6-8-15(11-14)26-3)24-17-10-5-4-9-16(17)23-18/h4-11,21,24-25H,12-13H2,1-3H3
InChiKey: TXYPIKAHPVRXEF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	Niemann-Pick disease, type C1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Niemann-Pick C1 protein precursor	Get druggable targets OG5_128206	All targets in OG5_128206
Echinococcus multilocularis	Niemann Pick C1 protein	Get druggable targets OG5_128206	All targets in OG5_128206
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128206	All targets in OG5_128206
Entamoeba histolytica	Niemann-Pick C1 protein, putative	Get druggable targets OG5_128206	All targets in OG5_128206
Echinococcus multilocularis	Niemann Pick C1 protein	Get druggable targets OG5_128206	All targets in OG5_128206
Schistosoma mansoni	niemann-pick C1 (NPC1)	Get druggable targets OG5_128206	All targets in OG5_128206
Echinococcus granulosus	Niemann Pick C1 protein	Get druggable targets OG5_128206	All targets in OG5_128206
Candida albicans	potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home	Get druggable targets OG5_128206	All targets in OG5_128206
Schistosoma japonicum	Niemann-Pick C1 protein precursor, putative	Get druggable targets OG5_128206	All targets in OG5_128206
Echinococcus multilocularis	expressed conserved protein	Get druggable targets OG5_128206	All targets in OG5_128206
Echinococcus granulosus	Niemann Pick C1 protein	Get druggable targets OG5_128206	All targets in OG5_128206
Schistosoma japonicum	Niemann-Pick C1 protein precursor, putative	Get druggable targets OG5_128206	All targets in OG5_128206
Echinococcus granulosus	expressed conserved protein	Get druggable targets OG5_128206	All targets in OG5_128206
Schistosoma japonicum	ko:K07003 Niemann Pick type C1, putative	Get druggable targets OG5_128206	All targets in OG5_128206
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128206	All targets in OG5_128206

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0068	0.2585	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0068	0.2585	0.4116
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0068	0.2585	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0068	0.2585	0.5
Brugia malayi	hypothetical protein	0.0068	0.2585	0.4116
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0068	0.2585	0.5
Leishmania major	hypothetical protein, conserved	0.0068	0.2585	0.5
Echinococcus multilocularis	3 ketodihydrosphingosine reductase	0.0068	0.2585	0.1448
Leishmania major	short chain dehydrogenase/reductase, putative	0.0068	0.2585	0.5
Loa Loa (eye worm)	oxidoreductase	0.0068	0.2585	0.4116
Schistosoma mansoni	short chain dehydrogenase	0.0068	0.2585	0.2663
Loa Loa (eye worm)	oxidoreductase	0.0068	0.2585	0.4116
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0068	0.2585	0.4116
Trypanosoma cruzi	hypothetical protein, conserved	0.0068	0.2585	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0068	0.2585	0.2663
Mycobacterium ulcerans	short chain dehydrogenase	0.0068	0.2585	0.5
Toxoplasma gondii	3-ketoacyl-CoA reductase, putative	0.0068	0.2585	0.5
Mycobacterium tuberculosis	Possible oxidoreductase	0.0068	0.2585	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0068	0.2585	0.2663
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0068	0.2585	0.4116
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2585	0.4116
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0068	0.2585	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0068	0.2585	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0068	0.2585	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0068	0.2585	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0068	0.2585	0.4116
Schistosoma mansoni	carbonyl reductase	0.0068	0.2585	0.2663
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0068	0.2585	0.5
Onchocerca volvulus		0.0068	0.2585	0.5
Echinococcus multilocularis	carbonyl reductase 1	0.0068	0.2585	0.1448
Mycobacterium ulcerans	short chain dehydrogenase	0.0068	0.2585	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0068	0.2585	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0068	0.2585	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0068	0.2585	0.2663
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0068	0.2585	0.4116
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0068	0.2585	0.5
Leishmania major	hypothetical protein, conserved	0.0068	0.2585	0.5
Mycobacterium tuberculosis	Possible iron-regulated short-chain dehydrogenase/reductase	0.0068	0.2585	0.5
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0068	0.2585	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0068	0.2585	0.2663
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0068	0.2585	0.4116
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0068	0.2585	0.5
Echinococcus multilocularis	Niemann Pick C1 protein	0.017	1	1
Schistosoma mansoni	steroid dehydrogenase	0.0068	0.2585	0.2663
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2585	0.4116
Mycobacterium ulcerans	short-chain dehydrogenase	0.0068	0.2585	0.5
Echinococcus multilocularis	transient receptor potential cation channel	0.0068	0.2585	0.1448
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0068	0.2585	0.4116
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0068	0.2585	0.5
Echinococcus granulosus	carbonyl reductase 1	0.0068	0.2585	0.1448
Trypanosoma cruzi	hypothetical protein, conserved	0.0068	0.2585	0.5
Echinococcus multilocularis	carbonyl reductase 1	0.0068	0.2585	0.1448
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0119	0.6279	1
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2585	0.4116
Mycobacterium ulcerans	short-chain dehydrogenase	0.0068	0.2585	0.5
Mycobacterium tuberculosis	Probable dehydrogenase	0.0068	0.2585	0.5
Mycobacterium tuberculosis	Probable short-chain dehydrogenase/reductase	0.0068	0.2585	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0068	0.2585	0.4116
Toxoplasma gondii	carbonyl reductase 1, putative	0.0068	0.2585	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0068	0.2585	0.2663
Mycobacterium ulcerans	short-chain dehydrogenase	0.0068	0.2585	0.5
Mycobacterium ulcerans	oxidoreductase	0.0068	0.2585	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0068	0.2585	0.5
Onchocerca volvulus		0.0068	0.2585	0.5
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0068	0.2585	0.5
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0068	0.2585	0.5
Echinococcus granulosus	Dehydrogenase:reductase SDR family	0.0068	0.2585	0.1448
Trypanosoma brucei	beta-ketoacyl-ACP reductase 3, putative	0.0068	0.2585	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0068	0.2585	0.5
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0068	0.2585	0.1448
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 1 homolog	0.0068	0.2585	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0068	0.2585	0.5
Echinococcus multilocularis	Dehydrogenase:reductase SDR family	0.0068	0.2585	0.1448
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0068	0.2585	0.2663
Leishmania major	pteridine reductase 1	0.0068	0.2585	0.5
Loa Loa (eye worm)	oxidoreductase	0.0068	0.2585	0.4116
Schistosoma mansoni	carbonyl reductase	0.0068	0.2585	0.2663
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0068	0.2585	0.5
Echinococcus granulosus	WW domain containing oxidoreductase	0.0068	0.2585	0.1448
Mycobacterium tuberculosis	Probable short-chain type oxidoreductase	0.0068	0.2585	0.5
Trypanosoma brucei	oxidoreductase-like protein	0.0068	0.2585	0.5
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2585	0.4116
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0068	0.2585	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0068	0.2585	0.4116
Toxoplasma gondii	sterol carrier protein-2 HAD-2SCP-2	0.0068	0.2585	0.5
Echinococcus granulosus	retinol dehydrogenase 11	0.0068	0.2585	0.1448
Trypanosoma brucei	3-keto-dihydrosphingosine reductase	0.0068	0.2585	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0068	0.2585	0.5
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0121	0.6413	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0068	0.2585	0.5
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2585	0.4116
Schistosoma mansoni	steroid dehydrogenase	0.0068	0.2585	0.2663
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0068	0.2585	0.5
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0068	0.2585	0.5
Schistosoma mansoni	oxidoreductase short chain dehydrogenase/reductase family	0.0068	0.2585	0.2663
Mycobacterium ulcerans	short chain dehydrogenase	0.0068	0.2585	0.5
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2585	0.4116
Mycobacterium tuberculosis	Probable oxidoreductase	0.0068	0.2585	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0068	0.2585	0.5
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0068	0.2585	0.1448
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0068	0.2585	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0068	0.2585	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0068	0.2585	0.2663
Trichomonas vaginalis	estradiol 17 beta-dehydrogenase, putative	0.0068	0.2585	1
Schistosoma mansoni	short chain dehydrogenase	0.0068	0.2585	0.2663
Mycobacterium ulcerans	dehydrogenase	0.0068	0.2585	0.5
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2585	0.4116
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0068	0.2585	0.5
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0068	0.2585	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0068	0.2585	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0068	0.2585	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0068	0.2585	0.5
Trypanosoma brucei	3-ketoacyl-CoA reductase, putative	0.0068	0.2585	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0068	0.2585	0.5
Echinococcus granulosus	carbonyl reductase 1	0.0068	0.2585	0.1448
Echinococcus multilocularis	Niemann Pick C1 protein	0.0119	0.6279	0.5709
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0068	0.2585	0.5
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2585	0.4116
Leishmania major	dehydrogenase-like protein	0.0068	0.2585	0.5
Mycobacterium tuberculosis	Decaprenylphosphoryl-D-2-keto erythro pentose reductase	0.0068	0.2585	0.5
Echinococcus granulosus	hypothetical protein	0.0068	0.2585	0.1448
Echinococcus multilocularis	oxidoreductase	0.0068	0.2585	0.1448
Echinococcus multilocularis	protein dispatched 1	0.0058	0.1855	0.0606
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0068	0.2585	1
Onchocerca volvulus		0.0068	0.2585	0.5
Schistosoma mansoni	patched 1	0.0051	0.1329	0.0257
Leishmania major	quinonoid dihydropteridine reductase	0.0068	0.2585	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0068	0.2585	0.5
Onchocerca volvulus		0.0068	0.2585	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0068	0.2585	0.5
Leishmania major	hypothetical protein, conserved	0.0068	0.2585	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0068	0.2585	0.5
Leishmania major	short chain dehydrogenase-like protein	0.0068	0.2585	0.5
Echinococcus granulosus	retinol dehydrogenase 11	0.0068	0.2585	0.1448
Giardia lamblia	Reductase, putative	0.0068	0.2585	0.5
Leishmania major	oxidoreductase-like protein	0.0068	0.2585	0.5
Plasmodium vivax	hypothetical protein, conserved	0.0068	0.2585	0.5
Leishmania major	short chain dehydrogenase/reductase, putative	0.0068	0.2585	0.5
Mycobacterium tuberculosis	Probable shortchain dehydrogenase	0.0068	0.2585	0.5
Mycobacterium ulcerans	dehydrogenase/reductase	0.0068	0.2585	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0068	0.2585	0.2663
Leishmania major	hypothetical protein, conserved	0.0068	0.2585	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0068	0.2585	0.2663
Schistosoma mansoni	carbonyl reductase	0.0068	0.2585	0.2663
Trichomonas vaginalis	hydroxyacyl dehydrogenase, putative	0.0068	0.2585	1
Plasmodium falciparum	oxidoreductase, short-chain dehydrogenase family, putative	0.0068	0.2585	0.5
Leishmania major	3-keto-dihydrosphingosine reductase	0.0068	0.2585	0.5
Loa Loa (eye worm)	oxidoreductase	0.0068	0.2585	0.4116
Mycobacterium ulcerans	short chain dehydrogenase	0.0068	0.2585	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0068	0.2585	0.4116
Loa Loa (eye worm)	dehydrogenase	0.0068	0.2585	0.4116
Loa Loa (eye worm)	dehydrogenase	0.0068	0.2585	0.4116
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0068	0.2585	1
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0068	0.2585	0.5
Echinococcus multilocularis	conserved hypothetical protein	0.0068	0.2585	0.1448
Schistosoma mansoni	steroid dehydrogenase	0.0068	0.2585	0.2663
Schistosoma mansoni	steroid dehydrogenase	0.0068	0.2585	0.2663
Mycobacterium tuberculosis	Possible short-chain dehydrogenase EphD	0.0068	0.2585	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0068	0.2585	0.2663
Giardia lamblia	Short-chain dehydrogenase, putative	0.0068	0.2585	0.5
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0068	0.2585	0.5
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0068	0.2585	0.5
Schistosoma mansoni	retinal dehydrogenase	0.0068	0.2585	0.2663
Brugia malayi	Hypothetical oxidoreductase F56D1.5	0.0068	0.2585	0.4116
Echinococcus multilocularis	retinol dehydrogenase 11	0.0068	0.2585	0.1448
Toxoplasma gondii	oxidoreductase, putative	0.0068	0.2585	0.5
Mycobacterium ulcerans	dehydrogenase/decarboxylase protein	0.0068	0.2585	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0068	0.2585	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0068	0.2585	0.4116
Leishmania major	quinonoid dihydropteridine reductase	0.0068	0.2585	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0068	0.2585	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0068	0.2585	0.5
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0068	0.2585	0.5
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0068	0.2585	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0068	0.2585	1
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0068	0.2585	1
Plasmodium falciparum	steroid dehydrogenase, putative	0.0068	0.2585	0.5
Plasmodium vivax	steroid dehydrogenase, putative	0.0068	0.2585	0.5
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0068	0.2585	0.5
Mycobacterium tuberculosis	Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1	0.0068	0.2585	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0068	0.2585	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0068	0.2585	0.2663
Mycobacterium ulcerans	short-chain membrane-associated dehydrogenase	0.0068	0.2585	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0068	0.2585	1
Brugia malayi	CHE-14 protein	0.0051	0.1329	0.2116
Loa Loa (eye worm)	hypothetical protein	0.0119	0.6279	1
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0068	0.2585	1
Schistosoma mansoni	short chain dehydrogenase	0.0068	0.2585	0.2663
Loa Loa (eye worm)	oxidoreductase	0.0068	0.2585	0.4116
Onchocerca volvulus		0.0068	0.2585	0.5
Echinococcus granulosus	3 ketodihydrosphingosine reductase	0.0068	0.2585	0.1448
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0068	0.2585	0.5
Trypanosoma brucei	beta-D-hydroxybutyrate dehydrogenase	0.0068	0.2585	0.5
Echinococcus granulosus	expressed conserved protein	0.0112	0.5753	0.5102
Onchocerca volvulus		0.0068	0.2585	0.5
Mycobacterium ulcerans	ketoacyl reductase	0.0068	0.2585	0.5
Onchocerca volvulus		0.0068	0.2585	0.5
Mycobacterium leprae	ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	0.0068	0.2585	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0068	0.2585	0.5
Trichomonas vaginalis	short-chain dehydrogenases/reductase, putative	0.0068	0.2585	1
Trichomonas vaginalis	steroid dehydrogenase, putative	0.0068	0.2585	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0068	0.2585	0.5
Brugia malayi	hypothetical protein	0.0068	0.2585	0.4116
Echinococcus granulosus	steroid dehydrogenase	0.0068	0.2585	0.1448
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.0068	0.2585	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0068	0.2585	0.2663
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0068	0.2585	1
Onchocerca volvulus		0.0068	0.2585	0.5
Echinococcus multilocularis	carbonyl reductase 1	0.0068	0.2585	0.1448
Leishmania major	quinonoid dihydropteridine reductase	0.0068	0.2585	0.5
Leishmania major	short chain dehydrogenase, putative	0.0068	0.2585	0.5
Loa Loa (eye worm)	hypothetical protein	0.0062	0.2166	0.345
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0068	0.2585	0.5
Echinococcus multilocularis	expressed conserved protein	0.0112	0.5753	0.5102
Schistosoma mansoni	short chain dehydrogenase	0.0068	0.2585	0.2663
Mycobacterium ulcerans	short chain dehydrogenase	0.0068	0.2585	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0068	0.2585	0.5
Toxoplasma gondii	oxidoreductase, putative	0.0068	0.2585	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0068	0.2585	0.2663
Leishmania major	hypothetical protein, conserved	0.0068	0.2585	0.5
Schistosoma mansoni	short-chain dehydrogenase/reductase	0.0068	0.2585	0.2663
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0068	0.2585	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0068	0.2585	0.5
Mycobacterium tuberculosis	Possible oxidoreductase	0.0068	0.2585	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0068	0.2585	0.4116
Onchocerca volvulus		0.0068	0.2585	0.5
Echinococcus granulosus	Niemann Pick C1 protein	0.0119	0.6279	0.5709
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0068	0.2585	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0068	0.2585	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0068	0.2585	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0068	0.2585	0.5
Onchocerca volvulus		0.0068	0.2585	0.5
Echinococcus granulosus	carbonyl reductase 1	0.0068	0.2585	0.1448
Echinococcus multilocularis	retinol dehydrogenase 13	0.0068	0.2585	0.1448
Mycobacterium ulcerans	short-chain type oxidoreductase	0.0068	0.2585	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0068	0.2585	0.5
Brugia malayi	dehydrogenases, short chain protein 9	0.0068	0.2585	0.4116
Mycobacterium ulcerans	short chain dehydrogenase	0.0068	0.2585	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0068	0.2585	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0068	0.2585	0.4116
Mycobacterium tuberculosis	Probable oxidoreductase	0.0068	0.2585	0.5
Brugia malayi	Dehydrogenases, short chain protein 2	0.0068	0.2585	0.4116
Schistosoma mansoni	short chain dehydrogenase	0.0068	0.2585	0.2663
Loa Loa (eye worm)	oxidoreductase	0.0068	0.2585	0.4116
Mycobacterium ulcerans	carveol-like dehydrogenase	0.0068	0.2585	0.5
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0051	0.1329	0.2116
Brugia malayi	D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor	0.0068	0.2585	0.4116
Echinococcus multilocularis	steroid dehydrogenase	0.0068	0.2585	0.1448
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0068	0.2585	0.4116
Mycobacterium ulcerans	short chain dehydrogenase	0.0068	0.2585	0.5
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2585	0.4116
Onchocerca volvulus		0.0068	0.2585	0.5
Giardia lamblia	Oxidoreductase, short chain dehydrogenase/reductase family	0.0068	0.2585	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0068	0.2585	0.5
Echinococcus granulosus	oxidoreductase	0.0068	0.2585	0.1448
Mycobacterium ulcerans	oxidoreductase	0.0068	0.2585	0.5
Loa Loa (eye worm)	short chain dehydrogenase/reductase family oxidoreductase	0.0068	0.2585	0.4116
Trypanosoma brucei	beta-ketoacyl-ACP reductase 2	0.0068	0.2585	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0068	0.2585	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0068	0.2585	0.5
Loa Loa (eye worm)	hypothetical protein	0.0051	0.1329	0.2116
Onchocerca volvulus	Sepiapterin reductase homolog	0.0068	0.2585	0.5
Echinococcus multilocularis	estradiol 17 beta dehydrogenase 12	0.0068	0.2585	0.1448
Mycobacterium ulcerans	short chain dehydrogenase	0.0068	0.2585	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0068	0.2585	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0068	0.2585	0.2663
Mycobacterium ulcerans	ketoacyl reductase	0.0068	0.2585	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0068	0.2585	0.4116
Mycobacterium tuberculosis	Possible ketoacyl reductase	0.0068	0.2585	0.5
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0068	0.2585	0.5
Echinococcus multilocularis	steroid dehydrogenase	0.0068	0.2585	0.1448
Mycobacterium ulcerans	ketoacyl reductase	0.0068	0.2585	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0068	0.2585	0.4116
Trypanosoma cruzi	hypothetical protein, conserved	0.0068	0.2585	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0068	0.2585	0.5
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0068	0.2585	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0068	0.2585	0.5
Schistosoma mansoni	3-keto-dihydrosphingosine reductase	0.0068	0.2585	0.2663
Brugia malayi	oxidoreductase	0.0068	0.2585	0.4116
Mycobacterium tuberculosis	Probable short chain alcohol dehydrogenase/reductase	0.0068	0.2585	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0068	0.2585	0.2663
Loa Loa (eye worm)	oxidoreductase	0.0068	0.2585	0.4116
Trypanosoma cruzi	hypothetical protein, conserved	0.0068	0.2585	0.5
Onchocerca volvulus		0.0068	0.2585	0.5
Leishmania major	short chain dehydrogenase, putative	0.0068	0.2585	0.5
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2585	0.4116
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0068	0.2585	0.5
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0068	0.2585	0.5
Echinococcus multilocularis	retinol dehydrogenase 11	0.0068	0.2585	0.1448
Brugia malayi	Retinol dehydrogenase 12	0.0068	0.2585	0.4116
Mycobacterium leprae	Probable oxidoreductase	0.0068	0.2585	0.5
Brugia malayi	Niemann-Pick C1 protein precursor	0.0119	0.6279	1
Leishmania major	quinonoid dihydropteridine reductase	0.0068	0.2585	0.5
Brugia malayi	dehydrogenases, short chain protein 2	0.0068	0.2585	0.4116
Loa Loa (eye worm)	hypothetical protein	0.0068	0.2585	0.4116
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0068	0.2585	1
Leishmania major	quinonoid dihydropteridine reductase	0.0068	0.2585	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0068	0.2585	0.5
Mycobacterium tuberculosis	Possible fatty acyl-CoA reductase	0.0068	0.2585	0.5
Mycobacterium leprae	Possible short-chain dehydrogenase EphD	0.0068	0.2585	0.5
Echinococcus multilocularis	carbonyl reductase 1	0.0068	0.2585	0.1448
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0068	0.2585	0.4116
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0068	0.2585	0.5
Trypanosoma cruzi	quinonoid dihydropteridine reductase, putative	0.0068	0.2585	0.5
Echinococcus granulosus	carbonyl reductase 1	0.0068	0.2585	0.1448
Schistosoma mansoni	short chain dehydrogenase	0.0068	0.2585	0.2663
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0068	0.2585	0.4116
Schistosoma mansoni	short chain dehydrogenase	0.0068	0.2585	0.2663
Echinococcus granulosus	hypothetical protein	0.0068	0.2585	0.1448
Giardia lamblia	Hypothetical protein	0.0068	0.2585	0.5
Loa Loa (eye worm)	oxidoreductase	0.0068	0.2585	0.4116
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0068	0.2585	0.5
Echinococcus granulosus	epidermal retinal dehydrogenase 2	0.0068	0.2585	0.1448
Onchocerca volvulus		0.0068	0.2585	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0068	0.2585	0.5
Echinococcus multilocularis	epidermal retinal dehydrogenase 2	0.0068	0.2585	0.1448
Loa Loa (eye worm)	oxidoreductase	0.0068	0.2585	0.4116
Brugia malayi	Dehydrogenases, short chain protein 30	0.0068	0.2585	0.4116
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0068	0.2585	0.4116
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0068	0.2585	0.5
Mycobacterium leprae	PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE	0.0068	0.2585	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0068	0.2585	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 3.9811 um	PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1366096
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Bibliographic References

No literature references available for this target.

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Detailed information for compound 908385