Detailed information for compound 909911

Basic information

Technical information
  • TDR Targets ID: 909911
  • Name: 5-[(5-chloro-2-nitrobenzoyl)amino]-4-cyano-N, N-diethyl-3-methylthiophene-2-carboxamide
  • MW: 420.87 | Formula: C18H17ClN4O4S
  • H donors: 1 H acceptors: 5 LogP: 4.39 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C(=O)c1sc(c(c1C)C#N)NC(=O)c1cc(Cl)ccc1[N+](=O)[O-])CC
  • InChi: 1S/C18H17ClN4O4S/c1-4-22(5-2)18(25)15-10(3)13(9-20)17(28-15)21-16(24)12-8-11(19)6-7-14(12)23(26)27/h6-8H,4-5H2,1-3H3,(H,21,24)
  • InChiKey: IZMKEISXKGWVAQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[(5-chloro-2-nitro-benzoyl)amino]-4-cyano-N,N-diethyl-3-methyl-thiophene-2-carboxamide
  • 5-[[(5-chloro-2-nitrophenyl)-oxomethyl]amino]-4-cyano-N,N-diethyl-3-methyl-2-thiophenecarboxamide
  • 5-[(5-chloro-2-nitro-phenyl)carbonylamino]-4-cyano-N,N-diethyl-3-methyl-thiophene-2-carboxamide
  • ZINC02741277
  • Oprea1_315547
  • IVK/8073921

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni adenoreceptor 0.0013 0.0171 0.0171
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0171 0.0171
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0123 0.2683 0.1846
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0013 0.0171 0.0171
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0013 0.0171 0.0171
Brugia malayi G-protein coupled receptor 0.0013 0.0171 0.0171
Echinococcus multilocularis pseudouridine metabolizing bifunctional protein 0.0051 0.1029 0.1029
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0188 0.4164 0.4164
Echinococcus granulosus NAD kinase 0.0239 0.5329 0.5329
Echinococcus multilocularis serotonin receptor 0.0013 0.0171 0.0171
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Echinococcus granulosus 7tm_1 domain containing protein 0.0013 0.0171 0.0171
Echinococcus granulosus orexin receptor type 2 0.0013 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0065 0.1356 0.104
Loa Loa (eye worm) hypothetical protein 0.0051 0.1026 0.1026
Echinococcus granulosus neuropeptide FF receptor 2 0.0013 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0188 0.4164 0.3497
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0188 0.4164 0.4164
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0013 0.0171 0.0171
Echinococcus granulosus g protein coupled receptor 0.0013 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Schistosoma mansoni poly(p)/ATP NAD kinase 0.0051 0.1026 0.1026
Leishmania major tagatose-6-phosphate kinase-like protein 0.0051 0.1029 0.0003
Echinococcus multilocularis neuropeptide receptor 0.0013 0.0171 0.0171
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0058 0.1204 0.0198
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Trichomonas vaginalis ribokinase, putative 0.0051 0.1029 0.079
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0013 0.0171 0.0171
Echinococcus multilocularis neuropeptide receptor A26 0.0013 0.0171 0.0171
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0171 0.0171
Schistosoma mansoni amine GPCR 0.0013 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Loa Loa (eye worm) melatonin receptor type 1A 0.0013 0.0171 0.0171
Brugia malayi hypothetical protein 0.0013 0.0171 0.0171
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0188 0.4164 0.3497
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.0171 0.0171
Echinococcus multilocularis g protein coupled receptor 0.0013 0.0171 0.0171
Schistosoma mansoni hypothetical protein 0.0013 0.0171 0.0171
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0123 0.2683 0.1846
Echinococcus granulosus adenosine kinase 0.0444 1 1
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0123 0.2683 0.1846
Echinococcus granulosus peptide allatostatin:somatostatin 0.0013 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Schistosoma mansoni myosin xvIII 0.0013 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Brugia malayi hypothetical protein 0.0013 0.0171 0.0171
Brugia malayi Dopamine receptor protein 2 0.0013 0.0171 0.0171
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0013 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0013 0.0171 0.0171
Entamoeba histolytica tagatose-6-phosphate kinase, putative 0.0051 0.1029 0.1041
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0123 0.2683 0.3846
Trichomonas vaginalis poly(p)/ATP NAD kinase, putative 0.0239 0.5329 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0171 0.0171
Schistosoma mansoni hypothetical protein 0.0013 0.0171 0.0171
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0065 0.1356 0.104
Echinococcus multilocularis allatostatin A receptor 0.0013 0.0171 0.0171
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.013 0.2835 0.2835
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0188 0.4164 0.4164
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0188 0.4164 0.4164
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0065 0.1354 0.1487
Brugia malayi Serotonin receptor 0.0013 0.0171 0.0171
Echinococcus multilocularis NAD kinase domain containing protein 1 0.0051 0.1026 0.1026
Echinococcus granulosus neuropeptide Y receptor 0.0013 0.0171 0.0171
Schistosoma mansoni hypothetical protein 0.0013 0.0171 0.0171
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0171 0.0171
Schistosoma mansoni amine GPCR 0.0013 0.0171 0.0171
Echinococcus granulosus neuropeptides capa receptor 0.0013 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0188 0.4164 0.4164
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0013 0.0171 0.0171
Toxoplasma gondii kinase, pfkB family protein 0.0444 1 1
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0188 0.4164 0.3497
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0171 0.0171
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0665 0.0665
Schistosoma mansoni alpha-1 adrenergic receptor 0.0013 0.0171 0.0171
Echinococcus granulosus sex peptide receptor 0.0013 0.0171 0.0171
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0013 0.0171 0.0171
Schistosoma mansoni hypothetical protein 0.0013 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Trypanosoma cruzi adenosine kinase, putative 0.0444 1 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0188 0.4164 0.3497
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Trypanosoma brucei adenosine kinase, putative 0.0444 1 1
Trichomonas vaginalis poly(p)/ATP NAD kinase, putative 0.0051 0.1026 0.0784
Echinococcus granulosus neuropeptide receptor A26 0.0013 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0188 0.4164 0.5
Echinococcus multilocularis orexin receptor type 2 0.0013 0.0171 0.0171
Echinococcus granulosus biogenic amine 5HT receptor 0.0013 0.0171 0.0171
Trypanosoma cruzi adenosine kinase, putative 0.0051 0.1029 0.0003
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.1168 0.0442
Echinococcus multilocularis G-protein coupled receptor, putative 0.0013 0.0171 0.0171
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0188 0.4164 0.7504
Trichomonas vaginalis poly(p)/ATP NAD kinase, putative 0.0239 0.5329 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Schistosoma mansoni biogenic amine (5HT) receptor 0.0013 0.0171 0.0171
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.013 0.2835 0.2835
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0123 0.2685 0.2685
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0058 0.1204 0.1204
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.1168 0.0158
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Schistosoma mansoni amine GPCR 0.0013 0.0171 0.0171
Echinococcus granulosus 7TM GPCR rhodopsin 0.0013 0.0171 0.0171
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0188 0.4164 0.4164
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0013 0.0171 0.0171
Echinococcus multilocularis neuropeptide receptor 0.0013 0.0171 0.0171
Brugia malayi Melatonin receptor type 1A 0.0013 0.0171 0.0171
Onchocerca volvulus 0.0051 0.1029 0.0988
Echinococcus granulosus tachykinin peptides receptor 99D 0.0013 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0013 0.0171 0.0171
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0188 0.4164 0.5
Schistosoma mansoni amine GPCR 0.0013 0.0171 0.0171
Toxoplasma gondii kinase, pfkB family protein 0.0051 0.1029 0.0003
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Loa Loa (eye worm) IRE protein kinase 0.0035 0.0665 0.0665
Brugia malayi hypothetical protein 0.0013 0.0171 0.0171
Entamoeba histolytica kinase, PfkB family 0.0051 0.1029 0.1041
Schistosoma mansoni biogenic amine receptor 0.0013 0.0171 0.0171
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0013 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.1168 0.0324
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0188 0.4164 0.5
Trypanosoma cruzi adenosine kinase, putative 0.0444 1 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0188 0.4164 0.3497
Echinococcus multilocularis serine:threonine protein kinase:endoribonuclease 0.0035 0.0665 0.0665
Brugia malayi neuropeptide F receptor 0.0013 0.0171 0.0171
Echinococcus granulosus g-protein coupled receptor 0.0013 0.0171 0.0171
Brugia malayi Dopamine receptor protein 1 0.0013 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0188 0.4164 0.7504
Entamoeba histolytica fructokinase, putative 0.0051 0.1029 0.1041
Loa Loa (eye worm) hypothetical protein 0.0444 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.0171 0.0171
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0188 0.4164 0.3497
Schistosoma mansoni neuropeptide receptor 0.0013 0.0171 0.0171
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0013 0.0171 0.0171
Echinococcus multilocularis neuropeptide s receptor 0.0013 0.0171 0.0171
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0188 0.4164 0.3497
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0188 0.4164 0.729
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.0171 0.0171
Schistosoma mansoni neuropeptide receptor 0.0013 0.0171 0.0171
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0171 0.0171
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0171 0.0171
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0188 0.4164 0.729
Echinococcus granulosus serotonin receptor 0.0013 0.0171 0.0171
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.1029 0.079
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0058 0.1204 0.0198
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0171 0.0171
Brugia malayi Serotonin receptor 0.0013 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0188 0.4164 0.3497
Schistosoma mansoni histamine h1 receptor 0.0013 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Schistosoma mansoni biogenic amine receptor 0.0013 0.0171 0.0171
Brugia malayi Ribokinase 0.0051 0.1029 0.1029
Leishmania major tagatose-6-phosphate kinase-like protein 0.0051 0.1029 0.0003
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0188 0.4164 0.7504
Echinococcus granulosus NAD kinase domain containing protein 1 0.0051 0.1026 0.1026
Schistosoma mansoni growth hormone secretagogue receptor 0.0013 0.0171 0.0171
Echinococcus granulosus neuropeptide receptor 0.0013 0.0171 0.0171
Schistosoma mansoni neuropeptide receptor 0.0013 0.0171 0.0171
Mycobacterium leprae Inorganic polyphosphate/ATP-NAD kinase PpnK (Poly(P)/ATP NAD kinase) 0.0189 0.4179 1
Echinococcus multilocularis g protein coupled receptor 0.0013 0.0171 0.0171
Trypanosoma brucei ribokinase, putative 0.0051 0.1029 0.0003
Echinococcus granulosus neuropeptide receptor 0.0013 0.0171 0.0171
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0013 0.0171 0.0171
Onchocerca volvulus 0.0394 0.8846 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0013 0.0171 0.0171
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0188 0.4164 0.4164
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0171 0.0171
Brugia malayi follicle stimulating hormone receptor 0.0013 0.0171 0.0171
Echinococcus multilocularis dro:myosuppressin receptor 0.0013 0.0171 0.0171
Brugia malayi AKH receptor 0.0013 0.0171 0.0171
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0188 0.4164 0.3497
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0171 0.0171
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0171 0.0171
Echinococcus granulosus somatostatin receptor 0.0013 0.0171 0.0171
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.0171 0.0171
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0171 0.0171
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0013 0.0171 0.0171
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0171 0.0171
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.1168 0.0324
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Entamoeba histolytica Hypothetical protein T24C12.3, putative 0.0051 0.1029 0.1041
Echinococcus granulosus calcium activated potassium channel 0.0006 0.0005 0.0005
Schistosoma mansoni opsin-like receptor 0.0013 0.0171 0.0171
Onchocerca volvulus NAD kinase 2, mitochondrial homolog 0.0051 0.1026 0.0985
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0013 0.0171 0.0171
Schistosoma mansoni amine GPCR 0.0013 0.0171 0.0171
Brugia malayi G protein-coupled receptor F59B2.13 0.0013 0.0171 0.0171
Echinococcus granulosus G protein coupled receptor 139 0.0013 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Echinococcus multilocularis neuropeptides capa receptor 0.0013 0.0171 0.0171
Treponema pallidum hypothetical protein 0.0239 0.5329 1
Echinococcus multilocularis neuropeptide Y receptor 0.0013 0.0171 0.0171
Echinococcus granulosus fmrfamide receptor 0.0013 0.0171 0.0171
Echinococcus granulosus biogenic amine 5HT receptor 0.0013 0.0171 0.0171
Schistosoma mansoni biogenic amine (5HT) receptor 0.0013 0.0171 0.0171
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Schistosoma mansoni neuropeptide F-like receptor 0.0013 0.0171 0.0171
Brugia malayi ORL1-like opioid receptor 0.0013 0.0171 0.0171
Trypanosoma brucei ribokinase, putative 0.0051 0.1029 0.0003
Brugia malayi RE15519p 0.0013 0.0171 0.0171
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0013 0.0171 0.0171
Echinococcus multilocularis fmrfamide receptor 0.0013 0.0171 0.0171
Echinococcus granulosus g protein coupled receptor 0.0013 0.0171 0.0171
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.1168 0.1168
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0171 0.0171
Brugia malayi G protein-coupled receptor 0.0013 0.0171 0.0171
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0013 0.0171 0.0171
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0013 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0188 0.4164 0.3497
Brugia malayi hypothetical protein 0.0013 0.0171 0.0171
Brugia malayi hypothetical protein 0.0013 0.0171 0.0171
Entamoeba histolytica ribokinase, putative 0.0051 0.1029 0.1041
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0013 0.0171 0.0171
Echinococcus multilocularis adenosine kinase 0.0444 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0013 0.0171 0.0171
Brugia malayi neuropeptide F receptor 0.0013 0.0171 0.0171
Schistosoma mansoni poly(p)/ATP NAD kinase 0.0239 0.5329 0.5329
Brugia malayi hypothetical protein 0.0013 0.0171 0.0171
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0188 0.4164 0.4164
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0123 0.2685 0.4337
Echinococcus multilocularis G protein coupled receptor 139 0.0013 0.0171 0.0171
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0013 0.0171 0.0171
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.0171 0.0171
Echinococcus multilocularis NAD kinase 0.0239 0.5329 0.5329
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0013 0.0171 0.0171
Brugia malayi hypothetical protein 0.0013 0.0171 0.0171
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0171 0.0171
Brugia malayi hypothetical protein 0.0013 0.0171 0.0171
Loa Loa (eye worm) G-protein coupled receptor 0.0013 0.0171 0.0171
Leishmania major putative PfkB family sugar kinase 0.0051 0.1029 0.0003
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0013 0.0171 0.0171
Schistosoma mansoni biogenic amine receptor 0.0013 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0123 0.2685 0.2685
Brugia malayi larval opioid receptor 0.0013 0.0171 0.0171
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0013 0.0171 0.0171
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0058 0.1204 0.0198
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0188 0.4164 0.3497
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.1168 0.1168
Schistosoma mansoni poly(p)/ATP NAD kinase 0.0051 0.1026 0.1026
Trichomonas vaginalis ribokinase, putative 0.0051 0.1029 0.079
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0188 0.4164 0.3497
Brugia malayi hypothetical protein 0.0013 0.0171 0.0171
Echinococcus granulosus serine:threonine protein kinase:endoribonuclease 0.0035 0.0665 0.0665
Loa Loa (eye worm) neuropeptide F receptor 0.0013 0.0171 0.0171
Echinococcus multilocularis fmrfamide receptor 0.0013 0.0171 0.0171
Trichomonas vaginalis poly(p)/ATP NAD kinase, putative 0.0051 0.1026 0.0784
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0013 0.0171 0.0171
Echinococcus granulosus hypothetical protein 0.0013 0.0171 0.0171
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0013 0.0171 0.0171
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0171 0.0171
Echinococcus multilocularis somatostatin receptor 0.0013 0.0171 0.0171
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0058 0.1204 0.0198
Echinococcus multilocularis calcium activated potassium channel 0.0006 0.0005 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0171 0.0171
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0188 0.4164 0.7504
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0171 0.0171
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0188 0.4164 0.4164
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.1081 0.1081
Echinococcus granulosus alpha 1A adrenergic receptor 0.0013 0.0171 0.0171
Mycobacterium ulcerans inorganic polyphosphate/ATP-NAD kinase 0.0239 0.5329 1
Echinococcus multilocularis sex peptide receptor 0.0013 0.0171 0.0171
Entamoeba histolytica inorganic polyphosphate/ATP-NAD kinase, putative 0.0051 0.1026 0.1033
Echinococcus multilocularis neuropeptides capa receptor 0.0013 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Trypanosoma cruzi adenosine kinase, putative 0.0051 0.1029 0.0003
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0188 0.4164 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0171 0.0171
Schistosoma mansoni opsin-like receptor 0.0013 0.0171 0.0171
Leishmania major ribokinase, putative 0.0051 0.1029 0.0003
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0013 0.0171 0.0171
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0171 0.0171
Brugia malayi sulfakinin receptor protein 0.0013 0.0171 0.0171
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.0171 0.0171
Brugia malayi putative neuropeptide receptor NPR1 0.0013 0.0171 0.0171
Loa Loa (eye worm) neuropeptide F receptor 0.0013 0.0171 0.0171
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0013 0.0171 0.0171
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0013 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0051 0.1029 0.1029
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Leishmania major adenosine kinase-like protein 0.0051 0.1029 0.0003
Onchocerca volvulus Putative pyridoxal kinase 0.0051 0.1029 0.0988
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0123 0.2683 0.1846
Schistosoma mansoni neuropeptide f receptor 76f 0.0013 0.0171 0.0171
Echinococcus multilocularis neuropeptide FF receptor 2 0.0013 0.0171 0.0171
Schistosoma mansoni neuropeptide receptor 0.0013 0.0171 0.0171
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Brugia malayi G-protein coupled receptor 0.0013 0.0171 0.0171
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.1168 0.1168
Echinococcus multilocularis ribokinase 0.0051 0.1029 0.1029
Schistosoma mansoni neuropeptide F-like receptor 0.0013 0.0171 0.0171
Schistosoma mansoni adenosine kinase 0.0444 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.1029 0.1029
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0058 0.1204 0.0198
Mycobacterium tuberculosis Inorganic polyphosphate/ATP-NAD kinase PpnK (poly(P)/ATP NAD kinase) 0.0189 0.4179 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0171 0.0171
Trichomonas vaginalis ribokinase, putative 0.0051 0.1029 0.079
Echinococcus granulosus neuropeptide s receptor 0.0013 0.0171 0.0171
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0013 0.0171 0.0171
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0013 0.0171 0.0171
Echinococcus granulosus ribokinase 0.0051 0.1029 0.1029
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0188 0.4164 1
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0188 0.4164 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0013 0.0171 0.0171
Giardia lamblia Inorganic polyphosphate/ATP-NAD kinase, putative 0.0239 0.5329 1
Brugia malayi Ribonuclease 2-5A family protein 0.0035 0.0665 0.0665
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0188 0.4164 0.3497
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0013 0.0171 0.0171
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0065 0.1354 0.1354
Echinococcus multilocularis serotonin receptor 0.0013 0.0171 0.0171
Echinococcus granulosus neuropeptide Y receptor 0.0013 0.0171 0.0171
Echinococcus granulosus allatostatin A receptor 0.0013 0.0171 0.0171
Trypanosoma cruzi ribokinase, putative 0.0051 0.1029 0.0003
Loa Loa (eye worm) G-protein coupled receptor 0.0013 0.0171 0.0171
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0013 0.0171 0.0171
Echinococcus granulosus neuropeptides capa receptor 0.0013 0.0171 0.0171
Brugia malayi Tachykinin-like peptides receptor 99D 0.0013 0.0171 0.0171
Brugia malayi Dopamine receptor 0.0013 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Loa Loa (eye worm) TYRA-2 protein 0.0013 0.0171 0.0171
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0171 0.0171
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0013 0.0171 0.0171
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0123 0.2685 0.2685
Echinococcus granulosus g protein coupled receptor 0.0013 0.0171 0.0171
Echinococcus multilocularis g protein coupled receptor 0.0013 0.0171 0.0171
Schistosoma mansoni opsin-like receptor 0.0013 0.0171 0.0171
Onchocerca volvulus NAD kinase 2, mitochondrial homolog 0.0051 0.1026 0.0985
Trypanosoma brucei adenosine kinase, putative 0.0444 1 1
Onchocerca volvulus Ribokinase homolog 0.0051 0.1029 0.0988
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0188 0.4164 1
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0123 0.2685 0.2685
Leishmania major adenosine kinase, putative 0.0444 1 1
Echinococcus granulosus pseudouridine metabolizing bifunctional protein 0.0051 0.1029 0.1029
Echinococcus multilocularis neuropeptide Y receptor 0.0013 0.0171 0.0171
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.1168 0.1168
Loa Loa (eye worm) hypothetical protein 0.0051 0.1026 0.1026
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0123 0.2685 0.2685
Schistosoma mansoni adenosine kinase 0.0444 1 1
Echinococcus granulosus dro:myosuppressin receptor 0.0013 0.0171 0.0171
Brugia malayi hypothetical protein 0.0051 0.1029 0.1029
Echinococcus multilocularis g-protein coupled receptor 0.0013 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0013 0.0171 0.0171
Schistosoma mansoni ribokinase 0.0051 0.1029 0.1029
Leishmania major adenosine kinase-like protein 0.0051 0.1029 0.0003
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0188 0.4164 0.7504
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0171 0.0171
Brugia malayi hypothetical protein 0.0013 0.0171 0.0171
Brugia malayi GnHR receptor homolog 0.0013 0.0171 0.0171
Brugia malayi GH09647p 0.0051 0.1026 0.1026
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0123 0.2685 0.4337
Brugia malayi putative neuropeptide receptor 0.0013 0.0171 0.0171
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0188 0.4164 0.3497
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0013 0.0171 0.0171

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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