Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.435 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1969 | 0.2655 | 0.6367 |
Entamoeba histolytica | cysteine protease, putative | 0.1969 | 0.2655 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.435 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1969 | 0.2655 | 0.6367 |
Giardia lamblia | Cathepsin B precursor | 0.246 | 0.417 | 0.5 |
Echinococcus multilocularis | cysteine protease | 0.1969 | 0.2655 | 0.2709 |
Brugia malayi | Cathepsin L-like precursor | 0.1969 | 0.2655 | 0.2709 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1969 | 0.2655 | 0.2709 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.435 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.435 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1969 | 0.2655 | 0.2709 |
Onchocerca volvulus | Cathepsin F homolog | 0.1969 | 0.2655 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1969 | 0.2655 | 0.2709 |
Echinococcus multilocularis | cysteine protease | 0.1969 | 0.2655 | 0.2709 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1969 | 0.2655 | 0.6367 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.4285 | 0.9801 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.1969 | 0.2655 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1969 | 0.2655 | 0.6367 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.435 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1969 | 0.2655 | 0.6367 |
Giardia lamblia | Cathepsin B precursor | 0.246 | 0.417 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.435 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.4285 | 0.9801 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1969 | 0.2655 | 0.6367 |
Loa Loa (eye worm) | cysteine protease | 0.1969 | 0.2655 | 0.2021 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.4285 | 0.9801 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.246 | 0.417 | 0.417 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.435 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.1969 | 0.2655 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.1969 | 0.2655 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1969 | 0.2655 | 0.6367 |
Leishmania major | cathepsin L-like protease | 0.435 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.4285 | 0.9801 | 1 |
Echinococcus multilocularis | cathepsin b | 0.4285 | 0.9801 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1969 | 0.2655 | 0.2709 |
Brugia malayi | Cathepsin L-like precursor | 0.1969 | 0.2655 | 0.2709 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1969 | 0.2655 | 0.2709 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1969 | 0.2655 | 0.6367 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.246 | 0.417 | 0.4254 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.1969 | 0.2655 | 0.2709 |
Giardia lamblia | Cathepsin B precursor | 0.246 | 0.417 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.1969 | 0.2655 | 0.2709 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.435 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1969 | 0.2655 | 0.2709 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.435 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1969 | 0.2655 | 0.6367 |
Leishmania major | cathepsin L-like protease | 0.435 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1969 | 0.2655 | 0.6367 |
Onchocerca volvulus | 0.1969 | 0.2655 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1382 | 0.0845 | 0.2026 |
Loa Loa (eye worm) | ctsf protein | 0.1969 | 0.2655 | 0.2021 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1969 | 0.2655 | 0.2709 |
Loa Loa (eye worm) | cathepsin B | 0.246 | 0.417 | 0.3712 |
Onchocerca volvulus | 0.1969 | 0.2655 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.435 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.1969 | 0.2655 | 0.2709 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.2902 | 0.5535 | 0.5535 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.3763 | 0.819 | 0.819 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.1969 | 0.2655 | 0.2709 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.435 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1969 | 0.2655 | 0.6367 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1382 | 0.0845 | 0.2026 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1969 | 0.2655 | 0.6367 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.4285 | 0.9801 | 0.9801 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1969 | 0.2655 | 0.6367 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1969 | 0.2655 | 0.6367 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.435 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1969 | 0.2655 | 0.2709 |
Onchocerca volvulus | 0.1969 | 0.2655 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.435 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.1969 | 0.2655 | 0.2709 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1969 | 0.2655 | 0.6367 |
Plasmodium vivax | vivapain-2 | 0.1969 | 0.2655 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1969 | 0.2655 | 0.2709 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.246 | 0.417 | 0.2063 |
Echinococcus granulosus | cathepsin l1 | 0.1382 | 0.0845 | 0.0862 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1969 | 0.2655 | 0.6367 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1969 | 0.2655 | 0.6367 |
Onchocerca volvulus | 0.1969 | 0.2655 | 1 | |
Brugia malayi | cathepsin L-like precursor | 0.1382 | 0.0845 | 0.0862 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.1969 | 0.2655 | 0.2021 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.1969 | 0.2655 | 0.2021 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1969 | 0.2655 | 0.6367 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.246 | 0.417 | 0.417 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1969 | 0.2655 | 1 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.4285 | 0.9801 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.246 | 0.417 | 1 |
Onchocerca volvulus | 0.1969 | 0.2655 | 1 | |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.1969 | 0.2655 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1969 | 0.2655 | 0.2021 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1382 | 0.0845 | 0.0862 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1969 | 0.2655 | 0.6367 |
Toxoplasma gondii | cathepsin B | 0.246 | 0.417 | 1 |
Echinococcus granulosus | cathepsin b | 0.4285 | 0.9801 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1382 | 0.0845 | 0.0862 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1969 | 0.2655 | 0.6367 |
Onchocerca volvulus | 0.1969 | 0.2655 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1969 | 0.2655 | 0.6367 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.435 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1969 | 0.2655 | 0.6367 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1969 | 0.2655 | 0.6367 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1969 | 0.2655 | 1 |
Loa Loa (eye worm) | fibroinase | 0.1969 | 0.2655 | 0.2021 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1969 | 0.2655 | 0.6367 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.1969 | 0.2655 | 1 |
Onchocerca volvulus | 0.1969 | 0.2655 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.435 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1382 | 0.0845 | 0.0862 |
Loa Loa (eye worm) | hypothetical protein | 0.4285 | 0.9801 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.4285 | 0.9801 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.1382 | 0.0845 | 0.0862 |
Onchocerca volvulus | Cathepsin L homolog | 0.1969 | 0.2655 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1382 | 0.0845 | 0.3182 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1969 | 0.2655 | 0.2655 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1969 | 0.2655 | 0.6367 |
Echinococcus multilocularis | cathepsin b | 0.4285 | 0.9801 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.