Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.0101 | 0.1627 | 0.1858 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0265 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0265 | 0.0153 |
Brugia malayi | fatty acid elongation protein 3 | 0.0101 | 0.1627 | 0.153 |
Toxoplasma gondii | integral membrane protein, GNS1/SUR4 family protein, putative | 0.0502 | 1 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0265 | 0.0153 |
Leishmania major | fatty acid elongase, putative | 0.0101 | 0.1627 | 0.1627 |
Leishmania major | fatty acid elongase, putative | 0.0101 | 0.1627 | 0.1627 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein homolog | 0.0101 | 0.1627 | 1 |
Echinococcus multilocularis | elongation of very long chain fatty acids | 0.0101 | 0.1627 | 0.1858 |
Leishmania major | fatty acid elongase, putative | 0.0502 | 1 | 1 |
Onchocerca volvulus | 0.0101 | 0.1627 | 1 | |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0101 | 0.1627 | 0.153 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0265 | 0.0153 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0265 | 0.0185 |
Brugia malayi | GNS1/SUR4 family protein | 0.0502 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0265 | 0.0265 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0419 | 0.8256 | 1 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0502 | 1 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0101 | 0.1627 | 0.1627 |
Plasmodium vivax | long chain polyunsaturated fatty acid elongation enzyme, putative | 0.0101 | 0.1627 | 0.153 |
Schistosoma mansoni | fatty acid acyl transferase-related | 0.0101 | 0.1627 | 0.1858 |
Leishmania major | fatty acid elongase, putative | 0.0101 | 0.1627 | 0.1627 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0231 | 0.4345 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0419 | 0.8256 | 0.8236 |
Brugia malayi | fatty acid elongation protein 3 | 0.0101 | 0.1627 | 0.153 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0265 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0265 | 0.0153 |
Leishmania major | fatty acid elongase, putative | 0.0101 | 0.1627 | 0.1627 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.0265 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.031 | 0.5981 | 0.7206 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0419 | 0.8256 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0265 | 0.0185 |
Echinococcus multilocularis | elongation of very long chain fatty acids | 0.0101 | 0.1627 | 0.1858 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0265 | 0.0185 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein 5 homolog | 0.0101 | 0.1627 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0265 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0419 | 0.8256 | 1 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0502 | 1 | 1 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0502 | 1 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.0265 | 0.5 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0502 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0265 | 0.0153 |
Trypanosoma brucei | elongation of very long chain fatty acids protein, putative | 0.0101 | 0.1627 | 0.153 |
Brugia malayi | fatty acid elongation protein 3 | 0.0101 | 0.1627 | 0.153 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0265 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0265 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0502 | 1 | 1 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0265 | 0.0153 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0265 | 0.0153 |
Onchocerca volvulus | 0.0101 | 0.1627 | 1 | |
Plasmodium vivax | GNS1/SUR4 domain containing protein | 0.0502 | 1 | 1 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein homolog | 0.0101 | 0.1627 | 1 |
Trypanosoma brucei | Long chain fatty acyl elongase | 0.0101 | 0.1627 | 0.153 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.0101 | 0.1627 | 0.1858 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0265 | 0.0153 |
Echinococcus granulosus | hormone sensitive lipase | 0.0419 | 0.8256 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.0265 | 0.5 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0101 | 0.1627 | 0.1627 |
Echinococcus granulosus | snurportin 1 | 0.031 | 0.5981 | 0.7206 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.0265 | 0.5 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0101 | 0.1627 | 0.1627 |
Plasmodium vivax | elongation of very long chain fatty acids protein 3, putative | 0.0101 | 0.1627 | 0.153 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0502 | 1 | 1 |
Toxoplasma gondii | GNS1/SUR4 family protein | 0.0502 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0024 | 0 | 0.5 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0101 | 0.1627 | 0.1627 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0265 | 0.0153 |
Plasmodium falciparum | long chain polyunsaturated fatty acid elongation enzyme, putative | 0.0101 | 0.1627 | 0.153 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0265 | 0.0265 |
Plasmodium falciparum | long chain fatty acid elongation enzyme, putative | 0.0502 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.1627 | 0.153 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0101 | 0.1627 | 0.153 |
Leishmania major | fatty acid elongase, putative | 0.0101 | 0.1627 | 0.1627 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0265 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0265 | 0.0265 |
Trypanosoma brucei | Fatty acid elongase | 0.0101 | 0.1627 | 0.153 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0101 | 0.1627 | 0.1627 |
Toxoplasma gondii | fatty acid elongase | 0.0101 | 0.1627 | 0.153 |
Brugia malayi | GNS1/SUR4 family protein | 0.0101 | 0.1627 | 0.153 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0265 | 0.0185 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.0101 | 0.1627 | 0.1858 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0265 | 0.0153 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0265 | 1 |
Brugia malayi | RNA, U transporter 1 | 0.0083 | 0.1232 | 0.1131 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.0101 | 0.1627 | 0.1858 |
Loa Loa (eye worm) | ELO-9 protein | 0.0101 | 0.1627 | 0.153 |
Trypanosoma brucei | Fatty acid elongase | 0.0101 | 0.1627 | 0.153 |
Leishmania major | long chain polyunsaturated fatty acid elongation enzyme-like protein | 0.0101 | 0.1627 | 0.1627 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.0265 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0101 | 0.1627 | 0.1627 |
Leishmania major | fatty acid elongase, putative | 0.0101 | 0.1627 | 0.1627 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0101 | 0.1627 | 0.1627 |
Plasmodium falciparum | fatty acid elongation protein, GNS1/SUR4 family, putative | 0.0502 | 1 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0101 | 0.1627 | 0.1627 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0265 | 0.0153 |
Loa Loa (eye worm) | GNS1/SUR4 family protein | 0.0502 | 1 | 1 |
Trypanosoma brucei | Fatty acid elongase | 0.0502 | 1 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0101 | 0.1627 | 0.1627 |
Brugia malayi | fatty acid elongation protein 3 | 0.0101 | 0.1627 | 0.153 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0265 | 0.0153 |
Echinococcus granulosus | elongation of very long chain fatty acids | 0.0101 | 0.1627 | 0.1858 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0265 | 0.0153 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0265 | 1 |
Brugia malayi | Hypothetical 34.1 kDa protein C40H1.4 in chromosome III | 0.0101 | 0.1627 | 0.153 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0101 | 0.1627 | 0.153 |
Echinococcus multilocularis | snurportin 1 | 0.031 | 0.5981 | 0.7206 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.031 | 0.5981 | 0.5934 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0101 | 0.1627 | 0.1627 |
Echinococcus granulosus | elongation of very long chain fatty acids | 0.0101 | 0.1627 | 0.1858 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0265 | 0.0153 |
Loa Loa (eye worm) | GNS1/SUR4 family protein | 0.0101 | 0.1627 | 0.153 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0419 | 0.8256 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0502 | 1 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.0265 | 0.0153 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.