Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0257 | 1 |
Trypanosoma brucei | Fatty acid elongase | 0.0102 | 0.164 | 0.1547 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0257 | 0.0257 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0102 | 0.164 | 0.164 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0102 | 0.164 | 0.1547 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.164 | 0.1547 |
Plasmodium falciparum | long chain fatty acid elongation enzyme, putative | 0.0505 | 1 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0102 | 0.164 | 0.164 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0257 | 0.0257 |
Plasmodium falciparum | long chain polyunsaturated fatty acid elongation enzyme, putative | 0.0102 | 0.164 | 0.1547 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0257 | 0.0147 |
Plasmodium vivax | elongation of very long chain fatty acids protein 3, putative | 0.0102 | 0.164 | 0.1547 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0257 | 0.5 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0505 | 1 | 1 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0102 | 0.164 | 0.164 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0207 | 0.3826 | 0.655 |
Toxoplasma gondii | GNS1/SUR4 family protein | 0.0505 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0102 | 0.164 | 0.164 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0302 | 0.5782 | 0.5735 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0257 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0257 | 0.0147 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0102 | 0.164 | 0.164 |
Onchocerca volvulus | 0.0102 | 0.164 | 1 | |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0257 | 0.0147 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0257 | 0.0147 |
Leishmania major | fatty acid elongase, putative | 0.0505 | 1 | 1 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.0102 | 0.164 | 0.2697 |
Trypanosoma brucei | Long chain fatty acyl elongase | 0.0102 | 0.164 | 0.1547 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein homolog | 0.0102 | 0.164 | 1 |
Plasmodium vivax | GNS1/SUR4 domain containing protein | 0.0505 | 1 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0505 | 1 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0257 | 0.0147 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0226 | 0.4201 | 1 |
Echinococcus granulosus | elongation of very long chain fatty acids | 0.0102 | 0.164 | 0.2697 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0257 | 0.0147 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0102 | 0.164 | 0.164 |
Loa Loa (eye worm) | GNS1/SUR4 family protein | 0.0102 | 0.164 | 0.1547 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0257 | 0.0147 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.3826 | 0.3757 |
Echinococcus granulosus | hormone sensitive lipase | 0.0207 | 0.3826 | 0.655 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0257 | 1 |
Brugia malayi | Hypothetical 34.1 kDa protein C40H1.4 in chromosome III | 0.0102 | 0.164 | 0.1547 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0102 | 0.164 | 0.1547 |
Trypanosoma brucei | Fatty acid elongase | 0.0505 | 1 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0102 | 0.164 | 0.164 |
Loa Loa (eye worm) | GNS1/SUR4 family protein | 0.0505 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0257 | 0.0147 |
Echinococcus granulosus | elongation of very long chain fatty acids | 0.0102 | 0.164 | 0.2697 |
Brugia malayi | fatty acid elongation protein 3 | 0.0102 | 0.164 | 0.1547 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0102 | 0.164 | 0.164 |
Leishmania major | fatty acid elongase, putative | 0.0102 | 0.164 | 0.164 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0257 | 0.0147 |
Plasmodium falciparum | fatty acid elongation protein, GNS1/SUR4 family, putative | 0.0505 | 1 | 1 |
Leishmania major | long chain polyunsaturated fatty acid elongation enzyme-like protein | 0.0102 | 0.164 | 0.164 |
Trypanosoma brucei | Fatty acid elongase | 0.0102 | 0.164 | 0.1547 |
Leishmania major | fatty acid elongase, putative | 0.0102 | 0.164 | 0.164 |
Leishmania major | fatty acid elongase, putative | 0.0102 | 0.164 | 0.164 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0257 | 1 |
Onchocerca volvulus | 0.0102 | 0.164 | 1 | |
Brugia malayi | RNA, U transporter 1 | 0.008 | 0.1192 | 0.1093 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.0102 | 0.164 | 0.2697 |
Brugia malayi | GNS1/SUR4 family protein | 0.0102 | 0.164 | 0.1547 |
Toxoplasma gondii | fatty acid elongase | 0.0102 | 0.164 | 0.1547 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0257 | 0.0257 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0257 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0257 | 0.0147 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.0102 | 0.164 | 0.2697 |
Leishmania major | fatty acid elongase, putative | 0.0102 | 0.164 | 0.164 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0505 | 1 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0207 | 0.3826 | 0.655 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0257 | 0.0257 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0257 | 0.0257 |
Brugia malayi | GNS1/SUR4 family protein | 0.0505 | 1 | 1 |
Loa Loa (eye worm) | ELO-9 protein | 0.0102 | 0.164 | 0.1547 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0257 | 0.0147 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0102 | 0.164 | 0.1547 |
Echinococcus multilocularis | elongation of very long chain fatty acids | 0.0102 | 0.164 | 0.2697 |
Leishmania major | fatty acid elongase, putative | 0.0505 | 1 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0102 | 0.164 | 0.164 |
Leishmania major | fatty acid elongase, putative | 0.0102 | 0.164 | 0.164 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein homolog | 0.0102 | 0.164 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0257 | 0.0147 |
Toxoplasma gondii | integral membrane protein, GNS1/SUR4 family protein, putative | 0.0505 | 1 | 1 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.0102 | 0.164 | 0.2697 |
Brugia malayi | fatty acid elongation protein 3 | 0.0102 | 0.164 | 0.1547 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0257 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0257 | 0.0147 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0505 | 1 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0257 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0257 | 0.5 |
Brugia malayi | fatty acid elongation protein 3 | 0.0102 | 0.164 | 0.1547 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0257 | 1 |
Trypanosoma brucei | elongation of very long chain fatty acids protein, putative | 0.0102 | 0.164 | 0.1547 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0257 | 0.0147 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0505 | 1 | 1 |
Echinococcus granulosus | snurportin 1 | 0.0302 | 0.5782 | 1 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0505 | 1 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0257 | 0.0257 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0257 | 0.5 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein 5 homolog | 0.0102 | 0.164 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0257 | 0.0257 |
Echinococcus multilocularis | elongation of very long chain fatty acids | 0.0102 | 0.164 | 0.2697 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0257 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0302 | 0.5782 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0207 | 0.3826 | 0.655 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0207 | 0.3826 | 0.655 |
Echinococcus multilocularis | snurportin 1 | 0.0302 | 0.5782 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0102 | 0.164 | 0.164 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0257 | 0.0147 |
Leishmania major | fatty acid elongase, putative | 0.0102 | 0.164 | 0.164 |
Brugia malayi | fatty acid elongation protein 3 | 0.0102 | 0.164 | 0.1547 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0257 | 0.5 |
Plasmodium vivax | long chain polyunsaturated fatty acid elongation enzyme, putative | 0.0102 | 0.164 | 0.1547 |
Schistosoma mansoni | fatty acid acyl transferase-related | 0.0102 | 0.164 | 0.2697 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.