TDR Targets

Basic information

Technical information

TDR Targets ID: 916316
Name: 5-(4-methoxyphenyl)-1,3-di(phenyl)pyrazole
MW: 326.391 | Formula: C22H18N2O
H donors: 0 H acceptors: 1 LogP: 5.19 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)c1cc(nn1c1ccccc1)c1ccccc1
InChi: 1S/C22H18N2O/c1-25-20-14-12-18(13-15-20)22-16-21(17-8-4-2-5-9-17)23-24(22)19-10-6-3-7-11-19/h2-16H,1H3
InChiKey: YTXHHPOUUVVWGT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Capra hircus	Cathepsin B	Starlite/ChEMBL	References
Capra hircus	Cathepsin H	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma cruzi	cysteine protease, putative	Cathepsin H	335 aa	341 aa	32.3 %
Trypanosoma cruzi	cysteine peptidase, putative	Cathepsin H	335 aa	332 aa	33.7 %
Echinococcus multilocularis	cathepsin l cysteine peptidase	Cathepsin H	335 aa	327 aa	44.3 %
Echinococcus multilocularis	cathepsin L	Cathepsin H	335 aa	300 aa	41.7 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin H	335 aa	376 aa	24.7 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin H	335 aa	343 aa	28.3 %
Dictyostelium discoideum	cysteine protease	Cathepsin B	335 aa	285 aa	24.2 %
Brugia malayi	Cathepsin L-like precursor	Cathepsin B	335 aa	307 aa	25.7 %
Echinococcus multilocularis	cathepsin l cysteine peptidase	Cathepsin H	335 aa	316 aa	39.6 %
Leishmania mexicana	cathepsin L-like protease, putative	Cathepsin H	335 aa	333 aa	35.1 %
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	Cathepsin B	335 aa	275 aa	33.5 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	308 aa	37.7 %
Dictyostelium discoideum	cathepsin L-like proteinase	Cathepsin B	335 aa	318 aa	25.5 %
Leishmania major	cathepsin L-like protease	Cathepsin H	335 aa	342 aa	36.5 %
Loa Loa (eye worm)	ctsf protein	Cathepsin H	335 aa	306 aa	36.6 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	325 aa	36.3 %
Trypanosoma cruzi	cysteine proteinase, putative	Cathepsin B	335 aa	278 aa	26.3 %
Leishmania braziliensis	cathepsin L-like protease	Cathepsin H	335 aa	331 aa	35.0 %
Plasmodium vivax	vivapain-2	Cathepsin H	335 aa	327 aa	36.1 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	297 aa	23.9 %
Schistosoma mansoni	cathepsin F (C01 family)	Cathepsin H	335 aa	325 aa	36.9 %
Giardia lamblia	Cathepsin L precursor	Cathepsin H	335 aa	282 aa	22.7 %
Leishmania mexicana		Cathepsin H	335 aa	333 aa	34.8 %
Theileria parva	cysteine proteinase, putative	Cathepsin H	335 aa	339 aa	28.3 %
Schistosoma mansoni	cathepsin S (C01 family)	Cathepsin H	335 aa	307 aa	30.3 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	325 aa	35.7 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	271 aa	26.9 %
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	Cathepsin B	335 aa	301 aa	27.6 %
Leishmania major	cathepsin L-like protease	Cathepsin H	335 aa	342 aa	36.3 %
Dictyostelium discoideum	hypothetical protein	Cathepsin H	335 aa	322 aa	31.7 %
Onchocerca volvulus		Cathepsin H	335 aa	327 aa	36.4 %
Leishmania braziliensis	cysteine peptidase A (CPA)	Cathepsin H	335 aa	300 aa	33.7 %
Onchocerca volvulus		Cathepsin H	335 aa	309 aa	36.9 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	308 aa	25.3 %
Dictyostelium discoideum	cysteine proteinase 1	Cathepsin B	335 aa	270 aa	25.2 %
Trypanosoma cruzi	cruzipain precursor, putative	Cathepsin H	335 aa	332 aa	33.7 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	273 aa	26.4 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	325 aa	35.7 %
Plasmodium knowlesi	knowpain-4	Cathepsin B	335 aa	300 aa	26.0 %
Babesia bovis	papain family cysteine protease containing protein	Cathepsin H	335 aa	311 aa	32.2 %
Echinococcus granulosus	cathepsin L cysteine proteinase	Cathepsin H	335 aa	321 aa	39.9 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin B	335 aa	276 aa	23.2 %
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Cathepsin B	335 aa	286 aa	26.9 %
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	325 aa	36.3 %
Toxoplasma gondii	cathepsin CPL	Cathepsin H	335 aa	311 aa	38.6 %
Trypanosoma cruzi	cysteine peptidase, putative	Cathepsin H	335 aa	332 aa	33.7 %
Toxoplasma gondii	cathepsin CPC1	Cathepsin B	335 aa	304 aa	28.6 %
Echinococcus multilocularis	cathepsin L cysteine protease	Cathepsin H	335 aa	316 aa	39.6 %
Plasmodium falciparum	dipeptidyl aminopeptidase 1	Cathepsin B	335 aa	371 aa	25.3 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	270 aa	27.0 %
Leishmania major	cathepsin L-like protease	Cathepsin H	335 aa	342 aa	36.3 %
Theileria parva	cysteine proteinase, putative	Cathepsin H	335 aa	337 aa	29.1 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	325 aa	36.3 %
Plasmodium knowlesi	dipeptidyl aminopeptidase 1, putative	Cathepsin B	335 aa	314 aa	24.5 %
Leishmania mexicana		Cathepsin H	335 aa	333 aa	34.8 %
Dictyostelium discoideum	cysteine proteinase 3	Cathepsin B	335 aa	275 aa	27.6 %
Leishmania infantum	cysteine peptidase A (CPA)	Cathepsin H	335 aa	335 aa	33.7 %
Leishmania major	cathepsin L-like protease	Cathepsin H	335 aa	342 aa	36.5 %
Plasmodium berghei	dipeptidyl aminopeptidase 1, putative	Cathepsin B	335 aa	319 aa	25.7 %
Dictyostelium discoideum	hypothetical protein	Cathepsin H	335 aa	348 aa	38.5 %
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	325 aa	36.3 %
Drosophila melanogaster	Cathepsin B1	Cathepsin H	335 aa	318 aa	26.4 %
Theileria parva	cathepsin C, putative	Cathepsin B	335 aa	282 aa	29.4 %
Schistosoma japonicum	ko:K01275 cathepsin C [EC3.4.14.1], putative	Cathepsin B	335 aa	327 aa	30.9 %
Plasmodium knowlesi	knowpain-3	Cathepsin H	335 aa	336 aa	35.7 %
Plasmodium berghei	dipeptidyl aminopeptidase 2	Cathepsin B	335 aa	315 aa	25.1 %
Leishmania donovani	cysteine peptidase A (CBA)	Cathepsin H	335 aa	334 aa	33.8 %
Leishmania major	cathepsin L-like protease	Cathepsin H	335 aa	342 aa	36.3 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	308 aa	37.0 %
Plasmodium yoelii	cathepsin c precursor	Cathepsin B	335 aa	319 aa	25.7 %
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	Cathepsin B	335 aa	273 aa	31.9 %
Plasmodium falciparum	cysteine proteinase falcipain 3	Cathepsin H	335 aa	343 aa	32.9 %
Theileria parva	cysteine proteinase	Cathepsin H	335 aa	323 aa	28.2 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin H	335 aa	314 aa	23.6 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	322 aa	35.4 %
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Cathepsin H	335 aa	322 aa	33.2 %
Giardia lamblia	Cathepsin L precursor	Cathepsin B	335 aa	280 aa	25.4 %
Dictyostelium discoideum	cysteine protease	Cathepsin B	335 aa	283 aa	25.8 %
Onchocerca volvulus		Cathepsin B	335 aa	313 aa	23.0 %
Brugia malayi	Cathepsin L-like precursor	Cathepsin B	335 aa	307 aa	26.1 %
Dictyostelium discoideum	hypothetical protein	Cathepsin H	335 aa	325 aa	33.5 %
Babesia bovis	cysteine protease 2	Cathepsin H	335 aa	339 aa	31.0 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	306 aa	36.6 %
Plasmodium knowlesi	knowpain-2	Cathepsin B	335 aa	304 aa	26.0 %
Dictyostelium discoideum	hypothetical protein	Cathepsin H	335 aa	281 aa	27.8 %
Echinococcus granulosus	cathepsin b	Cathepsin H	335 aa	324 aa	29.6 %
Brugia malayi	cathepsin B-like cysteine proteinase	Cathepsin H	335 aa	342 aa	24.6 %
Dictyostelium discoideum	cysteine proteinase	Cathepsin H	335 aa	292 aa	39.4 %
Dictyostelium discoideum	hypothetical protein	Cathepsin B	335 aa	290 aa	25.9 %
Giardia lamblia	Hypothetical protein	Cathepsin B	335 aa	273 aa	32.6 %
Plasmodium knowlesi	cysteine protease, putative	Cathepsin H	335 aa	271 aa	24.7 %
Trypanosoma cruzi	cysteine peptidase, putative	Cathepsin H	335 aa	314 aa	34.1 %
Plasmodium falciparum	cysteine proteinase falcipain 2b	Cathepsin H	335 aa	340 aa	33.2 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	270 aa	26.7 %
Giardia lamblia	Cathepsin L-like protease	Cathepsin H	335 aa	276 aa	24.6 %
Neospora caninum	hypothetical protein	Cathepsin B	335 aa	306 aa	28.1 %
Echinococcus multilocularis	cathepsin b	Cathepsin H	335 aa	311 aa	31.5 %
Giardia lamblia	Dipeptidyl-peptidase I precursor	Cathepsin B	335 aa	281 aa	25.6 %
Babesia bovis	cathepsin C precursor, putative	Cathepsin B	335 aa	307 aa	24.8 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	325 aa	36.3 %
Plasmodium yoelii	berghepain-2	Cathepsin H	335 aa	318 aa	33.0 %
Plasmodium yoelii	cysteine proteinase precursor	Cathepsin H	335 aa	358 aa	27.7 %
Theileria parva	cysteine proteinase, putative	Cathepsin H	335 aa	316 aa	27.5 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	325 aa	36.3 %
Leishmania major	cysteine peptidase A (CPA)	Cathepsin H	335 aa	338 aa	33.7 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	296 aa	23.6 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	324 aa	34.6 %
Plasmodium falciparum	serine repeat antigen 1	Cathepsin H	335 aa	287 aa	22.3 %
Leishmania major	cathepsin L-like protease	Cathepsin H	335 aa	342 aa	36.5 %
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	Cathepsin B	335 aa	286 aa	27.6 %
Dictyostelium discoideum	cysteine proteinase	Cathepsin H	335 aa	297 aa	38.7 %
Onchocerca volvulus	Protein MCM10 homolog	Cathepsin H	335 aa	313 aa	36.1 %
Plasmodium falciparum	dipeptidyl aminopeptidase 2	Cathepsin B	335 aa	302 aa	26.5 %
Plasmodium knowlesi	knowpain-1	Cathepsin B	335 aa	289 aa	21.8 %
Toxoplasma gondii	cathepsin B	Cathepsin H	335 aa	274 aa	26.3 %
Cryptosporidium parvum	preprocathepsin c precursor, putative	Cathepsin B	335 aa	281 aa	28.1 %
Theileria parva	cathepsin C, putative	Cathepsin B	335 aa	291 aa	26.8 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin H	335 aa	339 aa	26.8 %
Onchocerca volvulus		Cathepsin B	335 aa	327 aa	35.2 %
Brugia malayi	Papain family cysteine protease containing protein	Cathepsin H	335 aa	287 aa	34.1 %
Schistosoma japonicum	Disco-interacting protein 2 homolog B, putative	Cathepsin H	335 aa	350 aa	36.0 %
Echinococcus multilocularis	cathepsin L cysteine protease	Cathepsin H	335 aa	316 aa	39.2 %
Plasmodium vivax	vivapain-3	Cathepsin B	335 aa	301 aa	23.6 %
Giardia lamblia	Cathepsin L-like protease	Cathepsin B	335 aa	284 aa	23.6 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	325 aa	36.3 %
Leishmania mexicana		Cathepsin H	335 aa	272 aa	36.4 %
Leishmania infantum	cathepsin L-like protease	Cathepsin H	335 aa	324 aa	34.6 %
Cryptosporidium hominis	cryptopain precursor	Cathepsin H	335 aa	322 aa	32.9 %
Giardia lamblia	Cathepsin L precursor	Cathepsin B	335 aa	279 aa	25.4 %
Onchocerca volvulus		Cathepsin H	335 aa	325 aa	37.2 %
Echinococcus granulosus	cathepsin L	Cathepsin H	335 aa	300 aa	41.3 %
Giardia lamblia	Cathepsin L precursor	Cathepsin H	335 aa	270 aa	25.2 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	322 aa	34.8 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	271 aa	26.6 %
Cryptosporidium hominis	preprocathepsin c precursor	Cathepsin B	335 aa	278 aa	29.5 %
Plasmodium berghei	berghepain-2	Cathepsin H	335 aa	318 aa	33.6 %
Onchocerca volvulus	Cathepsin B-like cysteine proteinase 6 homolog	Cathepsin B	335 aa	315 aa	50.2 %
Schistosoma japonicum	Cathepsin C precursor, putative	Cathepsin B	335 aa	333 aa	26.7 %
Onchocerca volvulus		Cathepsin H	335 aa	328 aa	36.9 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	325 aa	36.3 %
Plasmodium vivax	unspecified product	Cathepsin B	335 aa	288 aa	21.9 %
Trypanosoma cruzi	cysteine proteinase, putative	Cathepsin B	335 aa	275 aa	25.8 %
Plasmodium falciparum	cysteine proteinase falcipain 2a	Cathepsin H	335 aa	329 aa	34.6 %
Plasmodium falciparum	cysteine proteinase falcipain 1	Cathepsin B	335 aa	297 aa	22.9 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin H	335 aa	337 aa	25.8 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	322 aa	35.4 %
Schistosoma mansoni	cathepsin F (C01 family)	Cathepsin H	335 aa	300 aa	38.3 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin H	335 aa	337 aa	25.8 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	325 aa	36.3 %
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	Cathepsin H	335 aa	315 aa	32.7 %
Echinococcus multilocularis	cysteine protease	Cathepsin H	335 aa	316 aa	40.2 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin B	335 aa	274 aa	21.5 %
Leishmania major	cathepsin L-like protease	Cathepsin H	335 aa	342 aa	36.5 %
Theileria parva	cysteine proteinase, putative	Cathepsin H	335 aa	334 aa	32.9 %
Theileria parva	cysteine proteinase, putative	Cathepsin H	335 aa	330 aa	26.4 %
Echinococcus granulosus	cysteine protease	Cathepsin H	335 aa	316 aa	39.2 %
Toxoplasma gondii	preprocathepsin c precursor, putative	Cathepsin B	335 aa	274 aa	24.5 %
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	Cathepsin B	335 aa	319 aa	25.1 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	325 aa	36.3 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin H	335 aa	322 aa	20.5 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin H	335 aa	331 aa	25.1 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin H	335 aa	337 aa	25.8 %
Dictyostelium discoideum	cysteine proteinase 5 precursor	Cathepsin B	335 aa	369 aa	21.4 %
Plasmodium vivax	vivapain-2	Cathepsin B	335 aa	309 aa	25.9 %
Leishmania mexicana	cathepsin L-like protease, putative	Cathepsin H	335 aa	333 aa	34.8 %
Leishmania braziliensis	cathepsin L-like protease	Cathepsin H	335 aa	331 aa	35.3 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	325 aa	36.3 %
Loa Loa (eye worm)	cysteine protease	Cathepsin H	335 aa	333 aa	35.1 %
Echinococcus granulosus	cathepsin L cysteine protease	Cathepsin H	335 aa	316 aa	38.9 %
Trypanosoma cruzi	cysteine peptidase, putative	Cathepsin H	335 aa	319 aa	34.5 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	325 aa	36.3 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin H	335 aa	337 aa	27.0 %
Leishmania braziliensis	cathepsin L-like protease	Cathepsin H	335 aa	331 aa	35.0 %
Theileria parva	cysteine proteinase, putative	Cathepsin B	335 aa	322 aa	23.3 %
Leishmania mexicana		Cathepsin H	335 aa	333 aa	35.1 %
Leishmania mexicana	cysteine peptidase A (CBA)	Cathepsin H	335 aa	308 aa	34.1 %
Echinococcus multilocularis	cysteine protease	Cathepsin H	335 aa	316 aa	40.2 %
Entamoeba histolytica	cysteine protease, putative	Cathepsin H	335 aa	298 aa	28.2 %
Theileria parva	cysteine protease, putative	Cathepsin H	335 aa	306 aa	34.0 %
Leishmania major	cathepsin L-like protease	Cathepsin H	335 aa	332 aa	36.7 %
Echinococcus multilocularis	cathepsin L	Cathepsin H	335 aa	312 aa	32.4 %
Onchocerca volvulus	Cathepsin L homolog	Cathepsin H	335 aa	325 aa	36.9 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	270 aa	27.4 %
Leishmania infantum	cathepsin L-like protease	Cathepsin H	335 aa	333 aa	37.2 %
Toxoplasma gondii	cathepsin CPC2	Cathepsin B	335 aa	269 aa	25.3 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	325 aa	36.3 %
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Cathepsin H	335 aa	331 aa	34.4 %
Plasmodium knowlesi	dipeptidyl aminopeptidase 2, putative	Cathepsin B	335 aa	286 aa	28.3 %
Schistosoma mansoni	cathepsin F (C01 family)	Cathepsin H	335 aa	296 aa	37.8 %
Neospora caninum	Cathepsin L, related	Cathepsin H	335 aa	291 aa	39.2 %
Drosophila melanogaster	CG6347 gene product from transcript CG6347-RA	Cathepsin H	335 aa	353 aa	35.7 %
Plasmodium vivax	vivapain-1	Cathepsin B	335 aa	288 aa	21.9 %
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin H	335 aa	325 aa	36.3 %
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Cathepsin B	335 aa	270 aa	27.4 %
Plasmodium berghei	berghepain-1	Cathepsin B	335 aa	286 aa	22.4 %
Echinococcus granulosus	cathepsin L	Cathepsin H	335 aa	312 aa	32.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0019	0	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0	0.5
Entamoeba histolytica	cysteine protease, putative	0.0019	0	0.5
Onchocerca volvulus		0.0019	0	0.5
Onchocerca volvulus		0.0019	0	0.5
Entamoeba histolytica	cysteine proteinase 1, putative	0.0019	0	0.5
Entamoeba histolytica	cysteine protease, putative	0.0019	0	0.5
Entamoeba histolytica	cysteine protease, putative	0.0019	0	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0	0.5
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.006	0.2688	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.006	0.2688	1
Plasmodium vivax	vivapain-1	0.0019	0	0.5
Plasmodium vivax	vivapain-2	0.0019	0	0.5
Entamoeba histolytica	cysteine protease, putative	0.0019	0	0.5
Entamoeba histolytica	cysteine protease, putative	0.0019	0	0.5
Entamoeba histolytica	cysteine protease, putative	0.0019	0	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0	0.5
Entamoeba histolytica	cysteine protease, putative	0.0019	0	0.5
Entamoeba histolytica	cysteine protease, putative	0.0019	0	0.5
Giardia lamblia	Cathepsin B precursor	0.006	0.2688	0.5
Entamoeba histolytica	cysteine protease, putative	0.0019	0	0.5
Echinococcus multilocularis	cathepsin b	0.0171	1	1
Echinococcus multilocularis	cathepsin b	0.0171	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	1	1
Onchocerca volvulus	Cathepsin F homolog	0.0019	0	0.5
Entamoeba histolytica	cysteine proteinase 2	0.0019	0	0.5
Entamoeba histolytica	cysteine protease, putative	0.0019	0	0.5
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0171	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0019	0	0.5
Onchocerca volvulus		0.0019	0	0.5
Onchocerca volvulus	Cathepsin L homolog	0.0019	0	0.5
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0019	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0171	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.006	0.2688	0.2688
Plasmodium vivax	vivapain-2	0.0019	0	0.5
Loa Loa (eye worm)	cathepsin B	0.006	0.2688	0.2688
Entamoeba histolytica	cysteine protease, putative	0.0019	0	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0	0.5
Entamoeba histolytica	cysteine protease, putative	0.0019	0	0.5
Echinococcus granulosus	cathepsin b	0.0171	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.006	0.2688	0.2688
Giardia lamblia	Cathepsin B precursor	0.006	0.2688	0.5
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0019	0	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.006	0.2688	1
Onchocerca volvulus		0.0019	0	0.5
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0019	0	0.5
Onchocerca volvulus		0.0019	0	0.5
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	1	1
Plasmodium vivax	vivapain-3	0.0019	0	0.5
Plasmodium vivax	unspecified product	0.0019	0	0.5
Onchocerca volvulus		0.0019	0	0.5
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0171	1	1
Entamoeba histolytica	cysteine protease, putative	0.0019	0	0.5
Giardia lamblia	Cathepsin B precursor	0.006	0.2688	0.5
Echinococcus granulosus	cathepsin b	0.0171	1	1
Onchocerca volvulus		0.0019	0	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0	0.5
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	1	1
Toxoplasma gondii	cathepsin B	0.006	0.2688	1
Entamoeba histolytica	cysteine protease, putative	0.0019	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)	= 1.56 nmol/min/ml	Inhibition of goat liver cathepsin H assessed as enzyme activity at 10 uM using BANA substrate pre-incubated 30 mins before substrate addition by colorimetry (Rvb = 3.70 +/- 0.0387 nmol/min/ml)	ChEMBL.	24913985
Activity (binding)	= 2.32 nmol/min/ml	Inhibition of goat liver cathepsin B assessed as enzyme activity at 10 uM using BANA substrate pre-incubated 30 mins before substrate addition by colorimetry (Rvb = 5.65 +/- 0.0276 nmol/min/ml)	ChEMBL.	24913985
Ki (binding)	= 3.33 uM	Competitive inhibition of goat liver cathepsin H using Leu-betaNA substrate by Lineweaver-Burk plot analysis	ChEMBL.	24913985
Ki (binding)	= 4.706 uM	Competitive inhibition of goat liver cathepsin B using BANA substrate by Lineweaver-Burk plot analysis	ChEMBL.	24913985

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3309807

Bibliographic References

No literature references available for this target.

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Detailed information for compound 916316