Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ROS proto-oncogene 1, receptor tyrosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | tyrosine protein kinase | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Echinococcus multilocularis | tyrosine protein kinase | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Loa Loa (eye worm) | TK protein kinase | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Brugia malayi | Protein kinase domain containing protein | Get druggable targets OG5_135644 | All targets in OG5_135644 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.9985 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.9985 | 1 |
Schistosoma mansoni | peroxidasin | 0.0297 | 0.9985 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0297 | 0.9985 | 1 |
Mycobacterium ulcerans | cytochrome C oxidase polypeptide I CtaD | 0.0156 | 0.3936 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0297 | 0.9985 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.9985 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0297 | 0.9985 | 1 |
Mycobacterium leprae | PROBABLE CYTOCHROME C OXIDASE POLYPEPTIDE I CTAD (CYTOCHROME AA3 SUBUNIT 1) | 0.0156 | 0.3936 | 0.5 |
Onchocerca volvulus | 0.0297 | 0.9985 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.9985 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0297 | 0.9985 | 1 |
Schistosoma mansoni | peroxidasin | 0.0297 | 0.9985 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.029 | 0.9682 | 0.9696 |
Mycobacterium tuberculosis | Probable cytochrome C oxidase polypeptide I CtaD (cytochrome AA3 subunit 1) | 0.0156 | 0.3936 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.9985 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0297 | 0.9985 | 1 |
Wolbachia endosymbiont of Brugia malayi | cytochrome c oxidase, subunit 2 | 0.0297 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.9985 | 1 |
Echinococcus granulosus | tyrosine protein kinase | 0.029 | 0.9682 | 0.9475 |
Onchocerca volvulus | Peroxidasin homolog | 0.0297 | 0.9985 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0297 | 0.9985 | 1 |
Schistosoma mansoni | cytochrome oxidase subunit | 0.0156 | 0.3936 | 0.3942 |
Brugia malayi | Animal haem peroxidase family protein | 0.0297 | 0.9985 | 1 |
Mycobacterium ulcerans | cytochrome C oxidase polypeptide I CtaD | 0.0156 | 0.3936 | 1 |
Schistosoma mansoni | cytochrome oxidase subunit | 0.0156 | 0.3936 | 0.3942 |
Onchocerca volvulus | Peroxidase homolog | 0.0297 | 0.9985 | 1 |
Brugia malayi | Peroxidasin | 0.0297 | 0.9985 | 1 |
Loa Loa (eye worm) | TK protein kinase | 0.029 | 0.9682 | 0.9696 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.9985 | 1 |
Plasmodium vivax | conserved Plasmodium protein, unknown function | 0.0207 | 0.6151 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0297 | 0.9985 | 1 |
Onchocerca volvulus | 0.0297 | 0.9985 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.9985 | 1 |
Schistosoma mansoni | cytochrome c oxidase subunit II | 0.0243 | 0.769 | 0.7701 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.9985 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0297 | 0.9985 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.9985 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.9985 | 1 |
Plasmodium falciparum | cytochrome c oxidase subunit 1 | 0.0156 | 0.3936 | 1 |
Schistosoma mansoni | cytochrome oxidase subunit | 0.0156 | 0.3936 | 0.3942 |
Onchocerca volvulus | Peroxidase homolog | 0.0297 | 0.9985 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0288 | 0.9609 | 0.9623 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.9985 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.9985 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0297 | 0.9985 | 1 |
Brugia malayi | hypothetical protein | 0.0297 | 0.9985 | 1 |
Echinococcus granulosus | peroxidasin | 0.0297 | 0.9985 | 0.9975 |
Brugia malayi | Animal haem peroxidase family protein | 0.0297 | 0.9985 | 1 |
Onchocerca volvulus | Cytochrome c oxidase subunit 1 homolog | 0.0156 | 0.3936 | 0.3179 |
Brugia malayi | Animal haem peroxidase family protein | 0.0297 | 0.9985 | 1 |
Onchocerca volvulus | 0.0156 | 0.3936 | 0.3179 | |
Schistosoma mansoni | cytochrome oxidase subunit | 0.0156 | 0.3936 | 0.3942 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.9985 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0297 | 0.9985 | 1 |
Onchocerca volvulus | 0.0297 | 0.9985 | 1 | |
Schistosoma mansoni | cytochrome-c oxidase | 0.009 | 0.1117 | 0.1118 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0297 | 0.9985 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0297 | 0.9985 | 1 |
Plasmodium vivax | cytochrome c oxidase subunit I | 0.0156 | 0.3936 | 0.56 |
Toxoplasma gondii | cytochrome C oxidase subunit IIb, putative | 0.009 | 0.1117 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 91.5 nM | Inhibition of ROS1 (unknown origin) assessed as remaining activity | ChEMBL. | 24997577 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.