Detailed information for compound 917782
Basic information
Technical information
- Name: Unnamed compound
- MW: 513.368 | Formula: C22H14F7N5O2
-
H donors: 1
H acceptors: 5
LogP: 4.28
Rotable bonds: 8
Rule of 5 violations (Lipinski): 2 - SMILES: Fc1ccc(c(c1)F)[C@](C(c1ccc(cn1)c1ccc(cc1)OC(F)(F)F)(F)F)(Cn1cnnn1)O
- InChi: 1S/C22H14F7N5O2/c23-15-4-7-17(18(24)9-15)20(35,11-34-12-31-32-33-34)21(25,26)19-8-3-14(10-30-19)13-1-5-16(6-2-13)36-22(27,28)29/h1-10,12,35H,11H2/t20-/m0/s1
- InChiKey: NCEHACHJIXJSPD-FQEVSTJZSA-N
Network
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Synonyms
No synonyms found for this compound
Targets
Known targets for this compound
No curated genes were found associated with this compound
Predicted pathogen targets for this compound
By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model
Ranking Plot
Putative Targets List
| Species | Potential target | Raw | Global | Species |
|---|---|---|---|---|
| Leishmania major | quinonoid dihydropteridine reductase | 0.0076 | 1 | 1 |
| Mycobacterium leprae | Possible short-chain dehydrogenase EphD | 0.0076 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0076 | 1 | 1 |
| Giardia lamblia | Reductase, putative | 0.0076 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0076 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0076 | 1 | 1 |
| Echinococcus granulosus | steroid dehydrogenase | 0.0076 | 1 | 0.5 |
| Brugia malayi | Retinol dehydrogenase 12 | 0.0076 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0076 | 1 | 0.5 |
| Entamoeba histolytica | estradiol 17-beta-dehydrogenase, putative | 0.0076 | 1 | 0.5 |
| Echinococcus multilocularis | retinol dehydrogenase 11 | 0.0076 | 1 | 0.5 |
| Onchocerca volvulus | 0.0076 | 1 | 0.5 | |
| Leishmania major | hypothetical protein, conserved | 0.0076 | 1 | 1 |
| Trypanosoma cruzi | 3-ketoacyl-CoA reductase, putative | 0.0076 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0076 | 1 | 1 |
| Loa Loa (eye worm) | cytochrome P450 family protein | 0.0035 | 0.2281 | 0.2281 |
| Loa Loa (eye worm) | oxidoreductase | 0.0076 | 1 | 1 |
| Schistosoma mansoni | retinal dehydrogenase | 0.0076 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0076 | 1 | 1 |
| Onchocerca volvulus | 0.0076 | 1 | 0.5 | |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0076 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0076 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0076 | 1 | 1 |
| Onchocerca volvulus | 0.0076 | 1 | 0.5 | |
| Trichomonas vaginalis | steroid dehydrogenase, putative | 0.0076 | 1 | 0.5 |
| Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0076 | 1 | 0.5 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0076 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0076 | 1 | 1 |
| Echinococcus multilocularis | Dehydrogenase:reductase SDR family | 0.0076 | 1 | 0.5 |
| Mycobacterium ulcerans | carveol-like dehydrogenase | 0.0076 | 1 | 1 |
| Onchocerca volvulus | Dehydrogenase\/reductase SDR family member 1 homolog | 0.0076 | 1 | 0.5 |
| Plasmodium falciparum | steroid dehydrogenase, putative | 0.0076 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0076 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0076 | 1 | 1 |
| Brugia malayi | Hypothetical oxidoreductase F56D1.5 | 0.0076 | 1 | 1 |
| Trypanosoma brucei | beta-D-hydroxybutyrate dehydrogenase | 0.0076 | 1 | 1 |
| Brugia malayi | Dehydrogenases, short chain protein 30 | 0.0076 | 1 | 1 |
| Mycobacterium tuberculosis | Decaprenylphosphoryl-D-2-keto erythro pentose reductase | 0.0076 | 1 | 0.5 |
| Mycobacterium leprae | ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE | 0.0076 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0076 | 1 | 0.5 |
| Loa Loa (eye worm) | oxidoreductase | 0.0076 | 1 | 1 |
| Mycobacterium tuberculosis | Possible oxidoreductase | 0.0076 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0076 | 1 | 1 |
| Echinococcus multilocularis | oxidoreductase | 0.0076 | 1 | 0.5 |
| Mycobacterium ulcerans | dehydrogenase/decarboxylase protein | 0.0076 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0076 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0076 | 1 | 1 |
| Onchocerca volvulus | 0.0076 | 1 | 0.5 | |
| Entamoeba histolytica | hypothetical protein, conserved | 0.0076 | 1 | 0.5 |
| Echinococcus granulosus | oxidoreductase | 0.0076 | 1 | 0.5 |
| Trypanosoma cruzi | short-chain dehydrogenase, putative | 0.0076 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0076 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0076 | 1 | 0.5 |
| Toxoplasma gondii | oxidoreductase, putative | 0.0076 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0076 | 1 | 0.5 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0076 | 1 | 1 |
| Schistosoma mansoni | short-chain dehydrogenase/reductase | 0.0076 | 1 | 0.5 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0076 | 1 | 1 |
| Onchocerca volvulus | 0.0076 | 1 | 0.5 | |
| Echinococcus multilocularis | transient receptor potential cation channel | 0.0076 | 1 | 0.5 |
| Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0076 | 1 | 1 |
| Mycobacterium tuberculosis | Probable dehydrogenase | 0.0076 | 1 | 0.5 |
| Loa Loa (eye worm) | oxidoreductase | 0.0076 | 1 | 1 |
| Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0076 | 1 | 0.5 |
| Trypanosoma brucei | 3-ketoacyl-CoA reductase, putative | 0.0076 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0076 | 1 | 1 |
| Trypanosoma brucei | oxidoreductase-like protein | 0.0076 | 1 | 1 |
| Onchocerca volvulus | Dehydrogenase\/reductase SDR family member 13 homolog | 0.0076 | 1 | 0.5 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0076 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0076 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0076 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0076 | 1 | 1 |
| Trypanosoma cruzi | 3-keto-dihydrosphingosine reductase | 0.0076 | 1 | 1 |
| Mycobacterium tuberculosis | Possible ketoacyl reductase | 0.0076 | 1 | 0.5 |
| Trypanosoma cruzi | NAD(P)-dependent oxidoreductase, putative | 0.0076 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0076 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0076 | 1 | 1 |
| Schistosoma mansoni | 3-keto-dihydrosphingosine reductase | 0.0076 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable short-chain type oxidoreductase | 0.0076 | 1 | 0.5 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0076 | 1 | 0.5 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0076 | 1 | 0.5 |
| Trypanosoma cruzi | short chain dehydrogenase, putative | 0.0076 | 1 | 1 |
| Onchocerca volvulus | 0.0076 | 1 | 0.5 | |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0076 | 1 | 1 |
| Trichomonas vaginalis | hydroxyacyl dehydrogenase, putative | 0.0076 | 1 | 0.5 |
| Echinococcus multilocularis | retinol dehydrogenase 13 | 0.0076 | 1 | 0.5 |
| Mycobacterium ulcerans | dehydrogenase/reductase | 0.0076 | 1 | 1 |
| Mycobacterium tuberculosis | Possible iron-regulated short-chain dehydrogenase/reductase | 0.0076 | 1 | 0.5 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0076 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0076 | 1 | 0.5 |
| Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0076 | 1 | 0.5 |
| Echinococcus multilocularis | 3 ketodihydrosphingosine reductase | 0.0076 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0076 | 1 | 1 |
| Mycobacterium ulcerans | dehydrogenase | 0.0076 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0076 | 1 | 0.5 |
| Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0076 | 1 | 1 |
| Wolbachia endosymbiont of Brugia malayi | Short-chain alcohol dehydrogenase family enzyme | 0.0076 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0076 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0076 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0076 | 1 | 0.5 |
| Mycobacterium leprae | PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE | 0.0076 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0076 | 1 | 0.5 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0076 | 1 | 0.5 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0076 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0076 | 1 | 1 |
| Mycobacterium tuberculosis | Possible oxidoreductase | 0.0076 | 1 | 0.5 |
| Echinococcus granulosus | epidermal retinal dehydrogenase 2 | 0.0076 | 1 | 0.5 |
| Onchocerca volvulus | 0.0076 | 1 | 0.5 | |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0076 | 1 | 1 |
| Echinococcus multilocularis | estradiol 17 beta dehydrogenase 12 | 0.0076 | 1 | 0.5 |
| Loa Loa (eye worm) | dehydrogenase | 0.0076 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0076 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0076 | 1 | 1 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0076 | 1 | 1 |
| Brugia malayi | Dehydrogenases, short chain protein 2 | 0.0076 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0076 | 1 | 1 |
| Echinococcus multilocularis | carbonyl reductase 1 | 0.0076 | 1 | 0.5 |
| Brugia malayi | D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor | 0.0076 | 1 | 1 |
| Mycobacterium leprae | Probable short-chain type dehydrogenase/reductase | 0.0076 | 1 | 0.5 |
| Leishmania major | short chain dehydrogenase, putative | 0.0076 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0076 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0076 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0076 | 1 | 1 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0076 | 1 | 1 |
| Giardia lamblia | Hypothetical protein | 0.0076 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0076 | 1 | 1 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0076 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0076 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0076 | 1 | 1 |
| Echinococcus multilocularis | steroid dehydrogenase | 0.0076 | 1 | 0.5 |
| Trypanosoma cruzi | short chain dehydrogenase, putative | 0.0076 | 1 | 1 |
| Trypanosoma cruzi | short-chain dehydrogenase, putative | 0.0076 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0076 | 1 | 0.5 |
| Echinococcus granulosus | carbonyl reductase 1 | 0.0076 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0076 | 1 | 0.5 |
| Brugia malayi | hypothetical protein | 0.0076 | 1 | 1 |
| Trichomonas vaginalis | estradiol 17 beta-dehydrogenase, putative | 0.0076 | 1 | 0.5 |
| Leishmania major | 3-keto-dihydrosphingosine reductase | 0.0076 | 1 | 1 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0076 | 1 | 1 |
| Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0076 | 1 | 1 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0076 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0076 | 1 | 1 |
| Schistosoma mansoni | carbonyl reductase | 0.0076 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0076 | 1 | 1 |
| Onchocerca volvulus | 0.0076 | 1 | 0.5 | |
| Echinococcus multilocularis | carbonyl reductase 1 | 0.0076 | 1 | 0.5 |
| Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0076 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type oxidoreductase | 0.0076 | 1 | 1 |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0076 | 1 | 0.5 |
| Toxoplasma gondii | oxidoreductase, putative | 0.0076 | 1 | 0.5 |
| Brugia malayi | oxidoreductase | 0.0076 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0076 | 1 | 0.5 |
| Leishmania major | short chain dehydrogenase-like protein | 0.0076 | 1 | 1 |
| Trypanosoma brucei | beta-ketoacyl-ACP reductase 2 | 0.0076 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0076 | 1 | 1 |
| Echinococcus granulosus | carbonyl reductase 1 | 0.0076 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain dehydrogenase | 0.0076 | 1 | 1 |
| Mycobacterium tuberculosis | Possible fatty acyl-CoA reductase | 0.0076 | 1 | 0.5 |
| Brugia malayi | dehydrogenases, short chain protein 9 | 0.0076 | 1 | 1 |
| Trypanosoma cruzi | beta-ketoacyl-ACP reductase 2, putative | 0.0076 | 1 | 1 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0076 | 1 | 1 |
| Echinococcus multilocularis | conserved hypothetical protein | 0.0076 | 1 | 0.5 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0076 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0076 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0076 | 1 | 0.5 |
| Loa Loa (eye worm) | short chain dehydrogenase/reductase family oxidoreductase | 0.0076 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0076 | 1 | 1 |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0076 | 1 | 0.5 |
| Trypanosoma cruzi | 3-keto-dihydrosphingosine reductase | 0.0076 | 1 | 1 |
| Toxoplasma gondii | 3-ketoacyl-CoA reductase, putative | 0.0076 | 1 | 0.5 |
| Loa Loa (eye worm) | dehydrogenase | 0.0076 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0076 | 1 | 0.5 |
| Trypanosoma cruzi | quinonoid dihydropteridine reductase, putative | 0.0076 | 1 | 1 |
| Echinococcus granulosus | Dehydrogenase:reductase SDR family | 0.0076 | 1 | 0.5 |
| Trypanosoma brucei | 3-keto-dihydrosphingosine reductase | 0.0076 | 1 | 1 |
| Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0076 | 1 | 0.5 |
| Onchocerca volvulus | 0.0076 | 1 | 0.5 | |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0076 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0076 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0076 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0076 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0076 | 1 | 0.5 |
| Schistosoma mansoni | carbonyl reductase | 0.0076 | 1 | 0.5 |
| Loa Loa (eye worm) | oxidoreductase | 0.0076 | 1 | 1 |
| Trypanosoma cruzi | NAD(P)-dependent oxidoreductase, putative | 0.0076 | 1 | 1 |
| Echinococcus granulosus | WW domain containing oxidoreductase | 0.0076 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable dehydrogenase/reductase | 0.0076 | 1 | 0.5 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0076 | 1 | 1 |
| Echinococcus granulosus | retinol dehydrogenase 11 | 0.0076 | 1 | 0.5 |
| Onchocerca volvulus | 0.0076 | 1 | 0.5 | |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0076 | 1 | 1 |
| Toxoplasma gondii | sterol carrier protein-2 HAD-2SCP-2 | 0.0076 | 1 | 0.5 |
| Onchocerca volvulus | Sepiapterin reductase homolog | 0.0076 | 1 | 0.5 |
| Trypanosoma brucei | beta-ketoacyl-ACP reductase 3, putative | 0.0076 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short chain alcohol dehydrogenase/reductase | 0.0076 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0076 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain membrane-associated dehydrogenase | 0.0076 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0076 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0076 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0076 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0076 | 1 | 1 |
| Echinococcus multilocularis | carbonyl reductase 1 | 0.0076 | 1 | 0.5 |
| Mycobacterium ulcerans | oxidoreductase | 0.0076 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0076 | 1 | 1 |
| Trypanosoma cruzi | short chain dehydrogenase/reductase, putative | 0.0076 | 1 | 1 |
| Echinococcus granulosus | carbonyl reductase 1 | 0.0076 | 1 | 0.5 |
| Leishmania major | pteridine reductase 1 | 0.0076 | 1 | 1 |
| Echinococcus multilocularis | retinol dehydrogenase 11 | 0.0076 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0076 | 1 | 1 |
| Echinococcus granulosus | hypothetical protein | 0.0076 | 1 | 0.5 |
| Mycobacterium ulcerans | oxidoreductase | 0.0076 | 1 | 1 |
| Leishmania major | hypothetical protein, conserved | 0.0076 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0076 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0076 | 1 | 1 |
| Toxoplasma gondii | carbonyl reductase 1, putative | 0.0076 | 1 | 0.5 |
| Entamoeba histolytica | short chain dehydrogenase family protein | 0.0076 | 1 | 0.5 |
| Mycobacterium ulcerans | ketoacyl reductase | 0.0076 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0076 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain dehydrogenase | 0.0076 | 1 | 1 |
| Onchocerca volvulus | Dehydrogenase\/reductase SDR family member 13 homolog | 0.0076 | 1 | 0.5 |
| Mycobacterium leprae | Probable oxidoreductase | 0.0076 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0076 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0076 | 1 | 1 |
| Echinococcus multilocularis | epidermal retinal dehydrogenase 2 | 0.0076 | 1 | 0.5 |
| Echinococcus multilocularis | carbonyl reductase 1 | 0.0076 | 1 | 0.5 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0076 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0076 | 1 | 0.5 |
| Entamoeba histolytica | hypothetical protein, conserved | 0.0076 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0076 | 1 | 1 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0076 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0076 | 1 | 1 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0076 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0076 | 1 | 1 |
| Mycobacterium tuberculosis | Probable dehydrogenase/reductase | 0.0076 | 1 | 0.5 |
| Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.0076 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0076 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0076 | 1 | 1 |
| Echinococcus granulosus | carbonyl reductase 1 | 0.0076 | 1 | 0.5 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0076 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0076 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0076 | 1 | 1 |
| Leishmania major | short chain dehydrogenase/reductase, putative | 0.0076 | 1 | 1 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0076 | 1 | 0.5 |
| Echinococcus granulosus | hypothetical protein | 0.0076 | 1 | 0.5 |
| Echinococcus multilocularis | steroid dehydrogenase | 0.0076 | 1 | 0.5 |
| Brugia malayi | Cytochrome P450 family protein | 0.0035 | 0.2281 | 0.2281 |
| Leishmania major | short chain dehydrogenase, putative | 0.0076 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0076 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0076 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0076 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0076 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0076 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0076 | 1 | 0.5 |
| Schistosoma mansoni | oxidoreductase short chain dehydrogenase/reductase family | 0.0076 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain dehydrogenase | 0.0076 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0076 | 1 | 0.5 |
| Plasmodium falciparum | oxidoreductase, short-chain dehydrogenase family, putative | 0.0076 | 1 | 0.5 |
| Trichomonas vaginalis | short-chain dehydrogenases/reductase, putative | 0.0076 | 1 | 0.5 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0076 | 1 | 0.5 |
| Entamoeba histolytica | oxidoreductase, short chain dehydrogenase/reductase family | 0.0076 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable shortchain dehydrogenase | 0.0076 | 1 | 0.5 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0076 | 1 | 0.5 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0076 | 1 | 0.5 |
| Mycobacterium tuberculosis | Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 | 0.0076 | 1 | 0.5 |
| Entamoeba histolytica | short chain dehydrogenase family protein | 0.0076 | 1 | 0.5 |
| Entamoeba histolytica | estradiol 17-beta-dehydrogenase, putative | 0.0076 | 1 | 0.5 |
| Trypanosoma cruzi | short chain dehydrogenase/reductase, putative | 0.0076 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0076 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0076 | 1 | 0.5 |
| Trypanosoma cruzi | beta-ketoacyl-ACP reductase 2, putative | 0.0076 | 1 | 1 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0076 | 1 | 0.5 |
| Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0076 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0076 | 1 | 1 |
| Entamoeba histolytica | 3-ketodihydrosphingosine reductase protein, putative | 0.0076 | 1 | 0.5 |
| Brugia malayi | dehydrogenases, short chain protein 2 | 0.0076 | 1 | 1 |
| Leishmania major | hypothetical protein, conserved | 0.0076 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0076 | 1 | 1 |
| Mycobacterium ulcerans | ketoacyl reductase | 0.0076 | 1 | 1 |
| Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0076 | 1 | 1 |
| Trypanosoma cruzi | 3-ketoacyl-CoA reductase, putative | 0.0076 | 1 | 1 |
| Echinococcus granulosus | 3 ketodihydrosphingosine reductase | 0.0076 | 1 | 0.5 |
| Giardia lamblia | Oxidoreductase, short chain dehydrogenase/reductase family | 0.0076 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0076 | 1 | 0.5 |
| Plasmodium vivax | steroid dehydrogenase, putative | 0.0076 | 1 | 0.5 |
| Mycobacterium leprae | Probable short-chain type dehydrogenase/reductase | 0.0076 | 1 | 0.5 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0076 | 1 | 0.5 |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0076 | 1 | 0.5 |
| Mycobacterium tuberculosis | Possible short-chain dehydrogenase EphD | 0.0076 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0076 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0076 | 1 | 1 |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0076 | 1 | 0.5 |
| Onchocerca volvulus | 0.0076 | 1 | 0.5 | |
| Entamoeba histolytica | hypothetical protein | 0.0076 | 1 | 0.5 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0076 | 1 | 1 |
| Mycobacterium ulcerans | ketoacyl reductase | 0.0076 | 1 | 1 |
| Onchocerca volvulus | 0.0076 | 1 | 0.5 | |
| Mycobacterium tuberculosis | Probable short-chain dehydrogenase/reductase | 0.0076 | 1 | 0.5 |
| Leishmania major | hypothetical protein, conserved | 0.0076 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0076 | 1 | 1 |
| Leishmania major | oxidoreductase-like protein | 0.0076 | 1 | 1 |
| Echinococcus granulosus | retinol dehydrogenase 11 | 0.0076 | 1 | 0.5 |
| Entamoeba histolytica | estradiol 17-beta-dehydrogenase, putative | 0.0076 | 1 | 0.5 |
| Leishmania major | hypothetical protein, conserved | 0.0076 | 1 | 1 |
| Plasmodium vivax | hypothetical protein, conserved | 0.0076 | 1 | 0.5 |
| Leishmania major | dehydrogenase-like protein | 0.0076 | 1 | 1 |
| Onchocerca volvulus | 0.0076 | 1 | 0.5 | |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0076 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0076 | 1 | 0.5 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0076 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0076 | 1 | 0.5 |
| Giardia lamblia | Short-chain dehydrogenase, putative | 0.0076 | 1 | 0.5 |
| Schistosoma mansoni | carbonyl reductase | 0.0076 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0076 | 1 | 0.5 |
| Loa Loa (eye worm) | oxidoreductase | 0.0076 | 1 | 1 |
| Leishmania major | short chain dehydrogenase/reductase, putative | 0.0076 | 1 | 1 |
| Mycobacterium ulcerans | short-chain dehydrogenase | 0.0076 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0076 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0076 | 1 | 0.5 |
Activities
| Activity type | Activity value | Assay description | Source | Reference |
|---|---|---|---|---|
| IC50 (ADMET) | = 79 uM | Inhibition of CYP3A4 in human hepatocytes using testosterone as substrate by HPLC/MS/MS method | ChEMBL. | 24948565 |
| MIC50 (functional) | = 0.001 ug ml-1 | Antifungal activity against Candida albicans by broth macrodilution method | ChEMBL. | 24948565 |
Phenotypes
Whole-cell/tissue/organism interactions
We have no records of whole-cell/tissue assays done with this compound
What does this mean?
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Annotated phenotypes:
We have no manually annotated phenotypes for this drug.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by
drugs, or by genetic manipulation of cells (e.g. gene knockouts or
knockdowns) is manually curated from the literature. These
descriptions help to describe the potential of the target for drug
development. If no information is available for this gene or if the
information is incomplete, this may mean that i) the papers
containing this information either appeared after the curation
effort for this organism was carried out or they were inadvertently
missed by curators; or that ii) the curation effort for this
organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
External resources for this compound
- ChEMBL: CHEMBL3311227
Bibliographic References
1 literature reference was collected for this gene.
If you have references for this compound, please enter them in a user comment (below) or Contact us.