Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2b receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | GNS1/SUR4 family protein | 0.0457 | 0.5 | 0.5 |
Loa Loa (eye worm) | GNS1/SUR4 family protein | 0.0457 | 0.5 | 0.5 |
Plasmodium vivax | GNS1/SUR4 domain containing protein | 0.0457 | 0.5 | 0.5 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0457 | 0.5 | 0.5 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0457 | 0.5 | 0.5 |
Toxoplasma gondii | integral membrane protein, GNS1/SUR4 family protein, putative | 0.0457 | 0.5 | 0.5 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0457 | 0.5 | 0.5 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0457 | 0.5 | 0.5 |
Plasmodium falciparum | fatty acid elongation protein, GNS1/SUR4 family, putative | 0.0457 | 0.5 | 0.5 |
Leishmania major | fatty acid elongase, putative | 0.0457 | 0.5 | 0.5 |
Leishmania major | fatty acid elongase, putative | 0.0457 | 0.5 | 0.5 |
Plasmodium falciparum | long chain fatty acid elongation enzyme, putative | 0.0457 | 0.5 | 0.5 |
Toxoplasma gondii | GNS1/SUR4 family protein | 0.0457 | 0.5 | 0.5 |
Trypanosoma brucei | Fatty acid elongase | 0.0457 | 0.5 | 0.5 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0457 | 0.5 | 0.5 |
Leishmania major | fatty acid elongase, putative | 0.0457 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 57.6 nM | Displacement of [3H]NECA from human adenosine A3 receptor expressed in CHO cells | ChEMBL. | 24972108 |
Ki (binding) | = 142 nM | Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cells | ChEMBL. | 24972108 |
Ki (binding) | = 1250 nM | Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cells | ChEMBL. | 24972108 |
Ki (binding) | = 4810 nM | Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity | ChEMBL. | 24972108 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.