Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1909 | 0.1909 |
Giardia lamblia | Cathepsin B precursor | 0.0055 | 0.2985 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0055 | 0.2985 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0166 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0055 | 0.2985 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0038 | 0.1909 | 0.1909 |
Giardia lamblia | Cathepsin B precursor | 0.0055 | 0.2985 | 0.5 |
Echinococcus granulosus | cathepsin b | 0.0166 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.0038 | 0.1909 | 0.1909 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1909 | 0.1909 |
Echinococcus multilocularis | cathepsin b | 0.0166 | 1 | 1 |
Mycobacterium ulcerans | hydrolase | 0.0046 | 0.2428 | 0.5 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0055 | 0.2985 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0091 | 0.5283 | 0.5283 |
Onchocerca volvulus | Matrilysin homolog | 0.0084 | 0.4807 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0084 | 0.4807 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 1 | 1 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0046 | 0.2428 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0055 | 0.2985 | 0.2985 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0038 | 0.1909 | 0.1909 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0166 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.2903 | 0.2903 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0046 | 0.2428 | 0.2428 |
Brugia malayi | Hemopexin family protein | 0.0053 | 0.2903 | 0.2903 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0166 | 1 | 1 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0137 | 0.8181 | 0.8181 |
Brugia malayi | Matrixin family protein | 0.0038 | 0.1909 | 0.1909 |
Loa Loa (eye worm) | matrixin family protein | 0.0084 | 0.4807 | 0.4807 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0007 | 0.00000011673 | 0.00000011673 |
Echinococcus multilocularis | cathepsin b | 0.0166 | 1 | 1 |
Onchocerca volvulus | 0.0053 | 0.2903 | 0.3431 | |
Echinococcus granulosus | cathepsin b | 0.0166 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0166 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0166 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1909 | 0.1909 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0055 | 0.2985 | 0.5 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0137 | 0.8181 | 0.8181 |
Loa Loa (eye worm) | cathepsin B | 0.0055 | 0.2985 | 0.2985 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0046 | 0.2428 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.2428 | 0.2428 |
Toxoplasma gondii | cathepsin B | 0.0055 | 0.2985 | 0.5 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0038 | 0.1909 | 0.1909 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0007 | 0.00000011673 | 0.00000011673 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0007 | 0.00000011673 | 0.00000011673 |
Brugia malayi | Matrixin family protein | 0.0038 | 0.1909 | 0.1909 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.009 | 0.5181 | 0.5181 |
Loa Loa (eye worm) | matrixin family protein | 0.0091 | 0.5283 | 0.5283 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 26 uM | Inhibition of bovine spleen cathepsin B using Z-Arg-Arg-AMC as substrate after 30 mins by fluorescence assay | ChEMBL. | 24960234 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.