Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | heat shock protein 83-1 | 0.0645 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0645 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0645 | 1 | 1 |
Echinococcus multilocularis | endoplasmin | 0.0514 | 0.655 | 0.655 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0514 | 0.655 | 0.655 |
Toxoplasma gondii | heat shock protein 90, putative | 0.0645 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0645 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0645 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0514 | 0.655 | 0.655 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0645 | 1 | 1 |
Schistosoma mansoni | heat shock protein | 0.0645 | 1 | 1 |
Toxoplasma gondii | heat shock protein HSP90 | 0.0645 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0645 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0645 | 1 | 1 |
Echinococcus granulosus | heat shock protein 90 | 0.0645 | 1 | 1 |
Loa Loa (eye worm) | endoplasmin | 0.0645 | 1 | 1 |
Leishmania major | lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative | 0.0514 | 0.655 | 0.655 |
Trichomonas vaginalis | endoplasmin, putative | 0.0396 | 0.345 | 0.345 |
Trichomonas vaginalis | heat shock protein, putative | 0.0645 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0645 | 1 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0514 | 0.655 | 0.655 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.0645 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0645 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0645 | 1 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0396 | 0.345 | 0.345 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0645 | 1 | 1 |
Plasmodium vivax | endoplasmin, putative | 0.0645 | 1 | 1 |
Plasmodium vivax | heat shock protein 86, putative | 0.0645 | 1 | 1 |
Loa Loa (eye worm) | heat shock protein 90 | 0.0645 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0645 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0645 | 1 | 1 |
Onchocerca volvulus | Heat shock protein 75 kDa, mitochondrial homolog | 0.0264 | 0 | 0.5 |
Trichomonas vaginalis | heat shock protein, putative | 0.0514 | 0.655 | 0.655 |
Echinococcus multilocularis | heat shock protein | 0.0645 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0645 | 1 | 1 |
Schistosoma mansoni | heat shock protein | 0.0645 | 1 | 1 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0645 | 1 | 1 |
Echinococcus granulosus | heat shock protein | 0.0645 | 1 | 1 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0645 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0645 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0645 | 1 | 1 |
Schistosoma mansoni | endoplasmin | 0.0645 | 1 | 1 |
Plasmodium falciparum | endoplasmin, putative | 0.0396 | 0.345 | 0.345 |
Leishmania major | heat shock protein 83-1 | 0.0645 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0645 | 1 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0514 | 0.655 | 0.655 |
Echinococcus granulosus | heat shock protein heat shock protein 90 alpha | 0.0514 | 0.655 | 0.655 |
Wolbachia endosymbiont of Brugia malayi | heat shock protein 90 | 0.0514 | 0.655 | 0.5 |
Leishmania major | heat shock protein 83-1 | 0.0645 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0645 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0645 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0381 | 0.3058 | 0.3058 |
Trypanosoma brucei | heat shock protein, putative | 0.0645 | 1 | 1 |
Echinococcus multilocularis | heat shock protein 90 | 0.0514 | 0.655 | 0.655 |
Treponema pallidum | heat shock protein 90 | 0.0514 | 0.655 | 0.5 |
Mycobacterium tuberculosis | Arylamine N-acetyltransferase Nat (arylamine acetylase) | 0.0583 | 0.8359 | 1 |
Mycobacterium leprae | PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) | 0.0514 | 0.655 | 0.5 |
Leishmania major | heat shock protein 83-1 | 0.0645 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0645 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0645 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0645 | 1 | 1 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0645 | 1 | 1 |
Brugia malayi | heat shock protein 90 | 0.0645 | 1 | 1 |
Trypanosoma brucei | Heat shock protein 83, putative | 0.0645 | 1 | 1 |
Plasmodium falciparum | heat shock protein 90 | 0.0645 | 1 | 1 |
Mycobacterium ulcerans | arylamine N-acetyltransferase Nat | 0.0583 | 0.8359 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0645 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0645 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0645 | 1 | 1 |
Echinococcus granulosus | endoplasmin | 0.0514 | 0.655 | 0.655 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0645 | 1 | 1 |
Echinococcus multilocularis | heat shock protein 90 | 0.0645 | 1 | 1 |
Echinococcus granulosus | heat shock protein 90 | 0.0514 | 0.655 | 0.655 |
Schistosoma mansoni | endoplasmin | 0.0645 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | > 100 uM | Cytotoxicity against mock-infected human MT4 cells assessed as reduction in proliferation after 96 hrs by MTT method | ChEMBL. | 25014745 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.