Detailed information for compound 922103

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 415.592 | Formula: C23H33N3O2S
  • H donors: 0 H acceptors: 2 LogP: 3.77 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CN(S(=O)(=O)Cc1ccccc1)Cc1ccc(cc1)N1CCN(CC1)C)C
  • InChi: 1S/C23H33N3O2S/c1-20(2)17-26(29(27,28)19-22-7-5-4-6-8-22)18-21-9-11-23(12-10-21)25-15-13-24(3)14-16-25/h4-12,20H,13-19H2,1-3H3
  • InChiKey: UNFKKRWCVCSPTC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAR-related orphan receptor C No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0683 0.0501
Entamoeba histolytica cysteine protease, putative 0.0053 0.0829 0.1613
Leishmania major cathepsin L-like protease 0.0191 0.5138 0.6132
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.013 0.3237 0.4008
Brugia malayi fibroinase precursor 0.0053 0.0829 0.0808
Loa Loa (eye worm) fibroinase 0.0191 0.5138 0.5043
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0053 0.0829 0.0868
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0191 0.5138 0.6362
Echinococcus multilocularis geminin 0.0191 0.5135 0.504
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0191 0.5138 0.6362
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0173 0.4554 0.564
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0061 0.1079 0.0905
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0173 0.4554 0.4448
Echinococcus multilocularis cathepsin b 0.0173 0.4554 0.4448
Plasmodium vivax unspecified product 0.0114 0.273 0.3459
Brugia malayi Cathepsin L-like cysteine proteinase 0.013 0.3237 0.3862
Echinococcus granulosus cathepsin l cysteine peptidase 0.0191 0.5138 0.5043
Brugia malayi Cathepsin L-like precursor 0.013 0.3237 0.3862
Entamoeba histolytica cysteine protease, putative 0.0114 0.273 0.5314
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0197 0.5313 0.6496
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0173 0.4554 0.4448
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.273 0.3101
Echinococcus granulosus cathepsin L cysteine proteinase 0.0191 0.5138 0.5043
Plasmodium falciparum serine repeat antigen 8 0.0053 0.0829 0.0868
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0135 0.3372 0.3509
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0191 0.5138 0.6362
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0114 0.273 0.3258
Brugia malayi Papain family cysteine protease containing protein 0.0053 0.0829 0.0808
Entamoeba histolytica cysteine protease, putative 0.0114 0.273 0.5314
Onchocerca volvulus 0.0191 0.5138 1
Giardia lamblia Cathepsin B precursor 0.0173 0.4554 0.5141
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0295 0.8378 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0295 0.8378 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0053 0.0829 0.065
Entamoeba histolytica cysteine proteinase 2 0.0114 0.273 0.5314
Entamoeba histolytica cysteine protease, putative 0.0114 0.273 0.5314
Entamoeba histolytica cysteine proteinase, putative 0.0114 0.273 0.5314
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0295 0.8378 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0061 0.1079 0.1126
Loa Loa (eye worm) cathepsin B 0.0173 0.4554 0.4448
Schistosoma mansoni cathepsin F (C01 family) 0.0191 0.5138 0.5043
Echinococcus multilocularis cathepsin L 0.0114 0.273 0.2588
Plasmodium vivax vivapain-1 0.0114 0.273 0.3459
Entamoeba histolytica cysteine proteinase, putative 0.0114 0.273 0.5314
Entamoeba histolytica cysteine protease, putative 0.0114 0.273 0.5314
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0191 0.5138 0.6739
Echinococcus granulosus cathepsin l1 0.0191 0.5138 0.5043
Trypanosoma cruzi cysteine proteinase, putative 0.0114 0.273 0.3258
Echinococcus granulosus cathepsin b 0.0173 0.4554 0.4448
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0191 0.5138 0.6362
Loa Loa (eye worm) hypothetical protein 0.0197 0.5313 0.5221
Trypanosoma cruzi cysteine peptidase, putative 0.0295 0.8378 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0286 0.8075 1
Entamoeba histolytica cysteine proteinase, putative 0.0114 0.273 0.5314
Plasmodium vivax vivapain-3 0.0114 0.273 0.3459
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0053 0.0829 0.065
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0286 0.8075 0.8038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0295 0.8378 1
Entamoeba histolytica cysteine protease, putative 0.0114 0.273 0.5314
Onchocerca volvulus Cathepsin F homolog 0.0191 0.5138 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0268 0.7531 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0829 0.065
Brugia malayi Papain family cysteine protease containing protein 0.0191 0.5138 0.6274
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0173 0.4554 0.4448
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0683 0.0623
Loa Loa (eye worm) hypothetical protein 0.013 0.3237 0.3104
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0191 0.5138 0.5043
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0268 0.7531 0.7483
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0191 0.5138 0.6362
Schistosoma mansoni hypothetical protein 0.0191 0.5135 0.504
Onchocerca volvulus 0.0191 0.5138 1
Giardia lamblia Cathepsin B precursor 0.0286 0.8075 1
Schistosoma mansoni cathepsin F (C01 family) 0.013 0.3237 0.3104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.013 0.3237 0.4008
Loa Loa (eye worm) cysteine protease 0.0191 0.5138 0.5043
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0053 0.0829 0.1027
Leishmania major cathepsin L-like protease 0.0191 0.5138 0.6132
Entamoeba histolytica cysteine protease, putative 0.0114 0.273 0.5314
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0191 0.5138 0.5043
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0191 0.5138 0.6362
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0053 0.0829 0.065
Toxoplasma gondii cathepsin CPC2 0.0135 0.3372 0.4333
Loa Loa (eye worm) hypothetical protein 0.0191 0.5138 0.5043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0191 0.5138 0.6362
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0191 0.5138 0.6362
Onchocerca volvulus 0.0191 0.5138 1
Leishmania major cathepsin L-like protease 0.0295 0.8378 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0114 0.273 0.2588
Loa Loa (eye worm) ctsf protein 0.0191 0.5138 0.5043
Echinococcus granulosus cathepsin L cysteine protease 0.0114 0.273 0.2588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0191 0.5138 0.6362
Loa Loa (eye worm) hypothetical protein 0.0061 0.1079 0.0905
Trypanosoma brucei cysteine peptidase C (CPC) 0.0173 0.4554 0.5329
Plasmodium falciparum cysteine proteinase falcipain 3 0.0191 0.5138 0.6739
Entamoeba histolytica cysteine proteinase, putative 0.0114 0.273 0.5314
Loa Loa (eye worm) hypothetical protein 0.0053 0.0829 0.065
Toxoplasma gondii cathepsin B 0.0173 0.4554 0.5944
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0191 0.5138 0.6362
Plasmodium falciparum serine repeat antigen 2 0.0053 0.0829 0.0868
Schistosoma mansoni cathepsin F (C01 family) 0.0191 0.5138 0.5043
Trypanosoma cruzi cysteine peptidase, putative 0.0191 0.5138 0.6132
Brugia malayi Papain family cysteine protease containing protein 0.0053 0.0829 0.0808
Echinococcus granulosus cathepsin L 0.0114 0.273 0.2588
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0187 0.4988 0.6177
Toxoplasma gondii cathepsin CPL 0.0191 0.5138 0.6739
Onchocerca volvulus 0.0191 0.5138 1
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0829 0.1027
Loa Loa (eye worm) hypothetical protein 0.0053 0.0829 0.065
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0114 0.273 0.2588
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0191 0.5138 0.6362
Plasmodium falciparum cysteine proteinase falcipain 1 0.0114 0.273 0.3459
Trypanosoma cruzi cysteine peptidase, putative 0.0114 0.273 0.3258
Entamoeba histolytica cysteine protease, putative 0.0053 0.0829 0.1613
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0053 0.0829 0.065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0191 0.5138 0.6362
Brugia malayi Papain family cysteine protease containing protein 0.0053 0.0829 0.0808
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0829 0.1027
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0347 1 1
Onchocerca volvulus 0.0191 0.5138 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0286 0.8075 1
Entamoeba histolytica cysteine protease, putative 0.0114 0.273 0.5314
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0286 0.8075 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0191 0.5138 0.6362
Leishmania major cathepsin L-like protease 0.0191 0.5138 0.6132
Echinococcus granulosus cathepsin l1 0.013 0.3237 0.3104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0191 0.5138 0.6362
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0053 0.0829 0.0868
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0053 0.0829 0.065
Entamoeba histolytica cysteine protease, putative 0.0053 0.0829 0.1613
Onchocerca volvulus Cathepsin L homolog 0.0191 0.5138 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.0829 0.0989
Loa Loa (eye worm) hypothetical protein 0.0033 0.0207 0.0015
Brugia malayi cathepsin B-like cysteine proteinase 0.0173 0.4554 0.5533
Plasmodium falciparum serine repeat antigen 6 0.0053 0.0829 0.0868
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0191 0.5138 0.5043
Entamoeba histolytica cysteine protease, putative 0.0053 0.0829 0.1613
Giardia lamblia Cathepsin B precursor 0.0173 0.4554 0.5141
Plasmodium falciparum serine repeat antigen 4 0.0053 0.0829 0.0868
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0295 0.8378 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0114 0.273 0.3381
Plasmodium falciparum serine repeat antigen 3 0.0053 0.0829 0.0868
Schistosoma mansoni cathepsin B (C01 family) 0.0053 0.0829 0.065
Brugia malayi RNA, U transporter 1 0.0093 0.2061 0.2371
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0295 0.8378 1
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0829 0.1027
Toxoplasma gondii cathepsin CPC1 0.0268 0.7531 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0053 0.0829 0.0808
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0053 0.0829 0.1027
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0053 0.0829 0.1613
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0295 0.8378 1
Entamoeba histolytica cysteine protease, putative 0.0114 0.273 0.5314
Leishmania major cathepsin L-like protease 0.0295 0.8378 1
Entamoeba histolytica cysteine proteinase, putative 0.0191 0.5138 1
Plasmodium falciparum serine repeat antigen 7 0.0053 0.0829 0.0868
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0053 0.0829 0.1027
Toxoplasma gondii preprocathepsin c precursor, putative 0.0268 0.7531 1
Brugia malayi Cathepsin L-like precursor 0.0191 0.5138 0.6274
Loa Loa (eye worm) hypothetical protein 0.013 0.3237 0.3104
Entamoeba histolytica cysteine protease, putative 0.0191 0.5138 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0829 0.1027
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0207 0.0019
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0829 0.1027
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0053 0.0829 0.1027
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0234 0.6477 0.7731
Onchocerca volvulus 0.0191 0.5138 1
Plasmodium falciparum serine repeat antigen 5 0.0053 0.0829 0.0868
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0053 0.0829 0.0868
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0295 0.8378 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0191 0.5138 0.6362
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0295 0.8378 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0191 0.5138 0.6362
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0191 0.5138 0.6362
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0164 0.4284 0.4172
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0286 0.8075 1
Schistosoma mansoni hypothetical protein 0.0191 0.5135 0.504
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0053 0.0829 0.065
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0286 0.8075 1
Schistosoma mansoni cathepsin s 0.0061 0.1079 0.0905
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0053 0.0829 0.065
Entamoeba histolytica cysteine protease, putative 0.0114 0.273 0.5314
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0268 0.7531 1
Schistosoma mansoni cathepsin S (C01 family) 0.0053 0.0829 0.065
Entamoeba histolytica hypothetical protein 0.0053 0.0829 0.1613
Leishmania major cysteine peptidase A (CPA) 0.0191 0.5138 0.6132
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0191 0.5138 0.6362
Echinococcus granulosus cysteine protease 0.0114 0.273 0.2588
Loa Loa (eye worm) hypothetical protein 0.0061 0.1079 0.0905
Brugia malayi cathepsin L-like cysteine proteinase 0.0053 0.0829 0.0808
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0114 0.273 0.2588
Trypanosoma cruzi cruzipain precursor, putative 0.0295 0.8378 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0829 0.1027
Loa Loa (eye worm) hypothetical protein 0.0173 0.4554 0.4448
Entamoeba histolytica cysteine protease, putative 0.0114 0.273 0.5314
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0135 0.3372 0.4333
Brugia malayi Cathepsin L-like precursor 0.0191 0.5138 0.6274
Brugia malayi Cathepsin L-like precursor 0.0191 0.5138 0.6274
Leishmania major cathepsin L-like protease 0.0191 0.5138 0.6132
Loa Loa (eye worm) hypothetical protein 0.0061 0.1079 0.0905
Schistosoma mansoni hypothetical protein 0.0347 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0829 0.1027
Echinococcus multilocularis cathepsin L cysteine protease 0.0191 0.5138 0.5043
Brugia malayi Papain family cysteine protease containing protein 0.0114 0.273 0.322
Echinococcus multilocularis cathepsin L 0.0053 0.0829 0.065
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0053 0.0829 0.0868
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0053 0.0829 0.0868
Plasmodium vivax unspecified product 0.0053 0.0829 0.0868
Echinococcus granulosus cathepsin b 0.0173 0.4554 0.4448
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0053 0.0829 0.065
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.273 0.3101
Plasmodium vivax unspecified product 0.0061 0.1079 0.1209
Trypanosoma cruzi cysteine protease, putative 0.0114 0.273 0.3258
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0829 0.1027
Loa Loa (eye worm) hypothetical protein 0.0053 0.0829 0.065
Giardia lamblia Cathepsin B precursor 0.0173 0.4554 0.5141
Onchocerca volvulus 0.013 0.3237 0.5588
Brugia malayi Cathepsin L-like precursor 0.0061 0.1079 0.1126
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0053 0.0829 0.0868
Trypanosoma cruzi cysteine peptidase, putative 0.0295 0.8378 1
Entamoeba histolytica cysteine proteinase, putative 0.013 0.3237 0.63
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0191 0.5138 0.6362
Brugia malayi cathepsin F-like cysteine proteinase 0.0053 0.0829 0.0808
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0061 0.1079 0.1126
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0286 0.8075 1
Brugia malayi Papain family cysteine protease containing protein 0.0114 0.273 0.322
Entamoeba histolytica cysteine proteinase, putative 0.0191 0.5138 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0191 0.5138 0.6739
Entamoeba histolytica cysteine proteinase 1, putative 0.0114 0.273 0.5314
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0053 0.0829 0.065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0191 0.5138 0.6362
Plasmodium falciparum serine repeat antigen 9 0.0053 0.0829 0.0868
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0268 0.7531 0.9249
Giardia lamblia Encystation-specific protease 0.0135 0.3372 0.3509
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0173 0.4554 0.4448
Onchocerca volvulus Cathepsin L homolog 0.0191 0.5138 1
Brugia malayi cathepsin L precursor 0.0053 0.0829 0.0808
Brugia malayi Cathepsin L-like precursor 0.0191 0.5138 0.6274
Plasmodium falciparum serine repeat antigen 1 0.0053 0.0829 0.0868
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0829 0.1027
Loa Loa (eye worm) hypothetical protein 0.0053 0.0829 0.065
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0173 0.4554 0.5435
Brugia malayi Cathepsin L-like precursor 0.013 0.3237 0.3862
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0191 0.5138 0.5043
Schistosoma mansoni hypothetical protein 0.0033 0.0207 0.0015
Echinococcus multilocularis cysteine protease 0.0191 0.5138 0.5043
Brugia malayi Cathepsin L-like precursor 0.0191 0.5138 0.6274
Echinococcus multilocularis cathepsin L cysteine protease 0.0191 0.5138 0.5043
Entamoeba histolytica cysteine protease, putative 0.0114 0.273 0.5314
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0053 0.0829 0.1613
Entamoeba histolytica cysteine protease, putative 0.0114 0.273 0.5314
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0164 0.4284 0.4172
Plasmodium vivax serine-repeat antigen (SERA) 0.0053 0.0829 0.0868
Trypanosoma cruzi cysteine peptidase, putative 0.0061 0.1079 0.1288
Leishmania major cathepsin L-like protease 0.0295 0.8378 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0191 0.5138 0.6362
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0191 0.5138 0.6362
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0173 0.4554 0.5435
Entamoeba histolytica cysteine protease, putative 0.0053 0.0829 0.1613
Echinococcus granulosus cathepsin L 0.0053 0.0829 0.065
Onchocerca volvulus 0.0191 0.5138 1
Echinococcus multilocularis snurportin 1 0.0347 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0191 0.5138 0.6362
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0114 0.273 0.3381
Schistosoma mansoni cathepsin C 0.0053 0.0829 0.065
Plasmodium vivax vivapain-2 0.0191 0.5138 0.6739
Echinococcus multilocularis cathepsin b 0.0173 0.4554 0.4448
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0268 0.7531 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0053 0.0829 0.0868
Echinococcus granulosus geminin 0.0191 0.5135 0.504
Brugia malayi cathepsin L-like precursor 0.013 0.3237 0.3862
Leishmania major cathepsin L-like protease 0.0191 0.5138 0.6132
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0295 0.8378 1
Echinococcus multilocularis cysteine protease 0.0191 0.5138 0.5043
Loa Loa (eye worm) hypothetical protein 0.013 0.3237 0.3104
Trypanosoma cruzi major cysteine proteinase, putative 0.0157 0.407 0.4857
Loa Loa (eye worm) hypothetical protein 0.0053 0.0829 0.065
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0173 0.4554 0.5435
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0268 0.7531 1
Brugia malayi Cathepsin L-like precursor 0.0191 0.5138 0.6274
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0053 0.0829 0.065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0829 0.1027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0295 0.8378 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0173 0.4554 0.4448
Trypanosoma cruzi cysteine peptidase, putative 0.0295 0.8378 1
Trypanosoma cruzi cruzipain precursor, putative 0.0061 0.1079 0.1288
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0191 0.5138 0.6362
Entamoeba histolytica cysteine protease, putative 0.0114 0.273 0.5314
Trypanosoma cruzi cysteine proteinase, putative 0.0114 0.273 0.3258
Plasmodium vivax vivapain-2 0.0191 0.5138 0.6739
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0053 0.0829 0.0868
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0135 0.3372 0.3509
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0191 0.5138 0.6362
Entamoeba histolytica cysteine protease, putative 0.0053 0.0829 0.1613
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0135 0.3372 0.4333

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 23 uM Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed as inhibition of SRC1 co-activator peptide recruitment after 3 hrs by TR-FRET analysis ChEMBL. 25017032
Efficacy (binding) = 75 % Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed as inhibition of SRC1 co-activator peptide recruitment after 3 hrs by TR-FRET analysis relative to apo-RORc ligand binding domain ChEMBL. 25017032
IC50 (binding) = 480 nM In Vitro Assay BINDINGDB. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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