Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | epidermal growth factor receptor | 0.0148 | 1 | 1 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0076 | 0.3143 | 0.368 |
Schistosoma mansoni | tyrosine kinase | 0.008 | 0.3485 | 0.32 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0148 | 1 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.008 | 0.3485 | 0.32 |
Loa Loa (eye worm) | guanine nucleotide regulatory protein | 0.0134 | 0.8696 | 0.8639 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0133 | 0.8542 | 1 |
Loa Loa (eye worm) | guanine nucleotide regulatory protein | 0.0134 | 0.8696 | 0.8639 |
Echinococcus multilocularis | transforming protein RhoA | 0.0134 | 0.8696 | 0.8659 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.008 | 0.3485 | 0.3299 |
Schistosoma mansoni | acetolactate synthase | 0.0114 | 0.6706 | 0.6562 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.8696 | 0.8639 |
Loa Loa (eye worm) | thiamine pyrophosphate enzyme | 0.0076 | 0.3156 | 0.2856 |
Schistosoma mansoni | tyrosine kinase | 0.0148 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0133 | 0.8542 | 1 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0133 | 0.8542 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.8696 | 0.8639 |
Echinococcus granulosus | transforming protein RhoA | 0.0134 | 0.8696 | 0.8639 |
Schistosoma mansoni | tyrosine kinase | 0.0079 | 0.3405 | 0.3117 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0076 | 0.3143 | 0.5 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | rho3, putative | 0.0134 | 0.8696 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.008 | 0.3485 | 0.32 |
Onchocerca volvulus | 0.0134 | 0.8696 | 0.5 | |
Brugia malayi | RAS-like GTP-binding protein RhoA | 0.0134 | 0.8696 | 0.8639 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0133 | 0.8542 | 1 |
Brugia malayi | RAS-like GTP-binding protein RhoA | 0.0134 | 0.8696 | 0.8639 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0133 | 0.8542 | 0.5 |
Echinococcus multilocularis | insulin receptor | 0.0047 | 0.042 | 0.0145 |
Schistosoma mansoni | tyrosine kinase | 0.008 | 0.3485 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.0079 | 0.3405 | 0.3117 |
Loa Loa (eye worm) | ILVBL protein | 0.008 | 0.3563 | 0.3281 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | acetolactate synthase | 0.0114 | 0.6706 | 0.6562 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0148 | 1 | 1 |
Entamoeba histolytica | Rho family GTPase | 0.0134 | 0.8696 | 0.5 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0133 | 0.8542 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0079 | 0.3405 | 0.3117 |
Echinococcus granulosus | transforming protein RhoA | 0.0134 | 0.8696 | 0.8639 |
Schistosoma mansoni | Rho2 GTPase | 0.0134 | 0.8696 | 0.8639 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0076 | 0.3143 | 0.368 |
Brugia malayi | RAS-like GTP-binding protein RhoA | 0.0134 | 0.8696 | 0.8639 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0047 | 0.042 | 0.0145 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0133 | 0.8542 | 0.5 |
Brugia malayi | Thiamine pyrophosphate enzyme, central domain containing protein | 0.0133 | 0.8542 | 0.8478 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0076 | 0.3143 | 0.5 |
Mycobacterium ulcerans | acetolactate synthase | 0.0076 | 0.3143 | 0.368 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0076 | 0.3143 | 1 |
Schistosoma mansoni | gtpase_rho | 0.0134 | 0.8696 | 0.8639 |
Echinococcus multilocularis | transforming protein RhoA | 0.0134 | 0.8696 | 0.8659 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.