TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 479.962 | Formula: C24H26ClN7O2
H donors: 2 H acceptors: 7 LogP: 5.05 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCCCc1ncc(c(n1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C)C(=O)O.Cl
InChi: 1S/C24H25N7O2.ClH/c1-3-4-9-21-25-14-20(24(32)33)23(26-21)31(2)15-16-10-12-17(13-11-16)18-7-5-6-8-19(18)22-27-29-30-28-22;/h5-8,10-14H,3-4,9,15H2,1-2H3,(H,32,33)(H,27,28,29,30);1H
InChiKey: ACDREOQGJQCHMZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	angiotensin II receptor, type 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	angiotensin II receptor, type 2	363 aa	398 aa	18.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0086	0.0015	0.002
Trichomonas vaginalis	G protein-coupled receptor kinase, putative	0.0086	0.0015	0.0029
Trypanosoma cruzi	cyclin, putative	0.0086	0.0015	0.0028
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.1066	0.1774	0.1774
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Trichomonas vaginalis	cyclins, putative	0.0086	0.0015	0.0028
Trypanosoma brucei	dual specificity tyrosine-phosphorylation-regulated kinase 2, putative	0.1525	0.2597	0.4868
Trypanosoma brucei	protein kinase, putative	0.0141	0.0114	0.0213
Trypanosoma brucei	cdc2-related kinase 1	0.1066	0.1774	0.3325
Trichomonas vaginalis	protein kinase atmrk1, putative	0.0086	0.0015	0.0029
Entamoeba histolytica	protein kinase, putative	0.0077	0.000000011732	0.000000025822
Trichomonas vaginalis	CMGC family protein kinase	0.0086	0.0015	0.0029
Trichomonas vaginalis	CMGC family protein kinase	0.0132	0.0098	0.0184
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.427	0.7523	0.7523
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.0015	0.0029
Plasmodium falciparum	glycogen synthase kinase 3	0.0533	0.0817	0.1531
Onchocerca volvulus		0.0086	0.0015	0.002
Echinococcus multilocularis	cyclin dependent kinase 5	0.1066	0.1774	0.1774
Trypanosoma brucei	ULK family serine/threonine-protein kinase, putative	0.0083	0.001	0.002
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Echinococcus multilocularis	snurportin 1	0.0328	0.0449	0.0449
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Echinococcus multilocularis	cyclin dependent kinase 5 activator 1	0.5651	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Echinococcus granulosus	mitogen activated protein kinase 15	0.0086	0.0015	0.0015
Leishmania major	protein kinase, putative,dual-specificity protein kinase, putative	0.1525	0.2597	0.4868
Onchocerca volvulus	Huntingtin homolog	0.0124	0.0084	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0015	0.0015
Echinococcus multilocularis	serine:threonine protein kinase NLK	0.0086	0.0015	0.0015
Brugia malayi	Cyclin C	0.0086	0.0016	0.0021
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Mycobacterium tuberculosis	Anchored-membrane serine/threonine-protein kinase PknF (protein kinase F) (STPK F)	0.0077	0	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.261	0.4544	0.4544
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0132	0.0098	0.0184
Loa Loa (eye worm)	haspin protein kinase	0.0086	0.0015	0.0015
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.261	0.4544	0.8516
Plasmodium vivax	serine/threonine kinase-1, putative	0.3051	0.5335	1
Leishmania major	protein kinase, putative	0.3051	0.5335	1
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0989	0.1636	0.1636
Loa Loa (eye worm)	CMGC/DYRK/DYRK2 protein kinase	0.1525	0.2597	0.2597
Mycobacterium ulcerans	serine/threonine-protein kinase B PknB	0.0077	0	0.5
Echinococcus granulosus	snurportin 1	0.0328	0.0449	0.0449
Mycobacterium tuberculosis	Transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A)	0.0077	0	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Brugia malayi	MAP kinase sur-1	0.0132	0.0098	0.0131
Schistosoma mansoni	serine/threonine protein kinase	0.1066	0.1774	0.1774
Echinococcus multilocularis	geminin	0.0172	0.017	0.017
Trypanosoma cruzi	Mitogen-activated protein kinase 10, putative	0.0086	0.0015	0.0029
Trichomonas vaginalis	CMGC family protein kinase	0.1525	0.2597	0.4868
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0132	0.0098	0.0184
Trypanosoma cruzi	cyclin 6, putative	0.0086	0.0015	0.0028
Trichomonas vaginalis	CMGC family protein kinase	0.0533	0.0817	0.1531
Trichomonas vaginalis	CMGC family protein kinase	0.3051	0.5335	1
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Plasmodium falciparum	protein kinase 5	0.1066	0.1774	0.3325
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.261	0.4544	0.8516
Entamoeba histolytica	protein kinase, putative	0.0533	0.0817	0.1798
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0084	0.0084
Echinococcus granulosus	cyclin B	0.0086	0.0015	0.0015
Onchocerca volvulus		0.0533	0.0817	0.1086
Trichomonas vaginalis	cyclin B, putative	0.0086	0.0015	0.0028
Entamoeba histolytica	protein kinase domain containing protein	0.1525	0.2597	0.5716
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Echinococcus multilocularis	protein kinase shaggy	0.0533	0.0817	0.0817
Echinococcus multilocularis	mitogen activated protein kinase	0.0132	0.0098	0.0098
Echinococcus granulosus	cyclin dependent kinase 9	0.0135	0.0103	0.0103
Trypanosoma brucei	kinetoplastid kinetochore protein 19	0.3051	0.5335	1
Trichomonas vaginalis	CMGC family protein kinase	0.1066	0.1774	0.3325
Echinococcus multilocularis	dual specificity	0.1525	0.2597	0.2597
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.1066	0.1774	0.3325
Echinococcus multilocularis	dual specificity	0.1525	0.2597	0.2597
Mycobacterium tuberculosis	Probable transmembrane serine/threonine-protein kinase E PknE (protein kinase E) (STPK E)	0.0077	0	0.5
Echinococcus multilocularis	cyclin dependent kinase 1	0.1066	0.1774	0.1774
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0533	0.0817	0.0817
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0152	0.0133	0.0133
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.261	0.4544	0.8516
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0533	0.0817	0.0817
Echinococcus granulosus	cyclin dependent kinase 9	0.0126	0.0087	0.0087
Echinococcus granulosus	cyclin dependent kinase 5	0.1066	0.1774	0.1774
Trichomonas vaginalis	serine/threonine kinase, putative	0.0086	0.0015	0.0029
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.427	0.7523	0.7523
Schistosoma mansoni	serine/threonine protein kinase	0.3051	0.5335	0.5335
Brugia malayi	Cell division protein kinase 2	0.0086	0.0015	0.002
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0132	0.0098	0.0184
Brugia malayi	Protein kinase domain containing protein	0.261	0.4544	0.604
Echinococcus granulosus	dual specificity	0.1525	0.2597	0.2597
Mycobacterium tuberculosis	Probable transmembrane serine/threonine-protein kinase I PknI (protein kinase I) (STPK I) (phosphorylase B kinase kinase) (hydro	0.0077	0	0.5
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0533	0.0817	0.1531
Chlamydia trachomatis	serine/threonine protein kinase	0.0077	0	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Echinococcus multilocularis	cyclin dependent kinase 9	0.0135	0.0103	0.0103
Mycobacterium ulcerans	Ser/Thr protein kinase	0.0077	0	0.5
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0328	0.0449	0.0449
Echinococcus multilocularis	oligomeric golgi complex subunit 3	0.0086	0.0016	0.0016
Echinococcus granulosus	dual specificity	0.261	0.4544	0.4544
Mycobacterium ulcerans	transmembrane serine/threonine-protein kinase PknQ	0.0077	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.2974	0.5197	0.5197
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.1066	0.1774	0.1774
Mycobacterium ulcerans	membrane-anchored serine/threonine-protein kinase	0.0077	0	0.5
Trypanosoma brucei	mitotic cyclin 6	0.0086	0.0015	0.0028
Echinococcus granulosus	mitogen activated protein kinase	0.0132	0.0098	0.0098
Echinococcus multilocularis	cyclin dependent kinase	0.1066	0.1774	0.1774
Trichomonas vaginalis	cyclins, putative	0.0086	0.0015	0.0028
Echinococcus granulosus	geminin	0.0172	0.017	0.017
Echinococcus granulosus	dual specificity protein kinase clk2	0.3051	0.5335	0.5335
Trichomonas vaginalis	cyclin B, putative	0.0086	0.0015	0.0028
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0086	0.0015	0.002
Trichomonas vaginalis	cyclin B, putative	0.0086	0.0015	0.0028
Mycobacterium tuberculosis	Probable transmembrane serine/threonine-protein kinase H PknH (protein kinase H) (STPK H)	0.0077	0	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.3051	0.5335	0.5335
Entamoeba histolytica	hypothetical protein	0.261	0.4544	1
Brugia malayi	Protein kinase domain containing protein	0.1066	0.1774	0.2358
Leishmania major	protein kinase, putative	0.3051	0.5335	1
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0533	0.0817	0.1531
Schistosoma mansoni	serine/threonine protein kinase	0.0132	0.0098	0.0098
Entamoeba histolytica	protein kinase, putative	0.1525	0.2597	0.5716
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.1066	0.1774	0.1774
Trichomonas vaginalis	CMGC family protein kinase	0.0086	0.0015	0.0029
Brugia malayi	Protein kinase domain containing protein	0.0086	0.0015	0.002
Brugia malayi	hypothetical protein	0.0124	0.0084	0.0112
Entamoeba histolytica	protein kinase domain containing protein	0.261	0.4544	1
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0155	0.014	0.0186
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.0015	0.0029
Brugia malayi	Dual-specificity tyrosine-phosphorylation regulated kinase 2	0.1525	0.2597	0.3452
Trichomonas vaginalis	CMGC family protein kinase	0.0132	0.0098	0.0184
Entamoeba histolytica	protein kinase, putative	0.261	0.4544	1
Echinococcus multilocularis	cyclin dependent kinase 7	0.016	0.0149	0.0149
Echinococcus multilocularis	cyclin dependent kinase 9	0.0126	0.0087	0.0087
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.3051	0.5335	1
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.3051	0.5335	1
Plasmodium falciparum	MO15-related protein kinase	0.0086	0.0015	0.0029
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.0015	0.0029
Schistosoma mansoni	hypothetical protein	0.0172	0.017	0.017
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.1066	0.1774	0.3325
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Mycobacterium leprae	Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B)	0.0077	0	0.5
Echinococcus multilocularis	cyclin dependent kinase 1	0.1066	0.1774	0.1774
Loa Loa (eye worm)	hypothetical protein	0.2532	0.4405	0.4405
Giardia lamblia	G2/mitotic-specific cyclin B	0.0086	0.0015	0.0028
Mycobacterium leprae	PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE L PKNL (PROTEIN KINASE L) (STPK L)	0.0077	0	0.5
Echinococcus granulosus	mitogen activated protein kinase 3	0.0132	0.0098	0.0098
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Mycobacterium ulcerans	Ser/Thr protein kinase	0.0077	0	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Trypanosoma cruzi	cdc2-related kinase 3	0.1066	0.1774	0.3325
Mycobacterium ulcerans	serine/threonine-protein kinase PknG	0.0077	0	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Chlamydia trachomatis	serine/threonine-protein kinase	0.0077	0	0.5
Trichomonas vaginalis	CMGC family protein kinase	0.0132	0.0098	0.0184
Toxoplasma gondii	cell-cycle-associated protein kinase DYRK2, putative	0.1525	0.2597	0.4868
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0132	0.0098	0.0184
Brugia malayi	RNA, U transporter 1	0.0087	0.0018	0.0024
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0533	0.0817	0.0817
Schistosoma mansoni	hypothetical protein	0.0328	0.0449	0.0449
Brugia malayi	intracellular kinase	0.0533	0.0817	0.1086
Giardia lamblia	Kinase, CMGC DYRK	0.1525	0.2597	0.4868
Echinococcus multilocularis	Cell division cycle 2 protein kinase	0.0086	0.0015	0.0015
Echinococcus granulosus	cyclin dependent kinase	0.1066	0.1774	0.1774
Echinococcus granulosus	Cell division cycle 2 protein kinase	0.0086	0.0015	0.0015
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Plasmodium vivax	protein kinase Crk2	0.1066	0.1774	0.3325
Echinococcus granulosus	hypothetical protein	0.2974	0.5197	0.5197
Mycobacterium tuberculosis	Serine/threonine-protein kinase transcriptional regulatory protein PknK (protein kinase K) (STPK K)	0.0077	0	0.5
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0086	0.0015	0.0028
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0533	0.0817	0.0817
Loa Loa (eye worm)	cyclin domain-containing protein	0.0155	0.014	0.014
Trichomonas vaginalis	CMGC family protein kinase	0.0132	0.0098	0.0184
Trichomonas vaginalis	CMGC family protein kinase	0.1066	0.1774	0.3325
Brugia malayi	Protein kinase domain containing protein	0.3051	0.5335	0.7092
Entamoeba histolytica	cell division protein kinase 2, putative	0.1066	0.1774	0.3905
Echinococcus multilocularis	muscleblind protein 1	0.0152	0.0133	0.0133
Trypanosoma brucei	Mitogen-activated protein kinase 10, putative	0.0086	0.0015	0.0029
Giardia lamblia	Kinase, CAMK CAMKL	0.0086	0.0015	0.0029
Trichomonas vaginalis	CMGC family protein kinase	0.1525	0.2597	0.4868
Echinococcus multilocularis	muscleblind protein	0.0152	0.0133	0.0133
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Trichomonas vaginalis	CMGC family protein kinase	0.1525	0.2597	0.4868
Trypanosoma cruzi	Mitogen-activated protein kinase 10, putative	0.0086	0.0015	0.0029
Trichomonas vaginalis	CMGC family protein kinase	0.1066	0.1774	0.3325
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Loa Loa (eye worm)	CMGC/CLK protein kinase	0.3051	0.5335	0.5335
Schistosoma mansoni	serine/threonine protein kinase	0.016	0.0149	0.0149
Brugia malayi	Serine/threonine-protein kinase Pim-3	0.427	0.7523	1
Schistosoma mansoni	cyclin-dependent kinase 5 activator	0.5651	1	1
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.1066	0.1774	0.1774
Mycobacterium tuberculosis	Serine/threonine-protein kinase PknG (protein kinase G) (STPK G)	0.0077	0	0.5
Loa Loa (eye worm)	CMGC/CDK/CRK7 protein kinase	0.0086	0.0015	0.0015
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0533	0.0817	0.1531
Trypanosoma brucei	cdc2-related kinase 3	0.1066	0.1774	0.3325
Entamoeba histolytica	protein kinase, putative	0.261	0.4544	1
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.3051	0.5335	1
Loa Loa (eye worm)	cyclin C	0.0086	0.0016	0.0016
Giardia lamblia	Kinase, CAMK CAMKL	0.0086	0.0015	0.0029
Trichomonas vaginalis	cyclins, putative	0.0086	0.0015	0.0028
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0132	0.0098	0.0184
Trichomonas vaginalis	CMGC family protein kinase	0.1525	0.2597	0.4868
Loa Loa (eye worm)	hypothetical protein	0.2705	0.4715	0.4715
Schistosoma mansoni	hypothetical protein	0.0172	0.017	0.017
Schistosoma mansoni	protein kinase	0.0086	0.0015	0.0015
Echinococcus multilocularis	dual specificity	0.261	0.4544	0.4544
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0132	0.0098	0.0098
Schistosoma mansoni	serine/threonine protein kinase	0.1525	0.2597	0.2597
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0533	0.0817	0.0817
Giardia lamblia	Kinase, CMGC MAPK	0.0132	0.0098	0.0184
Brugia malayi	cyclin-dependent kinase 7 homolog	0.0169	0.0164	0.0219
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Schistosoma mansoni	serine/threonine kinase	0.0086	0.0015	0.0015
Mycobacterium tuberculosis	Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B)	0.0077	0	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Giardia lamblia	Kinase, CMGC GSK	0.0533	0.0817	0.1531
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Schistosoma mansoni	serine/threonine protein kinase	0.1066	0.1774	0.1774
Mycobacterium ulcerans	serine/threonine-protein kinase PknF_2	0.0077	0	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Trypanosoma brucei	protein kinase, putative	0.0533	0.0817	0.1531
Echinococcus granulosus	cyclin dependent kinase 7	0.016	0.0149	0.0149
Entamoeba histolytica	protein kinase domain containing protein	0.0126	0.0087	0.0192
Trichomonas vaginalis	CMGC family protein kinase	0.0533	0.0817	0.1531
Loa Loa (eye worm)	CMGC/CDK/CDK9 protein kinase	0.0126	0.0087	0.0087
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Echinococcus granulosus	protein kinase shaggy	0.0533	0.0817	0.0817
Trypanosoma cruzi	cdc2-related kinase 1	0.1066	0.1774	0.3325
Echinococcus granulosus	serine:threonine protein kinase NLK	0.0086	0.0015	0.0015
Trypanosoma cruzi	dual specificity tyrosine-phosphorylation-regulated kinase 2, putative	0.1525	0.2597	0.4868
Mycobacterium ulcerans	serine/threonine-protein kinase a PknA	0.0077	0	0.5
Echinococcus multilocularis	dual specificity protein kinase clk2	0.3051	0.5335	0.5335
Trichomonas vaginalis	CMGC family protein kinase	0.0086	0.0015	0.0029
Trypanosoma cruzi	cyclin, putative	0.0086	0.0015	0.0028
Echinococcus granulosus	cyclin	0.0086	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.2532	0.4405	0.4405
Echinococcus granulosus	muscleblind protein	0.0152	0.0133	0.0133
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.427	0.7523	0.7523
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.0015	0.0029
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0086	0.0015	0.0015
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0132	0.0098	0.0098
Entamoeba histolytica	protein kinase domain containing protein	0.0533	0.0817	0.1798
Mycobacterium ulcerans	anchored-membrane serine/threonine-protein kinase PknF	0.0077	0	0.5
Brugia malayi	Muscleblind-like protein	0.0152	0.0133	0.0177
Loa Loa (eye worm)	hypothetical protein	0.2705	0.4715	0.4715
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.0015	0.0029
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Trichomonas vaginalis	CMGC family protein kinase	0.1525	0.2597	0.4868
Schistosoma mansoni	kinase	0.0126	0.0087	0.0087
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.1066	0.1774	0.3325
Mycobacterium leprae	Probable transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A)	0.0077	0	0.5
Chlamydia trachomatis	serine/threonine protein kinase	0.0077	0	0.5
Schistosoma mansoni	cyclin B	0.0086	0.0015	0.0015
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Schistosoma mansoni	serine/threonine protein kinase	0.0086	0.0015	0.0015
Echinococcus granulosus	cyclin dependent kinase 1	0.1066	0.1774	0.1774
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0132	0.0098	0.0184
Plasmodium vivax	serine/threonine protein kinase KIN, putative	0.0086	0.0015	0.0029
Loa Loa (eye worm)	hypothetical protein	0.5651	1	1
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0086	0.0015	0.0028
Trypanosoma cruzi	cdc2-related kinase 1	0.1066	0.1774	0.3325
Giardia lamblia	Kinase, CMGC GSK	0.0533	0.0817	0.1531
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Entamoeba histolytica	cyclin, putative	0.0086	0.0015	0.0033
Leishmania major	serine/threonine kinase-like protein, putative	0.0086	0.0015	0.0029
Brugia malayi	cyclin-dependent kinase 9	0.0126	0.0087	0.0116
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0132	0.0098	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0015	0.0015
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0533	0.0817	0.1531
Giardia lamblia	Kinase, CAMK CAMKL	0.0086	0.0015	0.0029
Echinococcus multilocularis	cyclin B	0.0086	0.0015	0.0015
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Echinococcus multilocularis		0.2974	0.5197	0.5197
Mycobacterium ulcerans	serine/threonine-protein kinase transcriptional regulatory protein PknK_2	0.0077	0	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Leishmania major	cyclin	0.0086	0.0015	0.0028
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0086	0.0015	0.0029
Entamoeba histolytica	protein kinase domain containing protein	0.0533	0.0817	0.1798
Mycobacterium ulcerans	serine/threonine-protein kinase transcriptional regulatory protein PknK_3	0.0077	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0152	0.0133	0.0133
Schistosoma mansoni	serine/threonine protein kinase	0.0126	0.0087	0.0087
Loa Loa (eye worm)	CMGC/CDK/CDK7 protein kinase	0.016	0.0149	0.0149
Trichomonas vaginalis	cyclin B, putative	0.0086	0.0015	0.0028
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.3051	0.5335	1
Trichomonas vaginalis	CMGC family protein kinase	0.0086	0.0015	0.0029
Onchocerca volvulus	Huntingtin homolog	0.0124	0.0084	0.0112
Echinococcus multilocularis	cyclin	0.0086	0.0016	0.0016
Schistosoma mansoni	g1/s-specific cyclin C	0.0086	0.0016	0.0016
Mycobacterium ulcerans	Ser/Thr protein kinase	0.0077	0	0.5
Entamoeba histolytica	cell division protein kinase 2, putative	0.1075	0.179	0.3939
Giardia lamblia	Kinase, CMGC CDK	0.1066	0.1774	0.3325
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.261	0.4544	0.4544
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Trypanosoma cruzi	cdc2-related kinase 3	0.1066	0.1774	0.3325
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.427	0.7523	0.7523
Brugia malayi	cell division control protein 2 homolog	0.1066	0.1774	0.2358
Mycobacterium ulcerans	Ser/Thr protein kinase	0.0077	0	0.5
Giardia lamblia	Kinase, CMGC CLK	0.3051	0.5335	1
Plasmodium vivax	cyclin dependent kinase 7 (cdk7), putative	0.0086	0.0015	0.0029
Giardia lamblia	Kinase, CMGC CDK	0.1066	0.1774	0.3325
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.261	0.4544	0.8516
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Toxoplasma gondii	cell-cycle-associated protein kinase CLK, putative	0.3051	0.5335	1
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Echinococcus granulosus	dual specificity	0.1525	0.2597	0.2597
Trypanosoma brucei	kinetoplastid kinetochore protein 10	0.3051	0.5335	1
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Schistosoma mansoni	serine/threonine protein kinase	0.016	0.0149	0.0149
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Brugia malayi	Protein kinase domain containing protein	0.427	0.7523	1
Leishmania major	mitogen-activated protein kinase, putative,map kinase-like protein	0.0086	0.0015	0.0029
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Entamoeba histolytica	protein kinase domain containing protein	0.0086	0.0015	0.0034
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Plasmodium falciparum	protein serine/threonine kinase-1	0.3051	0.5335	1
Echinococcus granulosus	oligomeric golgi complex subunit 3	0.0086	0.0016	0.0016
Schistosoma mansoni	serine/threonine protein kinase	0.427	0.7523	0.7523
Trichomonas vaginalis	cyclins, putative	0.0086	0.0015	0.0028
Trichomonas vaginalis	cyclin A, putative	0.0086	0.0015	0.0028
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.0015	0.0029
Trichomonas vaginalis	AGC family protein kinase	0.0086	0.0015	0.0029
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0132	0.0098	0.0184
Echinococcus granulosus	dual specificity	0.1525	0.2597	0.2597
Trichomonas vaginalis	CMGC family protein kinase	0.1525	0.2597	0.4868
Brugia malayi	hypothetical protein	0.2705	0.4715	0.6267
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.0015	0.0029
Echinococcus multilocularis	dual specificity	0.1525	0.2597	0.2597
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.427	0.7523	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Kd (binding)	= 7.15	Potency of the compound to antagonize the ability of angiotensin II to contract rabbit aorta	ChEMBL.	8410980

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1237155

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 922747