TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 362.488 | Formula: C22H22N2OS
H donors: 1 H acceptors: 1 LogP: 5.21 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCc1ccc(s1)C1Nc2ccccc2C(=O)N1[C@H](c1ccccc1)C
InChi: 1S/C22H22N2OS/c1-3-17-13-14-20(26-17)21-23-19-12-8-7-11-18(19)22(25)24(21)15(2)16-9-5-4-6-10-16/h4-15,21,23H,3H2,1-2H3/t15-,21?/m0/s1
InChiKey: CNNUXIFAUGMLRE-ZDGMYTEDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	membrane-anchored serine/threonine-protein kinase	0.0066	0	0.5
Mycobacterium leprae	PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE L PKNL (PROTEIN KINASE L) (STPK L)	0.0066	0	0.5
Trichomonas vaginalis	CMGC family protein kinase	0.0929	0.1777	0.3309
Loa Loa (eye worm)	hypothetical protein	0.2244	0.4483	0.4483
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Mycobacterium ulcerans	serine/threonine-protein kinase transcriptional regulatory protein PknK_2	0.0066	0	0.5
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0074	0.0016	0.0016
Trichomonas vaginalis	AGC family protein kinase	0.0074	0.0016	0.003
Trypanosoma brucei	protein kinase, putative	0.0123	0.0118	0.0219
Chlamydia trachomatis	serine/threonine protein kinase	0.0066	0	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Echinococcus multilocularis	cyclin dependent kinase	0.0929	0.1777	0.1777
Toxoplasma gondii	cell-cycle-associated protein kinase DYRK2, putative	0.1346	0.2634	0.4906
Echinococcus granulosus	cyclin dependent kinase 9	0.0118	0.0106	0.0106
Brugia malayi	RNA, U transporter 1	0.0081	0.003	0.0039
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0255	0.039	0.0725
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0255	0.039	0.0725
Trichomonas vaginalis	cyclins, putative	0.0077	0.0023	0.0043
Onchocerca volvulus	Huntingtin homolog	0.0124	0.0119	0.0155
Mycobacterium ulcerans	serine/threonine-protein kinase PknF_2	0.0066	0	0.5
Trichomonas vaginalis	CMGC family protein kinase	0.1346	0.2634	0.4906
Trichomonas vaginalis	CMGC family protein kinase	0.0255	0.039	0.0725
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0077	0.0023	0.0043
Echinococcus granulosus	cyclin dependent kinase 5	0.0929	0.1777	0.1777
Schistosoma mansoni	serine/threonine protein kinase	0.0141	0.0154	0.0154
Echinococcus multilocularis	cyclin dependent kinase 9	0.011	0.009	0.009
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Schistosoma mansoni	serine/threonine protein kinase	0.231	0.4619	0.4619
Echinococcus granulosus	dual specificity	0.1346	0.2634	0.2634
Echinococcus granulosus	serine:threonine protein kinase NLK	0.0074	0.0016	0.0016
Brugia malayi	MAP kinase sur-1	0.0115	0.0102	0.0133
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.231	0.4619	0.8602
Echinococcus multilocularis	muscleblind protein	0.0151	0.0174	0.0174
Trypanosoma brucei	cdc2-related kinase 3	0.0929	0.1777	0.3309
Echinococcus multilocularis	cyclin	0.0078	0.0024	0.0024
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0115	0.0102	0.019
Loa Loa (eye worm)	CMGC/CDK/CRK7 protein kinase	0.0074	0.0016	0.0016
Giardia lamblia	Kinase, CMGC CLK	0.2674	0.537	1
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.2674	0.537	1
Brugia malayi	Cell division protein kinase 2	0.0074	0.0016	0.0021
Echinococcus multilocularis	geminin	0.0171	0.0216	0.0216
Trichomonas vaginalis	CMGC family protein kinase	0.0115	0.0102	0.019
Trichomonas vaginalis	cyclin A, putative	0.0077	0.0023	0.0043
Mycobacterium ulcerans	Ser/Thr protein kinase	0.0066	0	0.5
Schistosoma mansoni	hypothetical protein	0.0171	0.0216	0.0216
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0077	0.0023	0.0043
Plasmodium vivax	serine/threonine kinase-1, putative	0.2674	0.537	1
Trichomonas vaginalis	cyclins, putative	0.0077	0.0023	0.0043
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0077	0.0023	0.003
Plasmodium falciparum	protein kinase 5	0.0929	0.1777	0.3309
Echinococcus granulosus	cyclin	0.0078	0.0024	0.0024
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.231	0.4619	0.8602
Giardia lamblia	Kinase, CMGC CDK	0.0929	0.1777	0.3309
Echinococcus multilocularis	dual specificity protein kinase clk2	0.2674	0.537	0.537
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0255	0.039	0.039
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0115	0.0102	0.019
Leishmania major	cyclin	0.0077	0.0023	0.0043
Trypanosoma brucei	kinetoplastid kinetochore protein 19	0.2674	0.537	1
Mycobacterium tuberculosis	Probable transmembrane serine/threonine-protein kinase I PknI (protein kinase I) (STPK I) (phosphorylase B kinase kinase) (hydro	0.0066	0	0.5
Echinococcus granulosus	cyclin dependent kinase 1	0.0929	0.1777	0.1777
Onchocerca volvulus		0.0077	0.0023	0.003
Entamoeba histolytica	protein kinase domain containing protein	0.1346	0.2634	0.5703
Echinococcus multilocularis	oligomeric golgi complex subunit 3	0.0078	0.0024	0.0024
Plasmodium vivax	cyclin dependent kinase 7 (cdk7), putative	0.0074	0.0016	0.003
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0115	0.0102	0.019
Schistosoma mansoni	serine/threonine protein kinase	0.3782	0.765	0.765
Schistosoma mansoni	serine/threonine protein kinase	0.2674	0.537	0.537
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0119	0.0119
Mycobacterium leprae	Probable transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A)	0.0066	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.231	0.4619	0.6037
Loa Loa (eye worm)	CMGC/DYRK/DYRK2 protein kinase	0.1346	0.2634	0.2634
Mycobacterium ulcerans	Ser/Thr protein kinase	0.0066	0	0.5
Mycobacterium tuberculosis	Serine/threonine-protein kinase transcriptional regulatory protein PknK (protein kinase K) (STPK K)	0.0066	0	0.5
Onchocerca volvulus		0.0255	0.039	0.0509
Chlamydia trachomatis	serine/threonine protein kinase	0.0066	0	0.5
Echinococcus granulosus	hypothetical protein	0.2608	0.5234	0.5234
Echinococcus multilocularis	cyclin dependent kinase 1	0.0929	0.1777	0.1777
Plasmodium falciparum	glycogen synthase kinase 3	0.0255	0.039	0.0725
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.231	0.4619	0.8602
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Echinococcus granulosus	mitogen activated protein kinase	0.0115	0.0102	0.0102
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Echinococcus multilocularis	snurportin 1	0.0303	0.0487	0.0487
Giardia lamblia	Kinase, CMGC DYRK	0.1346	0.2634	0.4906
Brugia malayi	hypothetical protein	0.0124	0.0119	0.0155
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.2674	0.537	1
Plasmodium vivax	protein kinase Crk2	0.0929	0.1777	0.3309
Trichomonas vaginalis	CMGC family protein kinase	0.0255	0.039	0.0725
Echinococcus granulosus	mitogen activated protein kinase 15	0.0074	0.0016	0.0016
Echinococcus multilocularis	cyclin dependent kinase 7	0.0141	0.0154	0.0154
Echinococcus multilocularis	dual specificity	0.231	0.4619	0.4619
Trichomonas vaginalis	CMGC family protein kinase	0.0074	0.0016	0.003
Trypanosoma cruzi	cdc2-related kinase 1	0.0929	0.1777	0.3309
Leishmania major	protein kinase, putative,dual-specificity protein kinase, putative	0.1346	0.2634	0.4906
Trypanosoma cruzi	cdc2-related kinase 1	0.0929	0.1777	0.3309
Mycobacterium tuberculosis	Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B)	0.0066	0	0.5
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0929	0.1777	0.1777
Echinococcus multilocularis	mitogen activated protein kinase	0.0115	0.0102	0.0102
Echinococcus granulosus	snurportin 1	0.0303	0.0487	0.0487
Mycobacterium tuberculosis	Anchored-membrane serine/threonine-protein kinase PknF (protein kinase F) (STPK F)	0.0066	0	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0115	0.0102	0.019
Trypanosoma cruzi	cdc2-related kinase 3	0.0929	0.1777	0.3309
Echinococcus multilocularis	dual specificity	0.1346	0.2634	0.2634
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0255	0.039	0.0725
Mycobacterium ulcerans	serine/threonine-protein kinase B PknB	0.0066	0	0.5
Echinococcus multilocularis	dual specificity	0.1346	0.2634	0.2634
Echinococcus multilocularis	protein kinase shaggy	0.0255	0.039	0.039
Loa Loa (eye worm)	cyclin C	0.0078	0.0024	0.0024
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0115	0.0102	0.0102
Toxoplasma gondii	cell-cycle-associated protein kinase CLK, putative	0.2674	0.537	1
Echinococcus granulosus	geminin	0.0171	0.0216	0.0216
Trichomonas vaginalis	cyclins, putative	0.0077	0.0023	0.0043
Echinococcus multilocularis	cyclin dependent kinase 1	0.0929	0.1777	0.1777
Echinococcus granulosus	dual specificity	0.231	0.4619	0.4619
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0255	0.039	0.039
Schistosoma mansoni	serine/threonine protein kinase	0.011	0.009	0.009
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Trichomonas vaginalis	CMGC family protein kinase	0.1346	0.2634	0.4906
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0255	0.039	0.039
Trichomonas vaginalis	cyclin B, putative	0.0077	0.0023	0.0043
Entamoeba histolytica	protein kinase domain containing protein	0.011	0.009	0.0196
Loa Loa (eye worm)	haspin protein kinase	0.0074	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.4924	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Brugia malayi	Protein kinase domain containing protein	0.0074	0.0016	0.0021
Trypanosoma cruzi	dual specificity tyrosine-phosphorylation-regulated kinase 2, putative	0.1346	0.2634	0.4906
Entamoeba histolytica	hypothetical protein	0.231	0.4619	1
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0115	0.0102	0.019
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Mycobacterium tuberculosis	Probable transmembrane serine/threonine-protein kinase E PknE (protein kinase E) (STPK E)	0.0066	0	0.5
Brugia malayi	Cyclin C	0.0078	0.0024	0.0032
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.231	0.4619	0.8602
Trichomonas vaginalis	CMGC family protein kinase	0.2674	0.537	1
Loa Loa (eye worm)	hypothetical protein	0.0863	0.1641	0.1641
Schistosoma mansoni	serine/threonine protein kinase	0.2674	0.537	0.537
Schistosoma mansoni	kinase	0.011	0.009	0.009
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Trichomonas vaginalis	CMGC family protein kinase	0.1346	0.2634	0.4906
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Schistosoma mansoni	protein kinase	0.0074	0.0016	0.0016
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0929	0.1777	0.3309
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0929	0.1777	0.1777
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0119	0.0119
Schistosoma mansoni	serine/threonine protein kinase	0.0115	0.0102	0.0102
Brugia malayi	Protein kinase domain containing protein	0.3782	0.765	1
Trichomonas vaginalis	AGC family protein kinase	0.0074	0.0016	0.003
Entamoeba histolytica	protein kinase domain containing protein	0.0074	0.0016	0.0034
Mycobacterium leprae	Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B)	0.0066	0	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Trypanosoma brucei	ULK family serine/threonine-protein kinase, putative	0.0071	0.0011	0.0021
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Trichomonas vaginalis	protein kinase atmrk1, putative	0.0074	0.0016	0.003
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0255	0.039	0.039
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0074	0.0016	0.003
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0255	0.039	0.0725
Trypanosoma brucei	cdc2-related kinase 1	0.0929	0.1777	0.3309
Trichomonas vaginalis	AGC family protein kinase	0.0074	0.0016	0.003
Trichomonas vaginalis	cyclins, putative	0.0077	0.0023	0.0043
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.3782	0.765	0.765
Echinococcus granulosus	cyclin B	0.0077	0.0023	0.0023
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.3782	0.765	0.765
Trypanosoma cruzi	cyclin, putative	0.0077	0.0023	0.0043
Trypanosoma brucei	Mitogen-activated protein kinase 10, putative	0.0074	0.0016	0.003
Trichomonas vaginalis	serine/threonine kinase, putative	0.0074	0.0016	0.003
Trypanosoma brucei	kinetoplastid kinetochore protein 10	0.2674	0.537	1
Giardia lamblia	Kinase, CAMK CAMKL	0.0074	0.0016	0.003
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Echinococcus granulosus	dual specificity	0.1346	0.2634	0.2634
Trichomonas vaginalis	CMGC family protein kinase	0.0115	0.0102	0.019
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Echinococcus multilocularis	dual specificity	0.1346	0.2634	0.2634
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.3782	0.765	0.765
Brugia malayi	Dual-specificity tyrosine-phosphorylation regulated kinase 2	0.1346	0.2634	0.3443
Loa Loa (eye worm)	hypothetical protein	0.2357	0.4716	0.4716
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Brugia malayi	cell division control protein 2 homolog	0.0929	0.1777	0.2322
Brugia malayi	Serine/threonine-protein kinase Pim-3	0.3782	0.765	1
Trichomonas vaginalis	CMGC family protein kinase	0.0929	0.1777	0.3309
Mycobacterium ulcerans	serine/threonine-protein kinase a PknA	0.0066	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.231	0.4619	1
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Leishmania major	protein kinase, putative	0.2674	0.537	1
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0929	0.1777	0.1777
Trichomonas vaginalis	CMGC family protein kinase	0.0074	0.0016	0.003
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.231	0.4619	0.4619
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Echinococcus granulosus	dual specificity protein kinase clk2	0.2674	0.537	0.537
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Brugia malayi	Muscleblind-like protein	0.0151	0.0174	0.0228
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Entamoeba histolytica	protein kinase, putative	0.1346	0.2634	0.5703
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.2674	0.537	1
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Echinococcus multilocularis	cyclin B	0.0077	0.0023	0.0023
Giardia lamblia	G2/mitotic-specific cyclin B	0.0077	0.0023	0.0043
Entamoeba histolytica	cyclin, putative	0.0077	0.0023	0.005
Schistosoma mansoni	serine/threonine protein kinase	0.0074	0.0016	0.0016
Chlamydia trachomatis	serine/threonine-protein kinase	0.0066	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.2608	0.5234	0.5234
Plasmodium falciparum	protein serine/threonine kinase-1	0.2674	0.537	1
Entamoeba histolytica	protein kinase domain containing protein	0.0255	0.039	0.0843
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0174	0.0174
Giardia lamblia	Kinase, CMGC MAPK	0.0115	0.0102	0.019
Mycobacterium ulcerans	transmembrane serine/threonine-protein kinase PknQ	0.0066	0	0.5
Loa Loa (eye worm)	CMGC/CDK/CDK7 protein kinase	0.0141	0.0154	0.0154
Trichomonas vaginalis	AGC family protein kinase	0.0074	0.0016	0.003
Entamoeba histolytica	cell division protein kinase 2, putative	0.0937	0.1793	0.3881
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0929	0.1777	0.3309
Schistosoma mansoni	g1/s-specific cyclin C	0.0078	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0023	0.0023
Echinococcus granulosus	cyclin dependent kinase 9	0.011	0.009	0.009
Mycobacterium ulcerans	serine/threonine-protein kinase PknG	0.0066	0	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Mycobacterium tuberculosis	Serine/threonine-protein kinase PknG (protein kinase G) (STPK G)	0.0066	0	0.5
Mycobacterium ulcerans	serine/threonine-protein kinase transcriptional regulatory protein PknK_3	0.0066	0	0.5
Schistosoma mansoni	cyclin-dependent kinase 5 activator	0.4924	1	1
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0077	0.0023	0.003
Entamoeba histolytica	cell division protein kinase 2, putative	0.0929	0.1777	0.3847
Giardia lamblia	Kinase, CMGC GSK	0.0255	0.039	0.0725
Plasmodium falciparum	MO15-related protein kinase	0.0074	0.0016	0.003
Trypanosoma cruzi	Mitogen-activated protein kinase 10, putative	0.0074	0.0016	0.003
Echinococcus granulosus	cyclin dependent kinase	0.0929	0.1777	0.1777
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0115	0.0102	0.019
Giardia lamblia	Kinase, CAMK CAMKL	0.0074	0.0016	0.003
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Brugia malayi	cyclin-dependent kinase 9	0.011	0.009	0.0118
Trichomonas vaginalis	cyclin B, putative	0.0077	0.0023	0.0043
Trichomonas vaginalis	AGC family protein kinase	0.0074	0.0016	0.003
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Trichomonas vaginalis	CMGC family protein kinase	0.0074	0.0016	0.003
Trypanosoma brucei	protein kinase, putative	0.0255	0.039	0.0725
Echinococcus multilocularis	Cell division cycle 2 protein kinase	0.0074	0.0016	0.0016
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0115	0.0102	0.0102
Leishmania major	mitogen-activated protein kinase, putative,map kinase-like protein	0.0074	0.0016	0.003
Trypanosoma cruzi	cyclin, putative	0.0077	0.0023	0.0043
Loa Loa (eye worm)	hypothetical protein	0.2244	0.4483	0.4483
Loa Loa (eye worm)	cyclin domain-containing protein	0.014	0.0152	0.0152
Trichomonas vaginalis	CMGC family protein kinase	0.1346	0.2634	0.4906
Mycobacterium ulcerans	Ser/Thr protein kinase	0.0066	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.2674	0.537	0.7019
Trichomonas vaginalis	cyclin B, putative	0.0077	0.0023	0.0043
Trypanosoma cruzi	cyclin 6, putative	0.0077	0.0023	0.0043
Onchocerca volvulus	Huntingtin homolog	0.0124	0.0119	0.0155
Giardia lamblia	Kinase, CMGC GSK	0.0255	0.039	0.0725
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.3782	0.765	1
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Mycobacterium ulcerans	anchored-membrane serine/threonine-protein kinase PknF	0.0066	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.2357	0.4716	0.4716
Schistosoma mansoni	serine/threonine protein kinase	0.0141	0.0154	0.0154
Echinococcus granulosus	mitogen activated protein kinase 3	0.0115	0.0102	0.0102
Schistosoma mansoni	serine/threonine protein kinase	0.0929	0.1777	0.1777
Plasmodium vivax	serine/threonine protein kinase KIN, putative	0.0074	0.0016	0.003
Schistosoma mansoni	serine/threonine kinase	0.0074	0.0016	0.0016
Trichomonas vaginalis	CMGC family protein kinase	0.1346	0.2634	0.4906
Giardia lamblia	Kinase, CAMK CAMKL	0.0074	0.0016	0.003
Mycobacterium tuberculosis	Probable transmembrane serine/threonine-protein kinase H PknH (protein kinase H) (STPK H)	0.0066	0	0.5
Echinococcus multilocularis	serine:threonine protein kinase NLK	0.0074	0.0016	0.0016
Schistosoma mansoni	hypothetical protein	0.0303	0.0487	0.0487
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0115	0.0102	0.019
Echinococcus multilocularis	muscleblind protein 1	0.0151	0.0174	0.0174
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Echinococcus multilocularis	cyclin dependent kinase 5	0.0929	0.1777	0.1777
Mycobacterium ulcerans	Ser/Thr protein kinase	0.0066	0	0.5
Trichomonas vaginalis	CMGC family protein kinase	0.0074	0.0016	0.003
Brugia malayi	intracellular kinase	0.0255	0.039	0.0509
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Echinococcus granulosus	protein kinase shaggy	0.0255	0.039	0.039
Loa Loa (eye worm)	CMGC/CDK/CDK9 protein kinase	0.011	0.009	0.009
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0303	0.0487	0.0487
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0115	0.0102	0.019
Trypanosoma cruzi	Mitogen-activated protein kinase 10, putative	0.0074	0.0016	0.003
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0174	0.0174
Trypanosoma cruzi	cdc2-related kinase 3	0.0929	0.1777	0.3309
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Entamoeba histolytica	protein kinase, putative	0.0255	0.039	0.0843
Schistosoma mansoni	cyclin B	0.0077	0.0023	0.0023
Echinococcus multilocularis	cyclin dependent kinase 5 activator 1	0.4924	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0929	0.1777	0.1777
Mycobacterium tuberculosis	Transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A)	0.0066	0	0.5
Giardia lamblia	Kinase, CMGC CDK	0.0929	0.1777	0.3309
Entamoeba histolytica	protein kinase, putative	0.231	0.4619	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0023	0.0023
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.2674	0.537	1
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0255	0.039	0.039
Entamoeba histolytica	protein kinase, putative	0.231	0.4619	1
Trichomonas vaginalis	G protein-coupled receptor kinase, putative	0.0074	0.0016	0.003
Trichomonas vaginalis	AGC family protein kinase	0.0074	0.0016	0.003
Trichomonas vaginalis	CMGC family protein kinase	0.0115	0.0102	0.019
Schistosoma mansoni	serine/threonine protein kinase	0.1346	0.2634	0.2634
Brugia malayi	hypothetical protein	0.2357	0.4716	0.6165
Schistosoma mansoni	hypothetical protein	0.0171	0.0216	0.0216
Echinococcus granulosus	dual specificity	0.1346	0.2634	0.2634
Trichomonas vaginalis	CMGC family protein kinase	0.0115	0.0102	0.019
Brugia malayi	Protein kinase domain containing protein	0.0929	0.1777	0.2322
Echinococcus multilocularis		0.2608	0.5234	0.5234
Trichomonas vaginalis	AGC family protein kinase	0.0074	0.0016	0.003
Entamoeba histolytica	protein kinase domain containing protein	0.0255	0.039	0.0843
Entamoeba histolytica	protein kinase, putative	0.0066	0.000000012437	0.000000026928
Brugia malayi	cyclin-dependent kinase 7 homolog	0.0149	0.017	0.0223
Echinococcus granulosus	Cell division cycle 2 protein kinase	0.0074	0.0016	0.0016
Leishmania major	serine/threonine kinase-like protein, putative	0.0074	0.0016	0.003
Echinococcus multilocularis	cyclin dependent kinase 9	0.0118	0.0106	0.0106
Trichomonas vaginalis	CMGC family protein kinase	0.0929	0.1777	0.3309
Loa Loa (eye worm)	CMGC/CLK protein kinase	0.2674	0.537	0.537
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0929	0.1777	0.1777
Trichomonas vaginalis	cyclin B, putative	0.0077	0.0023	0.0043
Echinococcus granulosus	oligomeric golgi complex subunit 3	0.0078	0.0024	0.0024
Trypanosoma brucei	dual specificity tyrosine-phosphorylation-regulated kinase 2, putative	0.1346	0.2634	0.4906
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0929	0.1777	0.3309
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Echinococcus granulosus	cyclin dependent kinase 7	0.0141	0.0154	0.0154
Brugia malayi	Cyclin, N-terminal domain containing protein	0.014	0.0152	0.0199
Trichomonas vaginalis	CMGC family protein kinase	0.1346	0.2634	0.4906
Trichomonas vaginalis	CAMK family protein kinase	0.0074	0.0016	0.003
Echinococcus granulosus	muscleblind protein	0.0151	0.0174	0.0174
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.3782	0.765	0.765
Trypanosoma brucei	mitotic cyclin 6	0.0077	0.0023	0.0043
Leishmania major	protein kinase, putative	0.2674	0.537	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3322083

Bibliographic References

No literature references available for this target.

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Detailed information for compound 924668