TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 364.183 | Formula: C16H11Cl2N3O3
H donors: 2 H acceptors: 3 LogP: 3.59 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)c1[nH]c2c(c1)cc(cn2)NC(=O)c1c(Cl)cccc1Cl
InChi: 1S/C16H11Cl2N3O3/c1-24-16(23)12-6-8-5-9(7-19-14(8)21-12)20-15(22)13-10(17)3-2-4-11(13)18/h2-7H,1H3,(H,19,21)(H,20,22)
InChiKey: INHKTKGJEIKALZ-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	SRC proto-oncogene, non-receptor tyrosine kinase	Starlite/ChEMBL	No references
Homo sapiens	ABL proto-oncogene 1, non-receptor tyrosine kinase	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase Yrk, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase ABL1	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus granulosus	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK/ABL protein kinase	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus multilocularis	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	protein-tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K08892 fyn-related kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Lyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase ABL1	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase ABL1, putative	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131234	All targets in OG5_131234
Brugia malayi	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Tyrosine-protein kinase transforming protein Abl, putative	Get druggable targets OG5_131234	All targets in OG5_131234
Brugia malayi	Tyrosine-protein kinase abl-1	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus granulosus	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Tyrosine-protein kinase transforming protein Abl, putative	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Srms	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FGR, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Abl	Get druggable targets OG5_131234	All targets in OG5_131234
Echinococcus multilocularis	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	inositol monophosphatase 1	0.0038	0.0156	0.0334
Schistosoma mansoni	tyrosine kinase	0.0251	0.1957	0.8238
Onchocerca volvulus	Alhambra homolog	0.003	0.009	0.0055
Brugia malayi	Tyrosine-protein kinase abl-1	0.0154	0.1134	0.1134
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0054	0.0289	0.062
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0063	0.0063
Plasmodium vivax	geranylgeranyl transferase type2 beta subunit, putative	0.0044	0.0207	1
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0063	0.0063
Trypanosoma cruzi	sterol 24-c-methyltransferase, putative	0.0372	0.2971	0.2971
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0054	0.0289	0.0423
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0068	0.0407	1
Echinococcus granulosus	transcription factor Dp 1	0.0039	0.0167	0.0358
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.022	0.0322
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0026	0.0055	0.0055
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0054	0.0289	0.062
Brugia malayi	hypothetical protein	0.0612	0.4997	0.4997
Trypanosoma cruzi	phospholipase A2-like protein, putative	0.015	0.1098	0.1098
Echinococcus granulosus	lysine specific demethylase 5A	0.0097	0.0654	0.1403
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.0361	0.1521
Onchocerca volvulus		0.0047	0.023	0.0338
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0361	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0572	0.4664	1
Loa Loa (eye worm)	hypothetical protein	0.0181	0.136	0.136
Echinococcus granulosus	vesicular acetylcholine transporter	0.022	0.1691	0.3626
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0062	0.0361	0.0775
Loa Loa (eye worm)	hypothetical protein	0.0612	0.4997	0.4997
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0306	0.0306
Schistosoma mansoni	nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)	0.0025	0.0046	0.0192
Schistosoma mansoni	sex comb on midleg homolog	0.0049	0.0249	0.1048
Schistosoma mansoni	phd/f-box containing protein	0.0026	0.0055	0.023
Brugia malayi	Phospholipase A2 family protein	0.0181	0.136	0.136
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.0194	0.9394
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.022	0.022
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.0044	0.0207	0.0207
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0063	0.0264
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.0194	0.5372
Echinococcus multilocularis	musashi	0.0027	0.0063	0.0092
Toxoplasma gondii	Rab geranylgeranyl transferase type II beta subunit, putative	0.0044	0.0207	0.5719
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0054	0.0289	0.062
Plasmodium vivax	JmjC domain containing protein	0.0026	0.0055	0.2643
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0026	0.0055	0.008
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0054	0.0289	0.0423
Echinococcus granulosus	histone acetyltransferase KAT2B	0.014	0.1018	0.2183
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.026	0.2026	0.296
Plasmodium vivax	farnesyltransferase beta subunit, putative	0.0044	0.0207	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0054	0.0289	0.0423
Trypanosoma cruzi	lanosterol synthase, putative	0.051	0.4138	0.4138
Trypanosoma brucei	Sterol methyltransferase, putative	0.0372	0.2971	0.2971
Onchocerca volvulus		0.0326	0.2588	0.5118
Brugia malayi	PHD-finger family protein	0.003	0.009	0.009
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.0361	0.1521
Echinococcus multilocularis	PHD finger protein rhinoceros	0.003	0.009	0.0131
Leishmania major	hypothetical protein, conserved	0.0026	0.0055	0.0055
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0	0.5
Echinococcus multilocularis	lysine specific demethylase 5A	0.0097	0.0654	0.0956
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0038	0.0156	0.4312
Trypanosoma brucei	sterol 24-c-methyltransferase, putative	0.0372	0.2971	0.2971
Trypanosoma cruzi	C-14 sterol reductase, putative	0.0099	0.0675	0.0675
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0056	0.0306	0.1288
Loa Loa (eye worm)	hypothetical protein	0.0616	0.5031	0.5031
Loa Loa (eye worm)	inositol-1	0.0038	0.0156	0.0156
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0068	0.0407	0.0407
Trypanosoma cruzi	C-14 sterol reductase, putative	0.0099	0.0675	0.0675
Plasmodium vivax	hypothetical protein, conserved	0.003	0.009	0.435
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0044	0.0207	1
Echinococcus multilocularis	inositol monophosphatase 1	0.0038	0.0156	0.0228
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0038	0.0156	0.4312
Schistosoma mansoni	hypothetical protein	0.0047	0.023	0.0967
Schistosoma mansoni	hypothetical protein	0.0037	0.0148	0.0621
Brugia malayi	S-adenosyl-methionine cycloartenol-C24-methyltransferase	0.0181	0.1364	0.1364
Echinococcus granulosus	histone acetyltransferase MYST2	0.0056	0.0306	0.0656
Schistosoma mansoni	tyrosine kinase	0.0054	0.0289	0.1218
Schistosoma mansoni	geranylgeranyl transferase type II beta subunit	0.0044	0.0207	0.087
Toxoplasma gondii	aldehyde dehydrogenase	0.0062	0.0361	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0043	0.0203	0.0434
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.003	0.009	0.0378
Trichomonas vaginalis	inositol monophosphatase, putative	0.0038	0.0156	0.7539
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.0044	0.0207	0.5719
Entamoeba histolytica	hypothetical protein	0.0037	0.0148	0.3624
Echinococcus granulosus	SAM and MBT domain containing protein	0.0049	0.0249	0.0534
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.022	0.0927
Echinococcus granulosus	PHD finger protein rhinoceros	0.003	0.009	0.0193
Plasmodium falciparum	geranylgeranyl transferase type2 beta subunit, putative	0.0044	0.0207	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0207	0.0207
Trichomonas vaginalis	dullard protein, putative	0.0025	0.0046	0.2202
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0054	0.0289	0.0423
Echinococcus multilocularis		0.0025	0.0046	0.0067
Trypanosoma cruzi	Emopamil binding protein, putative	0.03	0.2368	0.2368
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0056	0.0306	0.0447
Trypanosoma cruzi	sterol C-24 reductase, putative	0.0052	0.0272	0.0272
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.0044	0.0207	0.0207
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0068	0.0407	0.0407
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0046	0.0222	0.0324
Trypanosoma cruzi	sterol 24-c-methyltransferase, putative	0.0372	0.2971	0.2971
Loa Loa (eye worm)	jmjC domain-containing protein	0.0026	0.0055	0.0055
Loa Loa (eye worm)	jmjC domain-containing protein	0.0097	0.0654	0.0654
Trypanosoma brucei	phospholipase A1, putative	0.0326	0.2588	0.2588
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0059	0.0059
Loa Loa (eye worm)	platelet-activating factor acetylhydrolase	0.0326	0.2588	0.2588
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0148	0.0216
Schistosoma mansoni	Lamin B receptor (ERG24)	0.0099	0.0675	0.2841
Giardia lamblia	Prenyltransferase	0.0044	0.0207	1
Echinococcus granulosus	JmjC domain containing protein 4	0.0026	0.0055	0.0117
Echinococcus multilocularis	jumonji domain containing protein	0.0042	0.0189	0.0276
Brugia malayi	jmjC domain containing protein	0.0026	0.0055	0.0055
Echinococcus multilocularis	Rab geranylgeranyltransferase, beta subunit	0.0044	0.0207	0.0302
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0068	0.0407	0.0407
Plasmodium falciparum	geranylgeranyltransferase, putative	0.0044	0.0207	1
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.0194	0.9394
Brugia malayi	SRC-1	0.0054	0.0289	0.0289
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0063	0.0063
Brugia malayi	hypothetical protein	0.0228	0.1764	0.1764
Loa Loa (eye worm)	jmjC domain-containing protein	0.0062	0.036	0.036
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0056	0.0306	0.0656
Brugia malayi	jmjC domain containing protein	0.0097	0.0654	0.0654
Trypanosoma cruzi	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.03	0.2368	0.2368
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0114	0.0796	0.1162
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0207	0.0207
Echinococcus multilocularis	lamin dm0	0.0027	0.0063	0.0092
Onchocerca volvulus	Phospholipase A2 homolog	0.0181	0.136	0.2628
Entamoeba histolytica	hypothetical protein	0.0037	0.0148	0.3624
Loa Loa (eye worm)	jmjC domain-containing protein	0.0026	0.0055	0.0055
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0056	0.0306	0.0306
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0044	0.0207	1
Echinococcus multilocularis	jumonji domain containing 1A	0.0026	0.0055	0.008
Loa Loa (eye worm)	jmjC domain-containing protein	0.0026	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0063	0.0063
Brugia malayi	jmjC domain containing protein	0.0026	0.0055	0.0055
Onchocerca volvulus	Phospholipase A2 homolog	0.0519	0.4215	0.8415
Plasmodium vivax	NLI interacting factor-like phosphatase, putative	0.0025	0.0046	0.2202
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0043	0.0043
Trypanosoma cruzi	phospholipase A2-like protein, putative	0.015	0.1098	0.1098
Trypanosoma brucei	protein farnesyltransferase beta subunit	0.0044	0.0207	0.0207
Onchocerca volvulus		0.0326	0.2588	0.5118
Schistosoma mansoni	hypothetical protein	0.003	0.009	0.0378
Trypanosoma cruzi	sterol 24-c-methyltransferase, putative	0.0372	0.2971	0.2971
Schistosoma mansoni	lamin	0.0027	0.0063	0.0264
Echinococcus granulosus	tyrosine kinase	0.0046	0.0222	0.0476
Onchocerca volvulus		0.0612	0.4997	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0097	0.0654	0.2754
Plasmodium falciparum	phd finger protein, putative	0.003	0.009	0.435
Echinococcus multilocularis	survival motor neuron protein 1	0.0228	0.1764	0.2576
Echinococcus multilocularis	peregrin	0.0034	0.012	0.0175
Entamoeba histolytica	geranylgeranyl transferase beta subunit	0.0044	0.0207	0.5077
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0026	0.0055	0.023
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0046	0.0046
Echinococcus granulosus	lamin dm0	0.0027	0.0063	0.0135
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0097	0.0654	0.2754
Trichomonas vaginalis	geranylgeranyl transferase type beta subunit, putative	0.0044	0.0207	1
Plasmodium vivax	NLI interacting factor-like phosphatase, putative	0.0025	0.0046	0.2202
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.0044	0.0207	1
Entamoeba histolytica	NLI interacting factor-like phosphatase domain-containing protein	0.0025	0.0046	0.1118
Brugia malayi	Bromodomain containing protein	0.0034	0.012	0.012
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0054	0.0289	0.062
Loa Loa (eye worm)	PHD-finger family protein	0.003	0.009	0.009
Entamoeba histolytica	hypothetical protein	0.0037	0.0148	0.3624
Echinococcus multilocularis	polycomb protein SCMH1	0.0049	0.0249	0.0364
Brugia malayi	protein-tyrosine kinase	0.0046	0.0222	0.0222
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.0194	0.5372
Leishmania major	hypothetical protein, conserved	0.0025	0.0046	0.0046
Giardia lamblia	Histone acetyltransferase GCN5	0.0039	0.0164	0.7952
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0026	0.0055	0.0055
Schistosoma mansoni	nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)	0.0025	0.0046	0.0192
Leishmania major	lanosterol synthase, putative	0.0466	0.3768	0.3768
Entamoeba histolytica	protein farnesyltransferase beta subunit, putative	0.0044	0.0207	0.5077
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.022	0.022
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0043	0.0203	0.0296
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0026	0.0055	0.1511
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0034	0.0122	0.5
Loa Loa (eye worm)	hypothetical protein	0.003	0.009	0.009
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0038	0.0156	0.3827
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0054	0.0289	0.062
Schistosoma mansoni	inositol monophosphatase	0.0038	0.0156	0.0656
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0068	0.0407	0.0407
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0049	0.0249	0.1048
Echinococcus multilocularis	phd:f box containing protein	0.0026	0.0055	0.008
Trypanosoma brucei	C-14 sterol reductase, putative	0.0099	0.0675	0.0675
Trypanosoma cruzi	hypothetical protein, conserved	0.0025	0.0046	0.0046
Toxoplasma gondii	Dullard family phosphatase domain-containing protein	0.0025	0.0046	0.126
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0044	0.0207	0.0207
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.022	0.0472
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.022	0.0472
Schistosoma mansoni	jumonji domain containing protein	0.0026	0.0055	0.023
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0049	0.0249	0.0364
Trypanosoma cruzi	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.03	0.2368	0.2368
Schistosoma mansoni	lamin	0.0027	0.0063	0.0264
Trichomonas vaginalis	protein farnesyltransferase beta subunit, putative	0.0044	0.0207	1
Echinococcus granulosus	peregrin	0.0034	0.012	0.0257
Brugia malayi	Inositol-1	0.0038	0.0156	0.0156
Leishmania major	phospholipase A1, putative	0.0326	0.2588	0.2588
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.0044	0.0207	0.087
Loa Loa (eye worm)	hypothetical protein	0.0519	0.4215	0.4215
Brugia malayi	jmjC domain containing protein	0.0026	0.0055	0.0055
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0026	0.0055	0.2643
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0068	0.0407	0.1714
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0044	0.0207	0.0207
Trypanosoma brucei	sterol 24-c-methyltransferase, putative	0.0372	0.2971	0.2971
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0156	0.0156
Brugia malayi	Cytochrome P450 family protein	0.0022	0.0026	0.0026
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0062	0.0361	0.1509
Loa Loa (eye worm)	TK protein kinase	0.0038	0.0153	0.0153
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.022	0.1691	0.1691
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0056	0.0306	0.0447
Schistosoma mansoni	tyrosine kinase	0.0054	0.0289	0.1218
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0038	0.0153	0.0224
Echinococcus multilocularis	geranylgeranyl transferase type I beta subunit	0.0044	0.0207	0.0302
Trichomonas vaginalis	dullard protein, putative	0.0025	0.0046	0.2202
Brugia malayi	vesicular acetylcholine transporter unc-17	0.022	0.1691	0.1691
Schistosoma mansoni	protein farnesyltransferase subunit beta	0.0044	0.0207	0.087
Trichomonas vaginalis	dullard protein, putative	0.0025	0.0046	0.2202
Brugia malayi	Tyrosine-protein kinase abl-1	0.0114	0.0796	0.0796
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0156	0.0156
Echinococcus granulosus	geranylgeranyl transferase type I beta subunit	0.0044	0.0207	0.0443
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0026	0.0055	0.0055
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0361	1
Leishmania major	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.03	0.2368	0.2368
Echinococcus multilocularis	lysine specific demethylase 6a	0.0026	0.0055	0.008
Echinococcus multilocularis	protein farnesyltransferase subunit beta	0.0044	0.0207	0.0302
Trypanosoma cruzi	Emopamil binding protein, putative	0.03	0.2368	0.2368
Brugia malayi	jmjC domain containing protein	0.0026	0.0055	0.0055
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0038	0.0156	1
Brugia malayi	Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1	0.0025	0.0046	0.0046
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.022	0.0322
Schistosoma mansoni	vesicular acetylcholine transporter	0.022	0.1691	0.7119
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	0.0025	0.0046	0.2202
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.0044	0.0207	0.0207
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.0044	0.0207	0.087
Loa Loa (eye worm)	hypothetical protein	0.0228	0.1764	0.1764
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.0044	0.0207	1
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0068	0.0407	0.0407
Loa Loa (eye worm)	hypothetical protein	0.1205	1	1
Leishmania major	hypothetical protein, conserved	0.03	0.2368	0.2368
Echinococcus multilocularis	lamin	0.0027	0.0063	0.0092
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0044	0.0207	1
Loa Loa (eye worm)	SRC-1	0.0054	0.0289	0.0289
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.009	0.2488
Leishmania major	C-8 sterol isomerase-like protein	0.1205	1	1
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	0.022	0.1691	0.33
Leishmania major	sterol 24-c-methyltransferase, putative	0.0372	0.2971	0.2971
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0049	0.0249	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0659	0.0659
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.0044	0.0207	0.5719
Entamoeba histolytica	hypothetical protein	0.0037	0.0148	0.3624
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0062	0.0361	0.0361
Brugia malayi	intermediate filament protein	0.0027	0.0063	0.0063
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0054	0.0289	0.0423
Loa Loa (eye worm)	mbt repeat family protein	0.0049	0.0249	0.0249
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0054	0.0289	0.0423
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0038	0.0156	0.7539
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0197	0.1494	0.3204
Brugia malayi	mbt repeat family protein	0.0049	0.0249	0.0249
Echinococcus multilocularis	JmjC domain containing protein 4	0.0026	0.0055	0.008
Loa Loa (eye worm)	MBCTL1	0.0056	0.0306	0.0306
Plasmodium falciparum	protein farnesyltransferase subunit beta	0.0044	0.0207	1
Echinococcus granulosus	lamin	0.0027	0.0063	0.0135
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.0044	0.0207	0.0207
Onchocerca volvulus		0.0049	0.0249	0.0377
Loa Loa (eye worm)	cytochrome P450 family protein	0.0022	0.0026	0.0026
Brugia malayi	Platelet-activating factor acetylhydrolase, plasma/intracellular isoform II family protein	0.0326	0.2588	0.2588
Leishmania major	farnesyltransferase beta subunit	0.0044	0.0207	0.0207
Trypanosoma brucei	Mitochondrial import inner membrane translocase subunit TIM50	0.0025	0.0046	0.0046
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.0194	0.0416
Echinococcus granulosus	lamin b receptor	0.0099	0.0675	0.1447
Loa Loa (eye worm)	hypothetical protein	0.0181	0.1364	0.1364
Leishmania major	C-14 sterol reductase, putative	0.0099	0.0675	0.0675
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0197	0.1494	0.2183
Plasmodium falciparum	NLI interacting factor-like phosphatase, putative	0.0025	0.0046	0.2202
Trichomonas vaginalis	type I geranylgeranyltransferase beta subunit, putative	0.0044	0.0207	1
Leishmania major	sterol 24-c-methyltransferase, putative	0.0372	0.2971	0.2971
Trypanosoma cruzi	phospholipase A1, putative	0.0326	0.2588	0.2588
Echinococcus granulosus	polycomb protein SCMH1	0.0049	0.0249	0.0534
Echinococcus multilocularis	lamin b receptor	0.0099	0.0675	0.0986
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0054	0.0289	0.062
Echinococcus granulosus	jumonji domain containing 1A	0.0026	0.0055	0.0117
Schistosoma mansoni	survival motor neuron protein	0.0047	0.023	0.0967
Loa Loa (eye worm)	TK/ABL protein kinase	0.026	0.2026	0.2026
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.0194	0.9394
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0055	0.0055
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0068	0.0407	0.0407
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0572	0.4664	0.6814
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0272	0.0272
Echinococcus granulosus	survival motor neuron protein 1	0.0228	0.1764	0.3781
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0046	0.0222	0.0324
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.1205	1	1
Leishmania major	geranylgeranyltransferase, putative	0.0044	0.0207	0.0207
Schistosoma mansoni	phosphatidylserine receptor	0.0026	0.0055	0.023
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0038	0.0156	0.7539
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0148	0.0621
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0054	0.0289	0.0423
Schistosoma mansoni	hypothetical protein	0.0024	0.0043	0.0181
Schistosoma mansoni	hypothetical protein	0.0301	0.2376	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.022	0.0927
Trypanosoma brucei	C-8 sterol isomerase, putative	0.1205	1	1
Trypanosoma cruzi	sterol C-24 reductase, putative	0.0052	0.0272	0.0272
Onchocerca volvulus		0.03	0.2368	0.4671
Trypanosoma cruzi	geranylgeranyl transferase type II beta subunit, putative	0.0044	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0249	0.0249
Giardia lamblia	Nuclear LIM interactor-interacting factor 1	0.0025	0.0046	0.2202
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	0.0025	0.0046	0.2202
Echinococcus granulosus	phd:f box containing protein	0.0026	0.0055	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0055	0.0055
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0156	0.0156
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0068	0.0407	0.0595
Entamoeba histolytica	protein kinase, putative	0.0038	0.0153	0.3758
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0144	0.1052	0.443
Trypanosoma cruzi	phospholipase A1, putative	0.0326	0.2588	0.2588
Mycobacterium tuberculosis	Halimadienyl diphosphate synthase	0.0303	0.2396	1
Trypanosoma brucei	sterol 24-c-methyltransferase, putative	0.0194	0.1471	0.1471
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.022	0.0927
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0144	0.1052	0.1538
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0026	0.0055	0.0117
Echinococcus multilocularis	Carboxy terminal domain RNA polymerase II	0.0025	0.0046	0.0067
Trypanosoma cruzi	lanosterol synthase, putative	0.051	0.4138	0.4138
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0407	0.0407
Brugia malayi	acetyltransferase, GNAT family protein	0.0144	0.1052	0.1052
Echinococcus granulosus	jumonji domain containing protein	0.0042	0.0189	0.0405
Brugia malayi	hypothetical protein	0.0037	0.0148	0.0148
Echinococcus multilocularis	transcription factor Dp 1	0.0039	0.0167	0.0244
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.0207	0.0207
Echinococcus granulosus	intermediate filament protein	0.0027	0.0063	0.0135
Brugia malayi	Probable protein farnesyltransferase beta subunit, putative	0.0044	0.0207	0.0207
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0034	0.0122	0.0511
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0148	0.0316
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0054	0.0289	0.0423
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0831	0.6845	1
Brugia malayi	jmjC domain containing protein	0.0159	0.1177	0.1177
Schistosoma mansoni	protein phosphatase 2C	0.0026	0.0055	0.023
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	0.0025	0.0046	0.2202
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0159	0.1177	0.2524
Echinococcus granulosus	protein farnesyltransferase subunit beta	0.0044	0.0207	0.0443
Schistosoma mansoni	inositol monophosphatase	0.0038	0.0156	0.0656
Brugia malayi	mbt repeat family protein	0.0049	0.0249	0.0249
Giardia lamblia	Rab geranylgeranyltransferase	0.0044	0.0207	1
Entamoeba histolytica	Rab geranylgeranyltransferase beta subunit, putative	0.0044	0.0207	0.5077
Echinococcus granulosus	tyrosine protein kinase ABL1	0.026	0.2026	0.4344
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.009	0.2488
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0054	0.0289	0.0423
Loa Loa (eye worm)	TK protein kinase	0.0046	0.0222	0.0222
Echinococcus granulosus	tyrosine protein kinase HCK	0.0038	0.0153	0.0328
Echinococcus granulosus	Carboxy terminal domain RNA polymerase II	0.0025	0.0046	0.0098
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.023	0.023
Leishmania major	sterol C-24 reductase, putative	0.0052	0.0272	0.0272
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0068	0.0407	0.0873
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0156	0.0156
Schistosoma mansoni	jumonji domain containing protein	0.0139	0.1007	0.4237
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0046	0.0222	0.0476
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0054	0.0289	0.062
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0361	1
Plasmodium vivax	geranylgeranyltransferase, putative	0.0044	0.0207	1
Schistosoma mansoni	sex comb on midleg homolog	0.0049	0.0249	0.1048
Echinococcus multilocularis	vesicular acetylcholine transporter	0.022	0.1691	0.2471
Onchocerca volvulus		0.0326	0.2588	0.5118
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0046	0.0222	0.0324
Loa Loa (eye worm)	acetyltransferase	0.0144	0.1052	0.1052
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0026	0.0055	0.1511
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0062	0.0361	0.0528
Echinococcus granulosus	tyrosine protein kinase Blk	0.0046	0.0222	0.0476
Echinococcus granulosus	lysine specific demethylase 6a	0.0026	0.0055	0.0117
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.0207	0.0207
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	0.0025	0.0046	0.2202
Trichomonas vaginalis	protein farnesyltransferase beta subunit, putative	0.0044	0.0207	1
Trypanosoma brucei	lanosterol synthase	0.051	0.4138	0.4138
Giardia lamblia	PHD finger protein 15	0.003	0.009	0.435
Trypanosoma brucei	Emopamil binding protein, putative	0.03	0.2368	0.2368
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0054	0.0289	0.062
Entamoeba histolytica	acetyltransferase, GNAT family	0.0039	0.0164	0.4037
Plasmodium falciparum	histone acetyltransferase GCN5	0.0039	0.0164	0.7952
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0159	0.1177	0.172
Trypanosoma brucei	geranylgeranyl transferase type II beta subunit, putative	0.0044	0.0207	0.0207
Echinococcus granulosus	CTD small phosphatase protein like	0.0025	0.0046	0.0098

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 29 nM	Inhibition of Src kinase (unknown origin)	ChEMBL.	No reference
IC50 (binding)	= 37 nM	Inhibition of Abl kinase (unknown origin)	ChEMBL.	No reference
Inhibition (binding)	= 97 %	Inhibition of Src kinase (unknown origin) at 10 uM	ChEMBL.	No reference
Inhibition (binding)	= 97 %	Inhibition of Abl kinase (unknown origin) at 10 uM	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3347637

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 924985