Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | androgen receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | RNA binding protein | 0.0063 | 0.3204 | 0.3204 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0176 | 1 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0176 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0176 | 1 | 0.5 |
Echinococcus multilocularis | zinc finger protein Ran binding | 0.0063 | 0.3204 | 0.3204 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.3204 | 0.3204 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0176 | 1 | 1 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0063 | 0.3204 | 0.5 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0063 | 0.3204 | 0.3204 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0063 | 0.3204 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.3204 | 0.3204 |
Plasmodium vivax | hypothetical protein, conserved | 0.0176 | 1 | 0.5 |
Onchocerca volvulus | 0.0063 | 0.3204 | 0.3204 | |
Onchocerca volvulus | 0.0063 | 0.3204 | 0.3204 | |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0176 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0063 | 0.3204 | 0.5 |
Onchocerca volvulus | 0.0176 | 1 | 1 | |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0176 | 1 | 1 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0176 | 1 | 0.5 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0063 | 0.3204 | 0.5 |
Echinococcus multilocularis | Nuclear pore complex protein Nup153 | 0.0063 | 0.3204 | 0.3204 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0176 | 1 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0176 | 1 | 1 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.0063 | 0.3204 | 0.3204 |
Schistosoma mansoni | brg-1 associated factor | 0.0176 | 1 | 1 |
Onchocerca volvulus | 0.0063 | 0.3204 | 0.3204 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0063 | 0.3204 | 0.5 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0063 | 0.3204 | 0.3204 |
Echinococcus granulosus | ring and YY1 binding protein | 0.0063 | 0.3204 | 0.3204 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0063 | 0.3204 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.3204 | 0.3204 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0063 | 0.3204 | 0.3204 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0176 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0063 | 0.3204 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.3204 | 0.3204 |
Schistosoma mansoni | fusion | 0.0063 | 0.3204 | 0.3204 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0176 | 1 | 1 |
Brugia malayi | brahma associated protein 60 kDa | 0.0176 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.3204 | 0.3204 |
Leishmania major | hypothetical protein, conserved | 0.0063 | 0.3204 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0063 | 0.3204 | 0.5 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0176 | 1 | 1 |
Loa Loa (eye worm) | brahma associated protein | 0.0176 | 1 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0063 | 0.3204 | 0.3204 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0063 | 0.3204 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0063 | 0.3204 | 0.5 |
Chlamydia trachomatis | SWIB complex protein | 0.0176 | 1 | 0.5 |
Onchocerca volvulus | 0.0063 | 0.3204 | 0.3204 | |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0176 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 1 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0063 | 0.3204 | 0.5 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0063 | 0.3204 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.3204 | 0.3204 |
Echinococcus granulosus | Zinc finger RanBP2 type | 0.0063 | 0.3204 | 0.3204 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0063 | 0.3204 | 0.5 |
Echinococcus granulosus | zinc finger protein Ran binding | 0.0063 | 0.3204 | 0.3204 |
Onchocerca volvulus | Ubiquitin thioesterase ZRANB1 homolog | 0.0063 | 0.3204 | 0.3204 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0176 | 1 | 1 |
Brugia malayi | YY1-associated factor 2 | 0.0063 | 0.3204 | 0.3204 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0176 | 1 | 0.5 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0063 | 0.3204 | 0.5 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0063 | 0.3204 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 1 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0063 | 0.3204 | 0.3204 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0063 | 0.3204 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0063 | 0.3204 | 0.5 |
Echinococcus multilocularis | Zinc finger, RanBP2 type | 0.0063 | 0.3204 | 0.3204 |
Echinococcus multilocularis | ring and YY1 binding protein | 0.0063 | 0.3204 | 0.3204 |
Echinococcus granulosus | Nuclear pore complex protein Nup153 | 0.0063 | 0.3204 | 0.3204 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0063 | 0.3204 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 0.93 nM | Agonist activity at human androgen receptor expressed in mouse C2C12 cells by androgen-specific response element-driven luciferase reporter gene assay | ChEMBL. | 25121964 |
Emax (binding) | = 82 % | Agonist activity at human androgen receptor expressed in mouse C2C12 cells by androgen-specific response element-driven luciferase reporter gene assay relative to DHT | ChEMBL. | 25121964 |
Jss (ADMET) | = 1.1 ug/cm2.hr | Skin permeability in human cadaver skin in Franz diffusion cell system | ChEMBL. | 25121964 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.