Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0026 | 0.0151 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0038 | 0.0276 | 0.0581 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0094 | 0.0166 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0.0174 | 0.4979 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0038 | 0.0276 | 0.0581 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0026 | 0.0151 | 0.3145 |
Entamoeba histolytica | hypothetical protein | 0.0026 | 0.0151 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.1479 | 0.4559 |
Brugia malayi | Pre-SET motif family protein | 0.0034 | 0.0232 | 0.0604 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0898 | 0.275 |
Mycobacterium ulcerans | pyruvate kinase | 0.0038 | 0.0276 | 0.0581 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0196 | 0.0563 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0431 | 0.4794 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0.0174 | 0.4398 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0147 | 0.1479 | 0.1479 |
Echinococcus multilocularis | muscleblind protein | 0.0147 | 0.1479 | 0.1479 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0196 | 0.0491 |
Leishmania major | pyruvate kinase | 0.0038 | 0.0276 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.0431 | 0.1294 |
Onchocerca volvulus | 0.0034 | 0.0232 | 0.0119 | |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0094 | 0.1044 |
Mycobacterium ulcerans | dTDP-6-deoxy-L-lyxo-4-hexulose reductase RmlD | 0.0244 | 0.2558 | 0.7864 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.0094 | 0.1038 |
Echinococcus granulosus | pyruvate kinase | 0.0038 | 0.0276 | 0.0489 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0524 | 0.5642 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0147 | 0.1479 | 0.2622 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0232 | 0.2582 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0196 | 0.0491 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0232 | 0.2582 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0174 | 0.4398 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0276 | 0.0811 |
Trichomonas vaginalis | DTDP-4-dehydrorhamnose 3,5-epimerase, putative | 0.0305 | 0.3227 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.0196 | 0.0196 |
Echinococcus granulosus | neuropeptide s receptor | 0.0524 | 0.5642 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.0431 | 0.1228 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0026 | 0.0151 | 0.0961 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0026 | 0.015 | 0.0418 |
Echinococcus granulosus | pyruvate kinase | 0.0038 | 0.0276 | 0.0489 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.0174 | 0.4979 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0094 | 0.0094 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0094 | 0.0245 |
Echinococcus multilocularis | pyruvate kinase | 0.0038 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0174 | 0.0494 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0026 | 0.0151 | 0.3857 |
Brugia malayi | Muscleblind-like protein | 0.0147 | 0.1479 | 0.4518 |
Mycobacterium tuberculosis | dTDP-6-deoxy-L-lyxo-4-hexulose reductase RmlD (dTDP-rhamnose modification protein) (dTDP-rhamnose biosynthesis protein) (dTDP-rh | 0.0244 | 0.2558 | 0.7864 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0038 | 0.0276 | 1 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0026 | 0.0151 | 0.3857 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.0431 | 0.0763 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0026 | 0.015 | 0.974 |
Echinococcus multilocularis | lamin | 0.0031 | 0.0196 | 0.0196 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0038 | 0.0276 | 0.0581 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0174 | 0.0422 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0034 | 0.0232 | 0.0232 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0034 | 0.0232 | 0.0232 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0026 | 0.0151 | 0.3145 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0026 | 0.0151 | 0.0183 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0305 | 0.3227 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0094 | 0.1038 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.0196 | 0.0347 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.0431 | 0.0431 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0038 | 0.0276 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0038 | 0.0276 | 0.0811 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0021 | 0.0019 |
Mycobacterium tuberculosis | dTDP-4-dehydrorhamnose 3,5-epimerase RmlC (dTDP-4-keto-6-deoxyglucose 3,5-epimerase) (dTDP-L-rhamnose synthetase) (thymidine dip | 0.0305 | 0.3227 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0174 | 0.4979 |
Plasmodium vivax | pyruvate kinase, putative | 0.0038 | 0.0276 | 1 |
Echinococcus multilocularis | musashi | 0.0031 | 0.0196 | 0.0196 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.1479 | 0.4559 |
Onchocerca volvulus | 0.0305 | 0.3227 | 1 | |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.0174 | 0.4398 |
Mycobacterium ulcerans | dTDP-4-dehydrorhamnose 3,5-epimerase, RmlC | 0.0305 | 0.3227 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.019 | 0.0543 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0094 | 0.0898 | 0.2695 |
Trichomonas vaginalis | NAD dependent epimerase/dehydratase, putative | 0.0244 | 0.2558 | 0.7864 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.0196 | 0.0347 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0038 | 0.0276 | 0.0264 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0038 | 0.0276 | 0.0264 |
Schistosoma mansoni | pyruvate kinase | 0.0038 | 0.0276 | 0.307 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0038 | 0.0276 | 0.0406 |
Plasmodium falciparum | pyruvate kinase | 0.0038 | 0.0276 | 1 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0094 | 0.0898 | 1 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0094 | 0.0898 | 0.1592 |
Chlamydia trachomatis | pyruvate kinase | 0.0038 | 0.0276 | 1 |
Schistosoma mansoni | lamin | 0.0031 | 0.0196 | 0.218 |
Echinococcus multilocularis | pyruvate kinase | 0.003 | 0.0188 | 0.0188 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0026 | 0.0151 | 0.3857 |
Onchocerca volvulus | Huntingtin homolog | 0.0139 | 0.1391 | 0.3942 |
Giardia lamblia | Pyruvate kinase | 0.0038 | 0.0276 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0034 | 0.0232 | 0.784 |
Onchocerca volvulus | 0.0268 | 0.2821 | 0.8661 | |
Echinococcus multilocularis | pyruvate kinase | 0.0019 | 0.0073 | 0.0073 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0015 | 0.0021 | 0.0021 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0431 | 0.4794 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0038 | 0.0276 | 0.0742 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0026 | 0.0151 | 0.0183 |
Echinococcus granulosus | pyruvate kinase | 0.0019 | 0.0073 | 0.0129 |
Brugia malayi | dTDP-4-dehydrorhamnose 3,5-epimerase | 0.0305 | 0.3227 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0038 | 0.0276 | 0.0276 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0174 | 0.4398 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0196 | 0.0563 |
Leishmania major | pyruvate kinase | 0.0038 | 0.0276 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0094 | 0.1038 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0174 | 0.4979 |
Mycobacterium leprae | dTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC (dTDP-4-KETO-6-DEOXYGLUCOSE 3,5-EPIMERASE) (dTDP-L-RHAMNOSE SYNTHETASE) (THYMIDINE DIP | 0.0305 | 0.3227 | 1 |
Onchocerca volvulus | 0.0094 | 0.0898 | 0.2318 | |
Trypanosoma brucei | pyruvate kinase 1 | 0.0038 | 0.0276 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0038 | 0.0276 | 0.0264 |
Mycobacterium leprae | dTDP-6-deoxy-L-lyxo-4-hexulose reductase RmlD (dTDP-RHAMNOSE MODIFICATION PROTEIN) (dTDP-RHAMNOSE BIOSYNTHESIS PROTEIN) (dTDP-RH | 0.0169 | 0.1727 | 0.5123 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0038 | 0.0276 | 1 |
Brugia malayi | hypothetical protein | 0.0139 | 0.1391 | 0.424 |
Echinococcus granulosus | lamin | 0.0031 | 0.0196 | 0.0347 |
Echinococcus granulosus | pyruvate kinase | 0.0019 | 0.0073 | 0.0129 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0034 | 0.0232 | 0.784 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0038 | 0.0276 | 0.0742 |
Trichomonas vaginalis | set domain proteins, putative | 0.0268 | 0.2821 | 0.8705 |
Schistosoma mansoni | pyruvate kinase | 0.0038 | 0.0276 | 0.307 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0431 | 0.4794 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.015 | 0.0418 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0094 | 0.1038 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.0039 | 0.0075 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0026 | 0.0151 | 0.0183 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0034 | 0.0232 | 0.2582 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0034 | 0.0232 | 0.0411 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0232 | 0.0675 |
Loa Loa (eye worm) | pyruvate kinase | 0.0038 | 0.0276 | 0.0811 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0038 | 0.0276 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0236 | 0.2461 | 0.7599 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.1391 | 0.4283 |
Echinococcus granulosus | pyruvate kinase | 0.0019 | 0.0073 | 0.0129 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0062 | 0.0072 |
Onchocerca volvulus | Huntingtin homolog | 0.0139 | 0.1391 | 0.3942 |
Echinococcus multilocularis | pyruvate kinase | 0.0019 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | pyruvate kinase | 0.0038 | 0.0276 | 0.0811 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0524 | 0.5642 | 0.5642 |
Loa Loa (eye worm) | dTDP-4-dehydrorhamnose 3,5-epimerase | 0.0305 | 0.3227 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0236 | 0.2461 | 0.7617 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.0431 | 0.0431 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.0196 | 0.218 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0196 | 0.0563 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.0431 | 0.0763 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0026 | 0.0151 | 0.3857 |
Schistosoma mansoni | pyruvate kinase | 0.0019 | 0.0073 | 0.081 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0524 | 0.5642 | 0.5642 |
Echinococcus multilocularis | pyruvate kinase | 0.0019 | 0.0073 | 0.0073 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0094 | 0.0898 | 0.0898 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0232 | 0.2582 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0094 | 0.0171 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0033 | 0.0218 | 0.0387 |
Trichomonas vaginalis | NAD dependent epimerase/dehydratase, putative | 0.0136 | 0.1359 | 0.4037 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.1391 | 0.4283 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0094 | 0.1044 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0015 | 0.0021 | 0.0038 |
Schistosoma mansoni | lamin | 0.0031 | 0.0196 | 0.218 |
Wolbachia endosymbiont of Brugia malayi | nucleoside-diphosphate-sugar epimerase | 0.0075 | 0.069 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 12.3 uM | Antiproliferative activity against human DU145 cells after 3 days by fluorescence assay | ChEMBL. | 25155551 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.