Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Alpha amylase, catalytic domain containing protein | 0.0087 | 1 | 1 |
Toxoplasma gondii | 1,4-alpha-glucan-branching enzyme | 0.0021 | 0 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.0087 | 1 | 1 |
Trichomonas vaginalis | amylase, putative | 0.0021 | 0 | 0.5 |
Chlamydia trachomatis | glycogen hydrolase | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.0087 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0021 | 0 | 0.5 |
Mycobacterium tuberculosis | Trehalose synthase TreS | 0.0087 | 1 | 1 |
Toxoplasma gondii | Alpha-amylase AMY3, putative | 0.0021 | 0 | 0.5 |
Entamoeba histolytica | oligo-1,6-glucosidase, putative | 0.0087 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0021 | 0 | 0.5 |
Toxoplasma gondii | glycosyltransferase | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.0087 | 1 | 1 |
Mycobacterium leprae | Putative uncharacterized protein ML2045 | 0.0087 | 1 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | alpha amylase | 0.0087 | 1 | 1 |
Chlamydia trachomatis | 1,4-alpha-glucan branching enzyme | 0.0021 | 0 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0021 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable alpha-glucosidase AglA (maltase) (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidas | 0.0087 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0021 | 0 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | alpha glucosidase | 0.0087 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0021 | 0 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | alpha amylase | 0.0087 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | alpha glucosidase | 0.0087 | 1 | 1 |
Schistosoma mansoni | alpha-amylase | 0.0087 | 1 | 1 |
Trichomonas vaginalis | starch branching enzyme II, putative | 0.0021 | 0 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.0087 | 1 | 1 |
Giardia lamblia | 1,4-alpha-glucan branching enzyme | 0.0021 | 0 | 0.5 |
Trichomonas vaginalis | amylase, putative | 0.0021 | 0 | 0.5 |
Trichomonas vaginalis | amylase, putative | 0.0021 | 0 | 0.5 |
Toxoplasma gondii | alpha amylase, catalytic domain-containing protein | 0.0021 | 0 | 0.5 |
Trichomonas vaginalis | amylase, putative | 0.0021 | 0 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0021 | 0 | 0.5 |
Mycobacterium ulcerans | trehalose synthase TreS | 0.0087 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0021 | 0 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0021 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ratio (binding) | = 0.7 /M/s | Inhibition of recombinant Plasmodium falciparum GAPDH expressed in Escherichia coli assessed as ratio of kinact to Ki by Kitz-Wilson double-reciprocal plot | ChEMBL. | 25137375 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.