Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 404 uM | Cytotoxicity against human THP1 cells | ChEMBL. | 25173828 |
IC50 (functional) | = 66.6 uM | Antiparasitic activity against promastigote stage of Leishmania infantum infected in THP1 cells assessed as parasite growth inhibition after 24 hrs by hemocytometery | ChEMBL. | 25173828 |
IC50 (functional) | > 842.6 uM | Antiparasitic activity against epimastigote stage of Trypanosoma cruzi infected in Vero cells assessed as parasite growth inhibition after 24 hrs by hemocytometery | ChEMBL. | 25173828 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.