Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Dengue virus 2 | Genome polyprotein | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | 1,4-alpha-glucan branching enzyme | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | alpha amylase | 0.0073 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0017 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable alpha-glucosidase AglA (maltase) (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidas | 0.0073 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0017 | 0 | 0.5 |
Mycobacterium leprae | Putative uncharacterized protein ML2045 | 0.0073 | 1 | 0.5 |
Entamoeba histolytica | oligo-1,6-glucosidase, putative | 0.0073 | 1 | 1 |
Toxoplasma gondii | Alpha-amylase AMY3, putative | 0.0017 | 0 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.0073 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0017 | 0 | 0.5 |
Toxoplasma gondii | glycosyltransferase | 0.0017 | 0 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0017 | 0 | 0.5 |
Mycobacterium tuberculosis | Trehalose synthase TreS | 0.0073 | 1 | 1 |
Chlamydia trachomatis | glycogen hydrolase | 0.0017 | 0 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.0073 | 1 | 1 |
Schistosoma mansoni | alpha-amylase | 0.0073 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0017 | 0 | 0.5 |
Toxoplasma gondii | 1,4-alpha-glucan-branching enzyme | 0.0017 | 0 | 0.5 |
Trichomonas vaginalis | amylase, putative | 0.0017 | 0 | 0.5 |
Brugia malayi | Alpha amylase, catalytic domain containing protein | 0.0073 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0017 | 0 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0017 | 0 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0017 | 0 | 0.5 |
Trichomonas vaginalis | amylase, putative | 0.0017 | 0 | 0.5 |
Mycobacterium ulcerans | trehalose synthase TreS | 0.0073 | 1 | 1 |
Toxoplasma gondii | alpha amylase, catalytic domain-containing protein | 0.0017 | 0 | 0.5 |
Giardia lamblia | 1,4-alpha-glucan branching enzyme | 0.0017 | 0 | 0.5 |
Trichomonas vaginalis | amylase, putative | 0.0017 | 0 | 0.5 |
Trichomonas vaginalis | amylase, putative | 0.0017 | 0 | 0.5 |
Trichomonas vaginalis | starch branching enzyme II, putative | 0.0017 | 0 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.0073 | 1 | 1 |
Schistosoma mansoni | alpha-amylase | 0.0073 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0017 | 0 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0017 | 0 | 0.5 |
Echinococcus multilocularis | alpha glucosidase | 0.0073 | 1 | 1 |
Loa Loa (eye worm) | alpha amylase | 0.0073 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0017 | 0 | 0.5 |
Echinococcus granulosus | alpha glucosidase | 0.0073 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0017 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0017 | 0 | 0.5 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0017 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.4 uM | Inhibition of Dengue virus serotype 2 NS2B-NS3 protease by homogeneous fluorimetric assay | ChEMBL. | 25221663 |
Inhibition (binding) | = 7.9 % | Inhibition of thrombin (unknown origin) at 25 uM by homogeneous fluorimetric assay | ChEMBL. | 25221663 |
Inhibition (binding) | = 12.9 % | Inhibition of West Nile virus serotype 2 NS2B-NS3 protease at 50 uM by homogeneous fluorimetric assay | ChEMBL. | 25221663 |
Inhibition (binding) | = 82.3 % | Inhibition of Dengue virus serotype 2 NS2B-NS3 protease at 50 uM by homogeneous fluorimetric assay | ChEMBL. | 25221663 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.