Detailed information for compound 931447

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 408.399 | Formula: C19H22F2N4O4
  • H donors: 3 H acceptors: 3 LogP: 3.32 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CO[C@@H]1CC[C@H](CC1)NC(=O)c1n[nH]cc1NC(=O)c1ccc(cc1)OC(F)F
  • InChi: 1S/C19H22F2N4O4/c1-28-13-8-4-12(5-9-13)23-18(27)16-15(10-22-25-16)24-17(26)11-2-6-14(7-3-11)29-19(20)21/h2-3,6-7,10,12-13,19H,4-5,8-9H2,1H3,(H,22,25)(H,23,27)(H,24,26)/t12-,13-
  • InChiKey: GDUUTLYCUXTGQM-JOCQHMNTSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycogen synthase kinase 3 alpha References
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References
Homo sapiens cyclin A2 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 3 References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi major cysteine proteinase, putative 0.0048 0.0836 0.0333
Leishmania major cathepsin L-like protease 0.0223 0.6499 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0117 0.305 0.305
Brugia malayi cathepsin Z-like cysteine proteinase 0.0048 0.0836 0.0333
Loa Loa (eye worm) hypothetical protein 0.0052 0.0942 0.0942
Loa Loa (eye worm) hypothetical protein 0.0048 0.0836 0.0836
Echinococcus multilocularis cathepsin b 0.0331 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0996 0.1365
Leishmania major cathepsin L-like protease 0.0223 0.6499 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0136 0.367 0.5269
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0734 0.0225
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0048 0.0836 0.0333
Entamoeba histolytica protein kinase, putative 0.0117 0.305 0.4231
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.0996 0.0501
Brugia malayi Papain family cysteine protease containing protein 0.0048 0.0836 0.0333
Brugia malayi Papain family cysteine protease containing protein 0.0119 0.3132 0.2754
Giardia lamblia Cathepsin L precursor 0.0048 0.0836 0.1001
Brugia malayi Papain family cysteine protease containing protein 0.0048 0.0836 0.0333
Echinococcus granulosus protein kinase shaggy 0.0117 0.305 0.2668
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0053 0.0996 0.0794
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0048 0.0836 0.1115
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0048 0.0836 0.0333
Toxoplasma gondii cathepsin CPL 0.0223 0.6499 1
Trypanosoma brucei cdc2-related kinase 1 0.0053 0.0996 0.0794
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.0996 0.0996
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0996 0.0501
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.0996 0.0501
Plasmodium vivax glycogen synthase kinase 3, putative 0.0117 0.305 0.3909
Brugia malayi cathepsin L precursor 0.0048 0.0836 0.0333
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0048 0.0836 0.0333
Entamoeba histolytica protein kinase domain containing protein 0.0117 0.305 0.4231
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.0996 0.0794
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0223 0.6499 1
Leishmania major cathepsin L-like protease 0.0223 0.6499 1
Giardia lamblia Cathepsin B precursor 0.0136 0.367 1
Entamoeba histolytica cysteine protease, putative 0.0119 0.3132 0.4368
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0836 0.1115
Entamoeba histolytica cysteine protease, putative 0.0119 0.3132 0.4368
Giardia lamblia Kinase, CMGC GSK 0.0117 0.305 0.8029
Giardia lamblia Cysteine protease 0.0048 0.0836 0.1001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0223 0.6499 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0223 0.6499 0.6306
Brugia malayi Cathepsin L-like precursor 0.0223 0.6499 0.6306
Brugia malayi cathepsin F-like cysteine proteinase 0.0048 0.0836 0.0333
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0048 0.0836 0.1115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0223 0.6499 1
Giardia lamblia Hypothetical protein 0.0048 0.0836 0.1001
Trichomonas vaginalis cyclin A, putative 0.0039 0.0521 0.062
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0223 0.6499 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0048 0.0836 0.0528
Brugia malayi Cathepsin L-like precursor 0.0152 0.4203 0.3885
Echinococcus granulosus cathepsin b 0.0331 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0836 0.1115
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0223 0.6499 1
Leishmania major cathepsin L-like protease 0.0223 0.6499 1
Brugia malayi Cathepsin L-like precursor 0.0223 0.6499 0.6306
Entamoeba histolytica cysteine proteinase, putative 0.0119 0.3132 0.4368
Giardia lamblia Cathepsin L precursor 0.0048 0.0836 0.1001
Plasmodium vivax vivapain-2 0.0223 0.6499 1
Entamoeba histolytica hypothetical protein 0.0048 0.0836 0.0528
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.0996 0.0501
Trypanosoma cruzi major cysteine proteinase, putative 0.0048 0.0836 0.0333
Schistosoma mansoni cathepsin S (C01 family) 0.0048 0.0836 0.0333
Brugia malayi Cathepsin L-like precursor 0.0223 0.6499 0.6306
Loa Loa (eye worm) hypothetical protein 0.0039 0.0521 0.0521
Loa Loa (eye worm) hypothetical protein 0.0048 0.0836 0.0836
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0053 0.0996 0.0501
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0331 1 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.1567 0.1567
Loa Loa (eye worm) hypothetical protein 0.0331 1 1
Plasmodium falciparum protein kinase 5 0.0053 0.0996 0.0282
Giardia lamblia Encystation-specific protease 0.0048 0.0836 0.1001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0223 0.6499 1
Giardia lamblia Cathepsin L precursor 0.0048 0.0836 0.1001
Trichomonas vaginalis cyclin B, putative 0.0039 0.0521 0.062
Entamoeba histolytica cysteine protease, putative 0.0223 0.6499 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0048 0.0836 0.0333
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0223 0.6499 1
Plasmodium vivax vivapain-2 0.0223 0.6499 1
Entamoeba histolytica cysteine protease, putative 0.0048 0.0836 0.0528
Giardia lamblia Cysteine protease 0.0048 0.0836 0.1001
Entamoeba histolytica cysteine protease, putative 0.0048 0.0836 0.0528
Giardia lamblia Cathepsin L precursor 0.0048 0.0836 0.1001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0223 0.6499 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0119 0.3132 0.2754
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0119 0.3132 0.2754
Trypanosoma cruzi cysteine peptidase, putative 0.0223 0.6499 0.6306
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0223 0.6499 1
Onchocerca volvulus 0.0223 0.6499 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0048 0.0836 0.0333
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0048 0.0836 0.1115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.4203 0.6398
Loa Loa (eye worm) fibroinase 0.0223 0.6499 0.6499
Giardia lamblia Cathepsin B precursor 0.0136 0.367 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0734 0.0225
Echinococcus multilocularis cyclin dependent kinase 0.0053 0.0996 0.0501
Entamoeba histolytica cysteine protease, putative 0.0119 0.3132 0.4368
Trypanosoma brucei cdc2-related kinase 3 0.0053 0.0996 0.0794
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0223 0.6499 1
Entamoeba histolytica cysteine proteinase, putative 0.0119 0.3132 0.4368
Echinococcus granulosus cathepsin b 0.0331 1 1
Trypanosoma cruzi cysteine protease, putative 0.0119 0.3132 0.2754
Plasmodium vivax protein kinase Crk2 0.0053 0.0996 0.0282
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0223 0.6499 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0048 0.0836 0.1001
Plasmodium falciparum cysteine proteinase falcipain 1 0.0119 0.3132 0.4054
Plasmodium falciparum glycogen synthase kinase 3 0.0117 0.305 0.3909
Plasmodium vivax unspecified product 0.0071 0.1567 0.1291
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0223 0.6499 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0223 0.6499 1
Giardia lamblia Cathepsin L-like protease 0.0048 0.0836 0.1001
Loa Loa (eye worm) cathepsin B 0.0136 0.367 0.367
Loa Loa (eye worm) hypothetical protein 0.0152 0.4203 0.4203
Echinococcus granulosus cathepsin L cysteine proteinase 0.0223 0.6499 0.6306
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0223 0.6499 0.6306
Echinococcus granulosus cyclin dependent kinase 0.0053 0.0996 0.0501
Giardia lamblia Cathepsin L precursor 0.0048 0.0836 0.1001
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0331 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0223 0.6499 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0048 0.0836 0.0333
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0053 0.0996 0.0794
Echinococcus granulosus cathepsin L cysteine protease 0.0119 0.3132 0.2754
Onchocerca volvulus 0.0223 0.6499 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0223 0.6499 1
Entamoeba histolytica cysteine protease, putative 0.0048 0.0836 0.0528
Entamoeba histolytica cysteine proteinase, putative 0.0119 0.3132 0.4368
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0223 0.6499 1
Entamoeba histolytica cysteine protease, putative 0.0119 0.3132 0.4368
Entamoeba histolytica cysteine proteinase, putative 0.0223 0.6499 1
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0996 0.1365
Giardia lamblia Cathepsin B precursor 0.0048 0.0836 0.1001
Schistosoma mansoni cathepsin F (C01 family) 0.0152 0.4203 0.3885
Echinococcus multilocularis cathepsin L cysteine protease 0.0223 0.6499 0.6306
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0836 0.1115
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0048 0.0836 0.1115
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0136 0.367 0.3323
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.4203 0.6398
Plasmodium vivax vivapain-1 0.0119 0.3132 0.4054
Echinococcus multilocularis cathepsin L 0.0119 0.3132 0.2754
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0836 0.1115
Loa Loa (eye worm) hypothetical protein 0.0048 0.0836 0.0836
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0836 0.1115
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0048 0.0836 0.0333
Entamoeba histolytica cysteine proteinase, putative 0.0152 0.4203 0.616
Trypanosoma cruzi cysteine peptidase, putative 0.0223 0.6499 0.6306
Giardia lamblia Cysteine protease 0.0048 0.0836 0.1001
Entamoeba histolytica cysteine protease, putative 0.0119 0.3132 0.4368
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0117 0.305 0.2668
Giardia lamblia Kinase, CMGC CDK 0.0053 0.0996 0.1508
Loa Loa (eye worm) hypothetical protein 0.0152 0.4203 0.4203
Echinococcus multilocularis protein kinase shaggy 0.0117 0.305 0.2668
Echinococcus multilocularis cathepsin b 0.0331 1 1
Giardia lamblia Cathepsin L-like protease 0.0048 0.0836 0.1001
Echinococcus granulosus cyclin dependent kinase 5 0.0053 0.0996 0.0501
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0119 0.3132 0.4717
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0136 0.367 0.3323
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0223 0.6499 1
Trichomonas vaginalis cyclin B, putative 0.0039 0.0521 0.062
Loa Loa (eye worm) hypothetical protein 0.0048 0.0836 0.0836
Loa Loa (eye worm) cysteine protease 0.0223 0.6499 0.6499
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0071 0.1567 0.1104
Echinococcus granulosus cyclin dependent kinase 1 0.0053 0.0996 0.0501
Brugia malayi cathepsin L-like cysteine proteinase 0.0048 0.0836 0.0333
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0223 0.6499 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0119 0.3132 0.2754
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0048 0.0836 0.0836
Onchocerca volvulus 0.0223 0.6499 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0048 0.0836 0.1115
Giardia lamblia Kinase, CMGC GSK 0.0117 0.305 0.8029
Leishmania major cathepsin L-like protease 0.0223 0.6499 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0048 0.0836 0.1115
Trypanosoma cruzi cysteine peptidase, putative 0.0119 0.3132 0.2754
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0223 0.6499 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0331 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0223 0.6499 0.6306
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0048 0.0836 0.0836
Trichomonas vaginalis cyclins, putative 0.0039 0.0521 0.062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0119 0.3132 0.4368
Brugia malayi Cathepsin L-like precursor 0.0071 0.1567 0.1104
Entamoeba histolytica cysteine protease, putative 0.0119 0.3132 0.4368
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0223 0.6499 1
Brugia malayi cell division control protein 2 homolog 0.0053 0.0996 0.0501
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0734 0.0225
Brugia malayi Cathepsin L-like precursor 0.0223 0.6499 0.6306
Brugia malayi Cathepsin L-like precursor 0.0223 0.6499 0.6306
Echinococcus granulosus cathepsin l1 0.0223 0.6499 0.6306
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0223 0.6499 1
Schistosoma mansoni cathepsin B (C01 family) 0.0048 0.0836 0.0333
Brugia malayi Cathepsin L-like cysteine proteinase 0.0152 0.4203 0.3885
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0734 0.0225
Echinococcus granulosus cysteine protease 0.0119 0.3132 0.2754
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0048 0.0836 0.1001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0734 0.0225
Onchocerca volvulus 0.0223 0.6499 1
Trypanosoma brucei protein kinase, putative 0.0117 0.305 0.4231
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.0996 0.0501
Schistosoma mansoni cathepsin F (C01 family) 0.0223 0.6499 0.6306
Entamoeba histolytica cysteine protease, putative 0.0119 0.3132 0.4368
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0996 0.0501
Trypanosoma cruzi cruzipain precursor, putative 0.0071 0.1567 0.1104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0836 0.1115
Loa Loa (eye worm) hypothetical protein 0.0071 0.1567 0.1567
Trichomonas vaginalis CMGC family protein kinase 0.0117 0.305 0.4588
Entamoeba histolytica cysteine proteinase, putative 0.0223 0.6499 1
Trichomonas vaginalis cyclin B, putative 0.0039 0.0521 0.062
Onchocerca volvulus Cathepsin F homolog 0.0223 0.6499 1
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.1567 0.1104
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0996 0.1365
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0223 0.6499 0.6499
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0048 0.0836 0.1115
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0223 0.6499 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0223 0.6499 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0223 0.6499 1
Toxoplasma gondii cathepsin B 0.0136 0.367 0.5005
Entamoeba histolytica cysteine protease, putative 0.0119 0.3132 0.4368
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0048 0.0836 0.0528
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0223 0.6499 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0117 0.305 0.305
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0223 0.6499 1
Entamoeba histolytica cysteine protease, putative 0.0119 0.3132 0.4368
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0117 0.305 0.2668
Onchocerca volvulus 0.0048 0.0836 0.0528
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0223 0.6499 1
Entamoeba histolytica cysteine protease, putative 0.0119 0.3132 0.4368
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0117 0.305 0.3909
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0223 0.6499 1
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.0996 0.0501
Echinococcus multilocularis cysteine protease 0.0223 0.6499 0.6306
Giardia lamblia Cathepsin L precursor 0.0048 0.0836 0.1001
Entamoeba histolytica cysteine proteinase 1, putative 0.0119 0.3132 0.4368
Trypanosoma cruzi cruzipain precursor, putative 0.0223 0.6499 0.6306
Schistosoma mansoni cathepsin s 0.0071 0.1567 0.1104
Trypanosoma cruzi cysteine proteinase, putative 0.0119 0.3132 0.2754
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0048 0.0836 0.1115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0836 0.1115
Leishmania major cysteine peptidase A (CPA) 0.0223 0.6499 1
Echinococcus granulosus cathepsin L 0.0048 0.0836 0.0333
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0836 0.1115
Giardia lamblia Hypothetical protein 0.0048 0.0836 0.1001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0734 0.0225
Plasmodium falciparum cysteine proteinase falcipain 3 0.0223 0.6499 1
Entamoeba histolytica cysteine protease, putative 0.0048 0.0836 0.0528
Schistosoma mansoni cathepsin F (C01 family) 0.0223 0.6499 0.6306
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0734 0.0225
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0223 0.6499 1
Giardia lamblia Kinase, CMGC CDK 0.0053 0.0996 0.1508
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0136 0.367 0.5269
Onchocerca volvulus Cathepsin L homolog 0.0223 0.6499 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0071 0.1567 0.1567
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0734 0.0225
Trypanosoma cruzi cysteine proteinase, putative 0.0119 0.3132 0.2754
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0223 0.6499 1
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0117 0.305 0.4231
Plasmodium vivax unspecified product 0.0119 0.3132 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0119 0.3132 0.4368
Entamoeba histolytica cysteine proteinase 2 0.0119 0.3132 0.4368
Trichomonas vaginalis cyclins, putative 0.0039 0.0521 0.062
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0119 0.3132 0.2754
Leishmania major cathepsin L-like protease 0.0223 0.6499 1
Giardia lamblia Cathepsin B precursor 0.0048 0.0836 0.1001
Giardia lamblia Cathepsin B precursor 0.0048 0.0836 0.1001
Brugia malayi Papain family cysteine protease containing protein 0.0048 0.0836 0.0333
Brugia malayi Protein kinase domain containing protein 0.0053 0.0996 0.0501
Leishmania major cathepsin L-like protease 0.0223 0.6499 1
Entamoeba histolytica cysteine protease, putative 0.0048 0.0836 0.0528
Entamoeba histolytica cysteine protease, putative 0.0048 0.0836 0.0528
Onchocerca volvulus 0.0223 0.6499 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.0996 0.0996
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0136 0.367 0.5562
Trichomonas vaginalis cyclin B, putative 0.0039 0.0521 0.062
Leishmania major cathepsin L-like protease 0.0223 0.6499 1
Brugia malayi fibroinase precursor 0.0048 0.0836 0.0333
Giardia lamblia Cathepsin B precursor 0.0048 0.0836 0.1001
Brugia malayi Papain family cysteine protease containing protein 0.0119 0.3132 0.2754
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0048 0.0836 0.0333
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0048 0.0836 0.0836
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0734 0.0734
Echinococcus multilocularis cathepsin L 0.0048 0.0836 0.0333
Trichomonas vaginalis CMGC family protein kinase 0.0117 0.305 0.4588
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0048 0.0836 0.1115
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0331 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0048 0.0836 0.1115
Loa Loa (eye worm) hypothetical protein 0.0071 0.1567 0.1567
Schistosoma mansoni cathepsin C 0.0048 0.0836 0.0333
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0223 0.6499 1
Echinococcus granulosus cathepsin L 0.0119 0.3132 0.2754
Echinococcus multilocularis cyclin dependent kinase 5 0.0053 0.0996 0.0501
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0331 1 1
Onchocerca volvulus Cathepsin L homolog 0.0048 0.0836 0.0528
Giardia lamblia Cysteine protease 0.0048 0.0836 0.1001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0223 0.6499 1
Entamoeba histolytica protein kinase domain containing protein 0.0117 0.305 0.4231
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0053 0.0996 0.0996
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.0996 0.0501
Loa Loa (eye worm) ctsf protein 0.0223 0.6499 0.6499
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0117 0.305 0.2668
Brugia malayi cathepsin L-like precursor 0.0152 0.4203 0.3885
Echinococcus granulosus cathepsin l cysteine peptidase 0.0223 0.6499 0.6306
Loa Loa (eye worm) hypothetical protein 0.0223 0.6499 0.6499
Loa Loa (eye worm) hypothetical protein 0.0039 0.0521 0.0521
Trichomonas vaginalis cyclins, putative 0.0039 0.0521 0.062
Entamoeba histolytica cysteine protease, putative 0.0119 0.3132 0.4368
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0053 0.0996 0.0282
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0223 0.6499 1
Onchocerca volvulus 0.0152 0.4203 0.616
Onchocerca volvulus 0.0117 0.305 0.4231
Brugia malayi cathepsin F-like cysteine proteinase 0.0071 0.1567 0.1104
Echinococcus multilocularis cysteine protease 0.0223 0.6499 0.6306
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0223 0.6499 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0048 0.0836 0.1115
Entamoeba histolytica cysteine protease, putative 0.0119 0.3132 0.4368
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0048 0.0836 0.0333
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.0996 0.0794
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0119 0.3132 0.4368
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0223 0.6499 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0836 0.0836
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0152 0.4203 0.3885
Loa Loa (eye worm) hypothetical protein 0.0048 0.0836 0.0836
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0223 0.6499 0.6306
Trichomonas vaginalis cyclins, putative 0.0039 0.0521 0.062
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0048 0.0836 0.1001
Trypanosoma cruzi cysteine peptidase, putative 0.0223 0.6499 0.6306
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0223 0.6499 1
Giardia lamblia Cathepsin B precursor 0.0136 0.367 1
Brugia malayi intracellular kinase 0.0117 0.305 0.2668
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0119 0.3132 0.4717
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0223 0.6499 0.6499
Trypanosoma cruzi cysteine peptidase, putative 0.0223 0.6499 0.6306
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0223 0.6499 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0048 0.0836 0.1001
Echinococcus granulosus cathepsin l1 0.0152 0.4203 0.3885
Plasmodium vivax vivapain-3 0.0119 0.3132 0.4054
Brugia malayi Cathepsin L-like precursor 0.0152 0.4203 0.3885
Onchocerca volvulus Cathepsin L homolog 0.0223 0.6499 1
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0117 0.305 0.2668
Brugia malayi Cathepsin L-like precursor 0.0223 0.6499 0.6306
Onchocerca volvulus 0.0223 0.6499 1
Onchocerca volvulus 0.0223 0.6499 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0048 0.0836 0.0333
Loa Loa (eye worm) hypothetical protein 0.0152 0.4203 0.4203
Entamoeba histolytica cysteine protease, putative 0.0119 0.3132 0.4368
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0048 0.0836 0.0333
Giardia lamblia Cathepsin B precursor 0.0048 0.0836 0.1001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0223 0.6499 1

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 1.1 uM Trypanocidal activity against bloodstream stage of Trypanosoma brucei brucei assessed as inhibition of proliferation after 72 hrs ChEMBL. 25198388
EC50 (ADMET) = 2.5 uM Cytotoxicity against human MRC5 cells assessed as growth inhibition after 72 hrs ChEMBL. 25198388
IC50 (binding) < 0.005 uM Inhibition of human GSK3 using biotinylated GSP2 substrate by flashplate assay ChEMBL. 25198388
IC50 (binding) = 0.27 uM Inhibition of human CDK2/cyclin A using Biotin-C6-PKTPKKAKKL substrate ChEMBL. 25198388

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Trypanosoma brucei gambiense 25198388
Homo sapiens ChEMBL23 25198388

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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