Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | cysteine proteinase, putative | 0.0119 | 0.0274 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0165 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0308 | 0.2688 | 0.2688 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0119 | 0.0274 | 0.1018 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0181 | 0.1064 | 0.1064 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Plasmodium vivax | vivapain-2 | 0.0165 | 0.086 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0882 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0882 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0165 | 0.086 | 0.086 |
Loa Loa (eye worm) | tyrosinase 1 | 0.0181 | 0.1064 | 0.0812 |
Onchocerca volvulus | 0.0181 | 0.1064 | 1 | |
Entamoeba histolytica | cysteine protease, putative | 0.0165 | 0.086 | 1 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0308 | 0.2688 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0308 | 0.2688 | 0.5 |
Schistosoma mansoni | tyrosinase precursor | 0.0181 | 0.1064 | 0.1064 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0165 | 0.086 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0165 | 0.086 | 0.086 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0165 | 0.086 | 0.086 |
Echinococcus multilocularis | cathepsin b | 0.0882 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0165 | 0.086 | 0.3201 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0165 | 0.086 | 0.0603 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.086 | 0.0603 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0165 | 0.086 | 0.086 |
Loa Loa (eye worm) | cysteine protease | 0.0165 | 0.086 | 0.0603 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0181 | 0.1064 | 0.1064 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0165 | 0.086 | 0.086 |
Giardia lamblia | Cathepsin B precursor | 0.0308 | 0.2688 | 0.5 |
Toxoplasma gondii | cathepsin B | 0.0308 | 0.2688 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0165 | 0.086 | 0.3201 |
Echinococcus granulosus | cathepsin l1 | 0.0119 | 0.0274 | 0.0274 |
Schistosoma mansoni | tyrosinase precursor | 0.0181 | 0.1064 | 0.1064 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0165 | 0.086 | 0.086 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0165 | 0.086 | 0.3201 |
Echinococcus granulosus | cathepsin l1 | 0.0165 | 0.086 | 0.086 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0165 | 0.086 | 0.3201 |
Loa Loa (eye worm) | fibroinase | 0.0165 | 0.086 | 0.0603 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0308 | 0.2688 | 1 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0181 | 0.1064 | 0.0812 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0165 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Onchocerca volvulus | Cathepsin L homolog | 0.0165 | 0.086 | 0.7426 |
Brugia malayi | ShTK domain containing protein | 0.0181 | 0.1064 | 0.1064 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.1064 | 0.0812 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0165 | 0.086 | 0.086 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0119 | 0.0274 | 0.0274 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.0119 | 0.0274 | 0.0274 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0165 | 0.086 | 0.086 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0882 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0165 | 0.086 | 0.086 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0882 | 1 | 1 |
Onchocerca volvulus | 0.0181 | 0.1064 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0165 | 0.086 | 0.086 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0165 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Onchocerca volvulus | 0.0165 | 0.086 | 0.7426 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0165 | 0.086 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0165 | 0.086 | 0.086 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0181 | 0.1064 | 0.1064 |
Onchocerca volvulus | 0.0165 | 0.086 | 0.7426 | |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0165 | 0.086 | 1 |
Onchocerca volvulus | 0.0165 | 0.086 | 0.7426 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0181 | 0.1064 | 0.0812 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.0119 | 0.0274 | 0.0274 |
Onchocerca volvulus | 0.0165 | 0.086 | 0.7426 | |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.1064 | 0.0812 |
Brugia malayi | Cathepsin L-like precursor | 0.0165 | 0.086 | 0.086 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0882 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0165 | 0.086 | 0.086 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0165 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.0165 | 0.086 | 0.086 |
Loa Loa (eye worm) | ctsf protein | 0.0165 | 0.086 | 0.0603 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0165 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Onchocerca volvulus | 0.0165 | 0.086 | 0.7426 | |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0308 | 0.2688 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0119 | 0.0274 | 0.0274 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0165 | 0.086 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0165 | 0.086 | 0.7426 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0165 | 0.086 | 0.0603 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0165 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0181 | 0.1064 | 0.1064 |
Onchocerca volvulus | 0.0181 | 0.1064 | 1 | |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0165 | 0.086 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Onchocerca volvulus | 0.0181 | 0.1064 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0165 | 0.086 | 0.086 |
Onchocerca volvulus | 0.0165 | 0.086 | 0.7426 | |
Echinococcus granulosus | cathepsin b | 0.0882 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0882 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0308 | 0.2688 | 0.2688 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0165 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0165 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0119 | 0.0274 | 0.1018 |
Loa Loa (eye worm) | hypothetical protein | 0.0882 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0165 | 0.086 | 0.086 |
Onchocerca volvulus | Cathepsin L homolog | 0.0165 | 0.086 | 0.7426 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0165 | 0.086 | 0.3201 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0882 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0165 | 0.086 | 0.086 |
Giardia lamblia | Cathepsin B precursor | 0.0308 | 0.2688 | 0.5 |
Brugia malayi | cathepsin L-like precursor | 0.0119 | 0.0274 | 0.0274 |
Onchocerca volvulus | 0.0165 | 0.086 | 0.7426 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0181 | 0.1064 | 0.1064 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0119 | 0.0274 | 0.0274 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0165 | 0.086 | 0.086 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0165 | 0.086 | 0.3201 |
Loa Loa (eye worm) | cathepsin B | 0.0308 | 0.2688 | 0.2482 |
Plasmodium vivax | vivapain-2 | 0.0165 | 0.086 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0165 | 0.086 | 0.086 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 58 % | Antiinflammatory activity in mouse assessed as reduction in PMA-induced ear edema at 0.1 mg/ear administered topically measured after 24 hrs relative to control | ChEMBL. | 25240256 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.