Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cysteine protease | 0.0529 | 0.1142 | 0.0656 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0529 | 0.1142 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0623 | 0.1534 | 0.503 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.038 | 0.052 | 0.112 |
Onchocerca volvulus | 0.0529 | 0.1142 | 1 | |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0529 | 0.1142 | 0.0934 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0623 | 0.1534 | 0.503 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.038 | 0.052 | 0.0297 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Brugia malayi | Cathepsin L-like precursor | 0.0529 | 0.1142 | 0.0934 |
Onchocerca volvulus | 0.0529 | 0.1142 | 1 | |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0933 | 0.2822 | 0.2822 |
Plasmodium vivax | vivapain-2 | 0.0529 | 0.1142 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0529 | 0.1142 | 0.0934 |
Brugia malayi | Cathepsin L-like precursor | 0.038 | 0.052 | 0.0297 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0623 | 0.1534 | 0.503 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.2658 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Leishmania major | cathepsin L-like protease | 0.0623 | 0.1534 | 0.2332 |
Leishmania major | cathepsin L-like protease | 0.0623 | 0.1534 | 0.2332 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0529 | 0.1142 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Echinococcus multilocularis | cathepsin b | 0.2658 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0529 | 0.1142 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.2658 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0623 | 0.1534 | 0.1534 |
Entamoeba histolytica | cysteine proteinase, putative | 0.038 | 0.052 | 0.3182 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.031 | 0.023 | 0.023 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0529 | 0.1142 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Toxoplasma gondii | cathepsin B | 0.0933 | 0.2822 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0933 | 0.2822 | 0.2653 |
Brugia malayi | Cathepsin L-like precursor | 0.038 | 0.052 | 0.0297 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0623 | 0.1534 | 0.503 |
Onchocerca volvulus | 0.0529 | 0.1142 | 1 | |
Trypanosoma cruzi | cysteine protease, putative | 0.031 | 0.023 | 0.023 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0529 | 0.1142 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0529 | 0.1142 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0529 | 0.1142 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.038 | 0.052 | 0.112 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Loa Loa (eye worm) | hypothetical protein | 0.0529 | 0.1142 | 0.0656 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Echinococcus multilocularis | cysteine protease | 0.0529 | 0.1142 | 0.0934 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0529 | 0.1142 | 0.0934 |
Loa Loa (eye worm) | hypothetical protein | 0.2658 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0623 | 0.1534 | 0.503 |
Brugia malayi | cathepsin L-like precursor | 0.038 | 0.052 | 0.0297 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0623 | 0.1534 | 0.503 |
Loa Loa (eye worm) | cathepsin B | 0.0933 | 0.2822 | 0.2428 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Onchocerca volvulus | 0.0529 | 0.1142 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0529 | 0.1142 | 0.1142 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0529 | 0.1142 | 0.0656 |
Echinococcus granulosus | cathepsin l1 | 0.038 | 0.052 | 0.0297 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0623 | 0.1534 | 0.1534 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0529 | 0.1142 | 0.0656 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0623 | 0.1534 | 0.503 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.031 | 0.023 | 0.023 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0623 | 0.1534 | 0.1534 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Giardia lamblia | Cathepsin B precursor | 0.0933 | 0.2822 | 0.5 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0933 | 0.2822 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0529 | 0.1142 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0623 | 0.1534 | 0.503 |
Onchocerca volvulus | 0.0529 | 0.1142 | 1 | |
Onchocerca volvulus | 0.0529 | 0.1142 | 1 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0529 | 0.1142 | 0.0934 |
Brugia malayi | Cathepsin L-like precursor | 0.0529 | 0.1142 | 0.0934 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0474 | 0.0912 | 0.0912 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0529 | 0.1142 | 0.0934 |
Brugia malayi | Cathepsin L-like precursor | 0.0529 | 0.1142 | 0.0934 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0529 | 0.1142 | 0.0934 |
Echinococcus granulosus | cathepsin b | 0.2658 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.2658 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0623 | 0.1534 | 0.1534 |
Echinococcus multilocularis | cysteine protease | 0.0529 | 0.1142 | 0.0934 |
Giardia lamblia | Cathepsin B precursor | 0.0933 | 0.2822 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0933 | 0.2822 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0529 | 0.1142 | 0.0656 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.038 | 0.052 | 0.0297 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0623 | 0.1534 | 0.503 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0529 | 0.1142 | 0.0934 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.2658 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Onchocerca volvulus | Cathepsin F homolog | 0.0529 | 0.1142 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0529 | 0.1142 | 0.0934 |
Giardia lamblia | Cathepsin B precursor | 0.0933 | 0.2822 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Leishmania major | cathepsin L-like protease | 0.0623 | 0.1534 | 0.2332 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.2658 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0529 | 0.1142 | 0.0934 |
Echinococcus granulosus | cathepsin l1 | 0.0529 | 0.1142 | 0.0934 |
Loa Loa (eye worm) | ctsf protein | 0.0529 | 0.1142 | 0.0656 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0623 | 0.1534 | 0.503 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0529 | 0.1142 | 0.0934 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.031 | 0.023 | 0.023 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.2658 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0933 | 0.2822 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0529 | 0.1142 | 0.0934 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0623 | 0.1534 | 0.503 |
Brugia malayi | Cathepsin L-like precursor | 0.0529 | 0.1142 | 0.0934 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.031 | 0.023 | 0.023 |
Echinococcus granulosus | cathepsin b | 0.2658 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0529 | 0.1142 | 1 |
Onchocerca volvulus | 0.0529 | 0.1142 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 21.8 % | Antidepressant activity in C57BL/6 mouse assessed as decrease in immobility duration at 10 mg/kg, ig by tail suspension test | ChEMBL. | 25442321 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.