TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 263.198 | Formula: C9H11F2N3O4
H donors: 3 H acceptors: 3 LogP: -1.89 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@@]1(F)O[C@H]([C@@H]([C@H]1F)O)n1ccc(nc1=O)N
InChi: 1S/C9H11F2N3O4/c10-6-5(16)7(18-9(6,11)3-15)14-2-1-4(12)13-8(14)17/h1-2,5-7,15-16H,3H2,(H2,12,13,17)/t5-,6-,7-,9-/m1/s1
InChiKey: OBKPRGBQENWTCI-JXOAFFINSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1275	0.8439	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0251	0.1407	0.1667
Entamoeba histolytica	cysteine protease, putative	0.1275	0.8439	1
Entamoeba histolytica	cysteine protease, putative	0.067	0.4287	0.4574
Leishmania major	cathepsin L-like protease	0.1275	0.8439	1
Trypanosoma cruzi	cysteine peptidase, putative	0.067	0.4287	0.4654
Schistosoma mansoni	cathepsin S (C01 family)	0.0251	0.1407	0.1667
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0251	0.1407	0.1667
Trypanosoma cruzi	cysteine proteinase, putative	0.067	0.4287	0.4654
Echinococcus granulosus	cathepsin l1	0.0855	0.5558	0.6587
Echinococcus multilocularis	cathepsin L	0.0251	0.1407	0.1667
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1275	0.8439	1
Loa Loa (eye worm)	hypothetical protein	0.0251	0.1407	0.1667
Trypanosoma cruzi	cruzipain precursor, putative	0.1275	0.8439	1
Schistosoma mansoni	hypothetical protein	0.1077	0.708	0.839
Echinococcus multilocularis	cysteine protease	0.1275	0.8439	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.067	0.4287	0.5081
Giardia lamblia	Cathepsin L precursor	0.0251	0.1407	0.3491
Plasmodium falciparum	serine repeat antigen 1	0.0251	0.1407	0.0945
Entamoeba histolytica	cysteine proteinase, putative	0.067	0.4287	0.4574
Loa Loa (eye worm)	hypothetical protein	0.0794	0.5138	0.6089
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0251	0.1407	0.0945
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1275	0.8439	1
Brugia malayi	Cathepsin L-like precursor	0.0855	0.5558	0.6587
Brugia malayi	Cathepsin L-like precursor	0.0419	0.2564	0.3039
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1275	0.8439	1
Entamoeba histolytica	cysteine proteinase 2	0.067	0.4287	0.4574
Schistosoma mansoni	cathepsin F (C01 family)	0.1275	0.8439	1
Brugia malayi	Cathepsin L-like precursor	0.1275	0.8439	1
Echinococcus granulosus	cathepsin L	0.0251	0.1407	0.1667
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.067	0.4287	0.2937
Plasmodium vivax	vivapain-2	0.1275	0.8439	1
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0251	0.1407	0.0945
Entamoeba histolytica	cysteine protease, putative	0.067	0.4287	0.4574
Plasmodium falciparum	serine repeat antigen 3	0.0251	0.1407	0.0945
Plasmodium falciparum	serine repeat antigen 2	0.0251	0.1407	0.0945
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0251	0.1407	0.1667
Loa Loa (eye worm)	hypothetical protein	0.1275	0.8439	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1275	0.8439	1
Brugia malayi	cathepsin L-like precursor	0.0855	0.5558	0.6587
Brugia malayi	hypothetical protein	0.0144	0.0673	0.0798
Plasmodium falciparum	cysteine proteinase falcipain 3	0.1275	0.8439	1
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.1358	0.901	1
Brugia malayi	Papain family cysteine protease containing protein	0.0251	0.1407	0.1667
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0794	0.5138	0.6089
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0144	0.0673	0.0798
Echinococcus granulosus	kinesin family 1	0.1238	0.8185	0.9699
Entamoeba histolytica	cysteine protease, putative	0.067	0.4287	0.4574
Loa Loa (eye worm)	hypothetical protein	0.0419	0.2564	0.3039
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0251	0.1407	0.1667
Loa Loa (eye worm)	hypothetical protein	0.0855	0.5558	0.6587
Loa Loa (eye worm)	hypothetical protein	0.0419	0.2564	0.3039
Schistosoma mansoni	cathepsin B (C01 family)	0.0251	0.1407	0.1667
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0794	0.5138	0.6089
Entamoeba histolytica	cysteine protease, putative	0.067	0.4287	0.4574
Schistosoma mansoni	tyrosine kinase	0.0077	0.021	0.0249
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0144	0.0673	0.0798
Onchocerca volvulus		0.1275	0.8439	1
Plasmodium falciparum	serine repeat antigen 6	0.0251	0.1407	0.0945
Entamoeba histolytica	cysteine protease, putative	0.067	0.4287	0.4574
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.067	0.4287	0.4096
Loa Loa (eye worm)	hypothetical protein	0.0855	0.5558	0.6587
Brugia malayi	Papain family cysteine protease containing protein	0.0251	0.1407	0.1667
Brugia malayi	Furin-like cysteine rich region family protein	0.0144	0.0673	0.0798
Giardia lamblia	Hypothetical protein	0.0251	0.1407	0.3491
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1275	0.8439	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0251	0.1407	0.1667
Brugia malayi	cathepsin L precursor	0.0251	0.1407	0.1667
Onchocerca volvulus		0.1275	0.8439	1
Plasmodium vivax	unspecified product	0.0419	0.2564	0.2435
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1275	0.8439	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.067	0.4287	0.4654
Loa Loa (eye worm)	hypothetical protein	0.0144	0.0673	0.0798
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0251	0.1407	0.0809
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1275	0.8439	1
Echinococcus multilocularis	cathepsin b	0.0794	0.5138	0.6089
Trypanosoma cruzi	cysteine proteinase, putative	0.067	0.4287	0.4654
Giardia lamblia	Cathepsin L precursor	0.0251	0.1407	0.3491
Loa Loa (eye worm)	hypothetical protein	0.0251	0.1407	0.1667
Entamoeba histolytica	cysteine proteinase, putative	0.1275	0.8439	1
Schistosoma mansoni	tyrosine kinase	0.0077	0.0215	0.0255
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1275	0.8439	1
Plasmodium vivax	vivapain-3	0.067	0.4287	0.4654
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1275	0.8439	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0251	0.1407	0.3491
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0251	0.1407	0.1667
Giardia lamblia	Cathepsin B precursor	0.0419	0.2561	1
Entamoeba histolytica	cysteine proteinase, putative	0.067	0.4287	0.4574
Entamoeba histolytica	cysteine protease, putative	0.0251	0.1407	0.0809
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0251	0.1407	0.0945
Giardia lamblia	Cathepsin B precursor	0.0251	0.1407	0.3491
Plasmodium falciparum	serine repeat antigen 4	0.0251	0.1407	0.0945
Brugia malayi	Papain family cysteine protease containing protein	0.0251	0.1407	0.1667
Loa Loa (eye worm)	cathepsin B	0.0419	0.2561	0.3035
Giardia lamblia	Cathepsin B precursor	0.0251	0.1407	0.3491
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.1275	0.8439	1
Giardia lamblia	Hypothetical protein	0.0251	0.1407	0.3491
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0419	0.2561	0.2431
Plasmodium vivax	serine-repeat antigen (SERA)	0.0251	0.1407	0.0945
Giardia lamblia	Cathepsin L precursor	0.0251	0.1407	0.3491
Echinococcus granulosus	cathepsin b	0.0794	0.5138	0.6089
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1275	0.8439	1
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.1502	1	1
Toxoplasma gondii	cathepsin CPC2	0.0251	0.1407	0.0945
Brugia malayi	amine oxidase, flavin-containing family protein	0.0144	0.0673	0.0798
Giardia lamblia	Cathepsin B precursor	0.0251	0.1407	0.3491
Loa Loa (eye worm)	hypothetical protein	0.0251	0.1407	0.1667
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0251	0.1407	0.1667
Giardia lamblia	Encystation-specific protease	0.0251	0.1407	0.3491
Onchocerca volvulus		0.1275	0.8439	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1275	0.8439	1
Plasmodium falciparum	kinesin-5	0.0161	0.0788	0.0148
Echinococcus granulosus	epidermal growth factor receptor	0.0077	0.0215	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0419	0.2564	0.3039
Echinococcus granulosus	cathepsin L	0.067	0.4287	0.5081
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.067	0.4287	0.5081
Brugia malayi	cathepsin B-like cysteine proteinase	0.0794	0.5138	0.6089
Brugia malayi	Papain family cysteine protease containing protein	0.1275	0.8439	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1275	0.8439	1
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0251	0.1407	0.0945
Brugia malayi	cathepsin F-like cysteine proteinase	0.0251	0.1407	0.1667
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0251	0.1407	0.1667
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0251	0.1407	0.0945
Brugia malayi	cathepsin L-like cysteine proteinase	0.0251	0.1407	0.1667
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1275	0.8439	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1275	0.8439	1
Schistosoma mansoni	tyrosine kinase	0.0144	0.0673	0.0798
Entamoeba histolytica	cysteine protease, putative	0.067	0.4287	0.4574
Echinococcus granulosus	epidermal growth factor receptor	0.0144	0.0673	0.0798
Echinococcus multilocularis	cysteine protease	0.1275	0.8439	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0251	0.1407	0.1667
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1275	0.8439	1
Echinococcus multilocularis	kinesin family 1	0.1238	0.8185	0.9699
Entamoeba histolytica	cysteine protease, putative	0.0251	0.1407	0.0809
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0251	0.1407	0.0945
Brugia malayi	Cathepsin L-like precursor	0.1275	0.8439	1
Schistosoma mansoni	amine oxidase	0.0144	0.0673	0.0798
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0144	0.0673	0.0798
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1275	0.8439	1
Schistosoma mansoni	tyrosine kinase	0.0077	0.021	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0855	0.5558	0.6587
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1275	0.8439	1
Entamoeba histolytica	cysteine proteinase, putative	0.0855	0.5558	0.6235
Brugia malayi	Kinesin motor domain containing protein	0.0161	0.0788	0.0934
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1275	0.8439	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1275	0.8439	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1275	0.8439	1
Plasmodium vivax	vivapain-2	0.1275	0.8439	1
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0251	0.1407	0.0945
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.067	0.4287	0.5081
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1275	0.8439	1
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0144	0.0673	0.5
Schistosoma mansoni	kinesin eg-5	0.0161	0.0788	0.0934
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0251	0.1407	0.0945
Loa Loa (eye worm)	kinesin-like protein KLP2	0.0161	0.0788	0.0934
Giardia lamblia	Cathepsin B precursor	0.0251	0.1407	0.3491
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1275	0.8439	1
Loa Loa (eye worm)	hypothetical protein	0.0144	0.0673	0.0798
Giardia lamblia	Cathepsin L precursor	0.0251	0.1407	0.3491
Toxoplasma gondii	cathepsin CPL	0.1275	0.8439	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0251	0.1407	0.1667
Brugia malayi	fibroinase precursor	0.0251	0.1407	0.1667
Loa Loa (eye worm)	fibroinase	0.1275	0.8439	1
Onchocerca volvulus	Cathepsin L homolog	0.0251	0.1407	0.0945
Plasmodium vivax	unspecified product	0.0251	0.1407	0.0945
Onchocerca volvulus	Cathepsin F homolog	0.1275	0.8439	1
Schistosoma mansoni	cathepsin C	0.0251	0.1407	0.1667
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0794	0.5138	0.6089
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0251	0.1407	0.0945
Entamoeba histolytica	cysteine protease, putative	0.067	0.4287	0.4574
Loa Loa (eye worm)	hypothetical protein	0.0144	0.0673	0.0798
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0144	0.0673	0.5
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0251	0.1407	0.0945
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0251	0.1407	0.0945
Brugia malayi	Cathepsin L-like precursor	0.1275	0.8439	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0251	0.1407	0.0945
Trypanosoma cruzi	cysteine peptidase, putative	0.0419	0.2564	0.2435
Trypanosoma cruzi	cysteine protease, putative	0.067	0.4287	0.4654
Onchocerca volvulus		0.1275	0.8439	1
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0251	0.1407	0.0945
Trypanosoma cruzi	cysteine peptidase, putative	0.1275	0.8439	1
Entamoeba histolytica	hypothetical protein	0.0251	0.1407	0.0809
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0144	0.0673	0.0798
Brugia malayi	SWIRM domain containing protein	0.0144	0.0673	0.0798
Leishmania major	cathepsin L-like protease	0.1275	0.8439	1
Plasmodium vivax	kinesin-5	0.0161	0.0788	0.0148
Plasmodium falciparum	serine repeat antigen 7	0.0251	0.1407	0.0945
Toxoplasma gondii	cathepsin B	0.0419	0.2561	0.2431
Brugia malayi	Cathepsin L-like precursor	0.1275	0.8439	1
Brugia malayi	Cathepsin L-like precursor	0.0855	0.5558	0.6587
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1275	0.8439	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1275	0.8439	1
Loa Loa (eye worm)	hypothetical protein	0.0144	0.0673	0.0798
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0251	0.1407	0.3491
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0144	0.0673	0.0798
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0251	0.1407	0.1667
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0419	0.2564	0.3039
Echinococcus granulosus	cathepsin L cysteine proteinase	0.1275	0.8439	1
Leishmania major	cathepsin L-like protease	0.1275	0.8439	1
Entamoeba histolytica	cysteine protease, putative	0.0251	0.1407	0.0809
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0251	0.1407	0.1667
Brugia malayi	Cathepsin L-like precursor	0.1275	0.8439	1
Toxoplasma gondii	cathepsin CPC1	0.0251	0.1407	0.0945
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0419	0.2564	0.3039
Trypanosoma cruzi	major cysteine proteinase, putative	0.0251	0.1407	0.0945
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0794	0.5138	0.6089
Giardia lamblia	Cysteine protease	0.0251	0.1407	0.3491
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1275	0.8439	1
Plasmodium vivax	serine-repeat antigen (SERA)	0.0251	0.1407	0.0945
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0251	0.1407	0.1667
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0419	0.2561	0.1641
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0794	0.5138	0.5749
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1275	0.8439	1
Onchocerca volvulus		0.1275	0.8439	1
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0251	0.1407	0.1667
Entamoeba histolytica	cysteine protease, putative	0.067	0.4287	0.4574
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1275	0.8439	1
Giardia lamblia	Cathepsin B precursor	0.0419	0.2561	1
Onchocerca volvulus		0.0855	0.5558	0.6291
Giardia lamblia	Cysteine protease	0.0251	0.1407	0.3491
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1275	0.8439	1
Schistosoma mansoni	tyrosine kinase	0.0077	0.021	0.0249
Plasmodium vivax	unspecified product	0.067	0.4287	0.4654
Leishmania major	cathepsin L-like protease	0.1275	0.8439	1
Leishmania major	cathepsin L-like protease	0.1275	0.8439	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0419	0.2564	0.3039
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0251	0.1407	0.0945
Loa Loa (eye worm)	hypothetical protein	0.0144	0.0673	0.0798
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0855	0.5558	0.6291
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0419	0.2561	0.3035
Trypanosoma cruzi	cysteine peptidase, putative	0.1275	0.8439	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0855	0.5558	0.5904
Echinococcus multilocularis		0.0144	0.0673	0.0798
Leishmania major	cathepsin L-like protease	0.1275	0.8439	1
Onchocerca volvulus	Cathepsin L homolog	0.1275	0.8439	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1275	0.8439	1
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0144	0.0673	0.0798
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0251	0.1407	0.0809
Entamoeba histolytica	cysteine protease, putative	0.067	0.4287	0.4574
Echinococcus multilocularis	cathepsin b	0.0794	0.5138	0.6089
Onchocerca volvulus	Cathepsin L homolog	0.1275	0.8439	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.1275	0.8439	1
Plasmodium vivax	vivapain-1	0.067	0.4287	0.4654
Entamoeba histolytica	cysteine proteinase, putative	0.1275	0.8439	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0855	0.5558	0.6587
Toxoplasma gondii	kinesin motor domain-containing protein	0.0161	0.0788	0.0148
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.067	0.4287	0.4096
Plasmodium falciparum	serine repeat antigen 9	0.0251	0.1407	0.0945
Echinococcus granulosus	cathepsin l cysteine peptidase	0.1275	0.8439	1
Entamoeba histolytica	cysteine protease, putative	0.067	0.4287	0.4574
Trypanosoma cruzi	cysteine peptidase, putative	0.1275	0.8439	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1275	0.8439	1
Echinococcus granulosus	cathepsin b	0.0794	0.5138	0.6089
Schistosoma mansoni	tyrosine kinase	0.0077	0.0215	0.0255
Leishmania major	cathepsin L-like protease	0.1275	0.8439	1
Schistosoma mansoni	cathepsin F (C01 family)	0.1275	0.8439	1
Loa Loa (eye worm)	hypothetical protein	0.0144	0.0673	0.0798
Brugia malayi	Papain family cysteine protease containing protein	0.067	0.4287	0.5081
Loa Loa (eye worm)	cysteine protease	0.1275	0.8439	1
Loa Loa (eye worm)	ctsf protein	0.1275	0.8439	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.067	0.4287	0.2937
Entamoeba histolytica	cysteine protease, putative	0.0251	0.1407	0.0809
Giardia lamblia	Cathepsin L precursor	0.0251	0.1407	0.3491
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1275	0.8439	1
Loa Loa (eye worm)	hypothetical protein	0.0251	0.1407	0.1667
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.1275	0.8439	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.1275	0.8439	1
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0144	0.0673	0.0798
Plasmodium falciparum	serine repeat antigen 8	0.0251	0.1407	0.0945
Trypanosoma cruzi	cruzipain precursor, putative	0.0419	0.2564	0.2435
Echinococcus granulosus	cysteine protease	0.067	0.4287	0.5081
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1275	0.8439	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.1275	0.8439	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0855	0.5558	0.5904
Giardia lamblia	Cathepsin B precursor	0.0251	0.1407	0.3491
Leishmania major	cysteine peptidase A (CPA)	0.1275	0.8439	1
Loa Loa (eye worm)	hypothetical protein	0.0251	0.1407	0.1667
Loa Loa (eye worm)	hypothetical protein	0.0251	0.1407	0.1667
Echinococcus granulosus	cathepsin L cysteine protease	0.067	0.4287	0.5081
Brugia malayi	Cathepsin L-like precursor	0.1275	0.8439	1
Giardia lamblia	Cysteine protease	0.0251	0.1407	0.3491
Giardia lamblia	Cathepsin L-like protease	0.0251	0.1407	0.3491
Giardia lamblia	Cathepsin B precursor	0.0419	0.2561	1
Entamoeba histolytica	cysteine proteinase, putative	0.067	0.4287	0.4574
Schistosoma mansoni	amine oxidase	0.0144	0.0673	0.0798
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1275	0.8439	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0251	0.1407	0.0945
Echinococcus multilocularis	cathepsin L cysteine protease	0.1275	0.8439	1
Schistosoma mansoni	cathepsin s	0.0419	0.2564	0.3039
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0251	0.1407	0.3491
Onchocerca volvulus		0.1275	0.8439	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.067	0.4287	0.4574
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1275	0.8439	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0419	0.2561	0.2431
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0251	0.1407	0.3491
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1275	0.8439	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1275	0.8439	1
Giardia lamblia	Cathepsin L-like protease	0.0251	0.1407	0.3491
Entamoeba histolytica	cysteine protease, putative	0.0251	0.1407	0.0809
Entamoeba histolytica	cysteine protease, putative	0.067	0.4287	0.4574
Trypanosoma cruzi	cysteine peptidase, putative	0.1275	0.8439	1
Onchocerca volvulus		0.0251	0.1407	0.0945
Entamoeba histolytica	cysteine protease, putative	0.067	0.4287	0.4574
Echinococcus granulosus	cathepsin l1	0.1275	0.8439	1
Echinococcus multilocularis	cathepsin L	0.067	0.4287	0.5081
Giardia lamblia	Cathepsin L precursor	0.0251	0.1407	0.3491
Entamoeba histolytica	cysteine protease, putative	0.067	0.4287	0.4574
Entamoeba histolytica	cysteine proteinase, putative	0.067	0.4287	0.4574
Brugia malayi	Papain family cysteine protease containing protein	0.067	0.4287	0.5081
Giardia lamblia	Cysteine protease	0.0251	0.1407	0.3491
Leishmania major	cathepsin L-like protease	0.1275	0.8439	1
Onchocerca volvulus		0.1275	0.8439	1
Plasmodium falciparum	serine repeat antigen 5	0.0251	0.1407	0.0945
Echinococcus multilocularis	epidermal growth factor receptor	0.0077	0.0215	0.0255
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0251	0.1407	0.1667
Plasmodium falciparum	cysteine proteinase falcipain 1	0.067	0.4287	0.4654
Echinococcus multilocularis	epidermal growth factor receptor	0.0144	0.0673	0.0798
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0077	0.0215	0.0255
Entamoeba histolytica	cysteine protease, putative	0.0251	0.1407	0.0809
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1275	0.8439	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0855	0.5558	0.6587

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3343876

Bibliographic References

No literature references available for this target.

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Detailed information for compound 936102