Detailed information for compound 938229

Basic information

Technical information
  • TDR Targets ID: 938229
  • Name: 3-[(2-dimethylaminoacetyl)amino]-2-phenyl-N-[ (1S)-1-phenylpropyl]quinoline-4-carboxamide
  • MW: 466.574 | Formula: C29H30N4O2
  • H donors: 2 H acceptors: 3 LogP: 5.35 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC[C@@H](c1ccccc1)NC(=O)c1c(NC(=O)CN(C)C)c(nc2c1cccc2)c1ccccc1
  • InChi: 1S/C29H30N4O2/c1-4-23(20-13-7-5-8-14-20)31-29(35)26-22-17-11-12-18-24(22)30-27(21-15-9-6-10-16-21)28(26)32-25(34)19-33(2)3/h5-18,23H,4,19H2,1-3H3,(H,31,35)(H,32,34)/t23-/m0/s1
  • InChiKey: LHMMQMRETANOJC-QHCPKHFHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(2-dimethylamino-1-oxoethyl)amino]-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide
  • 3-[(2-dimethylaminoacetyl)amino]-2-phenyl-N-[(1S)-1-phenylpropyl]cinchoninamide
  • 3-(2-dimethylaminoethanoylamino)-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tachykinin receptor 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tachykinin peptides receptor 99D Get druggable targets OG5_131969 All targets in OG5_131969
Echinococcus granulosus tachykinin peptides receptor 99D Get druggable targets OG5_131969 All targets in OG5_131969
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.006 0.0138
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0098 0.0315 0.2575
Echinococcus granulosus AMP deaminase 2 0.0027 0.0021 0.0026
Schistosoma mansoni hypothetical protein 0.0104 0.0338 0.0541
Brugia malayi beta-lactamase family protein 0.0037 0.006 0.011
Schistosoma mansoni thyroid hormone receptor 0.0177 0.0639 0.1032
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.006 0.0109
Loa Loa (eye worm) runx1 0.006 0.0155 0.0335
Trypanosoma cruzi thymidine kinase, putative 0.1065 0.4308 1
Brugia malayi hypothetical protein 0.0992 0.4005 1
Onchocerca volvulus 0.0164 0.0587 0.3055
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0151 0.0829
Onchocerca volvulus 0.0037 0.006 0.0207
Schistosoma mansoni hypothetical protein 0.0048 0.0107 0.0165
Brugia malayi beta-NAC-like protein 0.0037 0.0061 0.0112
Echinococcus granulosus inositol monophosphatase 1 0.0076 0.0223 0.0353
Echinococcus multilocularis survival motor neuron protein 1 0.0992 0.4005 0.4001
Onchocerca volvulus Ribonuclease H1 homolog 0.0045 0.0094 0.0391
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0057 0.0144 0.1073
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0061 0.0111
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0189 0.0688 0.1686
Schistosoma mansoni adenosine deaminase 0.0084 0.0256 0.0407
Trypanosoma cruzi PAB1-binding protein , putative 0.013 0.0444 0.0986
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0038 0.0065 0.0109
Echinococcus granulosus thymidine kinase 0.1511 0.6148 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0065 0.0109
Echinococcus multilocularis isocitrate dehydrogenase 0.0065 0.0175 0.017
Mycobacterium ulcerans adenosine deaminase 0.0084 0.0256 0.1781
Trichomonas vaginalis thymidine kinase, putative 0.1065 0.4308 1
Schistosoma mansoni hypothetical protein 0.0315 0.1208 0.1958
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0047 0.0102 0.0189
Brugia malayi adenosine monophosphate deaminase 0.0027 0.0021 0.0014
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0098 0.0315 0.0309
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0058 0.0149 0.0233
Plasmodium vivax adenosine deaminase, putative 0.0084 0.0256 0.2057
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0061 0.0091
Echinococcus granulosus GPCR family 2 0.0048 0.0107 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0061 0.0111
Trypanosoma brucei thymidylate kinase, putative 0.0303 0.1161 0.2694
Plasmodium falciparum plasmepsin II 0.0057 0.0144 0.1073
Echinococcus granulosus Thymidine kinase 2 mitochondrial 0.1511 0.6148 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0065 0.0122
Loa Loa (eye worm) hypothetical protein 0.0104 0.0338 0.0795
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0223 0.047
Echinococcus multilocularis Protein lozenge 0.006 0.0155 0.0149
Schistosoma mansoni inositol monophosphatase 0.0076 0.0223 0.0353
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0102 0.0208
Echinococcus multilocularis AMP deaminase 2 0.0027 0.0021 0.0016
Giardia lamblia Cytidine deaminase 0.0164 0.0587 0.1171
Brugia malayi hypothetical protein 0.013 0.0444 0.1074
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.0688 0.0683
Trichomonas vaginalis cytidine deaminase, putative 0.0164 0.0587 0.1338
Trypanosoma brucei unspecified product 0.0052 0.0123 0.0286
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0463 0.0745
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0038 0.0065 0.0109
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0065 0.0122
Giardia lamblia Deoxynucleoside kinase 0.0416 0.1626 0.3636
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0463 0.0745
Loa Loa (eye worm) hypothetical protein 0.0038 0.0065 0.0109
Loa Loa (eye worm) aspartyl protease 6 0.0057 0.0144 0.0307
Trypanosoma brucei adenosine monophosphate deaminase, putative 0.0027 0.0021 0.005
Brugia malayi beta-lactamase 0.0037 0.006 0.011
Loa Loa (eye worm) hypothetical protein 0.0476 0.1874 0.4651
Loa Loa (eye worm) RNA binding protein 0.0134 0.0463 0.1109
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0048 0.0108 0.0437
Brugia malayi follicle stimulating hormone receptor 0.0248 0.0931 0.2294
Echinococcus granulosus Glycosyl transferase family 35 0.0112 0.037 0.0593
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.017 0.0611 0.1375
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0053 0.0092
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0063 0.0146
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0151 0.0829
Brugia malayi nuclear receptor NHR-88 0.0038 0.0065 0.0122
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0111 0.0105
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0098 0.0315 0.0731
Leishmania major ribonuclease H1, putative 0.0045 0.0094 0.0169
Plasmodium vivax aspartyl proteinase, putative 0.0057 0.0144 0.1073
Toxoplasma gondii aspartyl protease 0.0057 0.0144 0.1073
Leishmania major hypothetical protein, conserved 0.0119 0.04 0.0883
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0063 0.0116
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0098 0.0315 0.0684
Onchocerca volvulus 0.0038 0.0065 0.0233
Brugia malayi Steroid receptor seven-up type 2 0.0038 0.0065 0.0122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0023 0.0024
Brugia malayi hypothetical protein 0.0476 0.1874 0.4659
Loa Loa (eye worm) hypothetical protein 0.0038 0.0065 0.0109
Brugia malayi beta-lactamase family protein 0.0037 0.006 0.011
Trypanosoma cruzi ribonuclease H1, putative 0.0045 0.0094 0.0169
Schistosoma mansoni thymidylate kinase 0.0303 0.1161 0.1881
Schistosoma mansoni transcription factor LCR-F1 0.0147 0.0517 0.0832
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.006 0.0054
Schistosoma mansoni hypothetical protein 0.0303 0.1161 0.1881
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0098 0.0315 0.0736
Brugia malayi intermediate filament protein 0.0112 0.0372 0.0894
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0065 0.0096
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.017 0.0611 0.5172
Loa Loa (eye worm) MH2 domain-containing protein 0.0243 0.091 0.223
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0111 0.0171
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0038 0.0065 0.0122
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.0303 0.1161 1
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0057 0.0144 0.0307
Schistosoma mansoni coup transcription factor 0.0038 0.0065 0.0096
Entamoeba histolytica glycogen phosphorylase, putative 0.0048 0.0108 0.0201
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0223 0.047
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.0688 0.1112
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.006 0.0088
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0119 0.04 0.0883
Echinococcus granulosus concentrative Na nucleoside cotransporter 0.038 0.1477 0.2395
Loa Loa (eye worm) hypothetical protein 0.0152 0.0537 0.1295
Brugia malayi thymidylate synthase 0.017 0.0611 0.1491
Loa Loa (eye worm) hypothetical protein 0.0057 0.0143 0.0304
Leishmania major thymidylate kinase-like protein 0.0303 0.1161 0.2658
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0063 0.0116
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0038 0.0065 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0023 0.0024
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0038 0.0065 0.0059
Echinococcus granulosus ecdysone induced protein 78C 0.0038 0.0065 0.0096
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0038 0.0065 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0065 0.0122
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.0688 0.1112
Echinococcus multilocularis adenosine deaminase 0.0084 0.0256 0.025
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0037 0.0051
Schistosoma mansoni lipoxygenase 0.0056 0.014 0.022
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.006 0.0157 0.034
Brugia malayi Pre-SET motif family protein 0.0031 0.0037 0.0054
Loa Loa (eye worm) hypothetical protein 0.0074 0.0214 0.0483
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0223 0.0517
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0058 0.0149 0.0143
Loa Loa (eye worm) TAR-binding protein 0.0134 0.0463 0.1109
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0047 0.0102 0.0189
Echinococcus multilocularis thymidine kinase 0.1511 0.6148 0.6146
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0303 0.1161 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.0063 0.0096
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0065 0.0096
Toxoplasma gondii aspartyl protease ASP1 0.0057 0.0144 0.1073
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0057 0.0144 0.0307
Loa Loa (eye worm) hypothetical protein 0.0992 0.4005 1
Trichomonas vaginalis glycogen phosphorylase, putative 0.0112 0.037 0.0831
Loa Loa (eye worm) hypothetical protein 0.0057 0.0144 0.0307
Brugia malayi thymidylate kinase 0.0303 0.1161 0.287
Trypanosoma brucei cytidine deaminase 0.0164 0.0587 0.1364
Brugia malayi MH2 domain containing protein 0.0243 0.091 0.2241
Echinococcus multilocularis thymidine kinase 0.1511 0.6148 0.6146
Entamoeba histolytica cytidine deaminase, putative 0.0164 0.0587 0.132
Echinococcus granulosus survival motor neuron protein 1 0.0992 0.4005 0.6511
Brugia malayi aspartic protease BmAsp-2, identical 0.0057 0.0144 0.032
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.006 0.0109
Schistosoma mansoni AMP deaminase 0.0027 0.0021 0.0026
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0107 0.0229
Plasmodium falciparum plasmepsin IV 0.0057 0.0144 0.1073
Loa Loa (eye worm) hypothetical protein 0.0038 0.0065 0.0109
Plasmodium falciparum thymidylate kinase 0.0303 0.1161 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0152 0.0537 0.1307
Loa Loa (eye worm) hypothetical protein 0.0038 0.0065 0.0109
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0057 0.0144 0.1073
Brugia malayi aspartic protease BmAsp-1, identical 0.0057 0.0144 0.032
Schistosoma mansoni inositol monophosphatase 0.0076 0.0223 0.0353
Schistosoma mansoni intermediate filament proteins 0.0112 0.0372 0.0597
Schistosoma mansoni lozenge 0.006 0.0155 0.0243
Echinococcus multilocularis gamma secretase subunit aph 1 0.0758 0.3038 0.3034
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.0688 0.0683
Mycobacterium ulcerans cytidine deaminase 0.0164 0.0587 0.4794
Leishmania major hypothetical protein, conserved 0.0037 0.006 0.0089
Entamoeba histolytica hypothetical protein 0.0147 0.0517 0.1156
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.0876 0.7413
Toxoplasma gondii thymidylate kinase 0.0303 0.1161 1
Brugia malayi hypothetical protein 0.0057 0.0144 0.032
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.017 0.0611 0.1417
Toxoplasma gondii ribonuclease HI protein 0.0045 0.0094 0.0636
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0098 0.0315 0.0684
Schistosoma mansoni phosphoglucomutase 0.0045 0.0094 0.0144
Onchocerca volvulus 0.0476 0.1874 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0152 0.0537 0.1295
Loa Loa (eye worm) hypothetical protein 0.0148 0.0517 0.1245
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0038 0.0065 0.0096
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0102 0.0203
Plasmodium falciparum plasmepsin X 0.0057 0.0144 0.1073
Echinococcus multilocularis musashi 0.0112 0.0372 0.0367
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0053 0.0092
Schistosoma mansoni phosphoglucomutase 0.0045 0.0094 0.0144
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0057 0.0144 0.0225
Plasmodium vivax aspartyl protease, putative 0.0057 0.0144 0.1073
Schistosoma mansoni transcription factor btf3 0.0037 0.0061 0.009
Echinococcus granulosus Na+ dependent nucleoside transporter 0.038 0.1477 0.2395
Trichomonas vaginalis inositol monophosphatase, putative 0.0076 0.0223 0.0488
Echinococcus multilocularis microtubule associated protein 2 0.0676 0.2701 0.2696
Plasmodium falciparum plasmepsin IX 0.0057 0.0144 0.1073
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0098 0.0315 0.0684
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.017 0.0611 0.5005
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0057 0.0144 0.0138
Leishmania major hypothetical protein, conserved 0.013 0.0444 0.0986
Trypanosoma brucei ingi protein (ORF1) 0.0052 0.0123 0.0286
Loa Loa (eye worm) hypothetical protein 0.0057 0.0144 0.0307
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0065 0.0096
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0065 0.0175 0.017
Loa Loa (eye worm) hypothetical protein 0.0038 0.0065 0.0109
Brugia malayi Adenosine/AMP deaminase family protein 0.0084 0.0256 0.0601
Entamoeba histolytica glycogen phosphorylase, putative 0.0112 0.037 0.0813
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0151 0.0237
Brugia malayi hypothetical protein 0.0084 0.0254 0.0598
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0037 0.0051
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0139 0.0483 0.0777
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0038 0.0065 0.0109
Echinococcus granulosus FTZ F1 alpha 0.0038 0.0065 0.0096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0038 0.0065 0.0109
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0032 0.0044
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0038 0.0065 0.0096
Plasmodium falciparum ataxin-2 like protein, putative 0.013 0.0444 0.3711
Entamoeba histolytica adenosine deaminase, putative 0.0084 0.0256 0.0547
Trichomonas vaginalis thymidylate kinase, putative 0.0303 0.1161 0.2672
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0202 0.0744 0.1825
Mycobacterium ulcerans thymidylate kinase 0.0303 0.1161 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0124 0.0257
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.0688 0.1112
Toxoplasma gondii NAC domain-containing protein 0.0037 0.0061 0.0344
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0065 0.0175 0.0359
Echinococcus multilocularis concentrative Na+ nucleoside cotransporter 0.038 0.1477 0.1472
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0038 0.0065 0.0096
Loa Loa (eye worm) hypothetical protein 0.004 0.0074 0.0132
Brugia malayi Bromodomain containing protein 0.0078 0.0232 0.0542
Brugia malayi steroid hormone receptor 0.0038 0.0065 0.0122
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0047 0.0102 0.0189
Entamoeba histolytica adenosine deaminase, putative 0.0084 0.0256 0.0547
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0098 0.0315 0.2575
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0038 0.0065 0.0233
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0047 0.0102 0.0158
Echinococcus granulosus lamin 0.0112 0.0372 0.0597
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0065 0.0122
Loa Loa (eye worm) inositol-1 0.0076 0.0223 0.0505
Echinococcus granulosus gamma secretase subunit aph 1 0.0758 0.3038 0.4938
Loa Loa (eye worm) hypothetical protein 0.0057 0.0144 0.0307
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0098 0.0315 0.2071
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0038 0.0065 0.0122
Giardia lamblia Thymidine kinase 0.1065 0.4308 1
Plasmodium falciparum plasmepsin III 0.0057 0.0144 0.1073
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.0338 0.0808
Brugia malayi RNase H family protein 0.0045 0.0094 0.0196
Echinococcus multilocularis lamin 0.0112 0.0372 0.0367
Trypanosoma brucei thymidine kinase 0.1065 0.4308 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.006 0.0088
Leishmania major adenine aminohydrolase 0.0084 0.0256 0.0547
Schistosoma mansoni cathepsin D (A01 family) 0.0057 0.0144 0.0225
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0189 0.0688 0.1674
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0065 0.0175 0.017
Loa Loa (eye worm) hypothetical protein 0.0052 0.0124 0.0257
Leishmania major cytidine deaminase-like protein 0.0164 0.0587 0.132
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0166 0.0161
Loa Loa (eye worm) hypothetical protein 0.0043 0.0084 0.0158
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0061 0.0111
Trypanosoma cruzi cytidine deaminase-like protein 0.0164 0.0587 0.132
Entamoeba histolytica glycogenphosphorylase, putative 0.0048 0.0108 0.0201
Brugia malayi Pepsin A precursor 0.0057 0.0144 0.032
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0223 0.047
Brugia malayi RNA binding protein 0.0134 0.0463 0.1121
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0151 0.0302
Schistosoma mansoni thymidylate kinase 0.0303 0.1161 0.1881
Trypanosoma cruzi Aph-1 protein, putative 0.0295 0.1128 0.2581
Loa Loa (eye worm) thymidylate synthase 0.017 0.0611 0.1479
Loa Loa (eye worm) glycogen phosphorylase 0.0112 0.037 0.0875
Mycobacterium ulcerans thymidylate synthase 0.017 0.0611 0.5005
Echinococcus multilocularis FTZ F1 alpha 0.0038 0.0065 0.0059
Loa Loa (eye worm) hypothetical protein 0.0037 0.006 0.0096
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0303 0.1161 1
Brugia malayi cytidine deaminase, identical 0.0164 0.0587 0.1433
Echinococcus granulosus thymidylate kinase 0.0303 0.1161 0.1881
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0038 0.0059
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.006 0.011
Trypanosoma cruzi thymidylate kinase, putative 0.0303 0.1161 0.2658
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.0223 0.0488
Brugia malayi carbohydrate phosphorylase 0.0112 0.037 0.0887
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0038 0.0065 0.0096
Trichomonas vaginalis adenosine deaminase, putative 0.0084 0.0256 0.0565
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.0807 0.1973
Schistosoma mansoni hypothetical protein 0.0048 0.0107 0.0165
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0065 0.0175 0.1352
Echinococcus granulosus cytidine deaminase 0.0164 0.0587 0.0947
Loa Loa (eye worm) steroid hormone receptor 0.0038 0.0065 0.0109
Brugia malayi isocitrate dehydrogenase 0.0065 0.0175 0.04
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0047 0.0102 0.0237
Plasmodium vivax aspartyl proteinase, putative 0.0057 0.0144 0.1073
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0076 0.0223 0.047
Plasmodium vivax thymidylate kinase, putative 0.0303 0.1161 1
Plasmodium vivax basic transcription factor 3b, putative 0.0037 0.0061 0.0344
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0065 0.0175 0.0359
Schistosoma mansoni bromodomain containing protein 0.0066 0.0182 0.0286
Entamoeba histolytica hypothetical protein 0.0147 0.0517 0.1156
Brugia malayi Inositol-1 0.0076 0.0223 0.0519
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0151 0.0829
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0139 0.0483 0.0477
Echinococcus granulosus solute carrier family 28 0.038 0.1477 0.2395
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0098 0.0315 0.2317
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.017 0.0611 0.5005
Brugia malayi hypothetical protein 0.0057 0.0144 0.032
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0081 0.0242 0.0515
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0038 0.0065 0.0096
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0038 0.0065 0.0096
Brugia malayi Intermediate filament tail domain containing protein 0.0112 0.0372 0.0894
Entamoeba histolytica glycogen phosphorylase, putative 0.0048 0.0108 0.0201
Loa Loa (eye worm) hypothetical protein 0.0054 0.0132 0.0278
Trypanosoma brucei ribonuclease H1 0.0045 0.0094 0.0218
Echinococcus multilocularis solute carrier family 28 0.038 0.1477 0.1472
Echinococcus multilocularis glycogen phosphorylase 0.0112 0.037 0.0364
Toxoplasma gondii LsmAD domain-containing protein 0.013 0.0444 0.3711
Brugia malayi exodeoxyribonuclease III family protein 0.0098 0.0315 0.0749
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0151 0.1137
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0057 0.0144 0.0225
Loa Loa (eye worm) thymidylate kinase 0.0303 0.1161 0.286
Schistosoma mansoni gamma-secretase subunit aph-1 0.0758 0.3038 0.4938
Plasmodium vivax hypothetical protein, conserved 0.0037 0.006 0.0336
Echinococcus multilocularis ribonuclease H1 0.0045 0.0094 0.0088
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0068 0.019 0.1181
Toxoplasma gondii exonuclease III APE 0.0098 0.0315 0.2575
Loa Loa (eye worm) hypothetical protein 0.0057 0.0143 0.0304
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0038 0.0065 0.0059
Echinococcus granulosus transcription factor btf3 0.0037 0.0061 0.009
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0057 0.0144 0.0225
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0057 0.0144 0.0225
Entamoeba histolytica hypothetical protein 0.0147 0.0517 0.1156
Leishmania major thymidine kinase, putative 0.1065 0.4308 1
Trichomonas vaginalis cytidine deaminase, putative 0.0164 0.0587 0.1338
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0057 0.0144 0.0225
Schistosoma mansoni hypothetical protein 0.0202 0.0744 0.1202
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0065 0.0175 0.0407
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0063 0.0116
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0147 0.0517 0.0512
Loa Loa (eye worm) beta-lactamase 0.0037 0.006 0.0096
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0056 0.014 0.0135
Loa Loa (eye worm) hypothetical protein 0.0037 0.006 0.0096
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0065 0.0059
Schistosoma mansoni lamin 0.0112 0.0372 0.0597
Brugia malayi RNase H family protein 0.0045 0.0094 0.0196
Trypanosoma brucei transcription factor BTF3, putative 0.0037 0.0061 0.0141
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0057 0.0144 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0053 0.0092
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0463 0.0745
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0463 0.0745
Giardia lamblia CDC8 0.0303 0.1161 0.2531
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0053 0.0092
Brugia malayi nuclear hormone receptor 0.0038 0.0065 0.0122
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0048 0.0108 0.0437
Schistosoma mansoni steroid hormone receptor ad4bp 0.0038 0.0065 0.0096
Echinococcus multilocularis GPCR, family 2 0.0048 0.0107 0.0102
Loa Loa (eye worm) hypothetical protein 0.0038 0.0065 0.0109
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0057 0.0144 0.0304
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0057 0.0144 0.0225
Trichomonas vaginalis adenosine deaminase, putative 0.0084 0.0256 0.0565
Trichomonas vaginalis esterase, putative 0.0037 0.006 0.0109
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0037 0.0032
Onchocerca volvulus 0.0057 0.0144 0.066
Echinococcus granulosus ribonuclease H1 0.0045 0.0094 0.0144
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0047 0.0102 0.0189
Plasmodium vivax plasmepsin IV, putative 0.0057 0.0144 0.1073
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0147 0.0517 0.0832
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0063 0.0116
Schistosoma mansoni hypothetical protein 0.0147 0.0517 0.0832
Schistosoma mansoni glycogen phosphorylase 0.0048 0.0108 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0102 0.0208
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0063 0.0094
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.006 0.0088
Onchocerca volvulus 0.0148 0.0517 0.2677
Echinococcus multilocularis inositol monophosphatase 1 0.0076 0.0223 0.0217
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.0688 0.1112
Brugia malayi Calcitonin receptor-like protein seb-1 0.0152 0.0537 0.1307
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0061 0.0091
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0134 0.0463 0.1109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0102 0.0208
Echinococcus multilocularis Glycosyl transferase, family 35 0.0112 0.037 0.0364
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0242 0.0534
Mycobacterium leprae Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) 0.0084 0.0256 0.1781
Schistosoma mansoni phosphoglucomutase 0.0045 0.0094 0.0144
Brugia malayi Bromodomain containing protein 0.004 0.0074 0.0145
Plasmodium vivax SET domain protein, putative 0.0031 0.0037 0.0138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0024 0.0026
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0107 0.0102
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0057 0.0144 0.0225
Onchocerca volvulus Glycogen phosphorylase homolog 0.0112 0.037 0.188
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0151 0.0829
Trypanosoma cruzi ribonuclease H1, putative 0.0045 0.0094 0.0169
Schistosoma mansoni lamin 0.0112 0.0372 0.0597
Onchocerca volvulus 0.0057 0.0144 0.066
Echinococcus granulosus adenosine deaminase 0.0084 0.0256 0.0407
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0034 0.005
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.006 0.0109
Trypanosoma cruzi cytidine deaminase-like protein, putative 0.0164 0.0587 0.132
Echinococcus granulosus tachykinin peptides receptor 99D 0.0364 0.1412 0.229
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0024 0.0026
Echinococcus multilocularis ecdysone induced protein 78C 0.0038 0.0065 0.0059
Toxoplasma gondii isocitrate dehydrogenase 0.0065 0.0175 0.1352
Trypanosoma cruzi thymidine kinase, putative 0.1065 0.4308 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0098 0.0315 0.0503
Brugia malayi Eukaryotic aspartyl protease family protein 0.0057 0.0144 0.032
Onchocerca volvulus 0.0031 0.0037 0.0085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0038 0.0065 0.0109
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0758 0.3038 0.7574
Onchocerca volvulus Bile acid receptor homolog 0.0038 0.0065 0.0233
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0038 0.0065 0.0122
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0076 0.0223 0.1481
Trichomonas vaginalis thymidine kinase, putative 0.1065 0.4308 1
Schistosoma mansoni memapsin-2 (A01 family) 0.1419 0.577 0.9386
Echinococcus multilocularis transfer RNA-Ile 0.1511 0.6148 0.6146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0063 0.0116
Loa Loa (eye worm) hypothetical protein 0.013 0.0444 0.1062
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0107 0.0229
Brugia malayi RNase H family protein 0.0045 0.0094 0.0196
Loa Loa (eye worm) hypothetical protein 0.0037 0.006 0.0096
Trypanosoma brucei Aph-1 protein, putative 0.0295 0.1128 0.2618
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0053 0.0092
Brugia malayi photoreceptor-specific nuclear receptor 0.0038 0.0065 0.0122
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0098 0.0315 0.2317
Loa Loa (eye worm) hypothetical protein 0.0476 0.1874 0.4651
Trypanosoma brucei AMP deaminase, putative 0.0027 0.0021 0.005
Brugia malayi TAR-binding protein 0.0134 0.0463 0.1121
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0038 0.0065 0.0059
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.006 0.0089
Brugia malayi Isocitrate dehydrogenase 0.0065 0.0175 0.04
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.017 0.0611 0.5172
Onchocerca volvulus 0.0248 0.0931 0.4912
Trichomonas vaginalis set domain proteins, putative 0.0248 0.0931 0.2138
Trypanosoma cruzi PAB1-binding protein , putative 0.013 0.0444 0.0986
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0065 0.0059
Plasmodium vivax aspartyl protease, putative 0.0057 0.0144 0.1073
Loa Loa (eye worm) hypothetical protein 0.011 0.0364 0.086
Schistosoma mansoni glycogen phosphorylase 0.0112 0.037 0.0593
Onchocerca volvulus 0.0037 0.006 0.0207
Leishmania major basic transcription factor 3a, putative 0.0037 0.0061 0.0091
Schistosoma mansoni hypothetical protein 0.0139 0.0483 0.0777
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0038 0.0065 0.0122
Loa Loa (eye worm) isocitrate dehydrogenase 0.0065 0.0175 0.0387
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0047 0.0102 0.0189
Treponema pallidum thymidylate kinase (tmk) 0.0303 0.1161 1
Onchocerca volvulus Putative thymidylate kinase 0.0303 0.1161 0.6149
Loa Loa (eye worm) intermediate filament protein 0.0112 0.0372 0.0881
Trypanosoma brucei RNA helicase, putative 0.0315 0.1208 0.2805
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0107 0.0165
Loa Loa (eye worm) hypothetical protein 0.0112 0.0372 0.0881
Loa Loa (eye worm) hypothetical protein 0.0048 0.0107 0.0215
Trypanosoma brucei AMP deaminase, putative 0.0027 0.0021 0.005
Trypanosoma brucei AMP deaminase, putative 0.0027 0.0021 0.005
Plasmodium vivax ataxin-2 like protein, putative 0.013 0.0444 0.3711
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0054 0.0132 0.0127
Schistosoma mansoni hypothetical protein 0.0048 0.0107 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0038 0.0065 0.0122
Toxoplasma gondii cytidine and deoxycytidylate deaminase zinc-binding region domain-containing protein 0.0164 0.0587 0.4969
Brugia malayi Pre-SET motif family protein 0.0218 0.0807 0.1984
Schistosoma mansoni hypothetical protein 0.123 0.4989 0.8114
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0053 0.0274
Plasmodium falciparum plasmepsin VIII, putative 0.0057 0.0144 0.1073
Loa Loa (eye worm) hypothetical protein 0.0045 0.0092 0.0178
Brugia malayi hypothetical protein 0.0148 0.0517 0.1258
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.006 0.0109
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0057 0.0144 0.0225
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0111 0.0171
Plasmodium vivax plasmepsin V, putative 0.0057 0.0144 0.1073
Trypanosoma cruzi Aph-1 protein, putative 0.0295 0.1128 0.2581
Echinococcus granulosus thymidylate synthase 0.017 0.0611 0.0985
Echinococcus multilocularis geminin 0.123 0.4989 0.4986
Echinococcus granulosus microtubule associated protein 2 0.0676 0.2701 0.4388
Schistosoma mansoni hypothetical protein 0.0058 0.0149 0.0233
Treponema pallidum adenosine deaminase 0.0084 0.0256 0.1517
Echinococcus multilocularis sodium:nucleoside cotransporter 2 0.0248 0.0931 0.0926
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0107 0.0102
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0038 0.0065 0.0096
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0038 0.0065 0.0109
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0047 0.0102 0.0237
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0065 0.0175 0.0359
Schistosoma mansoni adenosine deaminase-related 0.0084 0.0256 0.0407
Loa Loa (eye worm) hypothetical protein 0.0084 0.0256 0.0588
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0065 0.0122
Echinococcus granulosus glycogen phosphorylase 0.0112 0.037 0.0593
Schistosoma mansoni ap endonuclease 0.0098 0.0315 0.0503
Loa Loa (eye worm) hypothetical protein 0.0037 0.006 0.0096
Schistosoma mansoni thyroid hormone receptor 0.0177 0.0639 0.1032
Plasmodium falciparum plasmepsin VII 0.0057 0.0144 0.1073
Toxoplasma gondii ABC1 family protein 0.0037 0.006 0.0336
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0057 0.0144 0.0225
Schistosoma mansoni retinoic acid receptor RXR 0.0038 0.0065 0.0096
Brugia malayi cytoplasmic intermediate filament protein 0.006 0.0157 0.0354
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0065 0.0175 0.1052
Loa Loa (eye worm) hypothetical protein 0.0049 0.0111 0.0224
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0068 0.019 0.1181
Leishmania major dihydrofolate reductase-thymidylate synthase 0.017 0.0611 0.1375
Chlamydia trachomatis thymidylate kinase 0.0303 0.1161 1
Trichomonas vaginalis ap endonuclease, putative 0.0098 0.0315 0.0703
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0038 0.0065 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0053 0.0092
Schistosoma mansoni hypothetical protein 0.0274 0.104 0.1684
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0065 0.0175 0.0277
Brugia malayi hypothetical protein 0.0081 0.0242 0.0568
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0065 0.0175 0.017
Entamoeba histolytica thymidine kinase, putative 0.1065 0.4308 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0047 0.0102 0.0097
Loa Loa (eye worm) hypothetical protein 0.0037 0.006 0.0096
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0151 0.0237
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0065 0.0175 0.0407
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0076 0.0223 0.1208
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0166 0.0261
Loa Loa (eye worm) hypothetical protein 0.0057 0.0143 0.0304
Schistosoma mansoni microtubule-associated protein tau 0.0676 0.2701 0.4388
Echinococcus granulosus thymidine kinase 0.1511 0.6148 1
Echinococcus multilocularis tar DNA binding protein 0.0134 0.0463 0.0458
Onchocerca volvulus 0.017 0.0611 0.3181
Loa Loa (eye worm) hypothetical protein 0.0057 0.0143 0.0304
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0065 0.0175 0.017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0024 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0038 0.0065 0.0122
Echinococcus multilocularis lamin dm0 0.0112 0.0372 0.0367
Mycobacterium tuberculosis Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) 0.0164 0.0587 0.4794
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.0063 0.0096
Plasmodium falciparum plasmepsin I 0.0057 0.0144 0.1073
Plasmodium falciparum plasmepsin V 0.0057 0.0144 0.1073
Mycobacterium tuberculosis Hypothetical protein 0.0081 0.0242 0.166
Echinococcus multilocularis transcription factor btf3 0.0037 0.0061 0.0055
Echinococcus granulosus glycogen phosphorylase 0.0112 0.037 0.0593
Entamoeba histolytica transcription factor BTF3, putative 0.0037 0.0061 0.0091
Trypanosoma cruzi thymidylate kinase, putative 0.0303 0.1161 0.2658
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0107 0.0215
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0038 0.0065 0.0096
Loa Loa (eye worm) transcription factor SMAD2 0.0243 0.091 0.223
Echinococcus granulosus tar DNA binding protein 0.0134 0.0463 0.0745
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0151 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0038 0.0065 0.0122
Loa Loa (eye worm) hypothetical protein 0.0037 0.006 0.0096
Plasmodium falciparum basic transcription factor 3b, putative 0.0037 0.0061 0.0344
Schistosoma mansoni ap endonuclease 0.0098 0.0315 0.0503
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0065 0.0175 0.1352
Onchocerca volvulus 0.0164 0.0587 0.3055
Onchocerca volvulus Protein ultraspiracle homolog 0.0038 0.0065 0.0233
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.0688 0.1112
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0037 0.0138
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0102 0.0217
Schistosoma mansoni glycogen phosphorylase 0.0112 0.037 0.0593
Toxoplasma gondii isocitrate dehydrogenase 0.0065 0.0175 0.1352
Schistosoma mansoni survival motor neuron protein 0.0202 0.0744 0.1202
Mycobacterium leprae PROBABLE CYTIDINE DEAMINASE CDD (CYTIDINE AMINOHYDROLASE) (CYTIDINE NUCLEOSIDE DEAMINASE) 0.0164 0.0587 0.4794
Onchocerca volvulus 0.0037 0.006 0.0207
Plasmodium vivax aspartyl protease, putative 0.0057 0.0144 0.1073
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0054 0.0132 0.0206
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.006 0.0089
Trichomonas vaginalis ribonuclease H1, putative 0.0045 0.0094 0.0189
Echinococcus multilocularis glycogen phosphorylase 0.0112 0.037 0.0364
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0076 0.0223 0.1767
Giardia lamblia Glycogen phosphorylase 0.0112 0.037 0.0655
Plasmodium falciparum adenosine deaminase 0.0084 0.0256 0.2057
Brugia malayi hypothetical protein 0.0147 0.0517 0.1256
Echinococcus granulosus intermediate filament protein 0.0112 0.0372 0.0597
Brugia malayi gamma-secretase subunit aph-1 0.0758 0.3038 0.7578
Echinococcus multilocularis thymidylate kinase 0.0303 0.1161 0.1156
Brugia malayi RNA recognition motif domain containing protein 0.0134 0.0463 0.1121
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0119 0.04 0.0883
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.0223 0.0488
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0065 0.0122
Echinococcus multilocularis thymidylate synthase 0.017 0.0611 0.0605
Entamoeba histolytica hypothetical protein 0.0037 0.0061 0.0091
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.006 0.0096
Schistosoma mansoni thymidine kinase 0.1511 0.6148 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0364 0.1412 0.1407
Schistosoma mansoni hypothetical protein 0.123 0.4989 0.8114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0053 0.0092
Loa Loa (eye worm) hypothetical protein 0.0038 0.0065 0.0109
Echinococcus multilocularis thyroid hormone receptor alpha 0.0177 0.0639 0.0634
Treponema pallidum exodeoxyribonuclease (exoA) 0.0098 0.0315 0.2071
Entamoeba histolytica Thymidylate kinase, putative 0.0303 0.1161 0.2658
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0107 0.0165
Trichomonas vaginalis thymidylate kinase, putative 0.0303 0.1161 0.2672
Schistosoma mansoni RAR-like nuclear receptor 0.0038 0.0065 0.0096
Onchocerca volvulus Adenosine deaminase homolog 0.0084 0.0256 0.1265
Echinococcus granulosus geminin 0.123 0.4989 0.8114
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0084 0.0256 0.2057
Echinococcus granulosus lamin dm0 0.0112 0.0372 0.0597
Trichomonas vaginalis ap endonuclease, putative 0.0098 0.0315 0.0703
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0052 0.0123 0.0286
Onchocerca volvulus 0.0112 0.0372 0.1894
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0151 0.0237
Trypanosoma brucei PAB1-binding protein , putative 0.013 0.0444 0.1031
Echinococcus multilocularis cytidine deaminase 0.0164 0.0587 0.0582
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0098 0.0315 0.0524
Trichomonas vaginalis glycogen phosphorylase, putative 0.0112 0.037 0.0831
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0074 0.0142
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0248 0.0931 0.2283
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0047 0.0102 0.0189
Giardia lamblia GTOR 0.0047 0.0102 0.002
Mycobacterium tuberculosis Probable adenosine deaminase Add (adenosine aminohydrolase) 0.0084 0.0256 0.1781
Onchocerca volvulus 0.0202 0.0744 0.3899
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.0065 0.0096
Schistosoma mansoni cathepsin D (A01 family) 0.0057 0.0144 0.0225
Schistosoma mansoni hypothetical protein 0.0048 0.0107 0.0165
Plasmodium falciparum ataxin-2 like protein, putative 0.013 0.0444 0.3711
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0065 0.0175 0.0277
Trypanosoma brucei ingi protein (ORF1) 0.0052 0.0123 0.0286
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0047 0.0102 0.0158
Loa Loa (eye worm) ICD-1 protein 0.0037 0.0061 0.0098
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0463 0.0745
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0112 0.0372 0.0881
Trichomonas vaginalis thymidine kinase, putative 0.1065 0.4308 1
Trypanosoma brucei hypothetical protein, conserved 0.0052 0.0123 0.0286
Onchocerca volvulus 0.0112 0.0372 0.1894
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0038 0.0065 0.0096
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.006 0.0109
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0111 0.0171
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0084 0.0256 0.2057
Toxoplasma gondii aspartyl protease ASP3 0.0057 0.0144 0.1073
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0056 0.014 0.022
Plasmodium falciparum plasmepsin VI 0.0057 0.0144 0.1073
Trypanosoma brucei thymidylate kinase, putative 0.0303 0.1161 0.2694
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0065 0.0122
Entamoeba histolytica hypothetical protein 0.0147 0.0517 0.1156
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0063 0.0058
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.017 0.0611 0.0985
Brugia malayi ecdysteroid receptor 0.0038 0.0065 0.0122
Entamoeba histolytica glycogen phosphorylase, putative 0.0112 0.037 0.0813
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0098 0.0315 0.0684
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.017 0.0611 0.5172

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 10.7 nM Binding affinity towards cloned human Tachykinin receptor 3 (hNK-3) expressed in CHO cells using [125I]-[MePhe7]-NKB ChEMBL. 10090788

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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