Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0492 | 0.8433 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1695 | 0.1607 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0492 | 0.8433 | 0.8367 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.008 | 0.0406 | 1 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.008 | 0.0406 | 0.2392 |
Leishmania major | fatty acid desaturase, putative | 0.008 | 0.0406 | 0.0406 |
Leishmania major | fatty-acid desaturase, putative | 0.0572 | 1 | 1 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.008 | 0.0406 | 0.0406 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.008 | 0.0406 | 0.2392 |
Onchocerca volvulus | 0.0572 | 1 | 1 | |
Onchocerca volvulus | 0.0572 | 1 | 1 | |
Leishmania major | delta-6 fatty acid desaturase | 0.008 | 0.0406 | 0.0406 |
Brugia malayi | Muscleblind-like protein | 0.0146 | 0.1695 | 0.1607 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.008 | 0.0406 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0492 | 0.8433 | 0.8367 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.3398 | 0.3728 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.008 | 0.0406 | 0.0406 |
Leishmania major | delta-5 fatty acid desaturase | 0.0234 | 0.3398 | 0.3398 |
Mycobacterium tuberculosis | Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f | 0.008 | 0.0406 | 1 |
Leishmania major | delta-4 fatty acid desaturase | 0.008 | 0.0406 | 0.0406 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0492 | 0.8433 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1695 | 0.1607 |
Mycobacterium ulcerans | transmembrane alkane 1-monooxygenase AlkB | 0.008 | 0.0406 | 1 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.008 | 0.0406 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.008 | 0.0406 | 1 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.008 | 0.0406 | 0.2392 |
Leishmania major | delta-12 fatty acid desaturase | 0.008 | 0.0406 | 0.0406 |
Loa Loa (eye worm) | FAT-3 protein | 0.0234 | 0.3398 | 0.3728 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.008 | 0.0406 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1831 | 0.1776 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3_2 | 0.008 | 0.0406 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0146 | 0.1695 | 1 |
Leishmania major | fatty acid desaturase, putative | 0.008 | 0.0406 | 0.0406 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.008 | 0.0406 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.008 | 0.0406 | 1 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.008 | 0.0406 | 1 |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.008 | 0.0406 | 0.2392 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.008 | 0.0406 | 0.0406 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0572 | 1 | 1 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0234 | 0.3398 | 0.3728 |
Schistosoma mansoni | fatty acid desaturase | 0.0234 | 0.3398 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0146 | 0.1695 | 1 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0572 | 1 | 1 |
Brugia malayi | acyl-CoA desaturase | 0.0492 | 0.8433 | 1 |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.008 | 0.0406 | 0.2392 |
Echinococcus multilocularis | muscleblind protein | 0.0146 | 0.1695 | 1 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.008 | 0.0406 | 0.0406 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0492 | 0.8433 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.