Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucosidase, beta (bile acid) 2 | Starlite/ChEMBL | References |
Homo sapiens | glucosidase, beta, acid | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0312 | 0.9788 | 1 |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 | |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.0288 | 0.7615 | 0.7593 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0312 | 0.9788 | 1 |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.9788 | 1 |
Brugia malayi | Ceramide glucosyltransferase | 0.0288 | 0.7615 | 0.7759 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0314 | 1 | 1 |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 | |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 | |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0314 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.9788 | 1 |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 | |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 | |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.0251 | 0.4265 | 0.4211 |
Echinococcus granulosus | bile acid beta glucosidase | 0.0251 | 0.4265 | 0.4211 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.0251 | 0.4265 | 0.4211 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0288 | 0.7615 | 0.7593 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.9788 | 1 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.0251 | 0.4265 | 0.4211 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.0288 | 0.7615 | 0.7759 |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 | |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0251 | 0.4265 | 0.4211 |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 | |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 | |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.1006 | 0.1027 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.0288 | 0.7615 | 1 |
Schistosoma mansoni | inositol transporter | 0.0314 | 1 | 1 |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.9788 | 1 |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0206 | 0.0093 | 0.0122 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.9788 | 1 |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 | |
Echinococcus granulosus | solute carrier family 5 | 0.0314 | 1 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0288 | 0.7615 | 0.7593 |
Schistosoma mansoni | inositol transporter | 0.0314 | 1 | 1 |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 | |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 | |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0314 | 1 | 1 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0314 | 1 | 1 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0206 | 0.0093 | 0.0122 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.1006 | 0.1027 |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 | |
Echinococcus multilocularis | solute carrier family 5 | 0.0314 | 1 | 1 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0251 | 0.4265 | 0.4211 |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.9788 | 1 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.0288 | 0.7615 | 0.7593 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of glucosylceramide synthase (unknown origin) assessed as catabolism of NBD-glucosylceramide | ChEMBL. | 25250725 | |
IC50 (binding) | = 100 nM | Inhibition of GBA2 (unknown origin) | ChEMBL. | 25250725 |
IC50 (binding) | = 2.5 uM | Inhibition of GBA1 (unknown origin) using beta-D-[1-14C]glucocerebroside assessed as 4-methylumbelliferrone by fluorimetry | ChEMBL. | 25250725 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.