Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | UDP-glucose ceramide glucosyltransferase | Starlite/ChEMBL | References |
Homo sapiens | glucosidase, beta (bile acid) 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | inositol transporter | 0.0314 | 1 | 1 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.0288 | 0.7615 | 1 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0206 | 0.0093 | 0.0122 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.9788 | 1 |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 | |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.9788 | 1 |
Schistosoma mansoni | inositol transporter | 0.0314 | 1 | 1 |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 | |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0288 | 0.7615 | 0.7593 |
Echinococcus granulosus | solute carrier family 5 | 0.0314 | 1 | 1 |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 | |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0314 | 1 | 1 |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 | |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 | |
Echinococcus multilocularis | solute carrier family 5 | 0.0314 | 1 | 1 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0251 | 0.4265 | 0.4211 |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.1006 | 0.1027 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0206 | 0.0093 | 0.0122 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0314 | 1 | 1 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.0288 | 0.7615 | 0.7593 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.9788 | 1 |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 | |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0312 | 0.9788 | 1 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.0288 | 0.7615 | 0.7593 |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 | |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0312 | 0.9788 | 1 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0314 | 1 | 1 |
Brugia malayi | Ceramide glucosyltransferase | 0.0288 | 0.7615 | 0.7759 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.9788 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.9788 | 1 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0314 | 1 | 1 |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 | |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 | |
Echinococcus granulosus | bile acid beta glucosidase | 0.0251 | 0.4265 | 0.4211 |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 | |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.0251 | 0.4265 | 0.4211 |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 | |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.0251 | 0.4265 | 0.4211 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0288 | 0.7615 | 0.7593 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.0251 | 0.4265 | 0.4211 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.0288 | 0.7615 | 0.7759 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.9788 | 1 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0251 | 0.4265 | 0.4211 |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.1006 | 0.1027 |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 | |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 | |
Onchocerca volvulus | 0.0206 | 0.0093 | 0.0122 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 100 nM | Inhibition of GBA2 (unknown origin) | ChEMBL. | 25250725 |
IC50 (binding) | = 2.5 uM | Inhibition of glucosylceramide synthase (unknown origin) assessed as catabolism of NBD-glucosylceramide | ChEMBL. | 25250725 |
IC50 (binding) | = 50 uM | Inhibition of GBA1 (unknown origin) using beta-D-[1-14C]glucocerebroside assessed as 4-methylumbelliferrone by fluorimetry | ChEMBL. | 25250725 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.