Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucosidase, beta, acid | Starlite/ChEMBL | References |
Homo sapiens | glucosidase, beta (bile acid) 2 | Starlite/ChEMBL | References |
Homo sapiens | UDP-glucose ceramide glucosyltransferase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.5719 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0288 | 0.4762 | 1 |
Leishmania major | fatty-acid desaturase, putative | 0.0418 | 1 | 0.5 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.0288 | 0.4762 | 1 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0384 | 0.8638 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.5719 | 1 |
Brugia malayi | acyl-CoA desaturase | 0.0384 | 0.8638 | 1 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.0288 | 0.4762 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.5719 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.1849 | 0.1027 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.5719 | 1 |
Onchocerca volvulus | 0.0418 | 1 | 1 | |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0312 | 0.5719 | 0.247 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0418 | 1 | 0.5 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0312 | 0.5719 | 0.6621 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.1849 | 0.1027 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.5719 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0288 | 0.4762 | 1 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.0288 | 0.4762 | 0.3905 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0384 | 0.8638 | 0.5 |
Onchocerca volvulus | 0.0418 | 1 | 1 | |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.0288 | 0.4762 | 0.5512 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.5719 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0418 | 1 | 1 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0384 | 0.8638 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 15 nM | Inhibition of GBA2 (unknown origin) | ChEMBL. | 25250725 |
IC50 (binding) | = 25 nM | Inhibition of glucosylceramide synthase (unknown origin) assessed as catabolism of NBD-glucosylceramide | ChEMBL. | 25250725 |
IC50 (binding) | = 3 uM | Inhibition of GBA1 (unknown origin) using beta-D-[1-14C]glucocerebroside assessed as 4-methylumbelliferrone by fluorimetry | ChEMBL. | 25250725 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.