Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | UDP-glucose ceramide glucosyltransferase | Starlite/ChEMBL | References |
Homo sapiens | glucosidase, beta, acid | Starlite/ChEMBL | References |
Homo sapiens | glucosidase, beta (bile acid) 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.1735 | 0.1027 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0373 | 0.7679 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 0.3196 | 0.4162 |
Onchocerca volvulus | 0.0434 | 0.9986 | 1 | |
Echinococcus granulosus | ceramide glucosyltransferase | 0.0288 | 0.4468 | 1 |
Onchocerca volvulus | 0.0316 | 0.5516 | 0.4843 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.5366 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.1735 | 0.1027 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0435 | 1 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.5366 | 1 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0373 | 0.7679 | 0.5 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.0288 | 0.4468 | 1 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.0288 | 0.4468 | 0.5818 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0312 | 0.5366 | 0.2798 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.5366 | 1 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.0288 | 0.4468 | 0.3633 |
Leishmania major | fatty-acid desaturase, putative | 0.0435 | 1 | 1 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0312 | 0.5366 | 0.6988 |
Onchocerca volvulus | 0.0434 | 0.9986 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0315 | 0.5503 | 0.7166 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0288 | 0.4468 | 0.5692 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0288 | 0.4468 | 0.5692 |
Loa Loa (eye worm) | FAT-3 protein | 0.0315 | 0.5503 | 0.7166 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0373 | 0.7679 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.5366 | 1 |
Schistosoma mansoni | fatty acid desaturase | 0.0316 | 0.5516 | 1 |
Brugia malayi | acyl-CoA desaturase | 0.0373 | 0.7679 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.5366 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0435 | 1 | 1 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0315 | 0.5503 | 0.3223 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.5366 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 10 nM | Inhibition of GBA2 (unknown origin) | ChEMBL. | 25250725 |
IC50 (binding) | = 2 uM | Inhibition of glucosylceramide synthase (unknown origin) assessed as catabolism of NBD-glucosylceramide | ChEMBL. | 25250725 |
IC50 (binding) | = 2 uM | Inhibition of GBA1 (unknown origin) using beta-D-[1-14C]glucocerebroside assessed as 4-methylumbelliferrone by fluorimetry | ChEMBL. | 25250725 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.