Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | UDP-glucose ceramide glucosyltransferase | Starlite/ChEMBL | References |
Homo sapiens | glucosidase, beta, acid | Starlite/ChEMBL | References |
Homo sapiens | glucosidase, beta (bile acid) 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.193 | 0.1027 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0312 | 0.312 | 0.5783 |
Echinococcus granulosus | bile acid beta glucosidase | 0.0251 | 0.2372 | 0.2497 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0205 | 0.1794 | 0.3 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.312 | 1 |
Brugia malayi | Ceramide glucosyltransferase | 0.0288 | 0.2826 | 0.5166 |
Brugia malayi | hypothetical protein | 0.0474 | 0.5128 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0088 | 0.0356 | 0.0424 |
Loa Loa (eye worm) | hypothetical protein | 0.0474 | 0.5128 | 1 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0251 | 0.2372 | 0.2823 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0251 | 0.2372 | 0.2823 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0739 | 0.84 | 0.84 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0253 | 0.2395 | 0.2526 |
Giardia lamblia | Ceramide glucosyltransferase | 0.0131 | 0.0879 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.312 | 1 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.0288 | 0.2826 | 0.2826 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0246 | 0.231 | 0.5 |
Chlamydia trachomatis | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase | 0.0773 | 0.8816 | 0.5 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.0288 | 0.2826 | 0.3062 |
Onchocerca volvulus | 0.0474 | 0.5128 | 1 | |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.0251 | 0.2372 | 0.2497 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0126 | 0.0826 | 0.0826 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0739 | 0.84 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.193 | 0.1027 |
Schistosoma mansoni | lipoxygenase | 0.0126 | 0.0826 | 0.0983 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0312 | 0.312 | 0.6084 |
Loa Loa (eye worm) | hypothetical protein | 0.0474 | 0.5128 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.1362 | 0.2656 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0089 | 0.0365 | 0.0365 |
Trichomonas vaginalis | set domain proteins, putative | 0.0254 | 0.24 | 0.4573 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 0.2395 | 0.467 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.312 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0223 | 0.202 | 0.3474 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0288 | 0.2826 | 0.3364 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0126 | 0.0826 | 0.0573 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.312 | 1 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.0288 | 0.2826 | 0.551 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.312 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0739 | 0.84 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0365 | 0.0712 |
Brugia malayi | hypothetical protein | 0.0253 | 0.2395 | 0.4262 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0223 | 0.202 | 0.3938 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0089 | 0.0365 | 0.0435 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.0251 | 0.2372 | 0.2372 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.0251 | 0.2372 | 0.2372 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0253 | 0.2395 | 0.2395 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0288 | 0.2826 | 0.3364 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.312 | 1 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.0288 | 0.2826 | 0.5166 |
Onchocerca volvulus | 0.0254 | 0.24 | 0.4273 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4 nM | Inhibition of GBA2 (unknown origin) | ChEMBL. | 25250725 |
IC50 (binding) | = 150 nM | Inhibition of glucosylceramide synthase (unknown origin) assessed as catabolism of NBD-glucosylceramide | ChEMBL. | 25250725 |
IC50 (binding) | = 2 uM | Inhibition of GBA1 (unknown origin) using beta-D-[1-14C]glucocerebroside assessed as 4-methylumbelliferrone by fluorimetry | ChEMBL. | 25250725 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.