Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucosidase, beta (bile acid) 2 | Starlite/ChEMBL | References |
Homo sapiens | UDP-glucose ceramide glucosyltransferase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.5605 | 1 |
Echinococcus granulosus | bile acid beta glucosidase | 0.0251 | 0.322 | 0.3049 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0251 | 0.322 | 0.3049 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.5605 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0423 | 1 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0288 | 0.4667 | 0.4532 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.5605 | 1 |
Onchocerca volvulus | 0.0284 | 0.4526 | 0.9571 | |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0423 | 1 | 1 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.0288 | 0.4667 | 0.4667 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.5605 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.5605 | 1 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.0251 | 0.322 | 0.3049 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.5605 | 1 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.0288 | 0.4667 | 0.4532 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0312 | 0.5605 | 0.5605 |
Schistosoma mansoni | alpha-glucosidase | 0.0423 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.1812 | 0.1027 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.1812 | 0.1027 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0423 | 1 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0423 | 1 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0288 | 0.4667 | 0.4532 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.0251 | 0.322 | 0.3049 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.0288 | 0.4667 | 0.4532 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.0251 | 0.322 | 0.3049 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.0288 | 0.4667 | 1 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0312 | 0.5605 | 0.1759 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0251 | 0.322 | 0.3049 |
Schistosoma mansoni | alpha-glucosidase | 0.0423 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2 nM | Inhibition of GBA2 (unknown origin) | ChEMBL. | 25250725 |
IC50 (binding) | = 70 nM | Inhibition of glucosylceramide synthase (unknown origin) assessed as catabolism of NBD-glucosylceramide | ChEMBL. | 25250725 |
IC50 (binding) | = 20 uM | Inhibition of GBA1 (unknown origin) using beta-D-[1-14C]glucocerebroside assessed as 4-methylumbelliferrone by fluorimetry | ChEMBL. | 25250725 |
IC50 (binding) | = 60 uM | Inhibition of intestinal lactase (unknown origin) | ChEMBL. | 25250725 |
IC50 (binding) | = 100 uM | Inhibition of intestinal sucrase (unknown origin) | ChEMBL. | 25250725 |
IC50 (binding) | > 100 uM | Inhibition of intestinal maltase (unknown origin) | ChEMBL. | 25250725 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.