TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 440.512 | Formula: C23H24N2O5S
H donors: 3 H acceptors: 5 LogP: 1.86 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: OCC(c1ccc(cc1)CN(C(=O)c1ccc(cc1)S(=O)(=O)Nc1ccccc1)C)O
InChi: 1S/C23H24N2O5S/c1-25(15-17-7-9-18(10-8-17)22(27)16-26)23(28)19-11-13-21(14-12-19)31(29,30)24-20-5-3-2-4-6-20/h2-14,22,24,26-27H,15-16H2,1H3
InChiKey: LJBXWGVECYNLLM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	LIM domain kinase 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K05743 LIM domain kinase 1, putative	Get druggable targets OG5_131191	All targets in OG5_131191
Echinococcus multilocularis	dual specificity testis specific protein kinase	Get druggable targets OG5_131191	All targets in OG5_131191
Schistosoma mansoni	protein kinase	Get druggable targets OG5_131191	All targets in OG5_131191
Echinococcus granulosus	dual specificity testis-specific protein kinase	Get druggable targets OG5_131191	All targets in OG5_131191
Schistosoma mansoni	protein kinase	Get druggable targets OG5_131191	All targets in OG5_131191

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	vivapain-2	0.0633	0.5687	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0633	0.5687	0.5687
Plasmodium falciparum	serine repeat antigen 1	0.0141	0.1163	0.2045
Entamoeba histolytica	cysteine proteinase, putative	0.0434	0.3853	0.5946
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0031	0.0155	0.0155
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0633	0.5687	1
Brugia malayi	cathepsin L precursor	0.0141	0.1163	0.1163
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0101	0.0799	0.1307
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0438	0.3896	0.6852
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0141	0.1163	0.1955
Onchocerca volvulus	Cathepsin L homolog	0.0633	0.5687	1
Echinococcus granulosus	cysteine protease	0.0341	0.2997	0.2997
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0633	0.5687	1
Entamoeba histolytica	cysteine protease, putative	0.0341	0.2997	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0199	0.17	0.17
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0141	0.1163	0.1955
Loa Loa (eye worm)	cathepsin B	0.0438	0.3896	0.3896
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0633	0.5687	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0633	0.5687	1
Entamoeba histolytica	cysteine proteinase, putative	0.0341	0.2997	0.4054
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0141	0.1163	0.1163
Toxoplasma gondii	cathepsin CPC1	0.0141	0.1163	0.2045
Brugia malayi	Papain family cysteine protease containing protein	0.0341	0.2997	0.2997
Loa Loa (eye worm)	hypothetical protein	0.0434	0.3853	0.3853
Toxoplasma gondii	cathepsin CPL	0.0633	0.5687	1
Leishmania major	cathepsin L-like protease	0.0633	0.5687	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0633	0.5687	0.5119
Leishmania major	cathepsin L-like protease	0.0633	0.5687	1
Onchocerca volvulus		0.0633	0.5687	1
Plasmodium vivax	unspecified product	0.0199	0.17	0.1187
Giardia lamblia	Cathepsin B precursor	0.0438	0.3896	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0341	0.2997	0.2997
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0021	0.0064	0.0064
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0438	0.3896	0.3343
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0633	0.5687	1
Plasmodium vivax	vivapain-3	0.0341	0.2997	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0633	0.5687	0.5687
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0633	0.5687	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0199	0.17	0.0608
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0141	0.1163	0.1955
Loa Loa (eye worm)	hypothetical protein	0.1102	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0141	0.1163	0.1163
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0141	0.1163	0.1955
Entamoeba histolytica	cysteine proteinase 2	0.0341	0.2997	0.4054
Schistosoma mansoni	cathepsin B (C01 family)	0.0141	0.1163	0.1163
Schistosoma mansoni	cathepsin F (C01 family)	0.0434	0.3853	0.3853
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0141	0.1163	0.2045
Leishmania major	cysteine peptidase A (CPA)	0.0633	0.5687	1
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0021	0.0064	0.0064
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0633	0.5687	1
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0021	0.0064	0.0064
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0021	0.0064	0.0064
Brugia malayi	Cathepsin L-like precursor	0.0633	0.5687	0.5687
Plasmodium falciparum	serine repeat antigen 8	0.0141	0.1163	0.2045
Toxoplasma gondii	cathepsin CPC2	0.0141	0.1163	0.2045
Onchocerca volvulus		0.0633	0.5687	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0341	0.2997	0.2075
Loa Loa (eye worm)	hypothetical protein	0.0633	0.5687	0.5687
Schistosoma mansoni	cathepsin F (C01 family)	0.0633	0.5687	0.5687
Giardia lamblia	Cathepsin B precursor	0.0438	0.3896	1
Brugia malayi	Papain family cysteine protease containing protein	0.0633	0.5687	0.5687
Plasmodium falciparum	serine repeat antigen 3	0.0141	0.1163	0.2045
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0141	0.1163	0.1163
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0141	0.1163	0.1955
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.1163	0.1955
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0109	0.0864	0.0864
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0031	0.0155	0.0155
Echinococcus multilocularis	cathepsin b	0.1102	1	1
Leishmania major	cathepsin L-like protease	0.0633	0.5687	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0633	0.5687	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0141	0.1163	0.1955
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0199	0.17	0.17
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0141	0.1163	0.1955
Plasmodium falciparum	serine repeat antigen 7	0.0141	0.1163	0.2045
Trypanosoma cruzi	cysteine peptidase, putative	0.0633	0.5687	0.5119
Schistosoma mansoni	protein kinase	0.015	0.1242	0.1242
Schistosoma mansoni	60S ribosomal protein L21	0.0017	0.0024	0.0024
Entamoeba histolytica	cysteine protease, putative	0.0341	0.2997	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0633	0.5687	1
Brugia malayi	Cathepsin L-like precursor	0.0633	0.5687	0.5687
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0141	0.1163	0.2045
Entamoeba histolytica	cysteine protease, putative	0.0341	0.2997	0.4054
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0633	0.5687	0.5687
Schistosoma mansoni	voltage-gated potassium channel	0.0119	0.0956	0.0956
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0141	0.1163	0.1955
Echinococcus granulosus	hyperpolarization activated cyclic	0.0021	0.0064	0.0064
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0633	0.5687	1
Entamoeba histolytica	cysteine proteinase, putative	0.0341	0.2997	0.4054
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0633	0.5687	0.5687
Brugia malayi	cathepsin F-like cysteine proteinase	0.0199	0.17	0.17
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0341	0.2997	0.2997
Brugia malayi	cathepsin L-like cysteine proteinase	0.0141	0.1163	0.1163
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0633	0.5687	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0341	0.2997	0.2997
Entamoeba histolytica	cysteine protease, putative	0.0341	0.2997	0.4054
Plasmodium falciparum	serine repeat antigen 6	0.0141	0.1163	0.2045
Plasmodium vivax	unspecified product	0.0341	0.2997	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0434	0.3853	0.3853
Onchocerca volvulus	Cathepsin L homolog	0.0141	0.1163	0.178
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0633	0.5687	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0633	0.5687	0.5119
Leishmania major	cathepsin L-like protease	0.0633	0.5687	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0633	0.5687	1
Schistosoma mansoni	voltage-gated potassium channel	0.0031	0.0155	0.0155
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0021	0.0064	0.0064
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0021	0.0064	0.0064
Brugia malayi	Papain family cysteine protease containing protein	0.0341	0.2997	0.2997
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0021	0.0064	0.0064
Onchocerca volvulus	Cathepsin L homolog	0.0633	0.5687	1
Schistosoma mansoni	voltage-gated potassium channel	0.0021	0.0064	0.0064
Plasmodium vivax	vivapain-1	0.0341	0.2997	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0633	0.5687	1
Leishmania major	cathepsin L-like protease	0.0633	0.5687	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0434	0.3853	0.6739
Echinococcus multilocularis	cysteine protease	0.0633	0.5687	0.5687
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0633	0.5687	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0341	0.2997	0.2997
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0141	0.1163	0.1955
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0633	0.5687	1
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0141	0.1163	0.2045
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0141	0.1163	0.1163
Echinococcus granulosus	cathepsin L	0.0341	0.2997	0.2997
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0633	0.5687	0.5687
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1102	1	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0434	0.3853	0.3853
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0633	0.5687	1
Entamoeba histolytica	cysteine proteinase, putative	0.0633	0.5687	1
Brugia malayi	Cathepsin L-like precursor	0.0633	0.5687	0.5687
Trypanosoma cruzi	cysteine proteinase, putative	0.0341	0.2997	0.2075
Loa Loa (eye worm)	hypothetical protein	0.0141	0.1163	0.1163
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0633	0.5687	0.5687
Echinococcus multilocularis	cysteine protease	0.0633	0.5687	0.5687
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0141	0.1163	0.1163
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0633	0.5687	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0199	0.17	0.17
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0141	0.1163	0.1955
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0633	0.5687	1
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0141	0.1163	0.2045
Entamoeba histolytica	cysteine protease, putative	0.0341	0.2997	0.4054
Brugia malayi	fibroinase precursor	0.0141	0.1163	0.1163
Echinococcus multilocularis	cathepsin L	0.0141	0.1163	0.1163
Plasmodium falciparum	serine repeat antigen 5	0.0141	0.1163	0.2045
Onchocerca volvulus		0.0633	0.5687	1
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.015	0.1242	0.1242
Schistosoma mansoni	cathepsin C	0.0141	0.1163	0.1163
Trypanosoma cruzi	cysteine peptidase, putative	0.0199	0.17	0.0608
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0438	0.3896	0.6816
Entamoeba histolytica	cysteine proteinase, putative	0.0341	0.2997	0.4054
Leishmania major	cathepsin L-like protease	0.0633	0.5687	1
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0021	0.0064	0.0064
Echinococcus granulosus	cathepsin l1	0.0434	0.3853	0.3853
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0109	0.0864	0.0864
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0141	0.1163	0.1163
Entamoeba histolytica	cysteine protease, putative	0.0341	0.2997	0.4054
Giardia lamblia	Cathepsin B precursor	0.0438	0.3896	1
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0021	0.0064	0.0064
Entamoeba histolytica	cysteine protease, putative	0.0341	0.2997	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0633	0.5687	0.5119
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0434	0.3853	0.3044
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0434	0.3853	0.6739
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0031	0.0155	0.0155
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0633	0.5687	1
Entamoeba histolytica	cysteine protease, putative	0.0341	0.2997	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0633	0.5687	0.5119
Schistosoma mansoni	cathepsin s	0.0199	0.17	0.17
Brugia malayi	Papain family cysteine protease containing protein	0.0141	0.1163	0.1163
Onchocerca volvulus		0.0633	0.5687	1
Echinococcus granulosus	cathepsin L	0.0141	0.1163	0.1163
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0109	0.0864	0.0864
Onchocerca volvulus		0.0141	0.1163	0.178
Trypanosoma cruzi	cysteine proteinase, putative	0.0341	0.2997	0.2075
Schistosoma mansoni	cathepsin F (C01 family)	0.0633	0.5687	0.5687
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0633	0.5687	1
Brugia malayi	Cathepsin L-like precursor	0.0633	0.5687	0.5687
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0141	0.1163	0.1163
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0341	0.2997	0.5217
Loa Loa (eye worm)	hypothetical protein	0.0141	0.1163	0.1163
Brugia malayi	Cathepsin L-like precursor	0.0434	0.3853	0.3853
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1102	1	1
Echinococcus granulosus	hyperpolarization activated cyclic	0.0021	0.0064	0.0064
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0633	0.5687	1
Loa Loa (eye worm)	hypothetical protein	0.0141	0.1163	0.1163
Loa Loa (eye worm)	hypothetical protein	0.0141	0.1163	0.1163
Brugia malayi	Cathepsin L-like precursor	0.0633	0.5687	0.5687
Trichomonas vaginalis	conserved hypothetical protein	0.0141	0.1163	0.1955
Entamoeba histolytica	cysteine proteinase, putative	0.0341	0.2997	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0633	0.5687	1
Echinococcus multilocularis	voltage gated potassium channel	0.0031	0.0155	0.0155
Trypanosoma cruzi	cysteine peptidase, putative	0.0341	0.2997	0.2075
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1102	1	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0341	0.2997	0.4054
Brugia malayi	cathepsin F-like cysteine proteinase	0.0141	0.1163	0.1163
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0633	0.5687	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.1163	0.1955
Onchocerca volvulus		0.0434	0.3853	0.6668
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0633	0.5687	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0438	0.3896	0.3093
Entamoeba histolytica	cysteine protease, putative	0.0341	0.2997	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.1163	0.1955
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0109	0.0864	0.0864
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0341	0.2997	0.527
Onchocerca volvulus		0.0633	0.5687	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0633	0.5687	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0633	0.5687	0.5687
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0141	0.1163	0.1163
Plasmodium vivax	vivapain-2	0.0633	0.5687	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0633	0.5687	1
Echinococcus multilocularis	cathepsin L	0.0341	0.2997	0.2997
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0633	0.5687	1
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0021	0.0064	0.0064
Trypanosoma cruzi	cysteine protease, putative	0.0341	0.2997	0.2075
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0633	0.5687	1
Loa Loa (eye worm)	hypothetical protein	0.0199	0.17	0.17
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0141	0.1163	0.1163
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1102	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0633	0.5687	0.5687
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0633	0.5687	1
Toxoplasma gondii	cathepsin B	0.0438	0.3896	0.6852
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0155	0.0155
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0141	0.1163	0.1163
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0633	0.5687	1
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0021	0.0064	0.0064
Brugia malayi	cathepsin L-like precursor	0.0434	0.3853	0.3853
Schistosoma mansoni	cathepsin S (C01 family)	0.0141	0.1163	0.1163
Loa Loa (eye worm)	fibroinase	0.0633	0.5687	0.5687
Entamoeba histolytica	cysteine protease, putative	0.0341	0.2997	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0633	0.5687	1
Loa Loa (eye worm)	cysteine protease	0.0633	0.5687	0.5687
Echinococcus granulosus	cathepsin b	0.1102	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0438	0.3896	0.3896
Leishmania major	cathepsin L-like protease	0.0633	0.5687	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0633	0.5687	1
Schistosoma mansoni	voltage-gated potassium channel	0.0017	0.0024	0.0024
Loa Loa (eye worm)	ctsf protein	0.0633	0.5687	0.5687
Entamoeba histolytica	cysteine protease, putative	0.0633	0.5687	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.1163	0.1955
Leishmania major	cathepsin L-like protease	0.0633	0.5687	1
Schistosoma mansoni	voltage-gated potassium channel	0.0031	0.0155	0.0155
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0021	0.0064	0.0064
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0021	0.0064	0.0064
Echinococcus granulosus	cathepsin l1	0.0633	0.5687	0.5687
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0341	0.2997	0.5217
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0021	0.0064	0.0064
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0021	0.0064	0.0064
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0141	0.1163	0.1163
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0633	0.5687	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0633	0.5687	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0633	0.5687	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0064	0.0064
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0633	0.5687	1
Echinococcus granulosus	voltage gated potassium channel	0.0031	0.0155	0.0155
Echinococcus multilocularis	cathepsin b	0.1102	1	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0141	0.1163	0.1163
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.1163	0.1955
Loa Loa (eye worm)	hypothetical protein	0.0141	0.1163	0.1163
Echinococcus granulosus	cathepsin b	0.1102	1	1
Echinococcus granulosus	PKC activated phosphatase 1 inhibitor	0.0034	0.0183	0.0183
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0101	0.0799	0.1307
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0633	0.5687	1
Plasmodium falciparum	serine repeat antigen 9	0.0141	0.1163	0.2045
Schistosoma mansoni	protein kinase	0.015	0.1242	0.1242
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0021	0.0064	0.0064
Schistosoma mansoni	protein phosphatase 1 inhibitor potentiated by protein kinase C	0.0034	0.0183	0.0183
Schistosoma mansoni	voltage-gated potassium channel	0.0119	0.0956	0.0956
Entamoeba histolytica	cysteine protease, putative	0.0341	0.2997	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0141	0.1163	0.1955
Loa Loa (eye worm)	hypothetical protein	0.0199	0.17	0.17
Onchocerca volvulus		0.0633	0.5687	1
Brugia malayi	Papain family cysteine protease containing protein	0.0141	0.1163	0.1163
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1102	1	1
Loa Loa (eye worm)	hypothetical protein	0.0434	0.3853	0.3853
Echinococcus multilocularis	cathepsin L cysteine protease	0.0633	0.5687	0.5687
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0732	0.0732
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0141	0.1163	0.1163
Loa Loa (eye worm)	hypothetical protein	0.0199	0.17	0.17
Echinococcus multilocularis	PKC activated phosphatase 1 inhibitor	0.0034	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0183	0.0183
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0633	0.5687	1
Loa Loa (eye worm)	hypothetical protein	0.0434	0.3853	0.3853
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0021	0.0064	0.0064
Entamoeba histolytica	cysteine protease, putative	0.0341	0.2997	0.4054
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.015	0.1242	0.1242
Entamoeba histolytica	cysteine protease, putative	0.0341	0.2997	0.4054
Onchocerca volvulus	Cathepsin F homolog	0.0633	0.5687	1
Onchocerca volvulus		0.0633	0.5687	1
Trichomonas vaginalis	conserved hypothetical protein	0.0141	0.1163	0.1955
Brugia malayi	hypothetical protein	0.0034	0.0183	0.0183
Plasmodium falciparum	serine repeat antigen 4	0.0141	0.1163	0.2045
Plasmodium falciparum	serine repeat antigen 2	0.0141	0.1163	0.2045
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0141	0.1163	0.1163
Loa Loa (eye worm)	hypothetical protein	0.0141	0.1163	0.1163
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0141	0.1163	0.1955
Brugia malayi	Papain family cysteine protease containing protein	0.0141	0.1163	0.1163
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0141	0.1163	0.1163
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0633	0.5687	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.092 uM	Inhibition of human full-length LIMK2 expressed in Sf9 cells assessed as incorporation of [33P] from ATP into biotinylated-cofilin substrate in presence of 300 uM ATP	ChEMBL.	25589930

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3355498

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 943029