Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucosidase, beta, acid | Starlite/ChEMBL | References |
Homo sapiens | UDP-glucose ceramide glucosyltransferase | Starlite/ChEMBL | References |
Homo sapiens | maltase-glucoamylase (alpha-glucosidase) | Starlite/ChEMBL | References |
Homo sapiens | glucosidase, beta (bile acid) 2 | Starlite/ChEMBL | References |
Homo sapiens | sucrase-isomaltase (alpha-glucosidase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.5605 | 1 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.0251 | 0.322 | 0.3049 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.5605 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.5605 | 1 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.0288 | 0.4667 | 0.4667 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0423 | 1 | 1 |
Onchocerca volvulus | 0.0284 | 0.4526 | 0.9571 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.5605 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0423 | 1 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0288 | 0.4667 | 0.4532 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.5605 | 1 |
Echinococcus granulosus | bile acid beta glucosidase | 0.0251 | 0.322 | 0.3049 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0251 | 0.322 | 0.3049 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.5605 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0423 | 1 | 1 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0312 | 0.5605 | 0.1759 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0251 | 0.322 | 0.3049 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.0288 | 0.4667 | 1 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.0251 | 0.322 | 0.3049 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.0288 | 0.4667 | 0.4532 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0288 | 0.4667 | 0.4532 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.0251 | 0.322 | 0.3049 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0423 | 1 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0423 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.1812 | 0.1027 |
Schistosoma mansoni | alpha-glucosidase | 0.0423 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.1812 | 0.1027 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0312 | 0.5605 | 0.5605 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.0288 | 0.4667 | 0.4532 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2 nM | Inhibition of GBA2 (unknown origin) | ChEMBL. | 25250725 |
IC50 (binding) | = 75 nM | Inhibition of glucosylceramide synthase (unknown origin) assessed as catabolism of NBD-glucosylceramide | ChEMBL. | 25250725 |
IC50 (binding) | = 300 nM | Inhibition of GBA1 (unknown origin) using beta-D-[1-14C]glucocerebroside assessed as 4-methylumbelliferrone by fluorimetry | ChEMBL. | 25250725 |
IC50 (binding) | = 0.2 uM | Inhibition of intestinal sucrase (unknown origin) | ChEMBL. | 25250725 |
IC50 (binding) | = 1.5 uM | Inhibition of intestinal maltase (unknown origin) | ChEMBL. | 25250725 |
IC50 (binding) | = 20 uM | Inhibition of intestinal lactase (unknown origin) | ChEMBL. | 25250725 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.