TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 375.442 | Formula: C18H21N3O4S
H donors: 3 H acceptors: 4 LogP: 2.15 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(NC1C(=O)N2C1SC([C@@H]2C(=O)O)(C)C)N/C=C(/c1ccccc1)\C
InChi: 1S/C18H21N3O4S/c1-10(11-7-5-4-6-8-11)9-19-17(25)20-12-14(22)21-13(16(23)24)18(2,3)26-15(12)21/h4-9,12-13,15H,1-3H3,(H,23,24)(H2,19,20,25)/b10-9+/t12?,13-,15?/m0/s1
InChiKey: GETDZIUHRCVXRH-YZVZDWPMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	cysteine proteinase, putative	0.0497	0.2748	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0933	0.6591	1
Plasmodium vivax	vivapain-2	0.0933	0.6591	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1319	1	1
Onchocerca volvulus	Cathepsin F homolog	0.0933	0.6591	1
Echinococcus multilocularis	cathepsin b	0.1319	1	1
Echinococcus granulosus	cathepsin L	0.02	0.0128	0.0128
Entamoeba histolytica	cysteine proteinase, putative	0.0497	0.2748	0.4054
Schistosoma mansoni	cathepsin F (C01 family)	0.0636	0.3971	0.3971
Echinococcus granulosus	carboxylesterase 5A	0.0289	0.0912	0.0912
Entamoeba histolytica	cysteine protease, putative	0.0497	0.2748	0.4054
Giardia lamblia	Cathepsin B precursor	0.0546	0.3181	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0933	0.6591	1
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.02	0.0128	0.0128
Toxoplasma gondii	cathepsin B	0.0546	0.3181	0.4724
Brugia malayi	Papain family cysteine protease containing protein	0.02	0.0128	0.0128
Trypanosoma cruzi	cysteine peptidase, putative	0.0933	0.6591	0.6547
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0933	0.6591	1
Entamoeba histolytica	cysteine protease, putative	0.0933	0.6591	1
Onchocerca volvulus	Cathepsin L homolog	0.0933	0.6591	1
Brugia malayi	cathepsin L-like precursor	0.0636	0.3971	0.3971
Loa Loa (eye worm)	hypothetical protein	0.02	0.0128	0.0128
Brugia malayi	cathepsin F-like cysteine proteinase	0.0297	0.098	0.098
Trypanosoma cruzi	cysteine peptidase, putative	0.0497	0.2748	0.2654
Echinococcus multilocularis	acetylcholinesterase	0.0289	0.0912	0.0912
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0933	0.6591	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0933	0.6591	0.6591
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0933	0.6591	1
Loa Loa (eye worm)	cathepsin B	0.0546	0.3181	0.3181
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.02	0.0128	0.0128
Brugia malayi	fibroinase precursor	0.02	0.0128	0.0128
Loa Loa (eye worm)	hypothetical protein	0.02	0.0128	0.0128
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.02	0.0128	0.0128
Brugia malayi	Papain family cysteine protease containing protein	0.02	0.0128	0.0128
Brugia malayi	cathepsin F-like cysteine proteinase	0.02	0.0128	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0289	0.0912	0.0912
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.02	0.0128	0.0128
Entamoeba histolytica	cysteine protease, putative	0.0497	0.2748	0.4054
Brugia malayi	Carboxylesterase family protein	0.0289	0.0912	0.0912
Leishmania major	cysteine peptidase A (CPA)	0.0933	0.6591	1
Schistosoma mansoni	cathepsin s	0.0297	0.098	0.098
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.02	0.0128	0.0128
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0933	0.6591	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0933	0.6591	0.6547
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0933	0.6591	1
Schistosoma mansoni	cathepsin S (C01 family)	0.02	0.0128	0.0128
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0636	0.3971	0.5946
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.02	0.0128	0.0128
Loa Loa (eye worm)	cysteine protease	0.0933	0.6591	0.6591
Entamoeba histolytica	cysteine proteinase, putative	0.0497	0.2748	0.4054
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0497	0.2748	0.2748
Trypanosoma cruzi	cysteine peptidase, putative	0.0297	0.098	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0557	0.3274	0.3274
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0933	0.6591	1
Onchocerca volvulus		0.0933	0.6591	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0933	0.6591	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0933	0.6591	0.6591
Entamoeba histolytica	cysteine protease, putative	0.0497	0.2748	0.4054
Loa Loa (eye worm)	ctsf protein	0.0933	0.6591	0.6591
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0933	0.6591	1
Echinococcus multilocularis	cysteine protease	0.0933	0.6591	0.6591
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0933	0.6591	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0933	0.6591	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0497	0.2748	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0497	0.2748	0.4054
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0933	0.6591	0.6591
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0933	0.6591	1
Loa Loa (eye worm)	hypothetical protein	0.0289	0.0912	0.0912
Loa Loa (eye worm)	hypothetical protein	0.1319	1	1
Schistosoma mansoni	voltage-gated potassium channel	0.0701	0.4541	0.4541
Plasmodium vivax	unspecified product	0.0497	0.2748	0.4054
Onchocerca volvulus		0.0933	0.6591	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0297	0.098	0.098
Leishmania major	cathepsin L-like protease	0.0933	0.6591	1
Echinococcus multilocularis	cathepsin L	0.0497	0.2748	0.2748
Toxoplasma gondii	cathepsin CPL	0.0933	0.6591	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0933	0.6591	0.6591
Brugia malayi	cathepsin Z-like cysteine proteinase	0.02	0.0128	0.0128
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0933	0.6591	0.6591
Echinococcus multilocularis	carboxylesterase 5A	0.0289	0.0912	0.0912
Brugia malayi	Cathepsin L-like precursor	0.0933	0.6591	0.6591
Echinococcus granulosus	cathepsin L	0.0497	0.2748	0.2748
Loa Loa (eye worm)	fibroinase	0.0933	0.6591	0.6591
Echinococcus granulosus	cathepsin L cysteine protease	0.0497	0.2748	0.2748
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0933	0.6591	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0933	0.6591	0.6591
Brugia malayi	Papain family cysteine protease containing protein	0.02	0.0128	0.0128
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1319	1	1
Echinococcus granulosus	cathepsin b	0.1319	1	1
Loa Loa (eye worm)	carboxylesterase	0.0289	0.0912	0.0912
Loa Loa (eye worm)	hypothetical protein	0.02	0.0128	0.0128
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0933	0.6591	1
Brugia malayi	Cathepsin L-like precursor	0.0933	0.6591	0.6591
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0933	0.6591	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0933	0.6591	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0933	0.6591	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0599	0.3649	0.5448
Schistosoma mansoni	cathepsin B (C01 family)	0.02	0.0128	0.0128
Echinococcus granulosus	cathepsin l1	0.0933	0.6591	0.6591
Entamoeba histolytica	cysteine proteinase, putative	0.0933	0.6591	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0933	0.6591	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0289	0.0912	0.0912
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0933	0.6591	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0497	0.2748	0.2654
Entamoeba histolytica	cysteine protease, putative	0.0497	0.2748	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0497	0.2748	0.4054
Brugia malayi	Carboxylesterase family protein	0.0289	0.0912	0.0912
Leishmania major	cathepsin L-like protease	0.0933	0.6591	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0546	0.3181	0.1127
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0546	0.3181	0.4724
Brugia malayi	Papain family cysteine protease containing protein	0.0497	0.2748	0.2748
Entamoeba histolytica	cysteine protease, putative	0.0497	0.2748	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0933	0.6591	1
Onchocerca volvulus		0.0933	0.6591	1
Brugia malayi	Papain family cysteine protease containing protein	0.0933	0.6591	0.6591
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0933	0.6591	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.02	0.0128	0.0128
Echinococcus multilocularis	cathepsin L cysteine protease	0.0933	0.6591	0.6591
Brugia malayi	cathepsin L precursor	0.02	0.0128	0.0128
Onchocerca volvulus		0.0636	0.3971	0.5946
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0933	0.6591	1
Schistosoma mansoni	voltage-gated potassium channel	0.0701	0.4541	0.4541
Leishmania major	cathepsin L-like protease	0.0933	0.6591	1
Echinococcus granulosus	cysteine protease	0.0497	0.2748	0.2748
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.02	0.0128	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0636	0.3971	0.3971
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.02	0.0128	0.0128
Schistosoma mansoni	cathepsin F (C01 family)	0.0933	0.6591	0.6591
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0933	0.6591	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1319	1	1
Giardia lamblia	Cathepsin B precursor	0.0546	0.3181	1
Entamoeba histolytica	cysteine protease, putative	0.0497	0.2748	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.02	0.0128	0.0128
Plasmodium vivax	vivapain-1	0.0497	0.2748	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0933	0.6591	0.6547
Plasmodium vivax	vivapain-3	0.0497	0.2748	0.4054
Echinococcus multilocularis	acetylcholinesterase	0.0289	0.0912	0.0912
Loa Loa (eye worm)	acetylcholinesterase 1	0.0289	0.0912	0.0912
Entamoeba histolytica	cysteine protease, putative	0.0497	0.2748	0.4054
Leishmania major	cathepsin L-like protease	0.0933	0.6591	1
Echinococcus multilocularis	cysteine protease	0.0933	0.6591	0.6591
Echinococcus granulosus	cathepsin b	0.1319	1	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0599	0.3649	0.5448
Echinococcus granulosus	acetylcholinesterase	0.0289	0.0912	0.0912
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0933	0.6591	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0642	0.4021	0.4021
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0933	0.6591	1
Echinococcus multilocularis	cathepsin L	0.02	0.0128	0.0128
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0933	0.6591	0.6591
Entamoeba histolytica	cysteine proteinase 1, putative	0.0497	0.2748	0.4054
Schistosoma mansoni	cathepsin C	0.02	0.0128	0.0128
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1319	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1319	1	1
Onchocerca volvulus		0.0933	0.6591	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0933	0.6591	1
Loa Loa (eye worm)	hypothetical protein	0.02	0.0128	0.0128
Trypanosoma cruzi	cruzipain precursor, putative	0.0297	0.098	0.0863
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.02	0.0128	0.0128
Loa Loa (eye worm)	hypothetical protein	0.02	0.0128	0.0128
Entamoeba histolytica	cysteine protease, putative	0.0497	0.2748	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0933	0.6591	1
Loa Loa (eye worm)	hypothetical protein	0.0297	0.098	0.098
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0642	0.4021	0.4021
Leishmania major	cathepsin L-like protease	0.0933	0.6591	1
Entamoeba histolytica	cysteine proteinase, putative	0.0933	0.6591	1
Brugia malayi	Cathepsin L-like precursor	0.0933	0.6591	0.6591
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0933	0.6591	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0933	0.6591	1
Entamoeba histolytica	cysteine proteinase, putative	0.0497	0.2748	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0546	0.3181	0.3181
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0933	0.6591	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0497	0.2748	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0636	0.3971	0.3971
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.02	0.0128	0.0128
Entamoeba histolytica	cysteine proteinase 2	0.0497	0.2748	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0636	0.3971	0.3971
Echinococcus granulosus	acetylcholinesterase	0.0289	0.0912	0.0912
Onchocerca volvulus	Cathepsin L homolog	0.0933	0.6591	1
Onchocerca volvulus		0.0933	0.6591	1
Giardia lamblia	Cathepsin B precursor	0.0546	0.3181	1
Brugia malayi	Cathepsin L-like precursor	0.0933	0.6591	0.6591
Trypanosoma cruzi	cysteine peptidase, putative	0.0933	0.6591	0.6547
Entamoeba histolytica	cysteine protease, putative	0.0497	0.2748	0.4054
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0642	0.4021	0.4021
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0497	0.2748	0.4054
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0546	0.3181	0.3093
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0933	0.6591	1
Entamoeba histolytica	cysteine protease, putative	0.0497	0.2748	0.4054
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0636	0.3971	0.3971
Loa Loa (eye worm)	hypothetical protein	0.0636	0.3971	0.3971
Leishmania major	cathepsin L-like protease	0.0933	0.6591	1
Brugia malayi	Cathepsin L-like precursor	0.0933	0.6591	0.6591
Trypanosoma cruzi	cysteine proteinase, putative	0.0497	0.2748	0.2654
Brugia malayi	Cathepsin L-like precursor	0.0297	0.098	0.098
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0933	0.6591	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0933	0.6591	0.6547
Loa Loa (eye worm)	hypothetical protein	0.0297	0.098	0.098
Entamoeba histolytica	cysteine proteinase, putative	0.0636	0.3971	0.5946
Plasmodium vivax	unspecified product	0.0297	0.098	0.1319
Echinococcus granulosus	cathepsin l1	0.0636	0.3971	0.3971
Brugia malayi	cathepsin L-like cysteine proteinase	0.02	0.0128	0.0128
Trypanosoma cruzi	cysteine protease, putative	0.0497	0.2748	0.2654
Echinococcus multilocularis	cathepsin b	0.1319	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0933	0.6591	0.6591
Plasmodium vivax	vivapain-2	0.0933	0.6591	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0497	0.2748	0.2654
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.02	0.0128	0.0128
Leishmania major	cathepsin L-like protease	0.0933	0.6591	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0636	0.3971	0.3893
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0933	0.6591	1
Loa Loa (eye worm)	hypothetical protein	0.0933	0.6591	0.6591
Brugia malayi	cathepsin Z-like cysteine proteinase	0.02	0.0128	0.0128
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0642	0.4021	0.4021
Loa Loa (eye worm)	hypothetical protein	0.02	0.0128	0.0128
Brugia malayi	Papain family cysteine protease containing protein	0.0497	0.2748	0.2748
Entamoeba histolytica	cysteine protease, putative	0.0497	0.2748	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0933	0.6591	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0636	0.3971	0.5946
Leishmania major	cathepsin L-like protease	0.0933	0.6591	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0933	0.6591	1
Loa Loa (eye worm)	hypothetical protein	0.0297	0.098	0.098
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0933	0.6591	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0297	0.098	0.098
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0933	0.6591	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0497	0.2748	0.2748
Brugia malayi	Cathepsin L-like precursor	0.0933	0.6591	0.6591
Onchocerca volvulus		0.0933	0.6591	1
Onchocerca volvulus		0.0933	0.6591	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0497	0.2748	0.2748
Brugia malayi	Cathepsin L-like precursor	0.0636	0.3971	0.3971
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0933	0.6591	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1204762

Bibliographic References

No literature references available for this target.

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Detailed information for compound 944846