Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0046 | 0.0145 | 0.0145 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.421 | 0.4125 |
Schistosoma mansoni | tyrosine kinase | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | FAT-3 protein | 0.0096 | 0.5176 | 0.5105 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0144 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0077 | 0.3217 | 0.3117 |
Schistosoma mansoni | tyrosine kinase | 0.0077 | 0.3217 | 0.3117 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.5176 | 0.5105 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0077 | 0.3299 | 0.32 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0144 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0077 | 0.3299 | 0.3299 |
Schistosoma mansoni | tyrosine kinase | 0.0077 | 0.3217 | 0.3117 |
Schistosoma mansoni | tyrosine kinase | 0.0077 | 0.3299 | 0.32 |
Leishmania major | delta-5 fatty acid desaturase | 0.0096 | 0.5176 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0077 | 0.3299 | 0.32 |
Echinococcus multilocularis | insulin receptor | 0.0046 | 0.0145 | 0.0145 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0144 | 1 | 1 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0077 | 0.3299 | 0.32 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0096 | 0.5176 | 0.5105 |
Schistosoma mansoni | fatty acid desaturase | 0.0096 | 0.5207 | 0.5136 |
Onchocerca volvulus | 0.0096 | 0.5207 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.