Detailed information for compound 946471

Basic information

Technical information
  • TDR Targets ID: 946471
  • Name: 2-(4-methoxyphenyl)-1,3-oxazole
  • MW: 175.184 | Formula: C10H9NO2
  • H donors: 0 H acceptors: 1 LogP: 1.97 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1ncco1
  • InChi: 1S/C10H9NO2/c1-12-9-4-2-8(3-5-9)10-11-6-7-13-10/h2-7H,1H3
  • InChiKey: KQGVUFHHBWEAIG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-methoxyphenyl)oxazole

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis smad 0.0033 0.0006 0.0016
Brugia malayi protein ZK524.3 0.0087 0.1014 0.1014
Schistosoma mansoni hypothetical protein 0.018 0.274 0.4127
Schistosoma mansoni tar DNA-binding protein 0.0137 0.1935 0.2915
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0006 0.0006
Brugia malayi hypothetical protein 0.0051 0.0326 0.0326
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.018 0.274 0.7487
Echinococcus multilocularis GPCR, family 2 0.018 0.274 0.7487
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0326 0.0891
Brugia malayi methionyl-tRNA synthetase 0.0087 0.1014 0.1014
Echinococcus multilocularis tar DNA binding protein 0.0137 0.1935 0.5288
Chlamydia trachomatis methionine--tRNA ligase 0.0087 0.1014 0.5
Treponema pallidum methionyl-tRNA synthetase 0.0087 0.1014 0.5
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0229 0.366 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0087 0.1014 0.1014
Brugia malayi MH2 domain containing protein 0.049 0.8561 0.8561
Toxoplasma gondii methionyl-tRNA synthetase 0.0229 0.366 1
Plasmodium falciparum methionine--tRNA ligase, putative 0.0087 0.1014 0.277
Leishmania major hypothetical protein, conserved 0.0051 0.0326 0.0891
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0326 0.0891
Echinococcus granulosus tar DNA binding protein 0.0137 0.1935 0.5288
Echinococcus granulosus Smad4 0.0033 0.0006 0.0016
Onchocerca volvulus 0.0141 0.2027 0.5
Plasmodium vivax methionine--tRNA ligase, putative 0.0087 0.1014 0.277
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0229 0.366 1
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0229 0.366 1
Schistosoma mansoni tar DNA-binding protein 0.0137 0.1935 0.2915
Schistosoma mansoni Smad4 0.0033 0.0006 0.0009
Loa Loa (eye worm) RNA binding protein 0.0137 0.1935 0.1935
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.018 0.274 0.7487
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0326 0.0891
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0229 0.366 1
Giardia lamblia Methionyl-tRNA synthetase 0.0229 0.366 1
Loa Loa (eye worm) Smad1 0.0033 0.0006 0.0006
Loa Loa (eye worm) MH2 domain-containing protein 0.049 0.8561 0.8561
Brugia malayi Smad1 0.0033 0.0006 0.0006
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0137 0.1935 0.1935
Loa Loa (eye worm) transcription factor SMAD2 0.049 0.8561 0.8561
Brugia malayi RNA recognition motif domain containing protein 0.0137 0.1935 0.1935
Loa Loa (eye worm) hypothetical protein 0.0087 0.1014 0.1014
Schistosoma mansoni hypothetical protein 0.018 0.274 0.4127
Brugia malayi MH2 domain containing protein 0.0033 0.0006 0.0006
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0326 0.0891
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0229 0.366 1
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0326 0.0891
Leishmania major methionyl-tRNA synthetase, putative 0.0229 0.366 1
Schistosoma mansoni tar DNA-binding protein 0.0137 0.1935 0.2915
Loa Loa (eye worm) hypothetical protein 0.0388 0.664 0.664
Schistosoma mansoni hypothetical protein 0.018 0.274 0.4127
Schistosoma mansoni smad1 5 8 and 0.0033 0.0006 0.0009
Brugia malayi Calcitonin receptor-like protein seb-1 0.0567 1 1
Treponema pallidum leucyl-tRNA synthetase 0.0087 0.1014 0.5
Echinococcus multilocularis leucyl tRNA synthetase 0.0087 0.1014 0.277
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0006 0.0016
Echinococcus granulosus methionine tRNA synthetase 0.0229 0.366 1
Schistosoma mansoni tar DNA-binding protein 0.0137 0.1935 0.2915
Loa Loa (eye worm) tyrosyl-tRNA synthetase 0.0141 0.2027 0.2027
Leishmania major leucyl-tRNA synthetase, putative 0.0087 0.1014 0.277
Plasmodium vivax hypothetical protein, conserved 0.0087 0.1014 0.277
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0006 0.0016
Schistosoma mansoni leucyl-tRNA synthetase 0.0087 0.1014 0.1527
Schistosoma mansoni hypothetical protein 0.018 0.274 0.4127
Brugia malayi TAR-binding protein 0.0137 0.1935 0.1935
Schistosoma mansoni methionine-tRNA synthetase 0.0087 0.1014 0.1527
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.018 0.274 0.7487
Echinococcus multilocularis methionine tRNA synthetase 0.0229 0.366 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0326 0.0891
Toxoplasma gondii tRNA ligases class I (M) protein 0.0087 0.1014 0.277
Loa Loa (eye worm) hypothetical protein 0.0051 0.0326 0.0326
Loa Loa (eye worm) hypothetical protein 0.0087 0.1014 0.1014
Brugia malayi methionyl-tRNA synthetase 0.0229 0.366 0.366
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0229 0.366 1
Schistosoma mansoni smad 0.0033 0.0006 0.0009
Brugia malayi MH1 domain containing protein 0.0033 0.0006 0.0006
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.018 0.274 0.274
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0006 0.0016
Loa Loa (eye worm) TAR-binding protein 0.0137 0.1935 0.1935
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0006 0.0016
Plasmodium falciparum methionine--tRNA ligase 0.0229 0.366 1
Schistosoma mansoni hypothetical protein 0.0388 0.664 1
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0229 0.366 0.366
Schistosoma mansoni smad1 5 8 and 0.0033 0.0006 0.0009
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0567 1 1
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0087 0.1014 0.277
Echinococcus granulosus smad 0.0033 0.0006 0.0016
Brugia malayi MH1 domain containing protein 0.0033 0.0006 0.0006
Schistosoma mansoni tar DNA-binding protein 0.0137 0.1935 0.2915
Loa Loa (eye worm) latrophilin receptor protein 2 0.018 0.274 0.274
Schistosoma mansoni smad1 5 8 and 0.0033 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.018 0.274 0.274
Plasmodium vivax methionine--tRNA ligase, putative 0.0229 0.366 1
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0326 0.0891
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0087 0.1014 0.277
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0087 0.1014 0.5
Echinococcus granulosus GPCR family 2 0.018 0.274 0.7487
Brugia malayi RNA binding protein 0.0137 0.1935 0.1935
Loa Loa (eye worm) hypothetical protein 0.0567 1 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.018 0.274 0.7487
Brugia malayi Latrophilin receptor protein 2 0.018 0.274 0.274
Echinococcus multilocularis Smad4 0.0033 0.0006 0.0016
Brugia malayi MH2 domain containing protein 0.0033 0.0006 0.0006
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0229 0.366 0.5
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0006 0.0009
Brugia malayi latrophilin 2 splice variant baaae 0.0388 0.664 0.664
Schistosoma mansoni methionine-tRNA synthetase 0.0229 0.366 0.5513
Chlamydia trachomatis leucine--tRNA ligase 0.0087 0.1014 0.5

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 100 uM Growth inhibition of adult Caenorhabditis elegans measured on day 3 by microscopy ChEMBL. 25488842

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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